Biography
Education
| Institution | Degree | Dept or School | End Date |
|---|---|---|---|
| Royal College of Pathologists | FRCPath | Histocompatibility and Immunogenetics | 2018 |
| American Board of Histocompatibility and Immunogenetics (ABHI) | D(ABHI) | Histocompatibility Testing | 2008 |
| Stanford University | Post-Doctoral Research | Immunogenetics | 2002 |
| All India Institute of Medical Sciences | Ph.D. | Histocompatibility & Immunogenetics | 1996 |
| University of Madras | M.Phil. | Endocrinology | 1989 |
| Bharathiyar University | M.Sc. | Zoology | 1988 |
| University of Madras | B.Sc. | Zoology | 1984 |
Awards & Honors
| Award | Conferred By | Date |
|---|---|---|
| Prof. NK Mehra Oration Award 2016 | Indian Society for Histocompatibility and Immunogenetics (ISHI) | 2016 |
| Certificate of Qualification, Histocompatibility Laboratory Director | New York State Department of Health | 2012 |
| Histocompatibility Laboratory Director | Department of Public Health, State of California | 2009 |
| Clinical Immunology Training Award | FIMSA & IUIS | 1996 |
| Shakuntala Amir Chand prize for the best Ph.D. thesis in Biomedical Sciences in India | Indian Council of Medical Research (ICMR) | 1996 |
| University First Rank in post-graduation (M.Sc.: Zoology, Biochemicstry, Molecular Biology) | Bharathiyar University, Coimbatore, India | 1988 |
Mentoring and Training Narrative
I provide mentorship to learners at all stages, including post-doctoral research fellows, residents, students, and visiting scholars, helping them navigate their career paths and achieve success. The current ongoing research projects include mapping HLA antibody binding epitopes, studying natural killer cell immunogenetic variables in solid organ transplant outcomes, developing molecular mismatch algorithms for functional immunogenomic matching to improve transplant outcomes, engineering bi-specific antibodies for targeted immune suppression, and analyzing HLA antibodies using AI-powered pattern recognition. We will provide all necessary resources and opportunities for learners to produce at least one significant publication.
Collaboration Interests
I am interested in:
- academic collaboration
- multicenter clinical research
- community and partner organizations
- companies and entrepreneurs
Research Narrative
Natural killer (NK) have been implicated in control and clearance of malignant and virally infected cells, regulation of adaptive immune responses, rejection of bone marrow transplants, autoimmunity and the maintenance of pregnancy. Human NK cells largely use a family of Human Leukocyte Antigen (HLA)-specific Killer cell Immunoglobulin-like Receptors (KIR) to recognize and respond to the unhealthy target cells. KIR and HLA loci are both polygenic and substantially polymorphic, and they map to distinct human chromosomes (Chromosomes 19 and 6, respectively).
KIR and HLA gene families segregate independently, yielding many individuals who express KIR receptors for which they lack HLA class I ligands, and vice versa, thus creating human diversity in the number and type of KIR-HLA inherited gene pairs, which potentially could influence the health and disease status of a given individual. The overall goal of our research is to understand the diversity of KIR receptors, HLA ligands, and KIR-HLA gene combinations in populations and their relevance in human health and disease.
Publications
- Assessing the interoperability of single antigen bead assays across vendors to enhance the accuracy and efficiency of HLA antibody measurement in transplant patients.| |
PubMed
- A scan of pleiotropic immune mediated disease genes identifies novel determinants of baseline FVIII inhibitor status in hemophilia A.| |
PubMed
- A Scan of Pleiotropic Immune Mediated Disease Genes Identifies Novel Determinants of Baseline FVIII Inhibitor Status in Hemophilia-A.| |
PubMed
- COVID-19 infection and vaccination rarely impact HLA antibody profile in waitlisted renal transplant candidates- a multicenter cohort.| |
PubMed
- Experimental and clinical data analysis for identification of COVID-19 resistant ACE2 mutations.| |
PubMed
- Human Bone Marrow Plasma Cell Atlas: Maturation and Survival Pathways Unraveled by Single Cell Analyses.| |
PubMed
- CD16+ natural killer cells in bronchoalveolar lavage are associated with antibody-mediated rejection and chronic lung allograft dysfunction.| |
PubMed
- Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression.| |
PubMed
- Cell Subset-Specific Chimerism Testing by Short Tandem Repeats Analysis for Engraftment Monitoring After Hematopoietic Stem Cell Transplantation.| |
PubMed
- Immune Cell Lineage-Specific Chimerism Testing by Next-Generation Sequencing for Engraftment Monitoring After Allogeneic Hematopoietic Stem Cell Transplantation.| |
PubMed