Biography
Awards & Honors
Award | Conferred By | Date |
---|---|---|
Prof. NK Mehra Oration Award 2016 | Indian Society for Histocompatibility and Immunogenetics (ISHI) | 2016 |
Certificate of Qualification, Histocompatibility Laboratory Director | New York State Department of Health | 2012 |
Histocompatibility Laboratory Director | Department of Public Health, State of California | 2009 |
Clinical Immunology Training Award | FIMSA & IUIS | 1996 |
Shakuntala Amir Chand prize for the best Ph.D. thesis in Biomedical Sciences in India | Indian Council of Medical Research (ICMR) | 1996 |
University First Rank in post-graduation (M.Sc.: Zoology, Biochemicstry, Molecular Biology) | Bharathiyar University, Coimbatore, India | 1988 |
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
Royal College of Pathologists | FRCPath | Histocompatibility and Immunogenetics | 2018 |
American Board of Histocompatibility and Immunogenetics (ABHI) | D(ABHI) | Histocompatibility Testing | 2008 |
Stanford University | Post-Doctoral Research | Immunogenetics | 2002 |
All India Institute of Medical Sciences | Ph.D. | Histocompatibility & Immunogenetics | 1996 |
University of Madras | M.Phil. | Endocrinology | 1989 |
Bharathiyar University | M.Sc. | Zoology | 1988 |
University of Madras | B.Sc. | Zoology | 1984 |
Collaboration Interests
I am interested in:
- CommunityAndStakeholderOrganizations
- AcademicCollaboration
- MulticenterClinicalResearch
- CompaniesAndEntrepreneurs
- ProspectiveDonors
Research Narrative
Natural killer (NK) have been implicated in control and clearance of malignant and virally infected cells, regulation of adaptive immune responses, rejection of bone marrow transplants, autoimmunity and the maintenance of pregnancy. Human NK cells largely use a family of Human Leukocyte Antigen (HLA)-specific Killer cell Immunoglobulin-like Receptors (KIR) to recognize and respond to the unhealthy target cells. KIR and HLA loci are both polygenic and substantially polymorphic, and they map to distinct human chromosomes (Chromosomes 19 and 6, respectively).
KIR and HLA gene families segregate independently, yielding many individuals who express KIR receptors for which they lack HLA class I ligands, and vice versa, thus creating human diversity in the number and type of KIR-HLA inherited gene pairs, which potentially could influence the health and disease status of a given individual. The overall goal of our research is to understand the diversity of KIR receptors, HLA ligands, and KIR-HLA gene combinations in populations and their relevance in human health and disease.
Publications
- A Scan of Pleiotropic Immune Mediated Disease Genes Identifies Novel Determinants of Baseline FVIII Inhibitor Status in Hemophilia-A.| | View in PubMed
- COVID-19 infection and vaccination rarely impact HLA antibody profile in waitlisted renal transplant candidates- a multicenter cohort.| | View in PubMed
- Experimental and clinical data analysis for identification of COVID-19 resistant ACE2 mutations.| | View in PubMed
- Human Bone Marrow Plasma Cell Atlas: Maturation and Survival Pathways Unraveled by Single Cell Analyses.| | View in PubMed
- CD16+ natural killer cells in bronchoalveolar lavage are associated with antibody-mediated rejection and chronic lung allograft dysfunction.| | View in PubMed
- Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression.| | View in PubMed
- KIR-HLA gene diversities and susceptibility to lung cancer.| | View in PubMed
- Individualized Constellation of Killer Cell Immunoglobulin-Like Receptors and Cognate HLA Class I Ligands that Controls Natural Killer Cell Antiviral Immunity Predisposes COVID-19.| | View in PubMed
- Concurrent use of two independent methods prevents erroneous HLA typing of deceased organ donors - An important strategy for patient safety and accurate virtual crossmatching for broader sharing.| | View in PubMed
- Solid-Phase C1q/C3d Fixing Readouts Correlate with High Median Fluorescence Intensity (MFI) De Novo Donor-Specific HLA Antibodies and C4dāŗ Antibody-Mediated Rejection in Kidney Transplant Recipients.| | View in PubMed
- Individualized genetic makeup that controls natural killer cell function influences the efficacy of isatuximab immunotherapy in patients with multiple myeloma.| | View in PubMed
- Concurrent typing of over 4000 samples by long-range PCR amplicon-based NGS and rSSO revealed the need to verify NGS typing for HLA allelic dropouts.| | View in PubMed
- COVID-19 does not impact HLA antibody profile in a series of waitlisted renal transplant candidates.| | View in PubMed
- Coexistence of inhibitory and activating killer-cell immunoglobulin-like receptors to the same cognate HLA-C2 and Bw4 ligands confer breast cancer risk.| | View in PubMed
- A Virtual Crossmatch-based Strategy Facilitates Sharing of Deceased Donor Kidneys for Highly Sensitized Recipients.| | View in PubMed
- Allele-level HLA matching reduces early rejection in lung transplant recipients.| | View in PubMed
- Quantitative HLA-class-II/factor VIII (FVIII) peptidomic variation in dendritic cells correlates with the immunogenic potential of therapeutic FVIII proteins in hemophilia A.| | View in PubMed
- De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans.| | View in PubMed
- Long-Term Safety, Immunologic Response, and Imaging Outcomes following Neural Stem Cell Transplantation for Pelizaeus-Merzbacher Disease.| | View in PubMed
- Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR.| | View in PubMed
- Gene signatures common to allograft rejection are associated with lymphocytic bronchitis.| | View in PubMed
- Association of HLA Antigen Mismatch With Risk of Developing Skin Cancer After Solid-Organ Transplant.| | View in PubMed
- Diversity of Killer Cell Immunoglobulin-Like Receptors and Disease.| | View in PubMed
- Inhibitory natural killer cell receptor KIR3DL1 with its ligand Bw4 constraints HIV-1 disease among South Indians.| | View in PubMed
- Genotypes associated with tacrolimus pharmacokinetics impact clinical outcomes in lung transplant recipients.| | View in PubMed
- Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy.| | View in PubMed
- KIR3DL1/HLA-B Subtypes Govern Acute Myelogenous Leukemia Relapse After Hematopoietic Cell Transplantation.| | View in PubMed
- HLA Mismatching Favoring Host-Versus-Graft NK Cell Activity Via KIR3DL1 Is Associated With Improved Outcomes Following Lung Transplantation.| | View in PubMed
- Short lung transplant donor telomere length is associated with decreased CLAD-free survival.| | View in PubMed
- The Impact of HLA Class I-Specific Killer Cell Immunoglobulin-Like Receptors on Antibody-Dependent Natural Killer Cell-Mediated Cytotoxicity and Organ Allograft Rejection.| | View in PubMed
- Donor-Reactive Regulatory T Cell Frequency Increases During Acute Cellular Rejection of Lung Allografts.| | View in PubMed
- Defining KIR and HLA Class I Genotypes at Highest Resolution via High-Throughput Sequencing.| | View in PubMed
- KIR and HLA Genotypes Implicated in Reduced Killer Lymphocytes Immunity Are Associated with Vogt-Koyanagi-Harada Disease.| | View in PubMed
- Donor-Recipient Matching for KIR Genotypes Reduces Chronic GVHD and Missing Inhibitory KIR Ligands Protect against Relapse after Myeloablative, HLA Matched Hematopoietic Cell Transplantation.| | View in PubMed
- CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1-Dependent IGF-1 Signaling.| | View in PubMed
- HLA Markers DQ8 and DR53 Are Associated With Lymphocytic Hypophysitis and May Aid in Differential Diagnosis.| | View in PubMed
- Human NK cells licensed by killer Ig receptor genes have an altered cytokine program that modifies CD4+ T cell function.| | View in PubMed
- Characterization of human killer immunoglobulin-like receptors (KIRs) among healthy Saudis.| | View in PubMed
- Gene-specific PCR typing of killer cell immunoglobulin-like receptors.| | View in PubMed
- Allele-level haplotype frequencies and pairwise linkage disequilibrium for 14 KIR loci in 506 European-American individuals.| | View in PubMed
- Observations regarding the immunogenicity of BDD-rFVIII derived from a mechanistic personalized medicine perspective.| | View in PubMed
- Overview of the killer cell immunoglobulin-like receptor system.| | View in PubMed
- Human diversity of killer cell immunoglobulin-like receptors and disease.| | View in PubMed
- The shaping of modern human immune systems by multiregional admixture with archaic humans.| | View in PubMed
- Comparison of KIR gene content profiles revealed a difference between northern and southern Persians in the distribution of KIR2DS5 and its linked loci.| | View in PubMed
- KIR-HLA mismatching in human renal allograft transplantation: emergence of a new concept.| | View in PubMed
- Immunogenetics as a tool in anthropological studies.| | View in PubMed
- HLA-DRB1*0102 is associated with TINU syndrome and bilateral, sudden-onset anterior uveitis but not with interstitial nephritis alone.| | View in PubMed
- Human-specific evolution and adaptation led to major qualitative differences in the variable receptors of human and chimpanzee natural killer cells.| | View in PubMed
- Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt-Koyanagi-Harada syndrome in Japanese individuals.| | View in PubMed
- Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis.| | View in PubMed
- Killer cell immunoglobulin-like receptors in HLA-B27-associated acute anterior uveitis, with and without axial spondyloarthropathy.| | View in PubMed
- KIR gene content diversity in four Iranian populations.| | View in PubMed
- A novel duplex SSP-PCR typing method for KIR gene profiling.| | View in PubMed
- A novel real-time PCR method for KIR genotyping.| | View in PubMed
- Combination of KIR 2DL2 and HLA-C1 (Asn 80) confers susceptibility to type 1 diabetes in Latvians.| | View in PubMed
- Different KIRs confer susceptibility and protection to adults with latent autoimmune diabetes in Latvian and Asian Indian populations.| | View in PubMed
- Variable interactions of recipient killer cell immunoglobulin-like receptors with self and allogenic human leukocyte antigen class I ligands may influence the outcome of solid organ transplants.| | View in PubMed
- KIR2DL5 alleles mark certain combination of activating KIR genes.| | View in PubMed
- KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease.| | View in PubMed
- Distinct diversity of KIR genes in three southern Indian populations: comparison with world populations revealed a link between KIR gene content and pre-historic human migrations.| | View in PubMed
- Comparison of the rapidly evolving KIR locus in Parsis and natives of India.| | View in PubMed
- Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals.| | View in PubMed
- Chain-terminating natural mutations affect the function of activating KIR receptors 3DS1 and 2DS3.| | View in PubMed
- Killer cell immunoglobulin-like receptors influence the innate and adaptive immune responses.| | View in PubMed
- Receptor-ligand analyses define minimal killer cell Ig-like receptor (KIR) in humans.| | View in PubMed
- HLA-DRB1 and -DQB1 alleles in mestizo patients with Vogt-Koyanagi-Harada's disease in Southern California.| | View in PubMed
- Human leukocyte antigen A29 subtypes associated with birdshot retinochoroidopathy.| | View in PubMed
- A sequencing-based typing method for HLA-DQA1 alleles.| | View in PubMed
- Anti-HLA class I antibody-mediated activation of the PI3K/Akt signaling pathway and induction of Bcl-2 and Bcl-xL expression in endothelial cells.| | View in PubMed
- Domain shuffling has been the main mechanism forming new hominoid killer cell Ig-like receptors.| | View in PubMed
- Predominance of group A KIR haplotypes in Japanese associated with diverse NK cell repertoires of KIR expression.| | View in PubMed
- Distinctive KIR and HLA diversity in a panel of north Indian Hindus.| | View in PubMed
- Conservation and variation in human and common chimpanzee CD94 and NKG2 genes.| | View in PubMed
- Comparison of chimpanzee and human leukocyte Ig-like receptor genes reveals framework and rapidly evolving genes.| | View in PubMed
- Molecular diversity of HLA-A*02 in Asian Indians: predominance of A*0211.| | View in PubMed
- Different NK cell surface phenotypes defined by the DX9 antibody are due to KIR3DL1 gene polymorphism.| | View in PubMed
- Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors.| | View in PubMed
- Short KIR haplotypes in pygmy chimpanzee (Bonobo) resemble the conserved framework of diverse human KIR haplotypes.| | View in PubMed
- Discovery of two novel variants of KIR2DS5 reveals this gene to be a common component of human KIR 'B' haplotypes.| | View in PubMed
- Cold reactive lymphocytotoxic antibodies in pulmonary tuberculosis: correlation with disease activity and HLA.| | View in PubMed
- Polymorphism in heat-shock protein 70-1 (HSP70-1) gene promoter region and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians.| | View in PubMed
- KIR2DL5, a novel killer-cell receptor with a D0-D2 configuration of Ig-like domains.| | View in PubMed
- Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans.| | View in PubMed
- A divergent non-classical class I gene conserved in salmonids.| | View in PubMed
- Polymorphic MHC molecules dictate cytokine profile and clinical disease in mycobacterial diseases.| | View in PubMed
- HLA class I profile in Asian Indian patients with pulmonary tuberculosis.| | View in PubMed
- HLA association and occurrence of autoantibodies in Asian-Indian patients with ulcerative colitis.| | View in PubMed
- Transporter associated with antigen-processing (TAP) genes and susceptibility to tuberculoid leprosy and pulmonary tuberculosis.| | View in PubMed
- HLA-DR polymorphism modulates the cytokine profile of Mycobacterium leprae HSP-reactive CD4+ T cells.| | View in PubMed
- Anti-IgG autoantibodies and possible immune regulatory mechanisms in patients with pulmonary tuberculosis.| | View in PubMed
- Correlation of serum interleukin-2 receptor-alpha levels with clinical manifestations in pulmonary tuberculosis.| | View in PubMed
- Direct role of HLA-B5 in influencing susceptibility to Takayasu aortoarteritis.| | View in PubMed
- Polymerase chain reaction--based sequence-specific oligonucleotide hybridization analysis of HLA class II antigens in pulmonary tuberculosis: relevance to chemotherapy and disease severity.| | View in PubMed
- Generation of DR51-associated DQA1, DQB1 haplotypes in Asian Indians.| | View in PubMed
- CD4+ T-cell responses to recombinant hsp65 and hsp18 of M. leprae and their trypsin-digested fragments in leprosy: diversity in HLA-DR restriction.| | View in PubMed
- Variants of HLA-DR2/DR51 group haplotypes and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians.| | View in PubMed
- Dorsolateral prostatic phosphomonoesterases and adenosine triphosphatases in hypo- and hyperthyroid rats.| | View in PubMed
- Asian Indian HLA-DR2-, DR4-, and DR52-related DR-DQ genotypes analyzed by polymerase chain reaction based nonradioactive oligonucleotide typing. Unique haplotypes and a novel DR4 subtype.| | View in PubMed
- Effects of alloxan induced diabetes on lipid profiles in renal cortex and medulla of mature albino rats.| | View in PubMed
- Ventral prostatic phosphomonoesterases and adenosine triphosphatases in hypo- and hyperthyroid albino rats.| | View in PubMed
- Human leukocyte antigen (HLA) in respiratory allergy.| | View in PubMed