Biography
Dr. Hobart W. Harris is an expert in treating surgical infections, diseases of the pancreas and biliary system and abdominal wall hernias, including pancreas, gallbladder and bile duct cancer, acute and chronic pancreatitis, islet autotransplantation for chronic pancreatitis, complex gallstone disease, intra-abdominal sepsis, serious infections of the skin and soft tissue, and enterocutaneous fistulas. He treats patients with complicated and often life-threatening conditions through the Complex Abdominal Surgery Program. Dr. Harris is also a pioneer and leader in the management and repair of complex ventral (incisional) hernias. Specifically, he is an expert at repairing gigantic ventral hernias, where closure of the defect and reconstructing the abdominal wall requires advanced techniques, such as progressive pneumoperiteum whereby the abdominal wall muscles are first stretched prior to repairing the hernia.
Dr. Harris earned his undergraduate, medical and public health degrees at Harvard University, before completing an internship and residency in general surgery at UCSF. After residency training, he completed a fellowship in Hepatobiliary Surgery at the University of Hong Kong, Queen Mary Hospital before joining the faculty at UCSF in 1994. Harris is a Fellow of the American College of Surgeons and is a member of numerous surgical and scientific societies including the American Surgical Association.
Videos
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
Harvard University | M.D. | School of Medicine | 1983 |
University of California, San Francisco | Residency | School of Medicine - Surgery |
Board Certifications
- American Board of Surgery, 1994
Clinical Expertise
Acute Pancreatitis
Bile Duct Injuries
Chronic Pancreatitis
Gall Bladder Disease
Ventral (Incisional) Hernia
Complex Abdominal Surgery
Recurrent Hernia
Laparoscopic Inguinal Hernia Repair
Gastrointestinal Cancer
Gastrointestinal Surgery
Intra-abdominal Sepsis
Pancreas Surgery
Pancreatic Cancer
Soft Tissue Infections
Enterocutaneous Fistula
Hepatobiliary Surgery
Clinical Trials
- Related Conditions: Laparotomy, Hernia| Start Date: | End Date:
- A Study of Fibrin Sealant Plus Silver Microparticles to Prevent Incisional Hernias Following Abdominal Surgery (NCT02584153)Related Conditions: Hernia, Ventral Hernia| Start Date: | End Date:
- Related Conditions: Hernia, Ventral Hernia| Start Date: | End Date:
In the News
Grants and Funding
- Research Training in Gastrointestinal Surgery | NIH | 1988-07-01 - 2021-06-30 | Role: Principal Investigator
- Complex Ventral Hernia Repair | NIH | 2013-07-15 - 2017-06-30 | Role: Principal Investigator
- Lipoproteins and Microbial Immunity | NIH | 2010-08-15 - 2015-07-31 | Role: Principal Investigator
- Lipoproteins Modulate the Hepatic Response to Endotoxin | NIH | 1999-05-01 - 2010-01-31 | Role: Principal Investigator
- General Clinical Research Center | NIH | 1974-10-01 - 2007-11-30 | Role: Co-Investigator
- CHYLOMICRON REMNANTS &ATHEROSCLEROSIS | NIH | 1988-11-05 - 1900-01-01 | Role: Principal Investigator
Research Narrative
Dr. Harris is Director of the Infection, Injury and Immunity Lab. His research focuses on surgical infections, innate immunity and the management of complex ventral hernias. He is also an innovator, inventor and entrepreneur in the surgical field.
Research Pathways
Publications
- Tertiary lymphoid structures sustain cutaneous B cell activity in hidradenitis suppurativa.| | View in PubMed
- Quality of life measures and cost analysis of biologic versus synthetic mesh for ventral hernia repair: The Preventing Recurrence in Clean and Contaminated Hernias randomized clinical trial.| | View in PubMed
- Data Requirement for Animal-Derived Wound Care Devices: Limitations of the 510(k) Regulatory Pathway.| | View in PubMed
- Feasibility of Gastrografin Use for Adhesive Small Bowel Obstruction in Low-Income Countries.| | View in PubMed
- Biologic Versus Synthetic Mesh in Ventral Hernia Repair: Participant-Level Analysis of Two Randomized Controlled Trials at Twenty-Four to Thirty-Six Months.| | View in PubMed
- Tertiary Lymphoid Structures Sustain Cutaneous B cell Activity in Hidradenitis Suppurativa.| | View in PubMed
- Expert Consensus for Key Features of Operative Reports of Ventral Hernia.| | View in PubMed
- Updated guideline for closure of abdominal wall incisions from the European and American Hernia Societies.| | View in PubMed
- Innovations for Incisional Hernia Prevention.| | View in PubMed
- Immunopathogenesis of hidradenitis suppurativa and response to anti-TNF-α therapy.| | View in PubMed
- Cost-Effectiveness Analysis of Inguinal Hernia Repair With Mesh Performed by Surgeons and Medical Doctors in Ghana.| | View in PubMed
- Early-life inflammation primes a T helper 2 cell-fibroblast niche in skin.| | View in PubMed
- Layilin Anchors Regulatory T Cells in Skin.| | View in PubMed
- Burden of Ionizing Radiation in the Diagnosis and Management of Necrotizing Pancreatitis.| | View in PubMed
- Preventing Recurrence in Clean and Contaminated Hernias Using Biologic Versus Synthetic Mesh in Ventral Hernia Repair: The PRICE Randomized Clinical Trial.| | View in PubMed
- Enhanced Stress Resilience Training in Surgeons: Iterative Adaptation and Biopsychosocial Effects in 2 Small Randomized Trials.| | View in PubMed
- Jejunal prolapse and incarceration following feeding tube exchange.| | View in PubMed
- Immunopathogenesis of hidradenitis suppurativa and response to anti-TNF-α therapy.| | View in PubMed
- Upper Gastrointestinal Endoscopy in an Academic General Surgical Program: Implications for Acute Care Surgeons.| | View in PubMed
- Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues.| | View in PubMed
- Key factors for implementing mindfulness-based burnout interventions in surgery.| | View in PubMed
- Integrating Robotic Technology Into Resident Training: Challenges and Recommendations From the Front Lines.| | View in PubMed
- Outcomes After Inguinal Hernia Repair With Mesh Performed by Medical Doctors and Surgeons in Ghana.| | View in PubMed
- Practice Patterns and Attitudes of Surgeons on the Use of Prophylactic Mesh to Prevent Parastola Hernia: A Cross-sectional Survey.| | View in PubMed
- Efficacy of Mindfulness-Based Cognitive Training in Surgery: Additional Analysis of the Mindful Surgeon Pilot Randomized Clinical Trial.| | View in PubMed
- Comparison of Tumor Regression Grading of Residual Pancreatic Ductal Adenocarcinoma Following Neoadjuvant Chemotherapy Without Radiation: Would Fewer Tier-Stratification Be Favorable Toward Standardization?| | View in PubMed
- Feasibility of Formal Mindfulness-Based Stress-Resilience Training Among Surgery Interns: A Randomized Clinical Trial.| | View in PubMed
- Secondary peritonitis: principles of diagnosis and intervention.| | View in PubMed
- A Coupled Magnetoelastic Strain Sensor Array for Guiding and Monitoring Hernia Repairs.| | View in PubMed
- Contemporary concepts in hernia prevention: Selected proceedings from the 2017 International Symposium on Prevention of Incisional Hernias.| | View in PubMed
- Silver microparticles plus fibrin tissue sealant prevents incisional hernias in rats.| | View in PubMed
- Burnout and Stress Among US Surgery Residents: Psychological Distress and Resilience.| | View in PubMed
- Impact of surgical intensive care unit interdisciplinary rounds on interprofessional collaboration and quality of care: Mixed qualitative-quantitative study.| | View in PubMed
- Integrating coupled magnetoelastic sensors onto a flexible hernia mesh for high dynamic range strain measurements.| | View in PubMed
- Preoperative FOLFIRINOX for borderline resectable pancreatic cancer: Is radiation necessary in the modern era of chemotherapy?| | View in PubMed
- Postoperative Prophylactic Antibiotic Use following Ventral Hernia Repair with Placement of Surgical Drains Reduces the Postoperative Surgical-Site Infection Rate.| | View in PubMed
- Towards a full-field strain sensor for guiding hernia repairs.| | View in PubMed
- Appendicitis within Morgagni Hernia and simultaneous Paraesophageal Hernia.| | View in PubMed
- Low-dose cyclophosphamide improves survival in a murine treatment model of sepsis.| | View in PubMed
- A prospective, randomized controlled trial of single-incision laparoscopic vs conventional 3-port laparoscopic appendectomy for treatment of acute appendicitis.| | View in PubMed
- Memory regulatory T cells reside in human skin.| | View in PubMed
- Clinical outcomes of biologic mesh: where do we stand?| | View in PubMed
- Biologic mesh for ventral hernia repair: a cautionary tale.| | View in PubMed
- Characterizing the global burden of surgical disease: a method to estimate inguinal hernia epidemiology in Ghana.| | View in PubMed
- Does increased experience with laparoscopic cholecystectomy yield more complex bile duct injuries?| | View in PubMed
- Heparin protects against septic mortality via apoE-antagonism.| | View in PubMed
- NKT cells: the culprits of sepsis?| | View in PubMed
- NKT cells in sepsis.| | View in PubMed
- Chylomicrons combined with endotoxin moderate microvascular permeability.| | View in PubMed
- An expanding role for apolipoprotein E in sepsis and inflammation.| | View in PubMed
- Prospective randomized trial of LC+LCBDE vs ERCP/S+LC for common bile duct stone disease.| | View in PubMed
- Open incisional hernia repair at an academic tertiary care medical center.| | View in PubMed
- Enteric fistulas: principles of management.| | View in PubMed
- Anaphylaxis caused by recurrent hydatid disease.| | View in PubMed
- Variation in annual volume at a university hospital does not predict mortality for pancreatic resections.| | View in PubMed
- Predicting strangulated small bowel obstruction: an old problem revisited.| | View in PubMed
- Apolipoprotein E-mediated immune regulation in sepsis.| | View in PubMed
- The future of general surgery.| | View in PubMed
- Actinomycosis mimicking a pancreatic head neoplasm diagnosed by EUS-guided FNA.| | View in PubMed
- The value of teaching anatomy to medical students.| | View in PubMed
- Pancreaticoduodenectomy: volume is not associated with outcome within an academic health care system.| | View in PubMed
- The surgical hospitalist: a new solution for emergency surgical care?| | View in PubMed
- Randomized, double-blind, placebo-controlled trial of cephalexin for treatment of uncomplicated skin abscesses in a population at risk for community-acquired methicillin-resistant Staphylococcus aureus infection.| | View in PubMed
- Chylomicron-bound LPS selectively inhibits the hepatocellular response to proinflammatory cytokines.| | View in PubMed
- The surgical hospitalist: a new model for emergency surgical care.| | View in PubMed
- Enhancing the mission of academic surgery by promoting scientific writing skills.| | View in PubMed
- Antibiotic use in the treatment of soft tissue abscesses: a survey of current practice.| | View in PubMed
- Exporting excellence for Whipple resection to refine the Leapfrog Initiative.| | View in PubMed
- Inappropriate antibiotic use in soft tissue infections.| | View in PubMed
- Applying Ockham's razor to pancreatitis prognostication: a four-variable predictive model.| | View in PubMed
- Statins attenuate sepsis.| | View in PubMed
- Triglyceride-rich lipoproteins as agents of innate immunity.| | View in PubMed
- Apolipoprotein E: from Alzheimer's to sepsis.| | View in PubMed
- Image of the month--quiz case. Traumatic intramuscular cyst of the duodenum.| | View in PubMed
- Cholecystectomy after endoscopic sphincterotomy for common bile duct stones: is surgery necessary?| | View in PubMed
- Early nonenhanced abdominal computed tomography can predict mortality in severe acute pancreatitis.| | View in PubMed
- Heat shock inhibits NF-kB activation in a dose- and time-dependent manner.| | View in PubMed
- Lipoproteins are protective beyond high-density lipoprotein cholesterol and heart disease.| | View in PubMed
- The evolution of endoscopy: wireless capsule cameras for the diagnosis of occult gastrointestinal bleeding and inflammatory bowel disease.| | View in PubMed
- Lipoprotein-bound endotoxin exerts an immunomodulatory effect on hepatocytes through the lipid A domain of LPS.| | View in PubMed
- An epidemic of methicillin-resistant Staphylococcus aureus soft tissue infections among medically underserved patients.| | View in PubMed
- Induction of cytokine tolerance requires internalization of Chylomicron-Bound LPS into hepatocytes.| | View in PubMed
- Gallbladder ascariasis in a patient with severe pancreatitis.| | View in PubMed
- Induction of cytokine tolerance in rodent hepatocytes by chylomicron-bound LPS is low-density lipoprotein receptor dependent.| | View in PubMed
- Lipoprotein-bound LPS induces cytokine tolerance in hepatocytes.| | View in PubMed
- Care of injection drug users with soft tissue infections in San Francisco, California.| | View in PubMed
- Chylomicron-bound endotoxin selectively inhibits NF-kappaB activation in rat hepatocytes.| | View in PubMed
- Hepatic endosomal trafficking of lipoprotein-bound endotoxin in rats.| | View in PubMed
- Endogenous lipoproteins impact the response to endotoxin in humans.| | View in PubMed
- Necrotizing pancreatitis during pregnancy: a rare cause and review of the literature.| | View in PubMed
- Extracellular matrix regulates the hepatocellular heat shock response.| | View in PubMed
- The lipemia of sepsis: triglyceride-rich lipoproteins as agents of innate immunity.| | View in PubMed
- Diet-induced protection against lipopolysaccharide includes increased hepatic NO production.| | View in PubMed
- Leukocytosis and free fluid are important indicators of isolated intestinal injury after blunt trauma.| | View in PubMed
- Obstructive jaundice alters Kupffer cell function independent of bacterial translocation.| | View in PubMed
- Recurrent pyogenic cholangitis.| | View in PubMed
- Chylomicrons alter the hepatic distribution and cellular response to endotoxin in rats.| | View in PubMed
- Changing management of gallstone disease during pregnancy.| | View in PubMed
- Surgical risk assessment and management in patients with HIV disease.| | View in PubMed
- Sepsis increases endocytosis of endotoxin into hepatocytes.| | View in PubMed
- The protective effect of serum lipoproteins against bacterial lipopolysaccharide.| | View in PubMed
- Chylomicrons enhance endotoxin excretion in bile.| | View in PubMed
- Chylomicrons alter the fate of endotoxin, decreasing tumor necrosis factor release and preventing death.| | View in PubMed
- Chylomicrons can inhibit endotoxin activity in vitro.| | View in PubMed
- Detection of endotoxin in triglyceride-rich lipoproteins in vitro.| | View in PubMed
- Human very low density lipoproteins and chylomicrons can protect against endotoxin-induced death in mice.| | View in PubMed
- Saphenous vein bypass to pedal arteries. An aggressive strategy for foot salvage.| | View in PubMed
- Identification of aortic thrombus by magnetic resonance imaging.| | View in PubMed
- Particle size distribution of lipoproteins from human atherosclerotic plaque: a preliminary report.| | View in PubMed