Biography
My second major area of research interest is advanced endovascular therapies for aortic aneurysms. The development and widespread adoption of endovascular stent-grafts for infrarenal aortic aneurysms and thoracic aortic aneurysms have dramatically reduced the physiologic demands, complication rates and length of hospitalization for patients undergoing infrarenal or thoracic aortic aneurysm repairs compared to open techniques. However, aneurysms of thoracoabdominal, paravisceral and/or pararenal aorta require even more demanding operations with a higher rate of complications and longer hospitalizations. For the past 4 years I have worked with Dr. Timothy Chuter and Dr. Linda Reilly in the UCSF Division of Vascular and Endovascular Surgery to develop the multi-branched endovascular thoracoabdominal aneurysm repair technique. The technique is being studied under an FDA IDE in a CHR-approved study at UCSF and the San Francisco VA. As the co-principal investigator, I am responsible for overseeing the regulatory and subject care activities for the study at the San Francisco VA. This work has included consultations in the outpatient clinic, planning and performing the multi-branched endovascular repairs and analyzing the results of the study.
Awards & Honors
Award | Conferred By | Date |
---|---|---|
Lim/Thomas Excellence in Teaching Award | UCSF Department of Surgery Chief Residents | 2018 |
Excellence in Teaching Award | UCSF Haile T. Debas Academy of Medical Educators | 2017 |
First place, Poster Competition | Society for Vascular Surgery Annual Meeting | 2011 |
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of California, San Francisco | Vascular Surgeyr Fellowship | School of Medicine | 2013 |
University of California, San Francisco | Vascular Surgery Fellowship | School of Medicine | 2011 |
University of California, San Francisco | General Surgery Residency | School of Medicine | 2010 |
Univeristy of Maryland, Baltimore | M.D. | School of Medicine | 2003 |
Bowdoin College | A.B | Biochemistry & German | 1999 |
Clinical Expertise
Aortic Dissection
Abdominal Aortic Aneurysm
Carotid Artery Disease
Complex Limb Revascularization
Critical Limb Ischemia
Diabetic Vascular Disease
Dialysis Access
Endovascular Aneurysm Repair
Mesenteric Artery Disease
Peripheral Artery Disease
Thoracic Aortic Aneurysm
Thoracic Outlet Syndrome
Clinical Trials
- Nectero EAST System Clinical Study (NCT06001918)Related Conditions: Abdominal Aortic Aneurysm, Aneurysm| Start Date: | End Date:
- Endovascular Exclusion of Thoracoabdominal And/or Paravisceral Abdominal Aortic Aneurysm (NCT00483249)Related Conditions: Aneurysm, Abdominal Aortic Aneurysm| Start Date: | End Date:
- Branched Aortic Arch Study (NCT00488696)Related Conditions: Aneurysm| Start Date: | End Date:
- Intima Versus Adventitia Drug Delivery to Elucidate Mechanisms of Restenosis: Magnetic Resonance Imaging (NCT02807779)Related Conditions: Peripheral Artery Disease, Vascular Disease, Chronic Limb-Threatening Ischemia, Critical Limb Ischemia, MRI, Neuroimaging| Start Date: | End Date:
- The Effects of Omega-3 Fatty Acids Supplementation on Endothelial Function and Inflammation (NCT01310270)Related Conditions: Peripheral Artery Disease, Vascular Disease| Start Date: | End Date:
- Related Conditions: Peripheral Artery Disease, Abdominal Aortic Aneurysm, Aneurysm| Start Date: | End Date:
- Related Conditions: Peripheral Artery Disease, Vascular Disease| Start Date: | End Date:
- The Use of Fish Oil to Reduce Inflammation Caused by a Peripheral Vascular Intervention (NCT02096757)Related Conditions: Peripheral Artery Disease, Vascular Disease| Start Date: | End Date:
- Dexamethasone Infusion to the Adventitia to Enhance Clinical Efficacy After Femoropopliteal Revascularization (NCT01507558)Related Conditions: Peripheral Artery Disease, Vascular Disease| Start Date: | End Date:
- Endothelial Function and Vein Graft Remodeling (NCT00831090)Related Conditions: Peripheral Artery Disease, Cardiovascular Disease, Vascular Disease| Start Date: | End Date:
- Related Conditions: Chronic Kidney Disease, Kidney Disease, Arteriovenous Fistula, Fistula| Start Date: | End Date:
In the News
Grants and Funding
- Transfusion Trigger after Operations in High Cardiac Risk Patients | VA Cooperative Studies Program | 2017-10-01 - 2022-02-28 | Role: Co-local Site Investigator
- Targeted Endovascular Treatment of Inflammation for Vascular Healing in Humans | NIH/NHLBI | 2015-08-18 - 2020-04-30 | Role: Co-Investigator
- Imaging Substudy, part of "A Phase 2 Study for the Evaluation of Safety and Efficacy of Humacyte's Human Acellular Vessel for Use as a Vascular Prosthesis for Femoro-Popliteal Bypass in Patients With Peripheral Arterial Disease" | Industry | 2016-06-13 - 2020-03-31 | Role: Principal Investigator
- Randomized, Multicenter, Controlled Trial to Compare Best Endovascular versus Best Surgical Therapy in Patients With Critical Limb Ischemia (BEST-CLI) | NIH/NHLBI | 2014-12-01 - 2019-12-31 | Role: Principal Investigator
Research Narrative
Dr. Gasper’s clinical interests include diseases of the aorta and its major branches, aneurysms and peripheral artery disease. Dr Gasper’s research has been focused on translational projects involving vascular physiology and venous remodeling after arteriovenous fistula and lower extremity bypass surgeries. He also been active in research involving pharmacologic therapies to reduce or prevent restenosis and has been involved in pre-clinical studies as well as clinical trials using a novel endovascular approach to deliver therapy to the artery adventitia.
Publications
- A Novel Preoperative Risk Score to Identify Patients at High Risk for Non-Home Discharge After Elective Open Abdominal Aortic Aneurysm Repair.| | PubMed
- Impact of the type of anesthesia on adverse events during transcarotid artery revascularization.| | PubMed
- Outcomes using inverted iliac limb bifurcate components in fenestrated/branched endografting.| | PubMed
- Early Opioid Use and Postoperative Delirium Following Open Abdominal Aortic Aneurysm Repair.| | PubMed
- Early and Late Aortic-Related Mortality and Rupture After Fenestrated-Branched Endovascular Aortic Repair of Thoracoabdominal Aortic Aneurysms: A Prospective Multicenter Cohort Study.| | PubMed
- Postdissection aortic aneurysm sac enlargement after fenestrated and branched endovascular aortic aneurysm repair.| | PubMed
- Practice patterns of antiplatelet and anticoagulant therapy after fenestrated/branched endovascular aortic repair.| | PubMed
- Preoperative risk factors for 1-year mortality in patients undergoing fenestrated endovascular aortic aneurysm repair in the US Aortic Research Consortium.| | PubMed
- Prospective randomized pilot trial comparing prophylactic and therapeutic cerebrospinal fluid drainage during complex endovascular thoracoabdominal aortic aneurysm repair.| | PubMed
- Relevance of BEST-CLI trial endpoints in a tertiary care limb preservation program.| | PubMed
- Secondary interventions following open vs endovascular revascularization for chronic limb threatening ischemia in the BEST-CLI trial.| | PubMed
- Predictors of amputation-free survival and wound healing after infrainguinal bypass with alternative conduits.| | PubMed
- Risk factors and associated outcomes of postoperative delirium after open abdominal aortic aneurysm repair.| | PubMed
- Descending thoracic aortic mural ulceration is associated with postoperative spinal cord ischemia after branched endovascular aortic aneurysm repair.| | PubMed
- Measurement of Abdominal Aortic Aneurysm Strain Using MR Deformable Image Registration: Accuracy and Relationship to Recent Aneurysm Progression.| | PubMed
- Development and Validation of a Novel Preoperative Risk Score to Identify Patients at Risk for Nonhome Discharge after Elective Endovascular Aortic Aneurysm Repair (EVAR).| | PubMed
- Decreasing prevalence of centers meeting the Society for Vascular Surgery abdominal aortic aneurysm guidelines in the United States.| | PubMed
- Outcomes of Elective and Non-elective Fenestrated-branched Endovascular Aortic Repair for Treatment of Thoracoabdominal Aortic Aneurysms.| | PubMed
- Update of T-branch use from the US Aortic Research Consortium.| | PubMed
- Severity of acute kidney injury is associated with decreased survival after fenestrated and branched endovascular aortic aneurysm repair.| | PubMed
- Mid-term Renal and Mesenteric Artery Outcomes During Fenestrated and Branched Endovascular Aortic Repair for Complex Abdominal and Thoracoabdominal Aortic Aneurysms in the United States Aortic Research Consortium.| | PubMed
- Predictors and outcomes of spinal cord injury following complex branched/fenestrated endovascular aortic repair in the US Aortic Research Consortium.| | PubMed
- Effect of bridging stent graft selection for directional branches on target artery outcomes of fenestrated-branched endovascular aortic repair in the United States Aortic Research Consortium.| | PubMed
- Dynamic Contrast-Enhanced MRI in Abdominal Aortic Aneurysms as a Potential Marker for Disease Progression.| | PubMed
- Comparison of single- and multistage strategies during fenestrated-branched endovascular aortic repair of thoracoabdominal aortic aneurysms.| | PubMed
- Cognitive Impairment is Common in a Veterans Affairs Population with Peripheral Arterial Disease.| | PubMed
- Open revascularization approach is associated with healing and ambulation after transmetatarsal amputation in patients with chronic limb threatening ischemia.| | PubMed
- Presenting limb severity is associated with long-term outcomes after infrainguinal revascularization for chronic limb-threatening ischemia.| | PubMed
- Expression of Concern: Association of tetraspanin CD9 with transmembrane TGFα confers alterations in cell-surface presentation of TGFα and cytoskeletal organization.| | PubMed
- Surgery or Endovascular Therapy for Chronic Limb-Threatening Ischemia.| | PubMed
- Racial and ethnic disparities in major adverse limb events persist for chronic limb threatening ischemia despite presenting limb threat severity after peripheral vascular intervention.| | PubMed
- Comparison of upper extremity and transfemoral access for fenestrated-branched endovascular aortic repair.| | PubMed
- Clinical Predictors and Outcomes Associated with Postoperative Delirium Following Infrainguinal Bypass Surgery.| | PubMed
- Correction to: The Resolution of Abdominal Pain: an Ominous Sign of Mesenteric Ischemia.| | PubMed
- Eptifibatide bridging therapy for staged carotid artery stenting and cardiac surgery: Safety and feasibility.| | PubMed
- Secondary interventions after fenestrated/branched aneurysm repairs are common and nondetrimental to long-term survival.| | PubMed
- Risk factors for venous thromboembolism after vascular surgery and implications for chemoprophylaxis strategies.| | PubMed
- High glucose macrophage exosomes enhance atherosclerosis by driving cellular proliferation & hematopoiesis.| | PubMed
- Understanding value and patient complexity among common inpatient vascular surgery procedures.| | PubMed
- Contemporary Experience with Paravisceral Aortic Aneurysm (PVAAA) Repair in a Tertiary Center.| | PubMed
- Depression Predicts Non-Home Discharge After Abdominal Aortic Aneurysm Repair.| | PubMed
- Patients with depression are less likely to go home after critical limb revascularization.| | PubMed
- The Resolution of Abdominal Pain: an Ominous Sign of Mesenteric Ischemia.| | PubMed
- A novel preoperative risk score for nonhome discharge after elective thoracic endovascular aortic repair.| | PubMed
- Impact of the coronavirus disease 2019 pandemic on an academic vascular practice and a multidisciplinary limb preservation program.| | PubMed
- Living in a Food Desert is Associated with 30-day Readmission after Revascularization for Chronic Limb-Threatening Ischemia.| | PubMed
- Increased Reintervention After Infrainguinal Revascularization for Chronic Limb-Threatening Ischemia in Women.| | PubMed
- Patient complexity by surgical specialty does not correlate with work relative value units.| | PubMed
- Quantitative measurement of atheroma burden: reproducibility in serial studies of atherosclerotic femoral arteries.| | PubMed
- Antegrade common femoral artery closure device use is associated with decreased complications.| | PubMed
- Growth of common iliac artery aneurysms coexisting with abdominal aortic aneurysms: associated factors and potential role of intraluminal thrombus.| | PubMed
- Intraluminal Thrombus Predicts Rapid Growth of Abdominal Aortic Aneurysms.| | PubMed
- Acute Insulin Resistance and Rapid Alterations in Neuronal Derived Blood Exosome Concentration After Branched Endovascular Aortic Aneurysm Repair.| | PubMed
- Strict Control of Blood Glucose With an Intravenous Insulin Infusion Decreases the Risk of Post-operative Lower Extremity Weakness After Complex Endovascular Aortic Aneurysm Repair.| | PubMed
- Multibranched endovascular aortic aneurysm repair in patients with and without chronic aortic dissections.| | PubMed
- Peripheral Artery Disease Is Associated with a Deficiency of Erythrocyte Membrane n-3 Polyunsaturated Fatty Acids.| | PubMed
- Fish Oil Increases Specialized Pro-resolving Lipid Mediators in PAD (The OMEGA-PAD II Trial).| | PubMed
- Leptinemia is Associated With Peripheral Artery Disease.| | PubMed
- Long-term durability of multibranched endovascular repair of thoracoabdominal and pararenal aortic aneurysms.| | PubMed
- Radial Artery Tonometry is Associated With Major Adverse Cardiac Events in Patients With Peripheral Artery Disease.| | PubMed
- Serum resistin is associated with impaired endothelial function and a higher rate of adverse cardiac events in patients with peripheral artery disease.| | PubMed
- Depression severity is associated with increased inflammation in veterans with peripheral artery disease.| | PubMed
- Frailty Is Associated with an Increased Risk of Major Adverse Cardiac Events in Patients with Stable Claudication.| | PubMed
- The impact of prior aortic surgery on outcomes after multibranched endovascular aortic aneurysm repair.| | PubMed
- Characterizing the relationship between flow-mediated vasodilation and radial artery tonometry in peripheral artery disease.| | PubMed
- Determinants of midterm functional outcomes, wound healing, and resources used in a hospital-based limb preservation program.| | PubMed
- Association between arterial stiffness and peripheral artery disease as measured by radial artery tonometry.| | PubMed
- Relationship between the omega-3 index and specialized pro-resolving lipid mediators in patients with peripheral arterial disease taking fish oil supplements.| | PubMed
- Medical therapy and intervention do not improve uncomplicated isolated mesenteric artery dissection outcomes over observation alone.| | PubMed
- Lower extremity weakness is associated with elevated blood and cerebrospinal fluid glucose levels following multibranched endovascular aortic aneurysm repair.| | PubMed
- Predictors of change in omega-3 index with fish oil supplementation in peripheral artery disease.| | PubMed
- Society for Vascular Surgery limb stage and patient risk correlate with outcomes in an amputation prevention program.| | PubMed
- Posttraumatic Stress Disorder Is Associated With Worse Endothelial Function Among Veterans.| | PubMed
- Low-profile versus standard-profile multibranched thoracoabdominal aortic stent grafts.| | PubMed
- Standard off-the-shelf versus custom-made multibranched thoracoabdominal aortic stent grafts.| | PubMed
- Isotropic 3D black blood MRI of abdominal aortic aneurysm wall and intraluminal thrombus.| | PubMed
- Vascular inflammation in a growing iliac artery aneurysm.| | PubMed
- Endovascular rescue after inadvertent false lumen stent graft implantation.| | PubMed
- Lower extremity weakness after endovascular aneurysm repair with multibranched thoracoabdominal stent grafts.| | PubMed
- Ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery in clinical research.| | PubMed
- Relationship between kidney disease and endothelial function in peripheral artery disease.| | PubMed
- Ferumoxytol-enhanced magnetic resonance angiography is a feasible method for the clinical evaluation of lower extremity arterial disease.| | PubMed
- Vitamin D deficiency is associated with mortality and adverse vascular access outcomes in patients with end-stage renal disease.| | PubMed
- Safety and feasibility of adjunctive dexamethasone infusion into the adventitia of the femoropopliteal artery following endovascular revascularization.| | PubMed
- Walking disability in patients with peripheral artery disease is associated with arterial endothelial function.| | PubMed
- Adventitial nab-rapamycin injection reduces porcine femoral artery luminal stenosis induced by balloon angioplasty via inhibition of medial proliferation and adventitial inflammation.| | PubMed
- Vein graft failure.| | PubMed
- Assessing the anatomic applicability of the multibranched endovascular repair of thoracoabdominal aortic aneurysm technique.| | PubMed
- A single nucleotide polymorphism in the p27(Kip1) gene is associated with primary patency of lower extremity vein bypass grafts.| | PubMed
- Vascular remodeling in autogenous arterio-venous fistulas by MRI and CFD.| | PubMed
- Thirty-day vein remodeling is predictive of midterm graft patency after lower extremity bypass.| | PubMed
- USPIO-enhanced MR angiography of arteriovenous fistulas in patients with renal failure.| | PubMed
- An integrated biochemical prediction model of all-cause mortality in patients undergoing lower extremity bypass surgery for advanced peripheral artery disease.| | PubMed
- Management of infrapopliteal peripheral arterial occlusive disease.| | PubMed
- Associations of endothelial dysfunction and arterial stiffness with intradialytic hypotension and hypertension.| | PubMed
- Assessing drug elution technologies in the superficial femoral artery.| | PubMed
- Excellent outcomes of laparoscopic esophagomyotomy for achalasia in patients older than 60 years of age.| | PubMed
- Has recognition of the relationship between mortality rates and hospital volume for major cancer surgery in California made a difference?: A follow-up analysis of another decade.| | PubMed
- Gastroesophageal reflux disease and connective tissue disorders: pathophysiology and implications for treatment.| | PubMed
- Predicting strangulated small bowel obstruction: an old problem revisited.| | PubMed
- Association of tetraspanin CD9 with transmembrane TGF{alpha} confers alterations in cell-surface presentation of TGF{alpha} and cytoskeletal organization.| | PubMed
- Lung transplantation in patients with connective tissue disorders and esophageal dysmotility.| | PubMed
- Palliation of thoracic malignancies.| | PubMed
- The outcome of laparoscopic Heller myotomy for achalasia is not influenced by the degree of esophageal dilatation.| | PubMed
- Antireflux surgery for patients with end-stage lung disease before and after lung transplantation.| | PubMed
- Angiogenic inhibition mediated by a DNAzyme that targets vascular endothelial growth factor receptor 2.| | PubMed
- Targeting tumor angiogenesis with gene therapy.| | PubMed