University of California San Francisco

Mary Knudson - 144x
M. Margaret Knudson, MD

Professor Emeritus of Surgery



1001 Potrero Avenue, #3A25
San Francisco, CA 94110
United States

Email: [email protected]
Phone: 415-206-8814
Fax: 628-206-5484


     M. Margaret "Peggy" Knudson, MD, FACS attended medical school and completed her general surgical residency at the University of Michigan in Ann Arbor. After a fellowship in pediatric surgery at Stanford University, she became involved with the development of trauma systems in California, with a special interest in pediatric trauma. After serving as the Associate Trauma Director at Stanford Medical Center, she joined the teaching faculty at the University of California, San Francisco in 1989. 

    Dr. Knudson has been on the front lines of treating trauma vitctims in major disasters including the 2010 Haitian earthquake and the crash of Asiana Airlines Flight 214 in San Francisco in July 2013. She has also served as visiting surgeon  at both Landstuhl Regional Medical Center in Germany and Balad Air Force Hospital in Iraq, treating soldiers injured on the battleflied. In 2012, Dr. Knudson was named to  U.S. News "America's Top Doctors," which reflects her inclusion as in the top 1% of physicians in the U.S. for one of her specialties. And in 2014 Dr. Knudson joined the Division of Member Services of the American College of Surgeons (ACS) and was named Medical Director for the Military Health System (MHS) Strategic-ACS Partnership. 

    Dr. Knudson also serves as the Vice Chair of the Committee on Trauma, a member of the Executive Committee, American College of Surgeons Committee on Trauma, Board of Managers, American Association for the Surgery of Trauma, on the editorial board of the Journal of Trauma, and as the Chair of the Western Trauma Association's Multi-center Trials Committee. Her major areas of research include simulation training for medical personnel, the prevention of thromboembolic complications in trauma patients, the use of ultrasound in trauma evaluation, resuscitation following hemorrhagic shock, and injury prevention.





    Institution Degree Dept or School End Date
    University of California, San Francisco Residency School of Medicine

    Board Certifications

    • American Board of Surgery, 1983
    • American Board of Surgery, Surgical Critical Care, 1988

    Clinical Expertise

    Breast Surgery
    General Surgery
    Pediatric Trauma Surgery
    Trauma Surgery

    Clinical Trials

    1. Related Conditions: Venous Thromboembolism| Start Date: | End Date:

    In the News

    October, 20, 2020 | UCSF Department of Surgery at Zuckerberg San Francisco General
    December, 04, 2018 | UCSF Department of Surgery at Zuckerberg San Francisco General
    June, 15, 2018 | UCSF Department of Surgery at Zuckerberg San Francisco General
    December, 14, 2017 | UCSF Department of Surgery at Zuckerberg San Francisco General
    March, 15, 2017 | UCSF Department of Surgery at Zuckerberg San Francisco General
    March, 05, 2017 | UCSF Department of Surgery at Zuckerberg San Francisco General
    February, 10, 2017 | UCSF Department of Surgery at Zuckerberg San Francisco General
    February, 02, 2015 | UCSF Department of Surgery at Zuckerberg San Francisco General
    May, 20, 2014 | UCSF Department of Surgery at Zuckerberg San Francisco General

    Grants and Funding

    • San Franisco Injury Center for Research and Prevention | NIH | 2007-08-01 - 2013-07-31 | Role: Principal Investigator
    • Injury prevention research centers | NIH | 1989-08-01 - 2008-03-31 | Role: Principal Investigator

    Research Narrative

    Dr. Knudson is involved in a number of projects related to injury and injury prevention: 

    • Resuscitation following Traumatic Brain Injury (Laboratory Study): In a controlled model of traumatic brain injury, the research group is using tissue oxygen probes placed at various locations to better define the brain injury and the effects of ventilation, oxygenation, hemorrhage, and resuscitation on tissue oxygen and capillary metabolism (Lactate/pyruvate/glutamate) following brain injury. 
    • A Comparison of Muscle Lactate Levels with Tissue Oxygen and Metabolism (Laboratory Study): In a small animal model, the research group is comparing serum and tissue lactate levels with other markers (tissue oxygen, bicarbonate, pyruvate) in order to better define the role of lactate as a measure of resuscitation. They are also measuring lactate levels following shock and resuscitation with fluids and various vasoactive agents.
    • Brain Tissue Oxygen Monitoring and Microdialysis Following Severe Traumatic Brain Injury (Clinical Study): Patients with severe brain injury who require ICP monitors are also being monitored with brain oxygen ad microdialysis probes in order to better define their brain injury and response to interventions.
    • Muscle Oxygen Monitoring in Critically Ill Patients (Clinical Study): Tissue oxygen levels measured in the muscle of critically ill trauma patients may be used to help guide resuscitation. The research group is comparing two methods of measuring tissue oxygen (direct probes versus near infra-red techniques) and correlating these measurements with microdialysis data as well as standard variable used to measure resuscitation (blood pressure, pulse, serum bicarbonate levels etc).
    • Posttraumatic Stress Disorder in Injured Children (Clinical Study): Injured children are particularly vulnerable to the development of PTSD. In a prospective study being conducted at Children's Hospital, Oakland, the research group is following children for up to one year post injury for the development of PTSD and comparing interventions designed to lessen these symptoms.
    • Use of ultrasound in patients with Solid Organ Injuries managed nonoperatively: (Clinical study) Using ultrasound, The research group is attempting to define the grade of liver/spleen/ or renal injuries resulting from blunt trauma and following these patients with serial ultrasound exams for progression of their injury, need for operative intervention based on the amount of hemorrhage, and the development of complications associated with non-operative management.
    • Prevention Research and Activities: Through the Injury Center, the research group is involved in a wide range of prevention projects that include pedestrian crashes, violent injuries, pediatric trauma, advocacy, and the development of educational programs in injury prevention for surgeons, medical students, and elementary students.
    • Posttraumatic Thromboembolism: (Analytical Study): Using the National Trauma Data Base, the research group is developing a report on the current incidence of DVT/PE in the United States following injury, describing risk factors, and analyzing the effectiveness of prevention strategies.
    • Simulation and Trauma: (Clinical Study): The research group is designing clinical scenarios that can be utilized in simulation in order to prepare senior surgical residents for their rotation on the trauma service. They hopes to validate the use of simulation for this purpose.
    • Outcome following isolated, mild traumatic brain injury: (Clinical Study) As part of a multi-institutional study, the research group is prospectively following patients with isolated brain injuries for their functional outcomes for a period of one year, and comparing outcomes in elderly versus younger patients.

    Research Interests

    • Trauma
    • Injury Prevention
    • Head Injuries
    • Pediatric Trauma
    • Resuscitation
    • Venous Thromboembolism
    • Ultrasound
    • Simulation


    1. Evidence-based Surgical Competency Outcomes from the Clinical Readiness Program.
      Andreatta P, Bowyer MW, Ritter EM, Remick K, Knudson MM, Elster EA| | View in PubMed
    2. Developing a National Trauma Research Action Plan: Results from the injury prevention research gap Delphi survey.
      Cooper Z, Herrera-Escobar JP, Phuong J, Braverman MA, Bonne S, Knudson MM, Rivara FP, Rowhani-Rahbar A, Price MA, Bulger EM, NTRAP Injury Prevention Panel| | View in PubMed
    3. A Perfect Storm: 2019 Scudder Oration on Trauma.
      Knudson MM| | View in PubMed
    4. Military-Civilian Partnerships in Training, Sustaining, Recruitment, Retention, and Readiness: Proceedings from an Exploratory First-Steps Meeting.
      Knudson MM, Elster EA, Bailey JA, Johannigman JA, Bailey PV, Schwab CW, Kirk GG, Woodson JA| | View in PubMed
    5. A Shared Ethos: The Military Health System Strategic Partnership with the American College of Surgeons.
      Knudson MM, Elster EE, Woodson J, Kirk G, Turner P, Hoyt DB| | View in PubMed
    6. Where do we go from here? Interim analysis to forge ahead in violence prevention.
      Dicker RA, Jaeger S, Knudson MM, Mackersie RC, Morabito DJ, Antezana J, Texada M| | View in PubMed
    7. Venous thromboembolism after trauma.
      Knudson MM, Ikossi DG| | View in PubMed
    8. Breast Cancer Beliefs and Behaviors at the San Francisco General Hospital.
      Rhoads KF, Luce JA, Knudson MM| | View in PubMed
    9. Nonoperative management of solid organ injuries. Past, present, and future.
      Knudson MM, Maull KI| | View in PubMed