Biography
Valerie M. Weaver, Ph.D., is the Director of the Center for Bioengineering and Tissue Regeneration in the Department of Surgery. She earned her Bachelor of Science degree at the University of Waterloo in Biochemistry/Chemistry in 1985, continuing her education for an Honors Bachelor of Science in Biochemistry at the University of Ottawa (graduating Summa cum Laude). Dr. Weaver earned her doctorate degree, Ph.D, from the University of Ottawa in Biochemistry in 1992.
After receiving her doctorate, Dr. Weaver was awarded the Molecular Cell Biology and Apoptosis Research Group and the Institute for Biological Sciences of Canada Postdoctoral Fellow from 1992-1994. From 1994-1998, she was distinguished as the Postdoctoral Fellow at the Lawrence Berkeley National Laboratory at the University of California, Berkeley, in the Cancer and Cell Biology Group, Life Sciences Division.
Following her fellowships, Dr. Weaver has held principle positions within academia. Prior to her appointment at UCSF, she was an Adjunct Associate Professor with the Department of Bioengineering at the University of Pennsylvania from 1999 to 2006. In her current position, she is an Professor with the Department of Surgery at the Universality of California, San Francisco.
Additionally, Dr. Weaver is the Director for the Center for Bioengineering & Tissue Regeneration with the Department of Surgery and UCSF, an Associate Professor in the Department of Anatomy at UCSF, and Adjunct Associate Professor for the department of Bioengineering at UPenn. From 1999 to 2006 she was a member at the Institute for Medicine and Engineering at UPenn.
Dr. Weaver's extensive honors and awards include: the Breast Cancer Scholar Award with the Department of Defense, the International Society of Differentiation Young Investigator Travel Award, the Alberta Heritable Foundation for Medical Research Lecturer Award, and the University of California Breast Cancer Research Program Postdoctoral Grant.
She also proudly serves on the Editorial Board for Cancer Biology & Therapy, was a guest editor in 2004 for J. Mammary Gland Biology and Neoplasia, and is currently an Ad Hoc Reviewer for several distinguished journals, including: Cancer Research, American Journal of Cell Biology, European Journal of Cell Biology, Molecular Carcinogenesis, Journal of the National Cancer Institute, Oncogene, FASEB Journal, Journal of Cell Science, Laboratory Investigation, Cancer Letters, Breast Cancer Research, Journal of Biological Chemistry, Molecular Biology of the Cell, Molecular and Cellular Biology, & Clinical Cancer Research.
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of California | Diversity, Equity, and Inclusion Champion Training | 04/2021 |
In the News
Grants and Funding
- Tissue mechanics reprograms the tissue to malignancy and metastasis | NIH | 2020-09-01 - 2027-08-31 | Role: Principal Investigator
- A physical sciences approach to investigate the role of exosomes in metastatic progression | NIH | 2021-09-16 - 2026-08-31 | Role: Co-Principal Investigator
- Targeting the Cancer Glycocalyx | NIH | 2019-03-01 - 2024-02-29 | Role: Co-Principal Investigator
- Reorienting the Glioblastoma Microenvironment to Respond to Immunotherapy | NIH | 2019-02-01 - 2024-01-31 | Role: Co-Principal Investigator
- Tissue Tension, RANK and Breast Cancer Risk | NIH | 2018-02-09 - 2023-01-31 | Role: Principal Investigator
- ECM geometrical and mechanical properties modulate RTK signaling | NIH | 2015-09-22 - 2021-08-31 | Role: Co-Principal Investigator
- Tension-Stat3-miR-mediated metastasis | NIH | 2015-04-01 - 2021-03-31 | Role: Principal Investigator
- Inside-Out Approaches to Improve Wound Repair by HoxB3 | NIH | 2016-07-15 - 2020-04-30 | Role: Principal Investigator
- A biophysical stromal basis for radiation sensitivity in ductal carcinoma in situ | NIH | 2014-05-05 - 2020-02-29 | Role: Co-Principal Investigator
- Advanced Methods to Evaluate Extracellular Matrix and Crosslinking in the Tumor M | NIH | 2014-05-02 - 2018-04-30 | Role: Co-Principal Investigator
- TGF-beta Suppression and Promotion of Mammary Carcinomas | NIH | 2000-05-20 - 2017-02-28 | Role: Co-Principal Investigator
- Biophysical and molecular dialogue of glioma cells and the brain microenvironment | NIH | 2011-09-26 - 2016-07-31 | Role: Co-Principal Investigator
- 2015 Fibronectin, Integrins & Related Molecules Gordon Research Conference & Gordon Research Seminar | NIH | 2015-05-01 - 2016-04-30 | Role: Principal Investigator
- Collagen remodeling and tumor progression | NIH | 2010-05-07 - 2016-02-29 | Role: Principal Investigator
- Role of Fibroblasts, Myeloid Cells and Matrix in PDAC | NIH | 2010-09-30 - 2015-08-31 | Role: Co-Principal Investigator
- Fundamental Mechanobiology of Tumor Progression | NIH | 2009-09-29 - 2015-07-31 | Role: Co-Investigator
- 2013 Fibronectin, Integrins & Related Molecules GRC/GRS | NIH | 2013-02-06 - 2014-01-31 | Role: Principal Investigator
- NFkB, tissue polarity and apoptosis resistance | NIH | 2000-07-01 - 2010-06-30 | Role: Principal Investigator
Research Narrative
Dr. Weaver has over 20 years of experience in leading interdisciplinary research in oncology, including leadership of significant program projects merging approaches in the physical/engineering sciences and biology. Her research focuses on the contribution of force, cell-intrinsic as well as extracellular matrix, to oncogenesis and tumor development. Her group employs 2- and 3-D in vitro cell culture techniques, clinical samples and animal models with force application techniques, and traction force and atomic force microscopy to assess the influence of the mechanical aspects of the cell environment on cell behavior and tumor progression. Dr. Weaver has been awarded many distinctions for her work demonstrating the critical importance of tissue structure in the treatment response of tumors, including the prestigious Department of Defense Era of Hope Breast Cancer Scholar Award for her innovative interdisciplinary research efforts on the effect of mechanical force on breast cancer progression and treatment response. Along with Dr. Jan Liphardt, PhD, UC Berkeley, she was awarded the prestigious Physical Sciences and Oncology Center Grant, whose aim is to integrate physical sciences approaches toward better understanding tumor biology. The Center encompasses close to 100 investigators in physics, engineering, mathematics, chemistry, cell and molecular biology, and clinical sciences from UC Berkeley, UCSF, and LBNL. In addition, Dr. Weaver a Co-PI on an NIH U01 grant with Dr. Werb on environmental stressors in mammary gland development and a Co-PI with Drs. Kalluri and Moses on role of fibroblasts, myeloid cells and matrix in PDAC.
Dr. Weaver is the TMEN-BCC co-PI with Dr. Bergers, as well as the leader of Project 3,in which she is testing the hypothesis that the mechanoproperties of SVZ-derived GBM, together with elevated cranial pressure and ECM stiffness, promote GBM aggressiveness and recurrence, in part by affecting the vascular and tumor stem cell compartment.
Publications
- Assessing Heterogeneity in the N-Telopeptides of Type I Collagen by Mass Spectrometry.| | View in PubMed
- Author Correction: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.| | View in PubMed
- Author Correction: Stiff matrix induces exosome secretion to promote tumour growth.| | View in PubMed
- Retraction Note: Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin.| | View in PubMed
- Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth.| | View in PubMed
- Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk.| | View in PubMed
- Expression of Concern: α6β4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-κB-dependent resistance to apoptosis in 3D mammary acini.| | View in PubMed
- The microenvironment dictates glycocalyx construction and immune surveillance.| | View in PubMed
- Design of a mucin-selective protease for targeted degradation of cancer-associated mucins.| | View in PubMed
- Tissue tension permits β-catenin phosphorylation to drive mesoderm specification in human embryonic stem cells.| | View in PubMed
- Correction: Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells.| | View in PubMed
- A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer.| | View in PubMed
- Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung.| | View in PubMed
- Author Correction: Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression.| | View in PubMed
- Correction: Lysyl Oxidase-like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer.| | View in PubMed
- Stiff matrix induces exosome secretion to promote tumour growth.| | View in PubMed
- Programming the Self-Organization of Endothelial Cells into Perfusable Microvasculature.| | View in PubMed
- Extracellular Matrix Glycation and Crosslinking in Mammary Tumor Progression.| | View in PubMed
- Novel cryo-tomography workflow reveals nanometer-scale responses of epithelial cells to matrix stiffness and dimensionality.| | View in PubMed
- Mechanosensitive Steroid Hormone Signaling and Cell Fate.| | View in PubMed
- Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer.| | View in PubMed
- ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells.| | View in PubMed
- Screening of organoids derived from patients with breast cancer implicates the repressor NCOR2 in cytotoxic stress response and antitumor immunity.| | View in PubMed
- Immunosuppressive glycoproteins associate with breast tumor fibrosis and aggression.| | View in PubMed
- NCI's publication affiliation conundrum: Reframing innovation to incentivize an equitable path for advocate representation.| | View in PubMed
- Mechanobiology: forcing the second act.| | View in PubMed
- Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis.| | View in PubMed
- Tissue mechanics in stem cell fate, development, and cancer.| | View in PubMed
- EPH/EPHRIN regulates cellular organization by actomyosin contractility effects on cell contacts.| | View in PubMed
- Adhesion-mediated mechanosignaling forces mitohormesis.| | View in PubMed
- Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree.| | View in PubMed
- Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer.| | View in PubMed
- Improving DCIS diagnosis and predictive outcome by applying artificial intelligence.| | View in PubMed
- Leveraging microenvironmental synthetic lethalities to treat cancer.| | View in PubMed
- Membrane Tension Locks In Pluripotency.| | View in PubMed
- Derivation of a nuclear heterogeneity image index to grade DCIS.| | View in PubMed
- Proteoglycans as Mediators of Cancer Tissue Mechanics.| | View in PubMed
- Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression.| | View in PubMed
- Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells.| | View in PubMed
- Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217.| | View in PubMed
- Zena Werb (1945-2020): Mourning the loss of a tissue microenvironment icon.| | View in PubMed
- In Memoriam - Zena Werb 1945-2020.| | View in PubMed
- Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix.| | View in PubMed
- Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice.| | View in PubMed
- Zena Werb 1945-2020.| | View in PubMed
- Fibrosis and cancer: A strained relationship.| | View in PubMed
- Tension in tumour cells keeps metabolism high.| | View in PubMed
- A framework for advancing our understanding of cancer-associated fibroblasts.| | View in PubMed
- Don't sugarcoat it: How glycocalyx composition influences cancer progression.| | View in PubMed
- Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics.| | View in PubMed
- Controlled modelling of human epiblast and amnion development using stem cells.| | View in PubMed
- Wnt4 from the Niche Controls the Mechano-Properties and Quiescent State of Muscle Stem Cells.| | View in PubMed
- Tissue mechanics, an important regulator of development and disease.| | View in PubMed
- The Extracellular Matrix Modulates the Metastatic Journey.| | View in PubMed
- Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference.| | View in PubMed
- A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma.| | View in PubMed
- Modeling Tissue Polarity in Context.| | View in PubMed
- Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells.| | View in PubMed
- Compartment resolved proteomics reveals a dynamic matrisome in a biomechanically driven model of pancreatic ductal adenocarcinoma.| | View in PubMed
- The Physical and Biochemical Properties of the Extracellular Matrix Regulate Cell Fate.| | View in PubMed
- New Horizons in Advocacy Engaged Physical Sciences and Oncology Research.| | View in PubMed
- Feeling Stress: The Mechanics of Cancer Progression and Aggression.| | View in PubMed
- Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma.| | View in PubMed
- Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers.| | View in PubMed
- Excess area dependent scaling behavior of nano-sized membrane tethers.| | View in PubMed
- A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression.| | View in PubMed
- Tissue Force Programs Cell Fate and Tumor Aggression.| | View in PubMed
- α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site.| | View in PubMed
- Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells.| | View in PubMed
- Lysyl Oxidase-like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer.| | View in PubMed
- Cell and tissue mechanics: the new cell biology frontier.| | View in PubMed
- Visualizing dynamic microvillar search and stabilization during ligand detection by T cells.| | View in PubMed
- Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis.| | View in PubMed
- Comprehensive characterization of DNA methylation changes in Fuchs endothelial corneal dystrophy.| | View in PubMed
- Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix.| | View in PubMed
- Tissue mechanics regulate brain development, homeostasis and disease.| | View in PubMed
- Force-dependent breaching of the basement membrane.| | View in PubMed
- Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer.| | View in PubMed
- From transformation to metastasis: deconstructing the extracellular matrix in breast cancer.| | View in PubMed
- Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells.| | View in PubMed
- Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression.| | View in PubMed
- Cellular adaptation to biomechanical stress across length scales in tissue homeostasis and disease.| | View in PubMed
- Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation.| | View in PubMed
- Visualizing mechanical modulation of nanoscale organization of cell-matrix adhesions.| | View in PubMed
- Mechanical Control of Epithelial-to-Mesenchymal Transitions in Development and Cancer.| | View in PubMed
- Site-Specific Modulation of Charge Controls the Structure and Stimulus Responsiveness of Intrinsically Disordered Peptide Brushes.| | View in PubMed
- Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.| | View in PubMed
- Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease.| | View in PubMed
- Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness.| | View in PubMed
- Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha.| | View in PubMed
- Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.| | View in PubMed
- Tumor-induced solid stress activates β-catenin signaling to drive malignant behavior in normal, tumor-adjacent cells.| | View in PubMed
- Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors.| | View in PubMed
- Monitoring developmental force distributions in reconstituted embryonic epithelia.| | View in PubMed
- STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma.| | View in PubMed
- Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration.| | View in PubMed
- Fighting the force: Potential of homeobox genes for tumor microenvironment regulation.| | View in PubMed
- Tumor mechanics and metabolic dysfunction.| | View in PubMed
- A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype.| | View in PubMed
- The extracellular matrix modulates the hallmarks of cancer.| | View in PubMed
- Extracellular matrix assembly: a multiscale deconstruction.| | View in PubMed
- The microenvironment matters.| | View in PubMed
- Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate.| | View in PubMed
- Multicellular architecture of malignant breast epithelia influences mechanics.| | View in PubMed
- The cancer glycocalyx mechanically primes integrin-mediated growth and survival.| | View in PubMed
- Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival.| | View in PubMed
- Understanding tissue context influences on intratumour heterogeneity.| | View in PubMed
- Deconstructing signaling in three dimensions.| | View in PubMed
- Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression.| | View in PubMed
- Rapid disorganization of mechanically interacting systems of mammary acini.| | View in PubMed
- Cell biology. Strength under tension.| | View in PubMed
- Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-β-deficient mouse mammary carcinomas.| | View in PubMed
- Collagen architecture in pregnancy-induced protection from breast cancer.| | View in PubMed
- Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin.| | View in PubMed
- YAP forces fibroblasts to feel the tension.| | View in PubMed
- MT1-MMP-dependent control of skeletal stem cell commitment via a β1-integrin/YAP/TAZ signaling axis.| | View in PubMed
- A physical sciences network characterization of non-tumorigenic and metastatic cells.| | View in PubMed
- Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer.| | View in PubMed
- Scanning angle interference microscopy reveals cell dynamics at the nanoscale.| | View in PubMed
- Morphogenesis: Laying down the tracks.| | View in PubMed
- The extracellular matrix: a dynamic niche in cancer progression.| | View in PubMed
- Exploring the link between human embryonic stem cell organization and fate using tension-calibrated extracellular matrix functionalized polyacrylamide gels.| | View in PubMed
- Extracellular matrix degradation and remodeling in development and disease.| | View in PubMed
- In situ force mapping of mammary gland transformation.| | View in PubMed
- Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth.| | View in PubMed
- Valerie Weaver: overcoming cancer's stiff resistance. Interview by Caitlin Sedwick.| | View in PubMed
- Balancing forces: architectural control of mechanotransduction.| | View in PubMed
- Tumor microenvironment and progression.| | View in PubMed
- Engineering strategies to recapitulate epithelial morphogenesis within synthetic three-dimensional extracellular matrix with tunable mechanical properties.| | View in PubMed
- The extracellular matrix at a glance.| | View in PubMed
- Effect of substrate stiffness and PDGF on the behavior of vascular smooth muscle cells: implications for atherosclerosis.| | View in PubMed
- Forcing form and function: biomechanical regulation of tumor evolution.| | View in PubMed
- Dynamic interplay between the collagen scaffold and tumor evolution.| | View in PubMed
- SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.| | View in PubMed
- HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype.| | View in PubMed
- Biophysics. Enforcing order on signaling.| | View in PubMed
- Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate.| | View in PubMed
- Matrix crosslinking forces tumor progression by enhancing integrin signaling.| | View in PubMed
- Mechanics, malignancy, and metastasis: the force journey of a tumor cell.| | View in PubMed
- Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension.| | View in PubMed
- The tissue diagnostic instrument.| | View in PubMed
- Multiscale modeling of form and function.| | View in PubMed
- CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis.| | View in PubMed
- A tense situation: forcing tumour progression.| | View in PubMed
- Biomechanical regulation of cell orientation and fate.| | View in PubMed
- Three-dimensional context regulation of metastasis.| | View in PubMed
- A human breast cell model of preinvasive to invasive transition.| | View in PubMed
- Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion.| | View in PubMed
- Integrin-mediated signalling through the MAP-kinase pathway.| | View in PubMed
- Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures.| | View in PubMed
- alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini.| | View in PubMed
- G'rab'bing the microenvironment for invasion.| | View in PubMed
- Mammary epithelial cell: influence of extracellular matrix composition and organization during development and tumorigenesis.| | View in PubMed
- Demystifying the effects of a three-dimensional microenvironment in tissue morphogenesis.| | View in PubMed
- The ultrastructure of MCF-10A acini.| | View in PubMed
- Forcing the third dimension.| | View in PubMed
- Analysis of protein expression during oxidative stress in breast epithelial cells using a stable isotope labeled proteome internal standard.| | View in PubMed
- Tensional homeostasis and the malignant phenotype.| | View in PubMed
- Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin.| | View in PubMed
- Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression.| | View in PubMed
- Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion.| | View in PubMed
- The tension mounts: mechanics meets morphogenesis and malignancy.| | View in PubMed
- Watch thy neighbor: cancer is a communal affair.| | View in PubMed
- Death in the third dimension: apoptosis regulation and tissue architecture.| | View in PubMed
- Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors.| | View in PubMed
- Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin.| | View in PubMed
- The tissue microenvironment as an epigenetic tumor modifier.| | View in PubMed
- The organizing principle: microenvironmental influences in the normal and malignant breast.| | View in PubMed
- Membrane-associated MMP regulators: novel cell adhesion tumor suppressor proteins?| | View in PubMed
- Tumour-stromal interactions. Integrins and cell adhesions as modulators of mammary cell survival and transformation.| | View in PubMed
- Lack of specificity of trans,trans-muconic acid as a benzene biomarker after ingestion of sorbic acid-preserved foods.| | View in PubMed
- E7-transduced human breast epithelial cells show partial differentiation in three-dimensional culture.| | View in PubMed
- Constitutive expression of Heregulin induces apoptosis in an erbB-2 overexpressing breast cancer cell line SKBr-3.| | View in PubMed
- Functional culture models to study mechanisms governing apoptosis in normal and malignant mammary epithelial cells.| | View in PubMed
- Tissue structure, nuclear organization, and gene expression in normal and malignant breast.| | View in PubMed
- Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology.| | View in PubMed
- Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus.| | View in PubMed
- Structural cues from the tissue microenvironment are essential determinants of the human mammary epithelial cell phenotype.| | View in PubMed
- Differentiation and cancer in the mammary gland: shedding light on an old dichotomy.| | View in PubMed
- Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies.| | View in PubMed
- Extracellular matrix: the central regulator of cell and tissue homeostasis.| | View in PubMed
- Degradation of nuclear matrix and DNA cleavage in apoptotic thymocytes.| | View in PubMed
- Extracellular matrix signaling from the cellular membrane skeleton to the nuclear skeleton: a model of gene regulation.| | View in PubMed
- The importance of the microenvironment in breast cancer progression: recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assay.| | View in PubMed
- The development of a functionally relevant cell culture model of progressive human breast cancer.| | View in PubMed
- Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes.| | View in PubMed