Biography
Mackersie is a certified by the American Board of General Surgery, general certificate with subspecialty in surgical critical care. His practice is in general and trauma surgery, which includes vascular and thoracic surgery. In addition, he is a regular attending on the Surgical Critical Care Service at Zuckerberg San Francisco General Hospital and Trauma Center and serves as Vice-Chief of Surgery there.
Dr. Mackersie is a graduate of UC Berkeley and Michigan State University Medical School. He completed his internship, residency and chief residency training in general surgery and surgical critical care at the University of California, San Francisco, where he continued his specialty training and completed a trauma research fellowship. Dr. Mackersie joined the faculty at the University of California, San Diego University Hospital from 1985-1991.
Dr. Mackersie was appointed the Trauma Medical Director in 1992 at the University of California/San Francisco General Hospital (now Zuckerberg San Francisco General) and has been instrumental in expanding the multidisciplinary activities related to the Trauma Program. Dr. Mackersie currently serves as an officer for several surgical organizations and is a Governor of the American College of Surgeons. Dr. Mackersie has been appointed Secretary/Treasurer for the American Association for the Surgery of Trauma. Dr. Mackersie has also expanded the Trauma Nurse Practitioner program, and has progressed in developing the first aero-medical transport facility at San Francisco General Hospital. He has also been appointed Commissioner for the State of California Emergency Medical Services Authority, which is appointed by the Governor/California Speaker of the House.
Dr. Mackersie continues to direct the national program in Trauma System Planning and Evaluation for the American College of Surgeons, which includes the development of national benchmarks for trauma systems and trauma centers, and the creation of national guidelines for trauma systems development.
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of California, San Francisco | Residency | School of Medicine |
Board Certifications
- American Board of Surgery, 1986
- American Board of Surgery, Surgical Critical Care, 1988
Clinical Expertise
General Surgery
Surgical Critical Care
Trauma Surgery
Vascular Surgery
In the News
Research Narrative
- Inflammatory Lung Injury following major injury: One of the main areas of focus has been post-traumatic inflammatory lung injury. This collaborative research effort has continued, with new reports of the clinical syndrome of ARDS (ref # 63), the impact of ARDS on specific outcomes (ref # 62), and a recent report examining surrogate serum markers predictive of inflammatory lung injury. (ref # 65). The most recent work, still in preparation (Abstract, WIP ref # 3), attemps to link elements of inflammation with post-traumatic coagulopathy, and to better define the nature of early coagulopathy (pre-massive transfusion) that follows shock, traumatic brain injury, and major organ injury.
- Ventilatory management of patients with ARDS (refs # 66,67). Technical clinical studies performed in ICU patients with ARDS that attempt to expand our understanding of "optimal" modes of lung protective ventilation (LPV) in the setting or acute lung injury. LPV strategies are one of the few, if not the only demonstrable intervention having an impact on the outcome from ARDS over the past 15 years.
- Violence prevention recidivism (Abstracts/WIP ref # 1). Work in progress, this is part of an ongoing clinical and programmatic study that screens victims of youth violence & assesses the likelihood of recidivism. "High risk" patients are then referred into a program linking hospital services with post-discharge neighborhood/community services for violence prevention. A randomized study is being designed to compare recidivism outcomes with and without programmatic influence.
Research Interests
- Trauma systems development
- Inflammatory lung injury following major injury
- Ventilatory management of patients with ARDS
- Violence Prevention
Publications
- Is state trauma funding associated with mortality among injured hospitalized patients?| | View in PubMed
- Characterizing re-triage guidelines: A scoping review of states' rules and regulations.| | View in PubMed
- Does Trauma Center Volume Account for the Association Between Trauma Center Verification Level and In-Hospital Mortality among Children Injured by Firearms in California?| | View in PubMed
- Re-triage moderates association between state trauma funding and lower mortality of trauma patients.| | View in PubMed
- Corrigendum to Surviving traumatic injury, only to die of acute drug poisoning: Should trauma centers be a path for intervention? [Surgery 170 (2021) pp 1249-54].| | View in PubMed
- Geographic Disparities in Re-triage Destinations Among Seriously Injured Californians.| | View in PubMed
- Defining obstacles to emergency transfer of trauma patients: An evaluation of retriage processes from nontrauma and lower-level Illinois trauma centers.| | View in PubMed
- The Association of Limited English Proficiency With Morbidity and Mortality After Trauma.| | View in PubMed
- Association of Race/Ethnicity With Substance Use Testing After Trauma: A Cross-Sectional Study.| | View in PubMed
- Limited English Proficiency Associated With Suboptimal Pain Assessment in Hospitalized Trauma Patients.| | View in PubMed
- Inequity in discharge pain management for trauma patients with limited English proficiency.| | View in PubMed
- Surviving traumatic injury, only to die of acute drug poisoning: Should trauma centers be a path for intervention?| | View in PubMed
- The DISTANCE study: Determining the impact of social distancing on trauma epidemiology during the COVID-19 epidemic-An interrupted time-series analysis.| | View in PubMed
- Emergency general surgery utilization and disparities during COVID-19: an interrupted time-series analysis.| | View in PubMed
- Describing the density of high-level trauma centers in the 15 largest US cities.| | View in PubMed
- F. William Blaisdell, MD: A leader for all time.| | View in PubMed
- Pelvic fracture pattern predicts the need for hemorrhage control intervention-Results of an AAST multi-institutional study.| | View in PubMed
- Reconsidering the Resources Needed for Multiple Casualty Events: Lessons Learned From the Crash of Asiana Airlines Flight 214.| | View in PubMed
- Current management of hemorrhage from severe pelvic fractures: Results of an American Association for the Surgery of Trauma multi-institutional trial.| | View in PubMed
- The Triage of Injured Patients: Mechanism of Injury, Regardless of Injury Severity, Determines Hospital Destination.| | View in PubMed
- Cervical spine clearance protocols in Level I, II, and III trauma centers in California.| | View in PubMed
- Recent developments in the assessment of the multiply injured trauma patient.| | View in PubMed
- Beyond emergency surgery: redefining acute care surgery.| | View in PubMed
- For the Care of the Underserved.| | View in PubMed
- Variability in California triage from 2005 to 2009: a population-based longitudinal study of severely injured patients.| | View in PubMed
- Cervical spine clearance protocols in level 1 trauma centers in the United States.| | View in PubMed
- Evaluating age in the field triage of injured persons.| | View in PubMed
- The forgotten trauma patient: outcomes for injured patients evaluated by emergency medical services but not transported to the hospital.| | View in PubMed
- Service: 2010 Western Trauma Association presidential address.| | View in PubMed
- Pitfalls in the evaluation and resuscitation of the trauma patient.| | View in PubMed
- Prospective randomized trial of LC+LCBDE vs ERCP/S+LC for common bile duct stone disease.| | View in PubMed
- Protein C depletion early after trauma increases the risk of ventilator-associated pneumonia.| | View in PubMed
- Where do we go from here? Interim analysis to forge ahead in violence prevention.| | View in PubMed
- Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis.| | View in PubMed
- Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway.| | View in PubMed
- In brief. Management of the trauma patient.| | View in PubMed
- Pitfalls in the evaluation and management of the trauma patient.| | View in PubMed
- The spontaneous breathing pattern and work of breathing of patients with acute respiratory distress syndrome and acute lung injury.| | View in PubMed
- Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?| | View in PubMed
- Field triage, and the fragile supply of "optimal resources" for the care of the injured patient.| | View in PubMed
- History of trauma field triage development and the American College of Surgeons criteria.| | View in PubMed
- Effects of tidal volume on work of breathing during lung-protective ventilation in patients with acute lung injury and acute respiratory distress syndrome.| | View in PubMed
- Work of breathing during lung-protective ventilation in patients with acute lung injury and acute respiratory distress syndrome: a comparison between volume and pressure-regulated breathing modes.| | View in PubMed
- Serum levels of Hsp60 correlate with the development of acute lung injury after trauma.| | View in PubMed
- Acute respiratory distress syndrome criteria in trauma patients: why the definitions do not work.| | View in PubMed
- An epidemic of methicillin-resistant Staphylococcus aureus soft tissue infections among medically underserved patients.| | View in PubMed
- The development of acute lung injury is associated with worse neurologic outcome in patients with severe traumatic brain injury.| | View in PubMed
- The effects of tidal volume demand on work of breathing during simulated lung-protective ventilation.| | View in PubMed
- Serum levels of Hsp 72 measured early after trauma correlate with survival.| | View in PubMed
- Multiinstitutional experience with the management of superior mesenteric artery injuries.| | View in PubMed
- Penetrating esophageal injuries: multicenter study of the American Association for the Surgery of Trauma.| | View in PubMed
- The effects of pressure control versus volume control assisted ventilation on patient work of breathing in acute lung injury and acute respiratory distress syndrome.| | View in PubMed
- Initial severity of metabolic acidosis predicts the development of acute lung injury in severely traumatized patients.| | View in PubMed
- Leukocytosis and free fluid are important indicators of isolated intestinal injury after blunt trauma.| | View in PubMed
- Gastric rupture and tension pneumoperitoneum complicating cardiopulmonary resuscitation: case report.| | View in PubMed
- Biological markers of acute lung injury: prognostic and pathogenetic significance.| | View in PubMed
- Trauma deaths in a mature urban vs rural trauma system. A comparison.| | View in PubMed
- Use of tissue oxygen tension measurements during resuscitation from hemorrhagic shock.| | View in PubMed
- Acute rupture of the diaphragm due to blunt trauma: diagnostic sensitivity and specificity of CT.| | View in PubMed
- Violence prevention involvement among trauma surgeons: description and preliminary evaluation.| | View in PubMed
- Risks, costs, and the expected complication of re-injury.| | View in PubMed
- Neurogenic pulmonary edema in fatal and nonfatal head injuries.| | View in PubMed
- High-risk behavior and the public burden for funding the costs of acute injury.| | View in PubMed
- Randomized study of algorithms for discontinuing tube thoracostomy drainage.| | View in PubMed
- Differential clearance of colloid and crystalloid solutions from the lung.| | View in PubMed
- The epidemiology of traumatic death. A population-based analysis.| | View in PubMed
- The etiology of missed cervical spine injuries.| | View in PubMed
- An evaluation of provider-related and disease-related morbidity in a level I university trauma service: directions for quality improvement.| | View in PubMed
- An analysis of errors causing morbidity and mortality in a trauma system: a guide for quality improvement.| | View in PubMed
- Can burst fractures be predicted from plain radiographs?| | View in PubMed
- Procuring donor organs for transplantation.| | View in PubMed
- Base deficit as an indicator of significant abdominal injury.| | View in PubMed
- The significance of critical care errors in causing preventable death in trauma patients in a trauma system.| | View in PubMed
- Prospective evaluation of epidural and intravenous administration of fentanyl for pain control and restoration of ventilatory function following multiple rib fractures.| | View in PubMed
- Organ procurement in patients with fatal head injuries. The fate of the potential donor.| | View in PubMed
- Blunt carotid artery dissection: incidence, associated injuries, screening, and treatment.| | View in PubMed
- Complications in evaluating abdominal trauma: diagnostic peritoneal lavage versus computerized axial tomography.| | View in PubMed
- The asymptomatic patient with suspected myocardial contusion.| | View in PubMed
- Use of end-tidal carbon dioxide tension for monitoring induced hypocapnia in head-injured patients.| | View in PubMed
- Pain management following trauma and burns.| | View in PubMed
- The economic burden of providing trauma care: what are the costs and who pays?| | View in PubMed
- Venous thromboembolism in patients with major trauma.| | View in PubMed
- Epidemiology and pathology of traumatic deaths occurring at a Level I Trauma Center in a regionalized system: the importance of secondary brain injury.| | View in PubMed
- Thoracotomy during trauma resuscitations--an appraisal by board-certified general surgeons.| | View in PubMed
- The impact of in-house surgeons and operating room resuscitation on outcome of traumatic injuries.| | View in PubMed
- Intra-abdominal injury following blunt trauma. Identifying the high-risk patient using objective risk factors.| | View in PubMed
- Base deficit as a guide to volume resuscitation.| | View in PubMed
- Major skeletal injuries in the obtunded blunt trauma patient: a case for routine radiologic survey.| | View in PubMed
- Video recording trauma resuscitations: an effective teaching technique.| | View in PubMed
- The role of pulmonary lymphatics in the clearance of hydrostatic pulmonary edema.| | View in PubMed
- Continuous epidural fentanyl analgesia: ventilatory function improvement with routine use in treatment of blunt chest injury.| | View in PubMed
- Impact of a trauma system on outcome of severely injured patients.| | View in PubMed
- Self-induced subcutaneous air mimicking a gas-forming infection.| | View in PubMed
- The prehospital use of external counterpressure: does MAST make a difference?| | View in PubMed
- Morphologic and physiologic correlates of increased extravascular lung water.| | View in PubMed
- Pulmonary extravascular fluid accumulation following intracranial injury.| | View in PubMed