University of California San Francisco

Mahesh H. Mankani, M.D.
Mahesh H. Mankani, MD

Associate Professor of Surgery
Division of Plastic and Reconstructive Surgery


    Dr. Mankani's Medical Career

    Dr. Mahesh Mankani was Associate Professor of Surgery in Residence and a Principal Investigator at the UCSF Surgical Research Laboratory at SFGH.  Dr. Mankani was a graduate of Stanford University and the University of Hawaii School of Medicine.  He did his General Surgery Residency at the University of Chicago where he also completed a Fellowship in Burn Surgery.  He then went on to the Georgetown University Medical Center where he completed his Plastic and Reconstructive Surgical Residency. 

    His Fellowship in Hand and Microsurgery was done at Brigham and Women's Hospital; his Clinical Fellowship in Surgery at the Harvard Medical School; and his Craniofacial and Skeletal Disease Fellowship at the NIH.  Dr. Mankani's area of clinical expertise was in Plastic and Reconstructive Surgery, Hand Surgery, and Burn Surgery.  His research focuses on the role of bone marrow stromal cells in bone formation and regeneration.


    • Stanford University,  Stanford, California, B.S., 1983
    • University of Hawaii, School of Medicine, Honolulu, Hawaii, M.D., 1988
    • The University of Chicago, Chicago, Illinois, Residency, General Surgery, 1988-1992 
    • Georgetown University Medical Center, Residency, Plastic and Reconstructive Surgery, Washington DC, 1993-1994  
    • Georgetown University Medical Center,  Chief Residency, Plastic and Reconstructive Surgery, Washington DC, 1994-1995, 
    • The University of Chicago, Chicago, Illinois, Fellowship, Burn Surgery, 1992-1993
    • Brigham and Women's Hospital; Boston, Massachusetts,Fellowship, Hand and Microsurgery, 1995-1996
    • Craniofacial and Skeletal Diseases Branch, NIDCR, National Institutes of Health, Fellow, 1996-2000

    Board Certifications

    • American Board of Plastic Surgery, 2002
    • American Board of Plastic Surgery, Subspecialty in Hand Surgery, 2003

    Clinical Expertise

    Acute Burn Reconstruction
    Acute Trauma Hand Surgery
    Breast Augmentation
    Breast Lift
    Breast Reconstruction
    Breast Reduction
    Facial Rejuvenation
    Hand and Microvascular Surgery
    Late Burn Reconstruction
    Microvascular Reconstruction
    Pediatric Hand Surgery
    Reconstructive Hand Surgery
    Rheumatoid Hand Disorders
    Skin Cancer Reconstruction
    Wound healing

    Research Narrative

    Dr. Mankani's Research Career

    Dr. Mankani's was a Fellow in the Craniofacial and Skeletal Diseases Branch at the National Institute of Dental and Craniofacial Research (NIH), and at his tenure here on the UCSF faculty, his long-term goal was to establish an interdisciplinary program to treat patients' bone abnormalities with cell-based therapies. He had established an active research program exploring the role of bone marrow stromal cells (BMSCs) in bone formation and remodeling, focusing on ways to enhance normal bone formation in patients with segmental bone defects and with osteoporosis.

    Dr. Mankani had focused his research in two areas: 1) developing techniques to engraft BMSCs and engineer bone, and 2) describing the role of BMSCs in bone formation and repair.


    Research Interests

    Treatment of bone abnormalities with cell-based therapies

    Exploring role of bone marrow stromal cells (BMSCs) in bone formation and remodeling

    Enhancing normal bone formation in patients with osteoporosis

    View Reseach Profile at UCSF Clinical & Translational Science Institute