Biography
Robert S. Warren, M.D. is a Professor of Surgery and a specialist in gastrointestinal and liver cancer. He earned a medical degree at the University of Minnesota, where he completed a general surgery residency. After completing an oncology research fellowship at Memorial Sloan-Kettering Cancer Center in New York, he was an associate physician at Rockefeller University in New York. A board-certified surgeon, Dr. Warren joined UCSF Medical Center in 1988. Highly respected by his peers, Dr. Warren was named to the list of U.S. News "America's Top Doctors," a distinction reserved for the top 1% of physicians in the nation for a given specialty. His research focuses on the biology of colorectal cancer and how it spreads.
Dr. Warren is involved in clinical and laboratory research, which has centered on the biology of colorectal cancer metastasis that includes Vascular Endothelial Growth Factor (VEGF), Insulin-Like Growth Factors and Their Binding Proteins AS Modulators of Growth of Colorectal Cancer Metastases and Cytogenetics of Colorectal Cancer Metastasis. The laboratory work focuses on two areas: 1) autocrine growth factors and angiogenesis in colorectal cancer 2) molecular features which predict clinical outcome in primary and metastatic colorectal cancer.
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of Minnesota | M.D. | School of Medicine | 1980 |
Board Certifications
- American Board of Surgery, 1989
Program Affiliations
- Surgical Oncology Program
- Surgical Oncology Laboratory
- UCSF Helen Diller Family Comprehensive Cancer Center
- UCSF Department of Surgery
In the News
Grants and Funding
- General Clinical Research Center | NIH | 1974-12-01 - 2009-03-31 | Role: Co-Investigator
- MOLECULAR MARKERS OF PROGNOSIS IN COLON CANCER | NIH | 2000-03-03 - 2006-02-28 | Role: Principal Investigator
- ROLE OF CYTOKINES IN CANCER PATIENTS UNDERGOING SURGERY | NIH | 1993-07-01 - 1999-06-30 | Role: Principal Investigator
Research Narrative
- Biology of colorectal cancer metastasis
- Molecular features which predict clinical outcome in primary and metastatic colorectal cancer
- Autocrine growth factors and angiogenesis in colorectal cancer
- Vascular Endothelial Growth Factor (VEGF) Hypoxia and Colon Cancer
- Insulin-Like Growth Factors and Their Binding Proteins As Modulators of Growth of Colorectal Cancer Metastases
- Cytogenetics of Colorectal Cancer Metastasis
Publications
- Metastatic colorectal adenocarcinoma tumor purity assessment from whole exome sequencing data.| | View in PubMed
- STAT3 regulates inflammatory cytokine production downstream of TNFR1 by inducing expression of TNFAIP3/A20.| | View in PubMed
- Synchronous Versus Metachronous Colorectal Liver Metastasis Yields Similar Survival in Modern Era.| | View in PubMed
- RBMS1 Suppresses Colon Cancer Metastasis through Targeted Stabilization of Its mRNA Regulon.| | View in PubMed
- A novel stratification of mesenteric mass involvement as a predictor of challenging mesenteric lymph node dissection by minimally invasive approach for ileal neuroendocrine tumors.| | View in PubMed
- Residual tumor volume discriminates prognosis after surgery for neuroendocrine liver metastasis.| | View in PubMed
- Prognostic impact of a large mesenteric mass >2 cm in ileal neuroendocrine tumors.| | View in PubMed
- Relative contribution of clinicopathological variables, genomic markers, transcriptomic subtyping and microenvironment features for outcome prediction in stage II/III colorectal cancer.| | View in PubMed
- High thymidylate synthase gene expression predicts poor outcome after resection of hepatocellular carcinoma.| | View in PubMed
- RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer.| | View in PubMed
- Mitogen Inducible Gene-6 Is a Prognostic Marker for Patients with Colorectal Liver Metastases.| | View in PubMed
- A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors.| | View in PubMed
- Sampling strategies to capture single-cell heterogeneity.| | View in PubMed
- Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer.| | View in PubMed
- Reply to L. Casadaban et al.| | View in PubMed
- A Study of Thymidylate Synthase Expression as a Biomarker for Resectable Colon Cancer: Alliance (Cancer and Leukemia Group B) 9581 and 89803.| | View in PubMed
- Association Between Results of a Gene Expression Signature Assay and Recurrence-Free Interval in Patients With Stage II Colon Cancer in Cancer and Leukemia Group B 9581 (Alliance).| | View in PubMed
- Unexpected insights for anti-EGFR cancer therapy.| | View in PubMed
- RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.| | View in PubMed
- CpG island methylator phenotype is associated with response to adjuvant irinotecan-based therapy for stage III colon cancer.| | View in PubMed
- Prognostic impact of deficient DNA mismatch repair in patients with stage III colon cancer from a randomized trial of FOLFOX-based adjuvant chemotherapy.| | View in PubMed
- Wild type p53 transcriptionally represses the SALL2 transcription factor under genotoxic stress.| | View in PubMed
- Association of TP53 mutational status and gender with survival after adjuvant treatment for stage III colon cancer: results of CALGB 89803.| | View in PubMed
- PTEN expression is consistent in colorectal cancer primaries and metastases and associates with patient survival.| | View in PubMed
- Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors.| | View in PubMed
- Biologic determinants of tumor recurrence in stage II colon cancer: validation study of the 12-gene recurrence score in cancer and leukemia group B (CALGB) 9581.| | View in PubMed
- Imaging a functional tumorigenic biomarker in the transformed epithelium.| | View in PubMed
- Lymph node sampling rates and predictors of nodal metastasis in pancreatic neuroendocrine tumor resections: the UCSF experience with 149 patients.| | View in PubMed
- Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer.| | View in PubMed
- Is there currently an established role for the use of predictive or prognostic molecular markers in the management of colorectal cancer? A point/counterpoint.| | View in PubMed
- Complete and safe resection of challenging retroperitoneal tumors: anticipation of multi-organ and major vascular resection and use of adjunct procedures.| | View in PubMed
- Documenting the natural history of patients with resected stage II adenocarcinoma of the colon after random assignment to adjuvant treatment with edrecolomab or observation: results from CALGB 9581.| | View in PubMed
- Microsatellite instability and loss of heterozygosity at chromosomal location 18q: prospective evaluation of biomarkers for stages II and III colon cancer--a study of CALGB 9581 and 89803.| | View in PubMed
- Pancreatic adenocarcinoma.| | View in PubMed
- Lack of NKX2.2 expression in bronchopulmonary typical carcinoid tumors: implications for patients with neuroendocrine tumor metastases and unknown primary site.| | View in PubMed
- Identification of unknown primary tumors in patients with neuroendocrine liver metastases.| | View in PubMed
- The ETS oncogene family transcription factor FEV identifies serotonin-producing cells in normal and neoplastic small intestine.| | View in PubMed
- p27Kip1 in stage III colon cancer: implications for outcome following adjuvant chemotherapy in cancer and leukemia group B protocol 89803.| | View in PubMed
- Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803.| | View in PubMed
- Mitogen-inducible gene-6 expression correlates with survival and is an independent predictor of recurrence in BRAF(V600E) positive papillary thyroid cancers.| | View in PubMed
- Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors.| | View in PubMed
- Association of family history with cancer recurrence and survival among patients with stage III colon cancer.| | View in PubMed
- Compound muscle action potentials and spontaneous electromyography can be used to identify and protect the femoral nerve during resection of large retroperitoneal tumors.| | View in PubMed
- Prognostic importance of superior diaphragmatic adenopathy at computed tomography in patients with resectable hepatic metastases from colorectal carcinoma.| | View in PubMed
- Introduction.| | View in PubMed
- Palliative care for patients with advanced pancreatic and biliary cancers.| | View in PubMed
- Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1alpha and Hdm2.| | View in PubMed
- Pancreatoblastoma in an adult: case report and review of the literature.| | View in PubMed
- Hepatic arterial infusion versus systemic therapy for hepatic metastases from colorectal cancer: a randomized trial of efficacy, quality of life, and molecular markers (CALGB 9481).| | View in PubMed
- Pancreatic adenocarcinoma: Clinical Practice Guidelines in Oncology.| | View in PubMed
- [Liver metastases from colorectal cancer. Is the practice of surgery based on the best clinical evidence possible?].| | View in PubMed
- Hypoxia-induced radioresistance is independent of hypoxia-inducible factor-1A in vitro.| | View in PubMed
- Fractional genomic alteration detected by array-based comparative genomic hybridization independently predicts survival after hepatic resection for metastatic colorectal cancer.| | View in PubMed
- Liver-directed therapies in colorectal cancer.| | View in PubMed
- Palliative techniques for hepatic cancer.| | View in PubMed
- Characterization of triacsin C inhibition of short-, medium-, and long-chain fatty acid: CoA ligases of human liver.| | View in PubMed
- Aggressive surgery for metastatic liver neuroendocrine tumors.| | View in PubMed
- beta-Catenin regulates vascular endothelial growth factor expression in colon cancer.| | View in PubMed
- Distinguishing features of self-limiting adult small-bowel intussusception identified at CT.| | View in PubMed
- Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria.| | View in PubMed
- Thorotrast-induced liver neoplasia: a collective review.| | View in PubMed
- Detection of hepatic metastases from cancers of the gastrointestinal tract by using noninvasive imaging methods (US, CT, MR imaging, PET): a meta-analysis.| | View in PubMed
- Liver-directed viral therapy for cancer p53-targeted adenoviruses and beyond.| | View in PubMed
- Expression and endocytosis of VEGF and its receptors in human colonic vascular endothelial cells.| | View in PubMed
- Quantitative fractionation of alkaline phosphatase isoenzymes according to their thermostability.| | View in PubMed
- Activity and longevity of insect growth regulators against mosquitoes.| | View in PubMed
- A double-blind controlled therapeutic trial of lorazepam vs medazepam in psychosomatic conditions in general practice.| | View in PubMed
- Analyses of rumen fluid from "sudden death", lactic acidotic and healthy cattle fed high concentrate ration.| | View in PubMed
- Action of propranolol on mitochondrial functions--effects on energized ion fluxes in the presence of valinomycin.| | View in PubMed
- Digitoxin metabolism by rat liver microsomes.| | View in PubMed