Biography
Awards & Honors
Award | Conferred By | Date |
---|---|---|
Prof. NK Mehra Oration Award 2016 | Indian Society for Histocompatibility and Immunogenetics (ISHI) | 2016 |
Certificate of Qualification, Histocompatibility Laboratory Director | New York State Department of Health | 2012 |
Histocompatibility Laboratory Director | Department of Public Health, State of California | 2009 |
Clinical Immunology Training Award | FIMSA & IUIS | 1996 |
Shakuntala Amir Chand prize for the best Ph.D. thesis in Biomedical Sciences in India | Indian Council of Medical Research (ICMR) | 1996 |
University First Rank in post-graduation (M.Sc.: Zoology, Biochemicstry, Molecular Biology) | Bharathiyar University, Coimbatore, India | 1988 |
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
Royal College of Pathologists | FRCPath | Histocompatibility and Immunogenetics | 2018 |
American Board of Histocompatibility and Immunogenetics (ABHI) | D(ABHI) | Histocompatibility Testing | 2008 |
Stanford University | Post-Doctoral Research | Immunogenetics | 2002 |
All India Institute of Medical Sciences | Ph.D. | Histocompatibility & Immunogenetics | 1996 |
University of Madras | M.Phil. | Endocrinology | 1989 |
Bharathiyar University | M.Sc. | Zoology | 1988 |
University of Madras | B.Sc. | Zoology | 1984 |
Collaboration Interests
I am interested in:
- ProspectiveDonors
- CompaniesAndEntrepreneurs
- CommunityAndStakeholderOrganizations
- MulticenterClinicalResearch
- AcademicCollaboration
Research Narrative
Natural killer (NK) have been implicated in control and clearance of malignant and virally infected cells, regulation of adaptive immune responses, rejection of bone marrow transplants, autoimmunity and the maintenance of pregnancy. Human NK cells largely use a family of Human Leukocyte Antigen (HLA)-specific Killer cell Immunoglobulin-like Receptors (KIR) to recognize and respond to the unhealthy target cells. KIR and HLA loci are both polygenic and substantially polymorphic, and they map to distinct human chromosomes (Chromosomes 19 and 6, respectively).
KIR and HLA gene families segregate independently, yielding many individuals who express KIR receptors for which they lack HLA class I ligands, and vice versa, thus creating human diversity in the number and type of KIR-HLA inherited gene pairs, which potentially could influence the health and disease status of a given individual. The overall goal of our research is to understand the diversity of KIR receptors, HLA ligands, and KIR-HLA gene combinations in populations and their relevance in human health and disease.
Publications
- A Scan of Pleiotropic Immune Mediated Disease Genes Identifies Novel Determinants of Baseline FVIII Inhibitor Status in Hemophilia-A.| | PubMed
- COVID-19 infection and vaccination rarely impact HLA antibody profile in waitlisted renal transplant candidates- a multicenter cohort.| | PubMed
- Experimental and clinical data analysis for identification of COVID-19 resistant ACE2 mutations.| | PubMed
- Human Bone Marrow Plasma Cell Atlas: Maturation and Survival Pathways Unraveled by Single Cell Analyses.| | PubMed
- CD16+ natural killer cells in bronchoalveolar lavage are associated with antibody-mediated rejection and chronic lung allograft dysfunction.| | PubMed
- Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression.| | PubMed
- KIR-HLA gene diversities and susceptibility to lung cancer.| | PubMed
- Individualized Constellation of Killer Cell Immunoglobulin-Like Receptors and Cognate HLA Class I Ligands that Controls Natural Killer Cell Antiviral Immunity Predisposes COVID-19.| | PubMed
- Concurrent use of two independent methods prevents erroneous HLA typing of deceased organ donors - An important strategy for patient safety and accurate virtual crossmatching for broader sharing.| | PubMed
- Solid-Phase C1q/C3d Fixing Readouts Correlate with High Median Fluorescence Intensity (MFI) De Novo Donor-Specific HLA Antibodies and C4dāŗ Antibody-Mediated Rejection in Kidney Transplant Recipients.| | PubMed
- Individualized genetic makeup that controls natural killer cell function influences the efficacy of isatuximab immunotherapy in patients with multiple myeloma.| | PubMed
- Concurrent typing of over 4000 samples by long-range PCR amplicon-based NGS and rSSO revealed the need to verify NGS typing for HLA allelic dropouts.| | PubMed
- COVID-19 does not impact HLA antibody profile in a series of waitlisted renal transplant candidates.| | PubMed
- Coexistence of inhibitory and activating killer-cell immunoglobulin-like receptors to the same cognate HLA-C2 and Bw4 ligands confer breast cancer risk.| | PubMed
- A Virtual Crossmatch-based Strategy Facilitates Sharing of Deceased Donor Kidneys for Highly Sensitized Recipients.| | PubMed
- Allele-level HLA matching reduces early rejection in lung transplant recipients.| | PubMed
- Quantitative HLA-class-II/factor VIII (FVIII) peptidomic variation in dendritic cells correlates with the immunogenic potential of therapeutic FVIII proteins in hemophilia A.| | PubMed
- De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans.| | PubMed
- Long-Term Safety, Immunologic Response, and Imaging Outcomes following Neural Stem Cell Transplantation for Pelizaeus-Merzbacher Disease.| | PubMed
- Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR.| | PubMed
- Gene signatures common to allograft rejection are associated with lymphocytic bronchitis.| | PubMed
- Association of HLA Antigen Mismatch With Risk of Developing Skin Cancer After Solid-Organ Transplant.| | PubMed
- Diversity of Killer Cell Immunoglobulin-Like Receptors and Disease.| | PubMed
- Inhibitory natural killer cell receptor KIR3DL1 with its ligand Bw4 constraints HIV-1 disease among South Indians.| | PubMed
- Genotypes associated with tacrolimus pharmacokinetics impact clinical outcomes in lung transplant recipients.| | PubMed
- Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy.| | PubMed
- KIR3DL1/HLA-B Subtypes Govern Acute Myelogenous Leukemia Relapse After Hematopoietic Cell Transplantation.| | PubMed
- HLA Mismatching Favoring Host-Versus-Graft NK Cell Activity Via KIR3DL1 Is Associated With Improved Outcomes Following Lung Transplantation.| | PubMed
- Short lung transplant donor telomere length is associated with decreased CLAD-free survival.| | PubMed
- The Impact of HLA Class I-Specific Killer Cell Immunoglobulin-Like Receptors on Antibody-Dependent Natural Killer Cell-Mediated Cytotoxicity and Organ Allograft Rejection.| | PubMed
- Donor-Reactive Regulatory T Cell Frequency Increases During Acute Cellular Rejection of Lung Allografts.| | PubMed
- Defining KIR and HLA Class I Genotypes at Highest Resolution via High-Throughput Sequencing.| | PubMed
- KIR and HLA Genotypes Implicated in Reduced Killer Lymphocytes Immunity Are Associated with Vogt-Koyanagi-Harada Disease.| | PubMed
- Donor-Recipient Matching for KIR Genotypes Reduces Chronic GVHD and Missing Inhibitory KIR Ligands Protect against Relapse after Myeloablative, HLA Matched Hematopoietic Cell Transplantation.| | PubMed
- CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1-Dependent IGF-1 Signaling.| | PubMed
- HLA Markers DQ8 and DR53 Are Associated With Lymphocytic Hypophysitis and May Aid in Differential Diagnosis.| | PubMed
- Human NK cells licensed by killer Ig receptor genes have an altered cytokine program that modifies CD4+ T cell function.| | PubMed
- Characterization of human killer immunoglobulin-like receptors (KIRs) among healthy Saudis.| | PubMed
- Gene-specific PCR typing of killer cell immunoglobulin-like receptors.| | PubMed
- Allele-level haplotype frequencies and pairwise linkage disequilibrium for 14 KIR loci in 506 European-American individuals.| | PubMed
- Observations regarding the immunogenicity of BDD-rFVIII derived from a mechanistic personalized medicine perspective.| | PubMed
- Overview of the killer cell immunoglobulin-like receptor system.| | PubMed
- Human diversity of killer cell immunoglobulin-like receptors and disease.| | PubMed
- The shaping of modern human immune systems by multiregional admixture with archaic humans.| | PubMed
- Comparison of KIR gene content profiles revealed a difference between northern and southern Persians in the distribution of KIR2DS5 and its linked loci.| | PubMed
- KIR-HLA mismatching in human renal allograft transplantation: emergence of a new concept.| | PubMed
- Immunogenetics as a tool in anthropological studies.| | PubMed
- HLA-DRB1*0102 is associated with TINU syndrome and bilateral, sudden-onset anterior uveitis but not with interstitial nephritis alone.| | PubMed
- Human-specific evolution and adaptation led to major qualitative differences in the variable receptors of human and chimpanzee natural killer cells.| | PubMed
- Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt-Koyanagi-Harada syndrome in Japanese individuals.| | PubMed
- Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis.| | PubMed
- Killer cell immunoglobulin-like receptors in HLA-B27-associated acute anterior uveitis, with and without axial spondyloarthropathy.| | PubMed
- KIR gene content diversity in four Iranian populations.| | PubMed
- A novel duplex SSP-PCR typing method for KIR gene profiling.| | PubMed
- A novel real-time PCR method for KIR genotyping.| | PubMed
- Combination of KIR 2DL2 and HLA-C1 (Asn 80) confers susceptibility to type 1 diabetes in Latvians.| | PubMed
- Different KIRs confer susceptibility and protection to adults with latent autoimmune diabetes in Latvian and Asian Indian populations.| | PubMed
- Variable interactions of recipient killer cell immunoglobulin-like receptors with self and allogenic human leukocyte antigen class I ligands may influence the outcome of solid organ transplants.| | PubMed
- KIR2DL5 alleles mark certain combination of activating KIR genes.| | PubMed
- KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease.| | PubMed
- Distinct diversity of KIR genes in three southern Indian populations: comparison with world populations revealed a link between KIR gene content and pre-historic human migrations.| | PubMed
- Comparison of the rapidly evolving KIR locus in Parsis and natives of India.| | PubMed
- Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals.| | PubMed
- Chain-terminating natural mutations affect the function of activating KIR receptors 3DS1 and 2DS3.| | PubMed
- Killer cell immunoglobulin-like receptors influence the innate and adaptive immune responses.| | PubMed
- Receptor-ligand analyses define minimal killer cell Ig-like receptor (KIR) in humans.| | PubMed
- HLA-DRB1 and -DQB1 alleles in mestizo patients with Vogt-Koyanagi-Harada's disease in Southern California.| | PubMed
- Human leukocyte antigen A29 subtypes associated with birdshot retinochoroidopathy.| | PubMed
- A sequencing-based typing method for HLA-DQA1 alleles.| | PubMed
- Anti-HLA class I antibody-mediated activation of the PI3K/Akt signaling pathway and induction of Bcl-2 and Bcl-xL expression in endothelial cells.| | PubMed
- Domain shuffling has been the main mechanism forming new hominoid killer cell Ig-like receptors.| | PubMed
- Predominance of group A KIR haplotypes in Japanese associated with diverse NK cell repertoires of KIR expression.| | PubMed
- Distinctive KIR and HLA diversity in a panel of north Indian Hindus.| | PubMed
- Conservation and variation in human and common chimpanzee CD94 and NKG2 genes.| | PubMed
- Comparison of chimpanzee and human leukocyte Ig-like receptor genes reveals framework and rapidly evolving genes.| | PubMed
- Molecular diversity of HLA-A*02 in Asian Indians: predominance of A*0211.| | PubMed
- Different NK cell surface phenotypes defined by the DX9 antibody are due to KIR3DL1 gene polymorphism.| | PubMed
- Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors.| | PubMed
- Short KIR haplotypes in pygmy chimpanzee (Bonobo) resemble the conserved framework of diverse human KIR haplotypes.| | PubMed
- Discovery of two novel variants of KIR2DS5 reveals this gene to be a common component of human KIR 'B' haplotypes.| | PubMed
- Cold reactive lymphocytotoxic antibodies in pulmonary tuberculosis: correlation with disease activity and HLA.| | PubMed
- Polymorphism in heat-shock protein 70-1 (HSP70-1) gene promoter region and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians.| | PubMed
- KIR2DL5, a novel killer-cell receptor with a D0-D2 configuration of Ig-like domains.| | PubMed
- Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans.| | PubMed
- A divergent non-classical class I gene conserved in salmonids.| | PubMed
- Polymorphic MHC molecules dictate cytokine profile and clinical disease in mycobacterial diseases.| | PubMed
- HLA class I profile in Asian Indian patients with pulmonary tuberculosis.| | PubMed
- HLA association and occurrence of autoantibodies in Asian-Indian patients with ulcerative colitis.| | PubMed
- Transporter associated with antigen-processing (TAP) genes and susceptibility to tuberculoid leprosy and pulmonary tuberculosis.| | PubMed
- HLA-DR polymorphism modulates the cytokine profile of Mycobacterium leprae HSP-reactive CD4+ T cells.| | PubMed
- Anti-IgG autoantibodies and possible immune regulatory mechanisms in patients with pulmonary tuberculosis.| | PubMed
- Correlation of serum interleukin-2 receptor-alpha levels with clinical manifestations in pulmonary tuberculosis.| | PubMed
- Direct role of HLA-B5 in influencing susceptibility to Takayasu aortoarteritis.| | PubMed
- Polymerase chain reaction--based sequence-specific oligonucleotide hybridization analysis of HLA class II antigens in pulmonary tuberculosis: relevance to chemotherapy and disease severity.| | PubMed
- Generation of DR51-associated DQA1, DQB1 haplotypes in Asian Indians.| | PubMed
- CD4+ T-cell responses to recombinant hsp65 and hsp18 of M. leprae and their trypsin-digested fragments in leprosy: diversity in HLA-DR restriction.| | PubMed
- Variants of HLA-DR2/DR51 group haplotypes and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians.| | PubMed
- Dorsolateral prostatic phosphomonoesterases and adenosine triphosphatases in hypo- and hyperthyroid rats.| | PubMed
- Asian Indian HLA-DR2-, DR4-, and DR52-related DR-DQ genotypes analyzed by polymerase chain reaction based nonradioactive oligonucleotide typing. Unique haplotypes and a novel DR4 subtype.| | PubMed
- Effects of alloxan induced diabetes on lipid profiles in renal cortex and medulla of mature albino rats.| | PubMed
- Ventral prostatic phosphomonoesterases and adenosine triphosphatases in hypo- and hyperthyroid albino rats.| | PubMed
- Human leukocyte antigen (HLA) in respiratory allergy.| | PubMed