University of California San Francisco

Julie Saba, MD, PhD
Julie Saba, MD, PhD

Professor, Pediatrics

Address

5700 Martin Luther King Jr Way, #2122B
Oakland, CA 94609
United States

Email: [email protected]

Awards & Honors

Award Conferred By Date
Eli Lilly Genetic Medicine Grand Challenge Winner Eli Lilly / Nucleate 2023
Nucleate Pillar Venture Prize Pillar VC / Nucleate 2023
Director, Swim Across America National Laboratory Children's Hospital and Research Center Oakland 2015
John and Edna Beck Chair in Pediatric Cancer Research Children's Hospital and Research Center Oakland 2012
American Society of Clinical Investigation member ASCI 2006

Education

Institution Degree Dept or School End Date
University of California Diversity, Equity, and Inclusion Champion Training 10/2020
Duke University Ph.D. Biochemistry/Cell Biology 05/1996
Duke University Medical Center Pediatric Fellowship Hematology/Oncology 07/1993
Duke University Medical Center Residency Pediatrics 07/1989
Johns Hopkins University M.A. Creative Writing 05/1986
University of Maryland School of Medicine M.D. Medicine 05/1985
Johns Hopkins University B.S. Natural Sciences 05/1981

Clinical Trials

  1. Natural History of Sphingosine Phosphate Lyase Insufficiency Syndrome (SPLIS) (NCT06669949)
    Related Conditions: SPLIS| Start Date: | End Date:
  2. SPL Insufficiency Syndrome (SPLIS)/NPHS14: a SPLIS Observational Study and Patient Registry (International) (NCT04885179)
    Related Conditions: Sphingolipidoses, Enzyme Deficiency, SPLIS| Start Date: | End Date:

Grants and Funding

  • Providing a cure for sphingosine phosphate lyase insufficiency syndrome (SPLIS) through adeno-associated viral mediated SGPL1 gene therapy | CIRM | 2022-04-01 - 2024-03-31 | Role: Principal Investigator
  • SPLIS Patient Finding | Catalyst Program (UCSF) | 2022-02-01 - 2023-02-06 | Role: Principal Investigator
  • Endogenous and Dietary Sphingolipids as Modulators in Inflammatory Bowel Disease | NIH | 2018-06-15 - 2022-05-31 | Role: Principal Investigator
  • S1P Lyase in colon cancer | NIH | 2007-07-01 - 2018-01-31 | Role: Principal Investigator
  • Agilent 6490 Triple Quadrupole Mass Spectrometer | NIH | 2014-06-01 - 2015-05-31 | Role: Principal Investigator
  • Sphingolipid Metabolism in Drosophila Development | NIH | 2003-09-01 - 2015-02-28 | Role: Principal Investigator
  • IVIS Spectrum small animal imaging system | NIH | 2013-06-15 - 2014-06-14 | Role: Principal Investigator
  • FASEB SRC on Lysophospholipd Mediators in Health and Disease | NIH | 2011-08-12 - 2012-08-11 | Role: Principal Investigator
  • Soy sphingadienes and related compounds in colon cancer chemoprevention and treat | NIH | 2009-09-01 - 2012-07-31 | Role: Principal Investigator
  • Endogenous sphingosine-1-phosphate as a radioprotector of intestinal tissues | NIH | 2007-09-01 - 2011-02-28 | Role: Principal Investigator
  • Sphingosine Phosphate:Regulation and Role in Cancer | NIH | 1998-09-01 - 2011-02-28 | Role: Principal Investigator
  • CERAMIDE MEDIATED SIGNAL TRANSDUCTION IN YEAST | NIH | 1993-07-01 - 1998-06-30 | Role: Principal Investigator

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 133
  1. Age-dependent reference intervals for cerebrospinal fluid (CSF) and urine heparan sulfate (HS) and dermatan sulfate (DS) and CSF gangliosides.
    Candice B. Herber, Shaohua Xiao, Deborah S. Gho, Ana-Claire Meyer, Jung Suh, Sarah Huntwork-Rodriguez, Julie D. Saba, Kristie L. White, Akhil Bhalla| | UCSF Research Profile
  2. Sphingosine phosphate lyase insufficiency syndrome as a primary immunodeficiency state.
    Gharagozlou S, Wright NM, Murguia-Favela L, Eshleman J, Midgley J, Saygili S, Mathew G, Lesmana H, Makkoukdji N, Gans M, Saba JD| | PubMed
  3. Factors influencing survival in sphingosine phosphate lyase insufficiency syndrome: a retrospective cross-sectional natural history study of 76 patients.
    Keller N, Midgley J, Khalid E, Lesmana H, Mathew G, Mincham C, Teig N, Khan Z, Khosla I, Mehr S, Guran T, Buder K, Xu H, Alhasan K, Buyukyilmaz G, Weaver N, Saba JD| | PubMed
  4. Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4 + cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype.
    Arcuschin CD, Kahrizi K, Sayaman RW, DiBenedetto C, Shen Y, Salaberry PJ, Zakroui O, Schwarzer C, Scapozza A, Betancur P, Saba JD, Coppé JP, Barcellos-Hoff MH, Kappes D, van 't Veer L, Schor IE, Muñoz DP| | PubMed
  5. 109 Chemical development of dual species–host and Aspergillus fumigatus–sphingosine-1-phosphate lyase inhibitors as therapeutic strategy in cystic fibrosis.
    C. Costantini, E. Camaioni, G. Pampalone, M. Dindo, M. Pariano, C. Stincardini, R. Galarini, F. Paoletti, R. Ronchetti, S. Giovagnoli, J. Saba, L. Romani, B. Cellini| | UCSF Research Profile
  6. Melanocortin-receptor 4 activation modulates proliferation and differentiation of rat postnatal hippocampal neural precursor cells.
    Carniglia L, Turati J, Saba J, López Couselo F, Romero AC, Caruso C, Durand D, Lasaga M| | PubMed
  7. The fate of intracellular S1P regulates lipid droplet turnover and lipotoxicity in pancreatic beta-cells.
    Tang Y, Majewska M, Leß B, Mehmeti I, Wollnitzke P, Semleit N, Levkau B, Saba JD, van Echten-Deckert G, Gurgul-Convey E| | PubMed
  8. AF1q is a universal marker of neuroblastoma that sustains N-Myc expression and drives tumorigenesis.
    Oskouian B, Lee JY, Asgharzadeh S, Khan R, Zhang M, Weisbrod JR, Choi YJ, Puri L, Aguilar AE, Zhao P, Saba JD| | PubMed
  9. Gene therapy with AAV9-SGPL1 in an animal model of lung fibrosis.
    Bhattacharyya A, Khan R, Lee JY, Tassew G, Oskouian B, Allende ML, Proia RL, Yin X, Ortega JG, Bhattacharya M, Saba JD| | PubMed
  10. Prevalence estimate of sphingosine phosphate lyase insufficiency syndrome in worldwide and select populations.
    Sedillo JC, Badduke C, Schrodi SJ, Scaria V, Onat OE, Alfadhel M, Ober C, Wentworth-Sheilds W, Steiner RD, Saba JD| | PubMed
  11. AAV-SPL 2.0, a Modified Adeno-Associated Virus Gene Therapy Agent for the Treatment of Sphingosine Phosphate Lyase Insufficiency Syndrome.
    Khan R, Oskouian B, Lee JY, Hodgin JB, Yang Y, Tassew G, Saba JD| | PubMed
  12. 148 Exploring dual targeting of host and microbial sphingosine-1-phosphate lyase as antimicrobial strategy in cystic fibrosis.
    C. Costantini, G. Pampalone, M. Pariano, T. Zelante, L. Macchioni, R. Galarini, E. Camaioni, F. Paoletti, F. Catalano, M. Davidescu, C. Stincardini, M. Bellet, J. Saba, G. Giardina, S. Giovagnoli, B. Cellini, L. Romani| | UCSF Research Profile
  13. Sphingosine phosphate lyase insufficiency syndrome: a systematic review.
    Pournasiri Z, Madani A, Nazarpack F, Sayer JA, Chavoshzadeh Z, Nili F, Tran P, Saba JD, Jamee M| | PubMed
  14. Neurological Consequences of Sphingosine Phosphate Lyase Insufficiency.
    Atreya KB, Saba JD| | PubMed
  15. Sphingosine Phosphate Lyase Is Upregulated in Duchenne Muscular Dystrophy, and Its Inhibition Early in Life Attenuates Inflammation and Dystrophy in Mdx Mice.
    De la Garza-Rodea AS, Moore SA, Zamora-Pineda J, Hoffman EP, Mistry K, Kumar A, Strober JB, Zhao P, Suh JH, Saba JD| | PubMed
  16. Analyzing Opposing Interactions Between Sphingosine 1-Phosphate Lyase and Influenza A Virus.
    Wolf JJ, Saba JD, Hahm B| | PubMed
  17. 521: Dual targeting of host and fungal sphingosine-1-phosphate lyase as antifungal strategy in cystic fibrosis.
    C. Costantini, M. Pariano, G. Pampalone, T. Zelante, L. Macchioni, R. Galarini, E. Costanzi, M. Bellet, S. Giovagnoli, J. Saba, B. Cellini, L. Romani| | UCSF Research Profile
  18. Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile.
    Spohner AK, Jakobi K, Trautmann S, Thomas D, Schumacher F, Kleuser B, Lütjohann D, El-Hindi K, Grösch S, Pfeilschifter J, Saba JD, Meyer Zu Heringdorf D| | PubMed
  19. Genotype/Phenotype Interactions and First Steps Toward Targeted Therapy for Sphingosine Phosphate Lyase Insufficiency Syndrome.
    Saba JD, Keller N, Wang JY, Tang F, Slavin A, Shen Y| | PubMed
  20. Efficacy of AAV9-mediated SGPL1 gene transfer in a mouse model of S1P lyase insufficiency syndrome.
    Zhao P, Tassew GB, Lee JY, Oskouian B, Muñoz DP, Hodgin JB, Watson GL, Tang F, Wang JY, Luo J, Yang Y, King S, Krauss RM, Keller N, Saba JD| | PubMed
  21. MRI Spectrum of Brain Involvement in Sphingosine-1-Phosphate Lyase Insufficiency Syndrome.
    Martin KW, Weaver N, Alhasan K, Gumus E, Sullivan BR, Zenker M, Hildebrandt F, Saba JD| | PubMed
  22. Responsiveness of sphingosine phosphate lyase insufficiency syndrome to vitamin B6 cofactor supplementation.
    Zhao P, Liu ID, Hodgin JB, Benke PI, Selva J, Torta F, Wenk MR, Endrizzi JA, West O, Ou W, Tang E, Goh DL, Tay SK, Yap HK, Loh A, Weaver N, Sullivan B, Larson A, Cooper MA, Alhasan K, Alangari AA, Salim S, Gumus E, Chen K, Zenker M, Hildebrandt F, Saba JD| | PubMed
  23. Correction to: Sphingadienes show therapeutic efficacy in neuroblastoma in vitro and in vivo by targeting the AKT signaling pathway.
    Zhao P, Aguilar AE, Lee JY, Paul LA, Suh JH, Puri L, Zhang M, Beckstead J, Witkowski A, Ryan RO, Saba JD| | PubMed
  24. Unraveling the β-amyloid clearance by astrocytes: Involvement of metabotropic glutamate receptor 3, sAPPα, and class-A scavenger receptor.
    Durand D, Turati J, Rudi MJ, Ramírez D, Saba J, Caruso C, Carniglia L, von Bernhardi R, Lasaga M| | PubMed
  25. Sphingosine 1-phosphate lyase promotes the type I interferon-mediated innate immune response to influenza but is subjected to degradation by influenza A virus NS1.
    Jennifer J Wolf, Chuan Xia, Madhuvanthi Vijayan, Yuleum Song, Caleb J Studstill, Hanh Ngo, Marc C Johnson, Julie D Saba, Stephen Alexander, Bumsuk Hahm| | UCSF Research Profile
  26. Fifty years of lyase and a moment of truth: sphingosine phosphate lyase from discovery to disease.
    Saba JD| | PubMed
  27. Sphingosine phosphate lyase insufficiency syndrome (SPLIS): A novel inborn error of sphingolipid metabolism.
    Choi YJ, Saba JD| | PubMed
  28. Astrocyte truncated tropomyosin receptor kinase B mediates brain-derived neurotrophic factor anti-apoptotic effect leading to neuroprotection.
    Saba J, Turati J, Ramírez D, Carniglia L, Durand D, Lasaga M, Caruso C| | PubMed
  29. Sphingosine-1-Phosphate Signaling and Metabolism Gene Signature in Pediatric Inflammatory Bowel Disease: A Matched-case Control Pilot Study.
    Suh JH, Degagné É, Gleghorn EE, Setty M, Rodriguez A, Park KT, Verstraete SG, Heyman MB, Patel AS, Irek M, Gildengorin GL, Hubbard NE, Borowsky AD, Saba JD| | PubMed
  30. Sphingadienes show therapeutic efficacy in neuroblastoma in vitro and in vivo by targeting the AKT signaling pathway.
    Zhao P, Aguilar AE, Lee JY, Paul LA, Suh JH, Puri L, Zhang M, Beckstead J, Witkowski A, Ryan RO, Saba JD| | PubMed
  31. S100 Calcium Binding Protein A6.
    Brian R. Dempsey, Anne C. Rintala-Dempsey, Gary S. Shaw, Igor Prudovsky, Thallapuranam Krishnaswamy Suresh Kumar, Rosario Donato, Rosario Donato, Guglielmo Sorci, Ileana Giambanco, Isadora Carolina Betim Pavan, Fernando Riback Silva, Ana Paula Morelli, Fernando Moreira Simabuco, Yuan Xiao Zhu, A. Keith Stewart, Jaime O. Claudio, Constance E. Runyan, H. William Schnaper, Sushant Singh, Sanjaya K. Sahoo, Muthu Periasamy, Erno Zádor, Magdolna Kósa, Chiung-Ya Chen, Yi-Ping Hsueh, Herman E. Popeijus, Alice Guyon, Laurence J. Miller, Sari S. Hannila, Manoj B. Menon, Akio Yamashita, Veerle Janssens, Ralf-Peter Czekay, Tessa M. Simone, Paul J. Higgins, David Della-Morte, Donatella Pastore, Barbara Capuani, Francesca Pacifici, Davide Lauro, Béatrice L. Charreau, Philip D. King, Matthew D. Blunt, Stephen G. Ward, Christophe Erneux, Stéphane Schurmans, Colin G. Rousseaux, Yasuyuki Saito, Yoji Murata, Takenori Kotani, Takashi Matozaki, Pedro Gomes, Xiaogang Chu, Ryan George, Raghavan Raju, Annegret Reinhold, Burkhart L. Schraven, Víctor Sorribas, Ali H. Jalloul, Robert T. Szerencsei, Tatiana P. Rogasevskaia, Paul P. M. Schnetkamp, Sylvia Y. M. Yao, James D. Young, Bruno Gasnier, Ian Forster, Andreas Werner, Laura R. de La Ballina, Tomás de Garay, Chloé C. Féral, Manuel Palacín, Meytal Landau, Mitsunori Fukuda, Jong Ran Lee, Salman Tamaddon-Jahromi, Venkateswarlu Kanamarlapudi, Julia Strebovsky, Jana Zimmer, Alexander H. Dalpke, Barbara Mariniello, Kaitlyn Ryan, Chin Chiang, Gianni Colotti, Andrea Ilari, Koji Shimozaki, Shiro Koizume, Yohei Miyagi, Aleksander Czogalla, Nadine Beckmann, Erich Gulbins, Katrin Anne Becker, Alexander Carpinteiro, Heidi Neubauer, Stuart Pitson, Ashok Kumar, Julie D. Saba, Samar Masoumi-Moghaddam, Afshin Amini, Sausan A. Moharram, Lars Rönnstrand, Julhash U. Kazi, Sausan A. Moharram, Lars Rönnstrand, Julhash U. Kazi, David A. Jans, Gurpreet Kaur, Cecilia Poderoso, Ana F. Castillo, Pablo G. Mele, Paula M. Maloberti, Ernesto J. Podestá, Su Jun Lim, Willis X. Li, Benjamin Skalkoyannis, Venkateswarlu Kanamarlapudi, Marc J. Tetel, Pui Man Rosalind Lai, Pradeep Kurup, Jian Xu, Manavi Chatterjee, Susan Goebel-Goody, Surojit Paul, Paul Lombroso, Wesley H. Brooks, Sreya Mukherjee, Malgorzata Kloc, Jacek Z. Kubiak, Pia Ragno, Jie Zhang, Zhi-wei Ye, Robert R. Bowers, Danyelle M. Townsend, Kenneth D. Tew, Mikko O. Laukkanen, Alessia Parascandolo, Niharika Swain, Rashmi Maruti Hosalkar, Payel Sen, Nilanjana Chatterjee, Blaine Bartholomew, Robert L. Geahlen, Ashley Bernardo, Shreya Prashar, Luke Molinaro, Ram Mishra, Sang-Ho Song, George J. Augustine, Niharika Swain, Rashmi Maruti Hosalkar, Samapika Routray, Valérie Drouet, Suzanne Lesage, Alexis Brice, Arie Horowitz| | UCSF Research Profile
  32. Sphingosine-1-Phosphate.
    Ashok Kumar, Julie D. Saba| | UCSF Research Profile
  33. The low down on sphingosine-1-phosphate lyase as a regulator of thymic egress.
    Saba JD| | PubMed
  34. S1P Lyase Regulation of Thymic Egress and Oncogenic Inflammatory Signaling.
    Kumar A, Zamora-Pineda J, Degagné E, Saba JD| | PubMed
  35. Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity.
    Hahn C, Tyka K, Saba JD, Lenzen S, Gurgul-Convey E| | PubMed
  36. An LC/MS/MS method for quantitation of chemopreventive sphingadienes in food products and biological samples.
    Suh JH, Makarova AM, Gomez JM, Paul LA, Saba JD| | PubMed
  37. SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production.
    Mitroi DN, Karunakaran I, Gräler M, Saba JD, Ehninger D, Ledesma MD, van Echten-Deckert G| | PubMed
  38. Obinutuzumab-induced serum sickness following salvage therapy for chronic lymphocytic leukemia.
    Saba J, Logan AC| | PubMed
  39. Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency.
    Lovric S, Goncalves S, Gee HY, Oskouian B, Srinivas H, Choi WI, Shril S, Ashraf S, Tan W, Rao J, Airik M, Schapiro D, Braun DA, Sadowski CE, Widmeier E, Jobst-Schwan T, Schmidt JM, Girik V, Capitani G, Suh JH, Lachaussée N, Arrondel C, Patat J, Gribouval O, Furlano M, Boyer O, Schmitt A, Vuiblet V, Hashmi S, Wilcken R, Bernier FP, Innes AM, Parboosingh JS, Lamont RE, Midgley JP, Wright N, Majewski J, Zenker M, Schaefer F, Kuss N, Greil J, Giese T, Schwarz K, Catheline V, Schanze D, Franke I, Sznajer Y, Truant AS, Adams B, Désir J, Biemann R, Pei Y, Ars E, Lloberas N, Madrid A, Dharnidharka VR, Connolly AM, Willing MC, Cooper MA, Lifton RP, Simons M, Riezman H, Antignac C, Saba JD, Hildebrandt F| | PubMed
  40. Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases.
    Carniglia L, Ramírez D, Durand D, Saba J, Turati J, Caruso C, Scimonelli TN, Lasaga M| | PubMed
  41. Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism.
    Mitroi DN, Deutschmann AU, Raucamp M, Karunakaran I, Glebov K, Hans M, Walter J, Saba J, Gräler M, Ehninger D, Sopova E, Shupliakov O, Swandulla D, van Echten-Deckert G| | PubMed
  42. Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress.
    Zamora-Pineda J, Kumar A, Suh JH, Zhang M, Saba JD| | PubMed
  43. Sphingosine-1-Phosphate.
    Ashok Kumar, Julie D. Saba| | UCSF Research Profile
  44. Regulation of Immune Cell Migration by Sphingosine-1-Phosphate.
    Kumar A, Saba JD| | PubMed
  45. Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat's in the fire.
    Suh JH, Saba JD| | PubMed
  46. A facile stable-isotope dilution method for determination of sphingosine phosphate lyase activity.
    Suh JH, Eltanawy A, Rangan A, Saba JD| | PubMed
  47. A B cell-dependent mechanism restrains T cell transendothelial migration.
    Saba JD| | PubMed
  48. Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs.
    Degagné E, Pandurangan A, Bandhuvula P, Kumar A, Eltanawy A, Zhang M, Yoshinaga Y, Nefedov M, de Jong PJ, Fong LG, Young SG, Bittman R, Ahmedi Y, Saba JD| | PubMed
  49. Tracking hippo in the cancer jungle.
    Suh JH, Saba JD| | PubMed
  50. S1pping fire: Sphingosine-1-phosphate signaling as an emerging target in inflammatory bowel disease and colitis-associated cancer.
    Degagné E, Saba JD| | PubMed
  51. Sphingosine phosphate lyase regulates myogenic differentiation via S1P receptor-mediated effects on myogenic microRNA expression.
    de la Garza-Rodea AS, Baldwin DM, Oskouian B, Place RF, Bandhuvula P, Kumar A, Saba JD| | PubMed
  52. Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P2/STAT3 Signaling Pathway.
    Smith GS, Kumar A, Saba JD| | PubMed
  53. A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity.
    Park K, Elias PM, Shin KO, Lee YM, Hupe M, Borkowski AW, Gallo RL, Saba J, Holleran WM, Uchida Y| | PubMed
  54. Immunohistochemical analysis of sphingosine phosphate lyase expression during murine development.
    Newbigging S, Zhang M, Saba JD| | PubMed
  55. Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues.
    Borowsky AD, Bandhuvula P, Kumar A, Yoshinaga Y, Nefedov M, Fong LG, Zhang M, Baridon B, Dillard L, de Jong P, Young SG, West DB, Saba JD| | PubMed
  56. S1P lyase in skeletal muscle regeneration and satellite cell activation: exposing the hidden lyase.
    Saba JD, de la Garza-Rodea AS| | PubMed
  57. The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA.
    Upadhyaya P, Kumar A, Byun HS, Bittman R, Saba JD, Hecht SS| | PubMed
  58. Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway.
    Loh KC, Leong WI, Carlson ME, Oskouian B, Kumar A, Fyrst H, Zhang M, Proia RL, Hoffman EP, Saba JD| | PubMed
  59. Chemopreventive sphingadienes downregulate Wnt signaling via a PP2A/Akt/GSK3β pathway in colon cancer.
    Kumar A, Pandurangan AK, Lu F, Fyrst H, Zhang M, Byun HS, Bittman R, Saba JD| | PubMed
  60. Corrigendum to “The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner” [Cell. Signal. 23(7) (2011) 1144-1152].
    Ashok Kumar, Hoe-Sup Byun, Robert Bittman, Julie D. Saba| | UCSF Research Profile
  61. S100 Calcium-Binding Protein.
    Brian R. Dempsey, Anne C. Rintala-Dempsey, Gary S. Shaw, Yuan Xiao Zhu, A. Keith Stewart, Jaime O. Claudio, Constance E. Runyan, H. William Schnaper, Philip D. King, Matthew D. Blunt, Stephen G. Ward, Annegret Reinhold, Burkhart L. Schraven, Mitsunori Fukuda, Jong Ran Lee, Julia Strebovsky, Alexander H. Dalpke, Barbara Mariniello, Kaitlyn Ryan, Chin Chiang, Ashok Kumar, Julie D. Saba, David A. Jans, Gurpreet Kaur, Marc J. Tetel, Pui Man Rosalind Lai, Pradeep Kurup, Jian Xu, Susan Goebel-Goody, Surojit Paul, Paul Lombroso, Pia Ragno, Robert R. Bowers, Danyelle M. Townsend, Kenneth D. Tew, Payel Sen, Nilanjana Chatterjee, Blaine Bartholomew, Arie Horowitz| | UCSF Research Profile
  62. Sphingosine-1-Phosphate.
    Brian R. Dempsey, Anne C. Rintala-Dempsey, Gary S. Shaw, Yuan Xiao Zhu, A. Keith Stewart, Jaime O. Claudio, Constance E. Runyan, H. William Schnaper, Philip D. King, Matthew D. Blunt, Stephen G. Ward, Annegret Reinhold, Burkhart L. Schraven, Mitsunori Fukuda, Jong Ran Lee, Julia Strebovsky, Alexander H. Dalpke, Barbara Mariniello, Kaitlyn Ryan, Chin Chiang, Ashok Kumar, Julie D. Saba, David A. Jans, Gurpreet Kaur, Marc J. Tetel, Pui Man Rosalind Lai, Pradeep Kurup, Jian Xu, Susan Goebel-Goody, Surojit Paul, Paul Lombroso, Pia Ragno, Robert R. Bowers, Danyelle M. Townsend, Kenneth D. Tew, Payel Sen, Nilanjana Chatterjee, Blaine Bartholomew, Arie Horowitz| | UCSF Research Profile
  63. Truth and consequences of sphingosine-1-phosphate lyase.
    Aguilar A, Saba JD| | PubMed
  64. A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration.
    McElwain MA, Ko DC, Gordon MD, Fyrst H, Saba JD, Nusse R| | PubMed
  65. Sphingolipid signaling and hematopoietic malignancies: to the rheostat and beyond.
    Loh KC, Baldwin D, Saba JD| | PubMed
  66. A monoclonal antibody to O-acetyl-GD2 ganglioside and not to GD2 shows potent anti-tumor activity without peripheral nervous system cross-reactivity.
    Alvarez-Rueda N, Desselle A, Cochonneau D, Chaumette T, Clemenceau B, Leprieur S, Bougras G, Supiot S, Mussini JM, Barbet J, Saba J, Paris F, Aubry J, Birklé S| | PubMed
  67. S1P lyase regulates DNA damage responses in vitro and in vivo.
    Julie Deane Saba, Ashok Kumar, Babak Oskouian, Henrik Fyrst, Meng Zhang| | UCSF Research Profile
  68. The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner.
    Kumar A, Byun HS, Bittman R, Saba JD| | PubMed
  69. S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart.
    Bandhuvula P, Honbo N, Wang GY, Jin ZQ, Fyrst H, Zhang M, Borowsky AD, Dillard L, Karliner JS, Saba JD| | PubMed
  70. S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism.
    Kumar A, Oskouian B, Fyrst H, Zhang M, Paris F, Saba JD| | PubMed
  71. Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking.
    Allende ML, Bektas M, Lee BG, Bonifacino E, Kang J, Tuymetova G, Chen W, Saba JD, Proia RL| | PubMed
  72. Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression.
    Zhao Y, Gorshkova IA, Berdyshev E, He D, Fu P, Ma W, Su Y, Usatyuk PV, Pendyala S, Oskouian B, Saba JD, Garcia JG, Natarajan V| | PubMed
  73. Erratum: An update on sphingosine-1-phosphate and other sphingolipid mediators.
    Henrik Fyrst, Julie D Saba| | UCSF Research Profile
  74. An update on sphingosine-1-phosphate and other sphingolipid mediators.
    Fyrst H, Saba JD| | PubMed
  75. S1P metabolism in cancer and other pathological conditions.
    Leong WI, Saba JD| | PubMed
  76. Synopsis of partial-body radiation diagnostic biomarkers and medical management of radiation injury workshop.
    Prasanna PG, Blakely WF, Bertho JM, Chute JP, Cohen EP, Goans RE, Grace MB, Lillis-Hearne PK, Lloyd DC, Lutgens LC, Meineke V, Ossetrova NI, Romanyukha A, Saba JD, Weisdorf DJ, Wojcik A, Yukihara EG, Pellmar TC| | PubMed
  77. Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver.
    Bektas M, Allende ML, Lee BG, Chen W, Amar MJ, Remaley AT, Saba JD, Proia RL| | PubMed
  78. Cancer treatment strategies targeting sphingolipid metabolism.
    Oskouian B, Saba JD| | PubMed
  79. Natural sphingadienes inhibit Akt-dependent signaling and prevent intestinal tumorigenesis.
    Fyrst H, Oskouian B, Bandhuvula P, Gong Y, Byun HS, Bittman R, Lee AR, Saba JD| | PubMed
  80. Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function.
    Serra M, Saba JD| | PubMed
  81. Normalization of diabetic wound healing.
    Francis-Goforth KN, Harken AH, Saba JD| | PubMed
  82. Lyase to live by: sphingosine phosphate lyase as a therapeutic target.
    Kumar A, Saba JD| | PubMed
  83. Sphingosine 1-phosphate lyase enzyme assay using a BODIPY-labeled substrate.
    Bandhuvula P, Li Z, Bittman R, Saba JD| | PubMed
  84. Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells.
    Tauseef M, Kini V, Knezevic N, Brannan M, Ramchandaran R, Fyrst H, Saba J, Vogel SM, Malik AB, Mehta D| | PubMed
  85. Sphingosine-1-phosphate lyase in development and disease: sphingolipid metabolism takes flight.
    Fyrst H, Saba JD| | PubMed
  86. Identification and characterization by electrospray mass spectrometry of endogenous Drosophila sphingadienes.
    Fyrst H, Zhang X, Herr DR, Byun HS, Bittman R, Phan VH, Harris GL, Saba JD| | PubMed
  87. A rapid fluorescence assay for sphingosine-1-phosphate lyase enzyme activity.
    Bandhuvula P, Fyrst H, Saba JD| | PubMed
  88. Disruption of sphingolipid metabolism elicits apoptosis-associated reproductive defects in Drosophila.
    Phan VH, Herr DR, Panton D, Fyrst H, Saba JD, Harris GL| | PubMed
  89. Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren.
    Bandhuvula P, Saba JD| | PubMed
  90. Sphingosine-1-phosphate metabolism and intestinal tumorigenesis: lipid signaling strikes again.
    Oskouian B, Saba J| | PubMed
  91. Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania.
    Zhang K, Pompey JM, Hsu FF, Key P, Bandhuvula P, Saba JD, Turk J, Beverley SM| | PubMed
  92. Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer.
    Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD| | PubMed
  93. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation.
    Kohno M, Momoi M, Oo ML, Paik JH, Lee YM, Venkataraman K, Ai Y, Ristimaki AP, Fyrst H, Sano H, Rosenberg D, Saba JD, Proia RL, Hla T| | PubMed
  94. S1P Lyase Expression Hypersensitizes Cells to DNA Damage and Other Stress Conditions via p53 and p38 Apoptosis Pathways.
    Julie Deane Saba, Babak Oskouian, Prathap Sooriyakumaran| | UCSF Research Profile
  95. Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression.
    Kitano M, Hla T, Sekiguchi M, Kawahito Y, Yoshimura R, Miyazawa K, Iwasaki T, Sano H, Saba JD, Tam YY| | PubMed
  96. Sphingosine-1-Phosphate Lyase.
    Julie D. Saba| | UCSF Research Profile
  97. Directed Donor Cord Blood Transplantation for Hematological Disorders.
    Mark C. Walters, Lynn Quirolo, Sandie Edwards, Joanna Lee, Shanda Robertson, Julie D. Saba, Elizabeth Trachtenberg, Keith C. Quirolo, Bert Lubin| | UCSF Research Profile
  98. The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity.
    Bandhuvula P, Tam YY, Oskouian B, Saba JD| | PubMed
  99. Regulation of sphingosine-1-phosphate lyase gene expression by members of the GATA family of transcription factors.
    Oskouian B, Mendel J, Shocron E, Lee MA, Fyrst H, Saba JD| | PubMed
  100. Sibling donor cord blood transplantation for thalassemia major: Experience of the Sibling Donor Cord Blood Program.
    Walters MC, Quirolo L, Trachtenberg ET, Edwards S, Hale L, Lee J, Morton-Wiley J, Quirolo K, Robertson S, Saba J, Lubin B| | PubMed
  101. gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis.
    Jiang Q, Wong J, Fyrst H, Saba JD, Ames BN| | PubMed
  102. Death and taxis: what non-mammalian models tell us about sphingosine-1-phosphate.
    Oskouian B, Saba JD| | PubMed
  103. Lysophospholipids in development: Miles apart and edging in.
    Saba JD| | PubMed
  104. Point-counterpoint of sphingosine 1-phosphate metabolism.
    Saba JD, Hla T| | PubMed
  105. Characterization of the Drosophila sphingosine kinases and requirement for Sk2 in normal reproductive function.
    Herr DR, Fyrst H, Creason MB, Phan VH, Saba JD, Harris GL| | PubMed
  106. Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis.
    Reiss U, Oskouian B, Zhou J, Gupta V, Sooriyakumaran P, Kelly S, Wang E, Merrill AH, Saba JD| | PubMed
  107. Characterization of free endogenous C14 and C16 sphingoid bases from Drosophila melanogaster.
    Fyrst H, Herr DR, Harris GL, Saba JD| | PubMed
  108. Sply regulation of sphingolipid signaling molecules is essential for Drosophila development.
    Herr DR, Fyrst H, Phan V, Heinecke K, Georges R, Harris GL, Saba JD| | PubMed
  109. Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans.
    Mendel J, Heinecke K, Fyrst H, Saba JD| | PubMed
  110. Comprehensive banking of sibling donor cord blood for children with malignant and nonmalignant disease.
    Reed W, Smith R, Dekovic F, Lee JY, Saba JD, Trachtenberg E, Epstein J, Haaz S, Walters MC, Lubin BH| | PubMed
  111. Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation.
    Birchwood CJ, Saba JD, Dickson RC, Cunningham KW| | PubMed
  112. Accumulation of phosphorylated sphingoid long chain bases results in cell growth inhibition in Saccharomyces cerevisiae.
    Kim S, Fyrst H, Saba J| | PubMed
  113. Molecular cloning - and functional characterization of the human sphingosine-1 -phosphate lyase gene.
    J. Zhou, U. Reiss, J. D. Saba| | UCSF Research Profile
  114. A high-performance liquid chromatographic method to measure sphingosine 1-phosphate and related compounds from sphingosine kinase assays and other biological samples.
    Caligan TB, Peters K, Ou J, Wang E, Saba J, Merrill AH| | PubMed
  115. The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses.
    MAO Cungui, Julie D. SABA, Lina M. OBEID| | UCSF Research Profile
  116. The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses.
    Mao C, Saba JD, Obeid LM| | PubMed
  117. The PLB2 gene of Saccharomyces cerevisiae confers resistance to lysophosphatidylcholine and encodes a phospholipase B/lysophospholipase.
    Fyrst H, Oskouian B, Kuypers FA, Saba JD| | PubMed
  118. The DPL1 gene is involved in mediating the response to nutrient deprivation in Saccharomyces cerevisiae.
    Gottlieb D, Heideman W, Saba JD| | PubMed
  119. YAP1 confers resistance to the fatty acid synthase inhibitor cerulenin through the transporter Flr1p in Saccharomyces cerevisiae.
    Oskouian B, Saba JD| | PubMed
  120. Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants.
    Lanterman MM, Saba JD| | PubMed
  121. Cost-effectiveness of antiviral drug therapy to reduce mother-to-child HIV transmission in sub-Saharan Africa.
    Marseille E, Kahn JG, Saba J| | PubMed
  122. Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast.
    Zhou J, Saba JD| | PubMed
  123. The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase.
    Saba JD, Nara F, Bielawska A, Garrett S, Hannun YA| | PubMed
  124. Ceramide: an intracellular mediator of apoptosis and growth suppression.
    Saba JD, Obeid LM, Hannun YA| | PubMed
  125. Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae.
    Fishbein JD, Dobrowsky RT, Bielawska A, Garrett S, Hannun YA| | PubMed
  126. A seven-month-old infant with fever and neutrophilic leukocytosis.
    Fishbein JD, Bruggers CS, Friedman NJ, Graham ML, Kurtzberg J| | PubMed
  127. Large-cell lymphoma presenting with a distinctive inflammatory dermatosis.
    Tope WD, Fishbein JD, White PF, Prose NS| | PubMed
  128. Pelger-Huet anomaly in an infant with multiple congenital anomalies.
    Fishbein JD, Falletta JM| | PubMed
  129. A piece of my mind. The poetry of medicine.
    Fishbein J| | PubMed
  130. Catheter-related sepsis refractory to antibiotics treated successfully with adjunctive urokinase infusion.
    Fishbein JD, Friedman HS, Bennett BB, Falletta JM| | PubMed
  131. Indicator enzyme assays. II. Adenylate kinase: application to human muscle biopsies and blood cells.
    Fishbein WN, Davis JI, Winkert JW, Fishbein JD| | PubMed
  132. Journal of Immunological Sciences
    Saba JD| UCSF Research Profile
  133. Sphingosine-1-phosphate signaling and metabolism gene signature in pediatric inflammatory bowel disease: a matched-case control pilot study
    Suh JH
    Degagné E
    Gleghorn EE
    Setty M
    Rodriguez A
    Park KT
    Verstraete SG
    Heyman MB
    Patel AS
    Irek M
    Gildengorin GL
    Hubbard NE
    Borowsky AD
    Saba JD    | UCSF Research Profile