Biography
Dr. Brakeman is an Associate Professor based at the UCSF Benioff Children's Hospital with a primary appointment in Pediatrics and a secondary appointment in the Division of Nephrology in the Department of Medicine. He completed his undergraduate training at UC Berkeley in biophysics before entering a combined MD/PhD program at the Johns Hopkins University School of Medicine. His thesis work consisted of evaluating the role of immediate early genes in learning and memory during brain development. He completed his MD and PhD degrees in 1997 before coming to UCSF to pursue residency in the Department of Pediatrics. Dr. Brakeman served as chief resident in pediatrics in 2000-2001 and then went on to become a fellow in the Division of Pediatric Nephrology at UCSF. During his fellowship, Dr. Brakeman began his renal research career, studying kidney development and the molecular mechanisms of kidney morphogenesis. Dr. Brakeman joined the UCSF faculty after completing his fellowship in 2004.
Since joining the UCSF faculty, Dr. Brakeman has developed clinical expertise in the evaluation and treatment of pediatric dialysis patients, pediatric chronic kidney disease, urinary tract infections and obstructive nephropathy.
Awards & Honors
Award | Conferred By | Date |
---|---|---|
Top Doctor | Marin Magazine | 2019 |
Top Doctor | San Francisco Magazine | 2019 |
Designated Nephrotic Syndrome Expert | Nephcure Kidney International | 2018 |
Excellence in Teaching Award | Haile T. Debas Academy of Medical Educators | 2016 |
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
John Hopkins University | M.D. | School of Medicine | 1997 |
University of California, San Francisco | Residency | School of Medicine |
Board Certifications
American Board of Pediatrics - General Pediatrics
American Board of Pediatrics - Pediatric Nephrology Subspecialty
Clinical Expertise
Chronic kidney disease
Obstructive nephropathy
Pediatric dialysis
Systemic lupus erythematous
Urinary tract infection
Clinical Trials
- Nephrotic Syndrome Study Network (NCT01209000)Related Conditions: Minimal Change Disease, Membranous Nephropathy, Focal Segmental Glomerulosclerosis, Kidney Disease, Glomerulonephritis| Start Date: | End Date:
In the News
Grants and Funding
- The Role of Nectin in Congenital Obstructive Nephropathy | NIH | 2004-09-01 - 2010-11-30 | Role: Principal Investigator
Research Narrative
The primary focus of Dr. Brakeman's research is the engineering of human renal epithelial cells for use in a bioartificial kidney. Work is currently underway at UCSF on a multi-center project to develop a bioartificial implantable renal assist device based on hemofiltration. One of the important components of an implantable bioartificial device is an active renal proximal tubule cell bioreactor that can provide some of the metabolic activity of renal tubules. Another critical function of the cellular bioreactor will be the reabsorption of salt and water in order to reduce the volume of the filtrate generated as much as possible before elimination via the bladder. Dr. Brakeman's lab is focused on engineering human proximal tubules cells to enhance sodium and water reabsorption for use in the bioartificial kidney. In addition, he is actively evaluating the use of the proximal tubule cell bioreactor for use in toxicology and pharmaceutical evaluation of novel compounds.
Dr. Brakeman's work is funded by the Roger's Family Foundation.
Research Interests
Kidney development
Artificial kidney engineering
Sodium and water transport
Publications
- Feasibility of an implantable bioreactor for renal cell therapy using silicon nanopore membranes.| | View in PubMed
- Persistent Increase in Serum Ferritin Levels despite Converting to Permanent Vascular Access in Pediatric Hemodialysis Patients: Pediatric Nephrology Research Consortium Study.| | View in PubMed
- COVID-19 in pediatric kidney transplantation: a follow-up report of the Improving Renal Outcomes Collaborative.| | View in PubMed
- Urologic Considerations in Pediatric Chronic Kidney Disease.| | View in PubMed
- Conversion to permanent vascular access is associated with improved markers of hemodialysis efficacy in children: Pediatric nephrology research consortium study.| | View in PubMed
- Association of Plasma Uremic Solute Levels with Residual Kidney Function in Children on Peritoneal Dialysis.| | View in PubMed
- COVID-19 in pediatric kidney transplantation: The Improving Renal Outcomes Collaborative.| | View in PubMed
- Plasma pseudouridine levels reflect body size in children on hemodialysis.| | View in PubMed
- Predictors of time to first cannulation for arteriovenous fistula in pediatric hemodialysis patients: Midwest Pediatric Nephrology Consortium study.| | View in PubMed
- Simple Rules Determine Distinct Patterns of Branching Morphogenesis.| | View in PubMed
- Correction to: Predictors of patency for arteriovenous fistulae and grafts in pediatric hemodialysis patients.| | View in PubMed
- Application of physiological shear stress to renal tubular epithelial cells.| | View in PubMed
- Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury.| | View in PubMed
- Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing.| | View in PubMed
- Outcome of participants with nephrotic syndrome in combined clinical trials of lupus nephritis.| | View in PubMed
- Predictors of patency for arteriovenous fistulae and grafts in pediatric hemodialysis patients.| | View in PubMed
- Peripheral Blood B Cell Depletion after Rituximab and Complete Response in Lupus Nephritis.| | View in PubMed
- Renal function outcomes in pediatric patients with symptomatic reflux into the transplanted kidney treated with redo ureteroneocystostomy.| | View in PubMed
- Afadin orients cell division to position the tubule lumen in developing renal tubules.| | View in PubMed
- Laser acupuncture reduces pain in pediatric kidney biopsies: a randomized controlled trial.| | View in PubMed
- A modular microfluidic bioreactor with improved throughput for evaluation of polarized renal epithelial cells.| | View in PubMed
- Preliminary Diffusive Clearance of Silicon Nanopore Membranes in a Parallel Plate Configuration for Renal Replacement Therapy.| | View in PubMed
- Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection.| | View in PubMed
- Acute changes in blood pressure in patients with neuroblastoma treated with ¹³¹I-metaiodobenzylguanidine (MIBG).| | View in PubMed
- De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity.| | View in PubMed
- Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells.| | View in PubMed
- Preso1 dynamically regulates group I metabotropic glutamate receptors.| | View in PubMed
- p120 catenin is required for normal renal tubulogenesis and glomerulogenesis.| | View in PubMed
- Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis.| | View in PubMed
- Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity.| | View in PubMed
- Renal repair and recovery.| | View in PubMed
- Transient hyperglycemia affects the extent of ischemia-reperfusion-induced renal injury in rats.| | View in PubMed
- Being overweight modifies the association between cardiovascular risk factors and microalbuminuria in adolescents.| | View in PubMed
- Vesicoureteral reflux, reflux nephropathy, and end-stage renal disease.| | View in PubMed
- Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway.| | View in PubMed
- Polarity proteins PAR6 and aPKC regulate cell death through GSK-3beta in 3D epithelial morphogenesis.| | View in PubMed
- Formation of multicellular epithelial structures.| | View in PubMed
- The scaffold protein, Homer1b/c, regulates axon pathfinding in the central nervous system in vivo.| | View in PubMed
- Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins.| | View in PubMed
- Homer: a protein that selectively binds metabotropic glutamate receptors.| | View in PubMed
- MR-based correction of brain PET measurements for heterogeneous gray matter radioactivity distribution.| | View in PubMed
- Magnetohydrodynamics of blood flow.| | View in PubMed