Biography
Awards & Honors
Award | Conferred By | Date |
---|---|---|
Pediatric Research Fund – CHRP Award | Stanford University, Stanford, CA | 2009/2010 |
Pediatric Research Fund – CHRP Award | Stanford University, Stanford, CA | 2008/2009 |
Deans Postdoctoral Fellowship | Stanford University, Stanford, CA | 2007/2008 |
Doctoral-Undergraduate Opportunities in Scholarship (DUOS) award for two consecutive years (2003 and | Miami University, Oxford, OH | 2003/2005 |
William Hale Charch Graduate Fellowship | Miami University, Oxford, OH | 2002/2003 |
Education
B.Sc. (Biology and Chemistry) Tribhuvan University, Kathmandu, Nepal
M.Sc. (Chemistry) Tribhuvan University, Kathmandu, Nepal, Advisor: Prof. Vishwanath Pd. Agrawal, PhD
Ph.D. (Biochemistry), Miami University, Oxford, OH, Advisor: Prof. Michael Crowder, PhD
N/A
Postdoctoral Training, Dept of Pediatrics-nephrology, Stanford University, Stanford, CA
Advisor: Prof. Minnie Sarwal MD. PhD.
In the News
Research Narrative
Dr. Sigdel's research is driven by two major factors. First, there is an unprecedented pressure to deliver new and improved diagnostic and treatment options to patients. Second, due to improved understanding of biological intricacies with ever improving molecular assays have placed us in a much better position to look for disease specific biomarkers that once validated can be used in the clinics in order to provide timely and accurate assessment of health status of patients.
Research Interests
Biomarker DIscovery
Proteomics
Immunology
Organ Transplantation
Liver Cancer
Kidney Transplantation
High Throughput Data
Bioinformatics
Research Pathways
Publications
- Proteome Analysis for Inflammation Related to Acute and Convalescent Infection.| | View in PubMed
- Transcriptional and spatial profiling of the kidney allograft unravels a central role for FcyRIII+ innate immune cells in rejection.| | View in PubMed
- Plasma proteome perturbation for CMV DNAemia in kidney transplantation.| | View in PubMed
- Perturbations in podocyte transcriptome and biological pathways induced by FSGS associated circulating factors.| | View in PubMed
- Longitudinal serum proteomics analyses identify unique and overlapping host response pathways in Lyme disease and West Nile virus infection.| | View in PubMed
- Perturbations of the T-cell immune repertoire in kidney transplant rejection.| | View in PubMed
- A reference tissue atlas for the human kidney.| | View in PubMed
- Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients.| | View in PubMed
- Multiplexed droplet single-cell sequencing (Mux-Seq) of normal and transplant kidney.| | View in PubMed
- FcER1: A Novel Molecule Implicated in the Progression of Human Diabetic Kidney Disease.| | View in PubMed
- A Comprehensive Urine Proteome Database Generated From Patients With Various Renal Conditions and Prostate Cancer.| | View in PubMed
- Use of the Tissue Common Rejection Module Score in Kidney Transplant as an Objective Measure of Allograft Inflammation.| | View in PubMed
- Corrigendum: Near-Single-Cell Proteomics Profiling of the Proximal Tubular and Glomerulus of the Normal Human Kidney.| | View in PubMed
- A multimodal and integrated approach to interrogate human kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project.| | View in PubMed
- Near-Single-Cell Proteomics Profiling of the Proximal Tubular and Glomerulus of the Normal Human Kidney.| | View in PubMed
- Peripheral Blood RNA Sequencing Unravels a Differential Signature of Coding and Noncoding Genes by Types of Kidney Allograft Rejection.| | View in PubMed
- Targeted Urine Metabolomics for Monitoring Renal Allograft Injury and Immunosuppression in Pediatric Patients.| | View in PubMed
- Avoidance of CNI and steroids using belatacept-Results of the Clinical Trials in Organ Transplantation 16 trial.| | View in PubMed
- A urine score for noninvasive accurate diagnosis and prediction of kidney transplant rejection.| | View in PubMed
- Assessment of 19 Genes and Validation of CRM Gene Panel for Quantitative Transcriptional Analysis of Molecular Rejection and Inflammation in Archival Kidney Transplant Biopsies.| | View in PubMed
- A urinary Common Rejection Module (uCRM) score for non-invasive kidney transplant monitoring.| | View in PubMed
- A Modified Injector and Sample Acquisition Protocol Can Improve Data Quality and Reduce Inter-Instrument Variability of the Helios Mass Cytometer.| | View in PubMed
- Characterizing pre-transplant and post-transplant kidney rejection risk by B cell immune repertoire sequencing.| | View in PubMed
- A Novel Multi-Biomarker Assay for Non-Invasive Quantitative Monitoring of Kidney Injury.| | View in PubMed
- Cell-Free DNA and CXCL10 Derived from Bronchoalveolar Lavage Predict Lung Transplant Survival.| | View in PubMed
- Optimizing Detection of Kidney Transplant Injury by Assessment of Donor-Derived Cell-Free DNA via Massively Multiplex PCR.| | View in PubMed
- The common rejection module in chronic rejection post lung transplantation.| | View in PubMed
- Urinary Virome Perturbations in Kidney Transplantation.| | View in PubMed
- Targeted Transcriptional Profiling of Kidney Transplant Biopsies.| | View in PubMed
- Corrigendum: Novel Non-Histocompatibility Antigen Mismatched Variants Improve the Ability to Predict Antibody-Mediated Rejection Risk in Kidney Transplant.| | View in PubMed
- Discovery of Immune Reactive Human Proteins by High-Density Protein Arrays and Customized Validation of Potential Biomarkers by ELISA.| | View in PubMed
- Fractionation of Soluble Proteins Using DEAE-Sepharose, SP-Sepharose, and Phenyl Sepharose Chromatographies for Proteomics.| | View in PubMed
- LC-SRM-Based Targeted Quantification of Urinary Protein Biomarkers.| | View in PubMed
- Optimization for Peptide Sample Preparation for Urine Peptidomics.| | View in PubMed
- Novel Non-Histocompatibility Antigen Mismatched Variants Improve the Ability to Predict Antibody-Mediated Rejection Risk in Kidney Transplant.| | View in PubMed
- Expression of Mitochondrial-Encoded Genes in Blood Differentiate Acute Renal Allograft Rejection.| | View in PubMed
- Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants.| | View in PubMed
- Assessment of Circulating Protein Signatures for Kidney Transplantation in Pediatric Recipients.| | View in PubMed
- Molecular and Functional Noninvasive Immune Monitoring in the ESCAPE Study for Prediction of Subclinical Renal Allograft Rejection.| | View in PubMed
- Prevalence and pattern of dyslipidemia in Nepalese individuals with type 2 diabetes.| | View in PubMed
- A combined biomarker and clinical panel for chronic graft versus host disease diagnosis.| | View in PubMed
- Advances in diagnostics for transplant rejection.| | View in PubMed
- Intragraft Antiviral-Specific Gene Expression as a Distinctive Transcriptional Signature for Studies in Polyomavirus-Associated Nephropathy.| | View in PubMed
- Self-antigens and rejection: a proteomic analysis.| | View in PubMed
- Mining the human urine proteome for monitoring renal transplant injury.| | View in PubMed
- Circulating CD40 autoantibody and suPAR synergy drives glomerular injury.| | View in PubMed
- A Computational Gene Expression Score for Predicting Immune Injury in Renal Allografts.| | View in PubMed
- Transcriptional Perturbations in Graft Rejection.| | View in PubMed
- Perturbations in the urinary exosome in transplant rejection.| | View in PubMed
- Mapping novel immunogenic epitopes in IgA nephropathy.| | View in PubMed
- A Three-Gene Assay for Monitoring Immune Quiescence in Kidney Transplantation.| | View in PubMed
- The kSORT assay to detect renal transplant patients at high risk for acute rejection: results of the multicenter AART study.| | View in PubMed
- Endothelial cell antibodies associated with novel targets and increased rejection.| | View in PubMed
- A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation.| | View in PubMed
- Optimization for peptide sample preparation for urine peptidomics.| | View in PubMed
- Identification of common blood gene signatures for the diagnosis of renal and cardiac acute allograft rejection.| | View in PubMed
- The identification of novel potential injury mechanisms and candidate biomarkers in renal allograft rejection by quantitative proteomics.| | View in PubMed
- Moving beyond HLA: a review of nHLA antibodies in organ transplantation.| | View in PubMed
- A rapid noninvasive assay for the detection of renal transplant injury.| | View in PubMed
- Multicenter evaluation of a standardized protocol for noninvasive gene expression profiling.| | View in PubMed
- Immune response profiling identifies autoantibodies specific to Moyamoya patients.| | View in PubMed
- The clinical impact of humoral immunity in pediatric renal transplantation.| | View in PubMed
- A common blood gene assay predates clinical and histological rejection in kidney and heart allografts.| | View in PubMed
- Discovery and customized validation of antibody targets by protein arrays and indirect ELISA.| | View in PubMed
- A peripheral blood diagnostic test for acute rejection in renal transplantation.| | View in PubMed
- Complete steroid avoidance is effective and safe in children with renal transplants: a multicenter randomized trial with three-year follow-up.| | View in PubMed
- Protein and peptide biomarkers in organ transplantation.| | View in PubMed
- Non-HLA antibodies to immunogenic epitopes predict the evolution of chronic renal allograft injury.| | View in PubMed
- Cell-free DNA as a measure of transplant injury.| | View in PubMed
- Characterization of Zn(II)-responsive ribosomal proteins YkgM and L31 in E. coli.| | View in PubMed
- Profiling of autoantibodies in IgA nephropathy, an integrative antibiomics approach.| | View in PubMed
- Recent advances in biomarker discovery in solid organ transplant by proteomics.| | View in PubMed
- The dual role of epithelial-to-mesenchymal transition in chronic allograft injury in pediatric renal transplantation.| | View in PubMed
- Functional proteogenomics--embracing complexity.| | View in PubMed
- Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes.| | View in PubMed
- Profiling the proteome in renal transplantation.| | View in PubMed
- Protein microarrays discover angiotensinogen and PRKRIP1 as novel targets for autoantibodies in chronic renal disease.| | View in PubMed
- Differential immunogenicity and clinical relevance of kidney compartment specific antigens after renal transplantation.| | View in PubMed
- Differentially expressed RNA from public microarray data identifies serum protein biomarkers for cross-organ transplant rejection and other conditions.| | View in PubMed
- Compartmental localization and clinical relevance of MICA antibodies after renal transplantation.| | View in PubMed
- Integrative urinary peptidomics in renal transplantation identifies biomarkers for acute rejection.| | View in PubMed
- Shotgun proteomics identifies proteins specific for acute renal transplant rejection.| | View in PubMed
- Protein microarrays identify antibodies to protein kinase Czeta that are associated with a greater risk of allograft loss in pediatric renal transplant recipients.| | View in PubMed
- Expression of complement components differs between kidney allografts from living and deceased donors.| | View in PubMed
- Identifying compartment-specific non-HLA targets after renal transplantation by integrating transcriptome and "antibodyome" measures.| | View in PubMed
- Interpreting the proteome and peptidome in transplantation.| | View in PubMed
- A randomized, prospective trial of rituximab for acute rejection in pediatric renal transplantation.| | View in PubMed
- The proteogenomic path towards biomarker discovery.| | View in PubMed
- Optimizing protein recovery for urinary proteomics, a tool to monitor renal transplantation.| | View in PubMed
- Interference of globin genes with biomarker discovery for allograft rejection in peripheral blood samples.| | View in PubMed
- Probing the adaptive response of Escherichia coli to extracellular Zn(II).| | View in PubMed
- Transcriptional response of Escherichia coli to TPEN.| | View in PubMed
- Phosphinate, sulfonate, and sulfonamidate dipeptides as potential inhibitors of Escherichia coli aminopeptidase N.| | View in PubMed
- A five-coordinate metal center in Co(II)-substituted VanX.| | View in PubMed
- Fractionation of soluble proteins in Escherichia coli using DEAE-, SP-, and phenyl sepharose chromatographies.| | View in PubMed
- L-alanine-p-nitroanilide is not a substrate for VanX.| | View in PubMed
- Over-expression, purification, and characterization of metallo-beta-lactamase ImiS from Aeromonas veronii bv. sobria.| | View in PubMed
- In vivo folding of recombinant metallo-beta-lactamase L1 requires the presence of Zn(II).| | View in PubMed