Biography
Deuse earned his medical degree from the University of Würzburg in Germany. He received advanced training in heart and lung surgery at the University Hospital of Munich and University Heart Center Hamburg. After obtaining board certification in Germany as a heart surgeon, he completed a fellowship in lung and heart-lung transplantation with Stanford Medicine.
After returning to Germany in 2009, Deuse was appointed director of heart and lung transplantation at the University Heart Center Hamburg. He achieved international acclaim for his development of innovative approaches to heart failure surgery, most notably minimally invasive techniques for implanting ventricular assist systems. He also demonstrated that high success rates could be achieved in mitral valve repair utilizing fully robot-assisted endoscopic surgery. Also known as keyhole surgery, this approach has many benefits for the patient, including substantially reduced postsurgical pain, shorter hospital stays and faster recovery.
Deuse has received numerous honors, including election to the board of directors of the International Society for Heart and Lung Transplantation.
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of California | Diversity, Equity, and Inclusion Champion Training | 2019 |
Collaboration Interests
I am interested in:
- PhysicianScientist
Clinical Expertise
Minimally Invasive Mitral Valve Surgery
Minimally Invasive Aortic Valve Surgery
Minimally Invasive Atrial Septal Defect (ASD) Closure
Aortic Valve Repair & Replacement
Acute Aortic Dissection Repair
Heart Transplantation
Lung Transplantation
Ventricular Assist Devices (VAD)
Ventricular Aneurysm
Arrhythmia
Coronary Artery Bypass Grafting (CABG)
Off-Pump Coronary Artery Bypass (OPCAB)
Foreign Languages Spoken
Program Affiliations
UCSF Heart & Vascular Center
In the News
Grants and Funding
- Hypo-immunogenic cardiomyocytes for myocardial repair | NIH | 2018-08-01 - 2022-06-30 | Role: Principal Investigator
- Microgravity as model for immunological senescence and its impact on tissue stem cells and regeneration | NIH | 2017-06-15 - 2022-06-30 | Role: Co-Principal Investigator
- Microgravity as model for immunological senescence and its impact on tissue stem cells and regeneration | NIH | 2017-06-15 - 2020-02-29 | Role: Co-Principal Investigator
Research Narrative
Dr. Deuse's research is focused on vascular biology and pathophysiology. His group was the among the first to elucdiate the novel pathways involved in the development of vascular intimal hyperplasia. Myointimal hyperplasia is a pathological process of the vascular system characterized by abnormal proliferation of smooth muscle cells of the vascular wall that leads to luminal obliteration and subsequent ischemia.
Myointimal hyperplasia may occur in patients after vessel injury during medical procedures (e.g. after balloon dilation or stent placement) or after pathological injury of the blood vessel (e.g. due to inflammation or toxic exposure). It can cause bypass graft failure and in-stent restenosis. To help prevent this and increase the success of treatments for vascular disease including coronary heart disease, his research group is working on the development of new preventive drug regimes and strategies.
Research Interests
Vascular Biology
Stem Cell Immunobiology
Transplant Immunology
Oxidative Stress and Apoptosis
Pulmonary Hypertension
Publications
- Clinical Improvement With Transcatheter Edge-to-Edge Tricuspid Repair Irrespective of Right Atrial Pressure.| | PubMed
- Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate.| | PubMed
- Four decades of progress in heart-lung transplantation: Two hundred seventy-one cases at a single institution.| | PubMed
- Lung Transplantation in Patients with Cystic Fibrosis: A Complex Task, A Changing Target.| | PubMed
- Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity.| | PubMed
- Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques.| | PubMed
- Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice.| | PubMed
- Hypoimmune anti-CD19 chimeric antigen receptor T cells provide lasting tumor control in fully immunocompetent allogeneic humanized mice.| | PubMed
- Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression.| | PubMed
- Morbidity and Mortality Associated With Blood Transfusions in Elective Adult Cardiac Surgery.| | PubMed
- Author Correction: Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients.| | PubMed
- Intercostal Nerve Cryoanalgesia Versus Thoracic Epidural Analgesia in Lung Transplantation: A Retrospective Single-Center Study.| | PubMed
- Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice.| | PubMed
- Shock, Thrombus, TAVR: A Challenging TAVR With Large Left-Ventricular Thrombus.| | PubMed
- Immunomodulation Therapy Using Tolerogenic Macrophages in a Rodent Model of Pulmonary Hypertension.| | PubMed
- The SIRPα-CD47 immune checkpoint in NK cells.| | PubMed
- Outcomes of transcatheter aortic valve replacement in end stage liver and renal disease.| | PubMed
- Subxiphoid Hybrid Epicardial-Endocardial Atrial Fibrillation Ablation and LAA Ligation: Initial Sub-X Hybrid MAZE Registry Results.| | PubMed
- Impact of Aortic Stenosis on Myofiber Stress: Translational Application of Left Ventricle-Aortic Coupling Simulation.| | PubMed
- The H-Y Antigen in Embryonic Stem Cells Causes Rejection in Syngeneic Female Recipients.| | PubMed
- Risk Factors and Outcomes of Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplantation.| | PubMed
- Frailty after lung transplantation is associated with impaired health-related quality of life and mortality.| | PubMed
- Impact of donor lung quality on post-transplant recipient outcome in the Lung Allocation Score era in Eurotransplant - a historical prospective study.| | PubMed
- A Cryoinjury Model to Study Myocardial Infarction in the Mouse.| | PubMed
- De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans.| | PubMed
- Bergeyella cardium: Clinical Characteristics and Draft Genome of an Emerging Pathogen in Native and Prosthetic Valve Endocarditis.| | PubMed
- Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients.| | PubMed
- Nontyphoidal Salmonella as a Cause of Mediastinal Abscess after Aortic Valve Replacement: A Case Report and Review of Postoperative Salmonella Infections.| | PubMed
- Analysis of Minimally Invasive Left Thoracotomy HVAD Implantation - A Single-Center Experience.| | PubMed
- Lung allocation score: the Eurotransplant model versus the revised US model - a cross-sectional study.| | PubMed
- Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study.| | PubMed
- Hybrid Open Minimally Invasive Transcatheter Mitral Valve Replacement.| | PubMed
- Balloon-based Injury to Induce Myointimal Hyperplasia in the Mouse Abdominal Aorta.| | PubMed
- Hybrid and surgical procedures for the treatment of persistent and longstanding persistent atrial fibrillation.| | PubMed
- Outcomes of Minimally Invasive Temporary Right Ventricular Assist Device Support for Acute Right Ventricular Failure During Minimally Invasive Left Ventricular Assist Device Implantation.| | PubMed
- Thalidomide treatment prevents chronic graft rejection after aortic transplantation in rats - an experimental study.| | PubMed
- Differences in Vascular Response between Balloon Overstretch and Stent Overexpansion in Nonatherosclerotic Porcine Coronary Arteries.| | PubMed
- Gender differences and outcomes in left ventricular assist device support: The European Registry for Patients with Mechanical Circulatory Support.| | PubMed
- The value of fluorine-18 deoxyglucose positron emission tomography scans in patients with ventricular assist device specific infections†.| | PubMed
- Lobar lung transplantation from deceased donors: A systematic review.| | PubMed
- Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency.| | PubMed
- Orthotopic tracheal transplantation using human bronchus: an original xenotransplant model of obliterative airway disorder.| | PubMed
- Acute Pulmonary Artery Obstruction as the Primary Manifestation of a Rapidly Growing Intimal Sarcoma in a 54-Year-Old Patient.| | PubMed
- A matched pairs analysis of non-rib-spreading, fully endoscopic, mini-incision technique versus conventional mini-thoracotomy for mitral valve repair.| | PubMed
- The Selective JAK1/3-Inhibitor R507 Mitigates Obliterative Airway Disease Both With Systemic Administration and Aerosol Inhalation.| | PubMed
- The MANDELA study: A multicenter, randomized, open-label, parallel group trial to refine the use of everolimus after heart transplantation.| | PubMed
- Sex Differences in Immunology: More Severe Development of Experimental Pulmonary Hypertension in Male Rats Exposed to Vascular Endothelial Growth Factor Receptor Blockade.| | PubMed
- Distal Airway Stem Cells are Essential for Lung Regeneration.| | PubMed
- Local MicroRNA Modulation Using a Novel Anti-miR-21-Eluting Stent Effectively Prevents Experimental In-Stent Restenosis.| | PubMed
- Mesenchymal stromal cell therapy: different sources exhibit different immunobiological properties.| | PubMed
- Immunobiology of fibrin-based engineered heart tissue.| | PubMed
- Concomitant minimally invasive HVAD and transapical aortic valve implantation.| | PubMed
- SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts.| | PubMed
- Thymoglobulin induction in heart transplantation: patient selection and implications for maintenance immunosuppression.| | PubMed
- Isolated permanent right ventricular assist device implantation with the HeartWare continuous-flow ventricular assist device: first results from the European Registry for Patients with Mechanical Circulatory Support.| | PubMed
- Clinical experience of combined HeartWare ventricular assist device and implantable cardioverter defibrillator therapy.| | PubMed
- HVAD implantation in right atrium-to-right pulmonary artery configuration.| | PubMed
- Introduction of the lung allocation score in Germany.| | PubMed
- Inducing myointimal hyperplasia versus atherosclerosis in mice: an introduction of two valid models.| | PubMed
- Dichloroacetate prevents restenosis in preclinical animal models of vessel injury.| | PubMed
- Minimally invasive implantation of biventricular assist devices.| | PubMed
- Do not touch the sternum--thoracotomy incisions for HVAD implantation.| | PubMed
- Efficacy of prophylactic intra-aortic balloon pump therapy in chronic heart failure patients undergoing cardiac surgery.| | PubMed
- Dual-chamber pacemaker implantation with left ventricular pacing in a patient with a right ventricular assist device.| | PubMed
- HVAD continuous flow assist device for ischemic ventricular septal rupture.| | PubMed
- Mechanically induced ventricular tachycardia by the HeartWare ventricular assist device.| | PubMed
- Everolimus in heart transplantation: an update.| | PubMed
- Bortezomib rescue therapy in a patient with recurrent antibody-mediated rejection after lung transplantation.| | PubMed
- Granulocyte colony-stimulating factor therapy is associated with a reduced incidence of acute rejection episodes or allograft vasculopathy in heart transplant recipients.| | PubMed
- Immunological properties of extraembryonic human mesenchymal stromal cells derived from gestational tissue.| | PubMed
- Minimal access median sternotomy for aortic valve replacement in elderly patients.| | PubMed
- Isolated permanent right ventricular assistance using the HVAD continuous-flow pump.| | PubMed
- Aspergillus galactomannan antigen for diagnosis and treatment monitoring in cerebral aspergillosis.| | PubMed
- ST-elevation myocardial infarction following heart transplantation as an unusual presentation of coronary allograft vasculopathy: a case report.| | PubMed
- The potassium channel KCa3.1 as new therapeutic target for the prevention of obliterative airway disease.| | PubMed
- Severe bacterial superinfection based on influenza A (H1N1) pneumonia in a heart-lung transplant recipient.| | PubMed
- Concomitant transcatheter aortic valve and left ventricular assist device implantation.| | PubMed
- Late profound muscle weakness following heart transplantation due to Danon disease.| | PubMed
- Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545.| | PubMed
- Clinical and functional correlates of early microvascular dysfunction after heart transplantation.| | PubMed
- Successful extracorporeal membrane oxygenation weaning after cardiac resynchronization therapy device implantation in a patient with end-stage heart failure.| | PubMed
- Human internal mammary artery (IMA) transplantation and stenting: a human model to study the development of in-stent restenosis.| | PubMed
- Cardiac paraganglioma: diagnostic and surgical challenges.| | PubMed
- Human leukocyte antigen I knockdown human embryonic stem cells induce host ignorance and achieve prolonged xenogeneic survival.| | PubMed
- Immunobiology of naïve and genetically modified HLA-class-I-knockdown human embryonic stem cells.| | PubMed
- Surgical technique of lower lobe lung transplantation.| | PubMed
- Bioluminescence imaging for assessment of immune responses following implantation of engineered heart tissue (EHT).| | PubMed
- Minimally invasive resection of a right atrial mass in a cardiac transplant recipient: a case report.| | PubMed
- Antibody response after a single dose of an AS03-adjuvanted split-virion influenza A (H1N1) vaccine in heart transplant recipients.| | PubMed
- Orthotopic aortic transplantation: a rat model to study the development of chronic vasculopathy.| | PubMed
- Transcatheter aortic valve implantation in a heart transplant recipient: a case report.| | PubMed
- Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells.| | PubMed
- Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting.| | PubMed
- Review of heart-lung transplantation at Stanford.| | PubMed
- Non-volume-loaded heart provides a more relevant heterotopic transplantation model.| | PubMed
- Heterotopic and orthotopic tracheal transplantation in mice used as models to study the development of obliterative airway disease.| | PubMed
- Asymptomatic infection with novel influenza A/H1N1 virus in a heart transplant recipient.| | PubMed
- Mechanisms behind local immunosuppression using inhaled tacrolimus in preclinical models of lung transplantation.| | PubMed
- Changing trends in infectious disease in heart transplantation.| | PubMed
- LAD-ligation: a murine model of myocardial infarction.| | PubMed
- Alternative technique for salvage of donor lungs with insufficient atrial cuffs.| | PubMed
- Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction.| | PubMed
- Imaging in-stent restenosis: an inexpensive, reliable, and rapid preclinical model.| | PubMed
- Heart-lung transplantation in situs inversus totalis.| | PubMed
- Right ventricular dysfunction predicts poor outcome following hemodynamically compromising rejection.| | PubMed
- A novel JAK3 inhibitor, R348, attenuates chronic airway allograft rejection.| | PubMed
- Heart transplantation in situs inversus totalis.| | PubMed
- Twenty-year survivors of heart transplantation at Stanford University.| | PubMed
- Novel immunosuppression: R348, a JAK3- and Syk-inhibitor attenuates acute cardiac allograft rejection.| | PubMed
- Prevention and inhibition but not reversion of chronic allograft vasculopathy by FK778.| | PubMed
- Introducing the first polymer-free leflunomide eluting stent.| | PubMed
- Fluoroscopy to assess late heart and lung perforation by a permanent ventricular pacemaker lead. A case complicated by isolated hemothorax.| | PubMed
- Effect of inhaled tacrolimus on cellular and humoral rejection to prevent posttransplant obliterative airway disease.| | PubMed
- Is the malononitrilamide FK778 better for the prevention of acute or chronic rejection?| | PubMed
- Stem cell transplantation: the lung barrier.| | PubMed
- Techniques for experimental heterotopic and orthotopic tracheal transplantations - When to use which model?| | PubMed
- Simplified protocol to isolate, purify, and culture expand mesenchymal stem cells.| | PubMed
- Experimental orthotopic tracheal transplantation: The Stanford technique.| | PubMed
- FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy.| | PubMed
- Inhibition of restenosis development after mechanical injury: a new field of application for malononitrilamides?| | PubMed
- The selective estrogen receptor-beta agonist biochanin A shows vasculoprotective effects without uterotrophic activity.| | PubMed
- Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase.| | PubMed
- FK778: new cellular and molecular mechanisms of action.| | PubMed
- Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease.| | PubMed
- Tracheal allograft transplantation in rats: the role of different immunosuppressants on preservation of respiratory epithelium.| | PubMed
- The phytoestrogen biochaninA weakens acute cardiac allograft rejection without affecting the reproductive system.| | PubMed
- FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation.| | PubMed
- FK778, a novel immunosuppressive agent, reduces early adhesion molecule up-regulation and prolongs cardiac allograft survival.| | PubMed
- Video and robotic-assisted minimally invasive mitral valve surgery: a comparison of the Port-Access and transthoracic clamp techniques.| | PubMed
- FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies.| | PubMed
- The interaction between FK778 and tacrolimus in the prevention of rat cardiac allograft rejection is dose dependent.| | PubMed
- Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model.| | PubMed
- Successful resection of a symptomatic right ventricular lipoma.| | PubMed
- Robotically assisted coronary artery bypass surgery with the ZEUS telemanipulator system.| | PubMed
- Correlation between mononuclear infiltration and changes in VASP phosphorylation patterns after heterotopic cardiac transplantation in the rat.| | PubMed
- Early and midterm results after coronary artery bypass grafting with and without cardiopulmonary bypass: which patient population benefits the most?| | PubMed
- New technique for chest opening in mice: U-sternotomy.| | PubMed
- Midterm results and quality of life after minimally invasive vs. conventional aortic valve replacement.| | PubMed
- Comparison of two stabilizer concepts for off-pump coronary artery bypass grafting.| | PubMed
- Robotically-assisted coronary artery surgery with and without cardiopulmonary bypass - from first clinical use to endoscopic operation.| | PubMed
- Effect of hemodynamics on graft rejection in the heterotopic heart transplantation model.| | PubMed