Biography
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of California | Diversity, Equity, and Inclusion Champion Training | 2019 |
Collaboration Interests
I am interested in:
- PhysicianScientist
Clinical Expertise
Minimally Invasive Mitral Valve Surgery
Minimally Invasive Aortic Valve Surgery
Minimally Invasive Atrial Septal Defect (ASD) Closure
Aortic Valve Repair & Replacement
Acute Aortic Dissection Repair
Heart Transplantation
Lung Transplantation
Ventricular Assist Devices (VAD)
Ventricular Aneurysm
Arrhythmia
Coronary Artery Bypass Grafting (CABG)
Off-Pump Coronary Artery Bypass (OPCAB)
Foreign Languages Spoken
Program Affiliations
UCSF Heart & Vascular Center
In the News
Grants and Funding
- Hypo-immunogenic cardiomyocytes for myocardial repair | NIH | 2018-08-01 - 2022-06-30 | Role: Principal Investigator
- Microgravity as model for immunological senescence and its impact on tissue stem cells and regeneration | NIH | 2017-06-15 - 2022-06-30 | Role: Co-Principal Investigator
- Microgravity as model for immunological senescence and its impact on tissue stem cells and regeneration | NIH | 2017-06-15 - 2020-02-29 | Role: Co-Principal Investigator
Research Narrative
Dr. Deuse's research is focused on vascular biology and pathophysiology. His group was the among the first to elucdiate the novel pathways involved in the development of vascular intimal hyperplasia. Myointimal hyperplasia is a pathological process of the vascular system characterized by abnormal proliferation of smooth muscle cells of the vascular wall that leads to luminal obliteration and subsequent ischemia.
Myointimal hyperplasia may occur in patients after vessel injury during medical procedures (e.g. after balloon dilation or stent placement) or after pathological injury of the blood vessel (e.g. due to inflammation or toxic exposure). It can cause bypass graft failure and in-stent restenosis. To help prevent this and increase the success of treatments for vascular disease including coronary heart disease, his research group is working on the development of new preventive drug regimes and strategies.
Research Interests
Vascular Biology
Stem Cell Immunobiology
Transplant Immunology
Oxidative Stress and Apoptosis
Pulmonary Hypertension
Publications
- Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate.| | View in PubMed
- Four decades of progress in heart-lung transplantation: Two hundred seventy-one cases at a single institution.| | View in PubMed
- Lung Transplantation in Patients with Cystic Fibrosis: A Complex Task, A Changing Target.| | View in PubMed
- Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity.| | View in PubMed
- Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques.| | View in PubMed
- Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice.| | View in PubMed
- Hypoimmune anti-CD19 chimeric antigen receptor T cells provide lasting tumor control in fully immunocompetent allogeneic humanized mice.| | View in PubMed
- Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression.| | View in PubMed
- Morbidity and Mortality Associated With Blood Transfusions in Elective Adult Cardiac Surgery.| | View in PubMed
- Author Correction: Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients.| | View in PubMed
- Intercostal Nerve Cryoanalgesia Versus Thoracic Epidural Analgesia in Lung Transplantation: A Retrospective Single-Center Study.| | View in PubMed
- Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice.| | View in PubMed
- Shock, Thrombus, TAVR: A Challenging TAVR With Large Left-Ventricular Thrombus.| | View in PubMed
- Immunomodulation Therapy Using Tolerogenic Macrophages in a Rodent Model of Pulmonary Hypertension.| | View in PubMed
- The SIRPα-CD47 immune checkpoint in NK cells.| | View in PubMed
- Outcomes of transcatheter aortic valve replacement in end stage liver and renal disease.| | View in PubMed
- Subxiphoid Hybrid Epicardial-Endocardial Atrial Fibrillation Ablation and LAA Ligation: Initial Sub-X Hybrid MAZE Registry Results.| | View in PubMed
- Impact of Aortic Stenosis on Myofiber Stress: Translational Application of Left Ventricle-Aortic Coupling Simulation.| | View in PubMed
- The H-Y Antigen in Embryonic Stem Cells Causes Rejection in Syngeneic Female Recipients.| | View in PubMed
- Risk Factors and Outcomes of Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplantation.| | View in PubMed
- Frailty after lung transplantation is associated with impaired health-related quality of life and mortality.| | View in PubMed
- Impact of donor lung quality on post-transplant recipient outcome in the Lung Allocation Score era in Eurotransplant - a historical prospective study.| | View in PubMed
- A Cryoinjury Model to Study Myocardial Infarction in the Mouse.| | View in PubMed
- De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans.| | View in PubMed
- Bergeyella cardium: Clinical Characteristics and Draft Genome of an Emerging Pathogen in Native and Prosthetic Valve Endocarditis.| | View in PubMed
- Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients.| | View in PubMed
- Nontyphoidal Salmonella as a Cause of Mediastinal Abscess after Aortic Valve Replacement: A Case Report and Review of Postoperative Salmonella Infections.| | View in PubMed
- Analysis of Minimally Invasive Left Thoracotomy HVAD Implantation - A Single-Center Experience.| | View in PubMed
- Lung allocation score: the Eurotransplant model versus the revised US model - a cross-sectional study.| | View in PubMed
- Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study.| | View in PubMed
- Hybrid Open Minimally Invasive Transcatheter Mitral Valve Replacement.| | View in PubMed
- Balloon-based Injury to Induce Myointimal Hyperplasia in the Mouse Abdominal Aorta.| | View in PubMed
- Hybrid and surgical procedures for the treatment of persistent and longstanding persistent atrial fibrillation.| | View in PubMed
- Outcomes of Minimally Invasive Temporary Right Ventricular Assist Device Support for Acute Right Ventricular Failure During Minimally Invasive Left Ventricular Assist Device Implantation.| | View in PubMed
- Thalidomide treatment prevents chronic graft rejection after aortic transplantation in rats - an experimental study.| | View in PubMed
- Differences in Vascular Response between Balloon Overstretch and Stent Overexpansion in Nonatherosclerotic Porcine Coronary Arteries.| | View in PubMed
- Gender differences and outcomes in left ventricular assist device support: The European Registry for Patients with Mechanical Circulatory Support.| | View in PubMed
- The value of fluorine-18 deoxyglucose positron emission tomography scans in patients with ventricular assist device specific infections†.| | View in PubMed
- Lobar lung transplantation from deceased donors: A systematic review.| | View in PubMed
- Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency.| | View in PubMed
- Orthotopic tracheal transplantation using human bronchus: an original xenotransplant model of obliterative airway disorder.| | View in PubMed
- Acute Pulmonary Artery Obstruction as the Primary Manifestation of a Rapidly Growing Intimal Sarcoma in a 54-Year-Old Patient.| | View in PubMed
- A matched pairs analysis of non-rib-spreading, fully endoscopic, mini-incision technique versus conventional mini-thoracotomy for mitral valve repair.| | View in PubMed
- The Selective JAK1/3-Inhibitor R507 Mitigates Obliterative Airway Disease Both With Systemic Administration and Aerosol Inhalation.| | View in PubMed
- The MANDELA study: A multicenter, randomized, open-label, parallel group trial to refine the use of everolimus after heart transplantation.| | View in PubMed
- Sex Differences in Immunology: More Severe Development of Experimental Pulmonary Hypertension in Male Rats Exposed to Vascular Endothelial Growth Factor Receptor Blockade.| | View in PubMed
- Distal Airway Stem Cells are Essential for Lung Regeneration.| | View in PubMed
- Local MicroRNA Modulation Using a Novel Anti-miR-21-Eluting Stent Effectively Prevents Experimental In-Stent Restenosis.| | View in PubMed
- Mesenchymal stromal cell therapy: different sources exhibit different immunobiological properties.| | View in PubMed
- Immunobiology of fibrin-based engineered heart tissue.| | View in PubMed
- Concomitant minimally invasive HVAD and transapical aortic valve implantation.| | View in PubMed
- SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts.| | View in PubMed
- Thymoglobulin induction in heart transplantation: patient selection and implications for maintenance immunosuppression.| | View in PubMed
- Isolated permanent right ventricular assist device implantation with the HeartWare continuous-flow ventricular assist device: first results from the European Registry for Patients with Mechanical Circulatory Support.| | View in PubMed
- Clinical experience of combined HeartWare ventricular assist device and implantable cardioverter defibrillator therapy.| | View in PubMed
- HVAD implantation in right atrium-to-right pulmonary artery configuration.| | View in PubMed
- Introduction of the lung allocation score in Germany.| | View in PubMed
- Inducing myointimal hyperplasia versus atherosclerosis in mice: an introduction of two valid models.| | View in PubMed
- Dichloroacetate prevents restenosis in preclinical animal models of vessel injury.| | View in PubMed
- Minimally invasive implantation of biventricular assist devices.| | View in PubMed
- Do not touch the sternum--thoracotomy incisions for HVAD implantation.| | View in PubMed
- Efficacy of prophylactic intra-aortic balloon pump therapy in chronic heart failure patients undergoing cardiac surgery.| | View in PubMed
- Dual-chamber pacemaker implantation with left ventricular pacing in a patient with a right ventricular assist device.| | View in PubMed
- HVAD continuous flow assist device for ischemic ventricular septal rupture.| | View in PubMed
- Mechanically induced ventricular tachycardia by the HeartWare ventricular assist device.| | View in PubMed
- Everolimus in heart transplantation: an update.| | View in PubMed
- Bortezomib rescue therapy in a patient with recurrent antibody-mediated rejection after lung transplantation.| | View in PubMed
- Granulocyte colony-stimulating factor therapy is associated with a reduced incidence of acute rejection episodes or allograft vasculopathy in heart transplant recipients.| | View in PubMed
- Immunological properties of extraembryonic human mesenchymal stromal cells derived from gestational tissue.| | View in PubMed
- Minimal access median sternotomy for aortic valve replacement in elderly patients.| | View in PubMed
- Isolated permanent right ventricular assistance using the HVAD continuous-flow pump.| | View in PubMed
- Aspergillus galactomannan antigen for diagnosis and treatment monitoring in cerebral aspergillosis.| | View in PubMed
- ST-elevation myocardial infarction following heart transplantation as an unusual presentation of coronary allograft vasculopathy: a case report.| | View in PubMed
- The potassium channel KCa3.1 as new therapeutic target for the prevention of obliterative airway disease.| | View in PubMed
- Severe bacterial superinfection based on influenza A (H1N1) pneumonia in a heart-lung transplant recipient.| | View in PubMed
- Concomitant transcatheter aortic valve and left ventricular assist device implantation.| | View in PubMed
- Late profound muscle weakness following heart transplantation due to Danon disease.| | View in PubMed
- Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545.| | View in PubMed
- Clinical and functional correlates of early microvascular dysfunction after heart transplantation.| | View in PubMed
- Successful extracorporeal membrane oxygenation weaning after cardiac resynchronization therapy device implantation in a patient with end-stage heart failure.| | View in PubMed
- Human internal mammary artery (IMA) transplantation and stenting: a human model to study the development of in-stent restenosis.| | View in PubMed
- Cardiac paraganglioma: diagnostic and surgical challenges.| | View in PubMed
- Human leukocyte antigen I knockdown human embryonic stem cells induce host ignorance and achieve prolonged xenogeneic survival.| | View in PubMed
- Immunobiology of naïve and genetically modified HLA-class-I-knockdown human embryonic stem cells.| | View in PubMed
- Surgical technique of lower lobe lung transplantation.| | View in PubMed
- Bioluminescence imaging for assessment of immune responses following implantation of engineered heart tissue (EHT).| | View in PubMed
- Minimally invasive resection of a right atrial mass in a cardiac transplant recipient: a case report.| | View in PubMed
- Antibody response after a single dose of an AS03-adjuvanted split-virion influenza A (H1N1) vaccine in heart transplant recipients.| | View in PubMed
- Orthotopic aortic transplantation: a rat model to study the development of chronic vasculopathy.| | View in PubMed
- Transcatheter aortic valve implantation in a heart transplant recipient: a case report.| | View in PubMed
- Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells.| | View in PubMed
- Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting.| | View in PubMed
- Review of heart-lung transplantation at Stanford.| | View in PubMed
- Non-volume-loaded heart provides a more relevant heterotopic transplantation model.| | View in PubMed
- Heterotopic and orthotopic tracheal transplantation in mice used as models to study the development of obliterative airway disease.| | View in PubMed
- Asymptomatic infection with novel influenza A/H1N1 virus in a heart transplant recipient.| | View in PubMed
- Mechanisms behind local immunosuppression using inhaled tacrolimus in preclinical models of lung transplantation.| | View in PubMed
- Changing trends in infectious disease in heart transplantation.| | View in PubMed
- LAD-ligation: a murine model of myocardial infarction.| | View in PubMed
- Alternative technique for salvage of donor lungs with insufficient atrial cuffs.| | View in PubMed
- Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction.| | View in PubMed
- Imaging in-stent restenosis: an inexpensive, reliable, and rapid preclinical model.| | View in PubMed
- Heart-lung transplantation in situs inversus totalis.| | View in PubMed
- Right ventricular dysfunction predicts poor outcome following hemodynamically compromising rejection.| | View in PubMed
- A novel JAK3 inhibitor, R348, attenuates chronic airway allograft rejection.| | View in PubMed
- Heart transplantation in situs inversus totalis.| | View in PubMed
- Twenty-year survivors of heart transplantation at Stanford University.| | View in PubMed
- Novel immunosuppression: R348, a JAK3- and Syk-inhibitor attenuates acute cardiac allograft rejection.| | View in PubMed
- Prevention and inhibition but not reversion of chronic allograft vasculopathy by FK778.| | View in PubMed
- Introducing the first polymer-free leflunomide eluting stent.| | View in PubMed
- Fluoroscopy to assess late heart and lung perforation by a permanent ventricular pacemaker lead. A case complicated by isolated hemothorax.| | View in PubMed
- Effect of inhaled tacrolimus on cellular and humoral rejection to prevent posttransplant obliterative airway disease.| | View in PubMed
- Is the malononitrilamide FK778 better for the prevention of acute or chronic rejection?| | View in PubMed
- Stem cell transplantation: the lung barrier.| | View in PubMed
- Techniques for experimental heterotopic and orthotopic tracheal transplantations - When to use which model?| | View in PubMed
- Simplified protocol to isolate, purify, and culture expand mesenchymal stem cells.| | View in PubMed
- Experimental orthotopic tracheal transplantation: The Stanford technique.| | View in PubMed
- FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy.| | View in PubMed
- Inhibition of restenosis development after mechanical injury: a new field of application for malononitrilamides?| | View in PubMed
- The selective estrogen receptor-beta agonist biochanin A shows vasculoprotective effects without uterotrophic activity.| | View in PubMed
- Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase.| | View in PubMed
- FK778: new cellular and molecular mechanisms of action.| | View in PubMed
- Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease.| | View in PubMed
- Tracheal allograft transplantation in rats: the role of different immunosuppressants on preservation of respiratory epithelium.| | View in PubMed
- The phytoestrogen biochaninA weakens acute cardiac allograft rejection without affecting the reproductive system.| | View in PubMed
- FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation.| | View in PubMed
- FK778, a novel immunosuppressive agent, reduces early adhesion molecule up-regulation and prolongs cardiac allograft survival.| | View in PubMed
- Video and robotic-assisted minimally invasive mitral valve surgery: a comparison of the Port-Access and transthoracic clamp techniques.| | View in PubMed
- FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies.| | View in PubMed
- The interaction between FK778 and tacrolimus in the prevention of rat cardiac allograft rejection is dose dependent.| | View in PubMed
- Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model.| | View in PubMed
- Successful resection of a symptomatic right ventricular lipoma.| | View in PubMed
- Robotically assisted coronary artery bypass surgery with the ZEUS telemanipulator system.| | View in PubMed
- Correlation between mononuclear infiltration and changes in VASP phosphorylation patterns after heterotopic cardiac transplantation in the rat.| | View in PubMed
- Early and midterm results after coronary artery bypass grafting with and without cardiopulmonary bypass: which patient population benefits the most?| | View in PubMed
- New technique for chest opening in mice: U-sternotomy.| | View in PubMed
- Comparison of two stabilizer concepts for off-pump coronary artery bypass grafting.| | View in PubMed
- Robotically-assisted coronary artery surgery with and without cardiopulmonary bypass - from first clinical use to endoscopic operation.| | View in PubMed
- Effect of hemodynamics on graft rejection in the heterotopic heart transplantation model.| | View in PubMed