Biography
Awards & Honors
Award | Conferred By | Date |
---|---|---|
George H. A. Clowes Jr., MD, FACS, Memorial Research Career Development Award | The American College of Surgeons | 2023/2028 |
UCSF Holly Smith Award for Exceptional Service to the School of Medicine | University of California San Francisco | 2023 |
40 under 40 female surgeons, The Association of Women Surgeons | The American Association for the Surgery of Trauma | 2022 |
Canizaro Award, The American Association for the Surgery of Trauma | The American Association for the Surgery of Trauma | 2021 |
UCSF Clinical and Translational Science Institute Mentor of the Year | University of California San Francisco | 2021 |
Department of Surgery Muriel Steele Society Influential Women in Surgery Honor Roll | University of California San Francisco | 2019/2022 |
Irene Perstein Award | University of California San Francisco | 2019 |
Department of Surgery Robert C Lim Jr. MD & Arthur N Thomas M | University of California San Francisco | 2019 |
Trauma Research Scholarship | Eastern Association for the Surgery of Trauma | 2018 |
Excellence in Research Award | Surgical Critical Care Program Directors Society Board of Directors | 2017 |
Fred H. & Esther E. Nusz Resident Achievement Award | University of California San Francisco | 2016 |
Haile T. Debas Resident Teaching Award | University of California San Francisco | 2016 |
Earl G Young First Place Winner | Western Trauma Association | 2014 |
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of California San Francisco | Diversity, Equity, and Inclusion Champion Training | 2019 | |
University of California San Francisco | Trauma Surgery | 2018 | |
University of California San Francisco | Surgical Critical Care | 2017 | |
University of California San Francisco | General Surgery Residency | 2016 | |
University of Colorado | MD | 2009 | |
University of California Santa Barbara | BS | Biological Sciences | 2005 |
Board Certifications
- American Board of Surgery, Surgery
- American Board of Surgery, Surgical Critical Care
Mentoring and Training Narrative
Dr. Kornblith is a mentor for a diverse learner pool. Her mentees are in pursuit of academic scientific agendas across various points in their careers, various specialties, and various institutions (including other University of California campuses). She works with undergraduate students from various universities to learn important activities of translational research including data collection via chart review, clotting assays, plasma organization, transport of biospecimens, and laboratory clerical activities. She serves as a mentor for UCSF medical students in the UCSF School of Medicine Deep Explore program and Clinical Microsystems Course, and has UCSF medical students in her laboratory. She is a designated clinical and research advisor to residents in the UCSF Department of Surgery. Dr. Kornblith was awarded the 2021 UCSF CTSI Mentor of the Year Award. In addition. Dr. Kornblith mentors beyond UCSF via participating on Thesis Statement Review Committees and dissertation committees at the University of California, Berkeley. In addition, Dr. Kornblith mentors in the San Francisco BUILD Student Training program which is an NIH-funded pipeline/pathway program support historically underrepresented undergraduate students from San Francisco State University to pursue graduate study (PhD, MD-PhD, or Masters) in the biomedical sciences.
Collaboration Interests
Dr. Kornblith is a surgeon scientist focused on translational studies in the field of Trauma with a particular interest in elucidating the mechanisms and mediators of trauma-induced coagulopathy and resuscitation techniques for post-traumatic hemorrhage. She has essential research experience studying post-injury platelet biology and technical expertise in functional laboratory measures of coagulation. She has extensive experience and expertise in the nuances of biospecimen collection in severely injured patients. She is trained in clinical research design and biostatistics from the Clinical and Translational Science Institute at UCSF. She is funded by the National Institutes of Health, the Department of Defense, the American College of Surgeons, the Eastern Association for the Surgery of Trauma, the UCSF School of Medicine Irene Perstein Award, and the Doris Duke Chartiable Foundation. She collaborates cross-disciplinary and multi-institutionally to advance knowledge within her field of interest.
I am interested in:
- CommunityAndStakeholderOrganizations
- Press
- AcademicCollaboration
- AcademicSenateCommitteeService
- CompaniesAndEntrepreneurs
- MulticenterClinicalResearch
- PhysicianScientist
- ProspectiveDonors
Clinical Expertise
Acute Care Surgery
General Surgery
Surgical Critical Care
Trauma Surgery
Clinical Trials
- Complex And Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure - UCSF (NCT05966454)Related Conditions: Appendicitis| Start Date: | End Date:
- Post-Injury Platelet Biology: Mechanisms and Outcomes (NCT03682757)Related Conditions: Wound and Injuries, Blood Platelets, Endothelium| Start Date: | End Date:
Book Chapters
- Diane A. Schwartz, Lucy Z. Kornblith, John B. Holcomb, Mitchell Jay Cohen. “Chapter 128. Multitrauma Derangement in Hemostasis and Thrombosis.” In: Marder et al: Hemostasis and Thrombosis: Basic Principles and Clinical Practice, 6th eds. 2013.
- Rochelle Dicker, Lucy Z. Kornblith. “Chapter 26. Acute Abdominal Pain.” In: Vincent et al: Textbook of Critical Care, 7th eds. 2017.
- Anamaria J. Robles, Lucy Z. Kornblith. “Coagulopathy in Trauma”. In: Dynamed Plus, 2017.
- Zachary Matthay, Lucy Z. Kornblith. “Platelets.” In: Trauma Induced Coagulopathy, 2nd eds. 2019.
Research Activities and Funding
The Platelet Transcriptome and Organ Failure After Injury: Discovering Molecular Biomarkers and Preventative Targets through Interrogating Novel RNA Modifications NIH/NIGMS 1R35GM150656-01Sep 1, 2023 - Aug 31, 2028 Role: Principal Investigator | ||||
Platelet Biology: Mechanisms and Outcomes George H. A. Clowes, Jr., MD, FACS, Memorial Research Career Development Award, American College of Surgeons Jul 1, 2023 - Jun 20, 2028 Role: Principal Investigator | ||||
Freeze Dried Platelet Extracellular Vesicles as a Hemostatic Adjunct to Resuscitation for Prolonged Field Care DOD/USAMRAA W81XWH2010216Jul 1, 2020 - Jun 30, 2022 Role: Co-Investigator | ||||
The ACCT Study: Assessing COVID-19 Associated Coagulopathy and Thrombosis NIH/NCATS UL1TR001872Jun 1, 2020 - May 31, 2021 Role: Principal Investigator | ||||
Post-Injury Platelet Genomics University of California School of Medicine Irene Perstein Award Aug 1, 2019 - Jul 31, 2020 Role: Primary Investigator |
Faculty Mentoring
Dr. Kornblith is a mentor for a diverse learner pool. Her mentees are in pursuit of academic scientific agendas across various points in their careers, various specialties, and various institutions (including other University of California campuses). She works with undergraduate students from various universities to learn important activities of translational research including data collection via chart review, clotting assays, plasma organization, transport of biospecimens, and laboratory clerical activities. She serves as a mentor for UCSF medical students in the UCSF School of Medicine Deep Explore program and Clinical Microsystems Course, and has UCSF medical students in her laboratory. She is a designated clinical and research advisor to residents in the UCSF Department of Surgery. Dr. Kornblith was awarded the 2021 UCSF CTSI Mentor of the Year Award. In addition. Dr. Kornblith mentors beyond UCSF via participating on Thesis Statement Review Committees and dissertation committees at the University of California, Berkeley. In addition, Dr. Kornblith mentors in the San Francisco BUILD Student Training program which is an NIH-funded pipeline/pathway program support historically underrepresented undergraduate students from San Francisco State University to pursue graduate study (PhD, MD-PhD, or Masters) in the biomedical sciences.
- Available to Mentor as: (Review Mentor Role Definitions):
- Career Mentor
- Co-Mentor
- Lead Research / Scholarly Mentor
- Project Mentor
- Contact for Mentoring:
- Email (see above)
Learn about the Faculty Mentoring Program and the CTSI Mentor Development Program
Collaboration Interests
- Academic Collaboration
- Academic Senate Committee Service
- Multicenter Clinical Research
- Community and Stakeholder Organizations
- Companies and Entrepreneurs
- Press
- Prospective Donors
- Physician-Scientist
In the News
Grants and Funding
- The Platelet Transcriptome and Organ Failure After Injury: Discovering Molecular Biomarkers and Preventative Targets through Interrogating Novel RNA Modifications | NIH/NIGMS | 2023-09-01 - 2028-08-31 | Role: Principal Investigator
- Platelet Biology: Mechanisms and Outcomes | George H. A. Clowes, Jr., MD, FACS, Memorial Research Career Development Award, American College of Surgeons | 2023-07-01 - 2028-06-20 | Role: Principal Investigator
- Post-Injury Platelet Biology: Mechanisms and Outcomes | NIH | 2018-09-20 - 2023-08-31 | Role: Principal Investigator
- Freeze Dried Platelet Extracellular Vesicles as a Hemostatic Adjunct to Resuscitation for Prolonged Field Care | DOD/USAMRAA | 2020-07-01 - 2022-06-30 | Role: Co-Investigator
- The ACCT Study: Assessing COVID-19 Associated Coagulopathy and Thrombosis | NIH/NCATS | 2020-06-01 - 2021-05-31 | Role: Principal Investigator
- Post-Injury Platelet Genomics | University of California School of Medicine Irene Perstein Award | 2019-08-01 - 2020-07-31 | Role: Primary Investigator
- Post-Injury Platelet Function | Eastern Association for the Surgery of Trauma | 2018-08-01 - 2019-07-31 | Role: Principal Investigator
Research Interests
Acute Traumatic Coagulopathy
Whole Blood
Platelets
Functional Coagulation
Transfusion
Lung Injury
Tracheostomy
Publications
- A National Analysis of Racial and Sex Disparities Among Interhospital Transfers for Emergency General Surgery Patients and Associated Outcomes.| | View in PubMed
- The Injured Monocyte: The Link to Chronic Critical Illness and Mortality Following Injury.| | View in PubMed
- Effects of inflammation on thrombosis and outcomes in COVID-19: secondary analysis of the ATTACC/ACTIV-4a trial.| | View in PubMed
- Effect of therapeutic-dose heparin on severe acute kidney injury and death in noncritically ill patients hospitalized for COVID-19: a prespecified secondary analysis of the ACTIV4a and ATTACC randomized trial.| | View in PubMed
- Effect of the P-Selectin Inhibitor Crizanlizumab on Survival Free of Organ Support in Patients Hospitalized for COVID-19: A Randomized Controlled Trial.| | View in PubMed
- Current use and utility of magnetic resonance cholangiopancreatography, endoscopic retrograde cholangiopancreatography, and pancreatic duct stents: A secondary analysis from the Western Trauma Association multicenter trials group on pancreatic injuries.| | View in PubMed
- Effect of P2Y12 Inhibitors on Organ Support-Free Survival in Critically Ill Patients Hospitalized for COVID-19: A Randomized Clinical Trial.| | View in PubMed
- γ' fibrinogen levels as a biomarker of COVID-19 respiratory disease severity.| | View in PubMed
- Traumatic Brain Injury, Electrolyte Levels, and Associated Outcomes: A Systematic Review.| | View in PubMed
- National analysis of motorcycle associated injuries and fatalities: Wearing helmet saves lives.| | View in PubMed
- Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19.| | View in PubMed
- Association of SARS-CoV-2 nucleocapsid viral antigen and the receptor for advanced glycation end products with development of severe disease in patients presenting to the emergency department with COVID-19.| | View in PubMed
- Outcomes of Transfusion With Whole Blood, Component Therapy, or Both in Adult Civilian Trauma Patients: A Systematic Review and Meta-Analysis.| | View in PubMed
- Effects of the circulating environment of COVID-19 on platelet and neutrophil behavior.| | View in PubMed
- Establishing a core outcomes set for massive transfusion: An Eastern Association for the Surgery of Trauma modified Delphi method consensus study.| | View in PubMed
- Analysis of Bicyclist Injuries and Fatalities in The United States: The Need for Effective & Sustainable Prevention Policies.| | View in PubMed
- Gamma' Fibrinogen Levels As a Biomarker of COVID-19 Severity.| | View in PubMed
- Trauma care during times of conflict: Strategic targeting of medical resources & operational logistics to save more lives.| | View in PubMed
- "Importance of catecholamine signaling in the development of platelet exhaustion after traumatic injury": Reply.| | View in PubMed
- National analysis of whole blood and component versus component transfusions in civilian trauma patients who underwent a thoracotomy or laparotomy: Toward improving patient outcomes and quality of care.| | View in PubMed
- Gamma' fibrinogen levels as a biomarker of COVID-19 respiratory disease severity.| | View in PubMed
- COVID-19-associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective.| | View in PubMed
- Analysis of Biomechanics of Motor Vehicle Collisions for Passenger Cars: Implications for Passenger Vehicle Safety and Future Car Design Innovations.| | View in PubMed
- Analysis of Surgical Residents' Salaries and Associated Funding During Eight Residency Training Cycles: Toward Improving Future Residents' Benefits and Compensation.| | View in PubMed
- P2.02: Save the Environment: Liver Transplantation Restores A Circulating Environment That Supports Healthy Platelet Aggregation Within Two Hours of Reperfusion.| | View in PubMed
- Nationwide analysis of proximity of American College of Surgeons-verified and state-designated trauma centers to the nearest highway exit and associated prehospital motor vehicle collision fatalities.| | View in PubMed
- Gender Distribution & Rank of Authorship in Surgical Literature.| | View in PubMed
- Developing a decision instrument to guide abdominal-pelvic imaging of blunt trauma patients: Methodology and protocol of the NEXUS abdominal-pelvic imaging study.| | View in PubMed
- Platelet Transfusion for Trauma Resuscitation.| | View in PubMed
- Nationwide Analysis of Biomechanics of Motor Vehicle Collisions Involving Passenger Vehicle and Associated Outcomes: Towards Improving Vehicle Safety Standards and Regulations.| | View in PubMed
- Importance of catecholamine signaling in the development of platelet exhaustion after traumatic injury.| | View in PubMed
- Comprehensive Assessment of Burnout Among Surgical Trainees and Practicing Surgeons: A Systematic Review.| | View in PubMed
- Postinjury platelet aggregation and venous thromboembolism.| | View in PubMed
- Tissue plasminogen activator resistance is an early predictor of posttraumatic venous thromboembolism: A prospective study from the CLOTT research group.| | View in PubMed
- Surgical stabilization of iatrogenic rib fractures following cardiopulmonary resuscitation.| | View in PubMed
- Beta-Blocker Therapy in Patients With Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis.| | View in PubMed
- Author Correction: Trauma-induced coagulopathy.| | View in PubMed
- A comparison of management and outcomes following blunt versus penetrating pancreatic trauma: A secondary analysis from the Western Trauma Association Multicenter Trials Group on Pancreatic Injuries.| | View in PubMed
- Cigarette Smoke Exposure and Acute Respiratory Distress Syndrome in Sepsis: Epidemiology, Clinical Features, and Biologic Markers.| | View in PubMed
- Outcomes after emergency general surgery and trauma care in incarcerated individuals: An EAST multicenter study.| | View in PubMed
- The National Blood Shortage-An Impetus for Change.| | View in PubMed
- A new trauma frontier: Exploratory pilot study of platelet transcriptomics in trauma patients.| | View in PubMed
- Challenging Traditional Paradigms in Posttraumatic Pulmonary Thromboembolism.| | View in PubMed
- Prehospital end-tidal carbon dioxide is predictive of death and massive transfusion in injured patients: An Eastern Association for Surgery of Trauma multicenter trial.| | View in PubMed
- Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non-Critically Ill Hospitalized Patients With COVID-19: A Randomized Clinical Trial.| | View in PubMed
- A Parallel Pandemic: Increased Firearm Injuries at Five Northern California Trauma Centers During the COVID-19 Pandemic: An Interrupted Time-series Analysis.| | View in PubMed
- Don't mess with the pancreas! A multicenter analysis of the management of low-grade pancreatic injuries.| | View in PubMed
- Impact of Transfusion Ratios on Mortality after Ultramassive Transfusion Across Nontrauma Surgical Specialties: An Eastern Association for the Surgery of Trauma Multicenter Study.| | View in PubMed
- Risk factors for venous thromboembolism after vascular surgery and implications for chemoprophylaxis strategies.| | View in PubMed
- Platelets amplify endotheliopathy in COVID-19.| | View in PubMed
- Abstract 109: Platelets Amplify Endotheliopathy In Covid-19.| | View in PubMed
- Venous Thromboembolism After Vascular Surgery: Is More Aggressive Chemoprophylaxis Warranted?.| | View in PubMed
- Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.| | View in PubMed
- Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.| | View in PubMed
- Multi-center validation of the Bowel Injury Predictive Score (BIPS) for the early identification of need to operate in blunt bowel and mesenteric injuries.| | View in PubMed
- Outcomes after ultramassive transfusion in the modern era: An Eastern Association for the Surgery of Trauma multicenter study.| | View in PubMed
- A multicenter trial of current trends in the diagnosis and management of high-grade pancreatic injuries.| | View in PubMed
- Trauma-induced coagulopathy.| | View in PubMed
- The DISTANCE study: Determining the impact of social distancing on trauma epidemiology during the COVID-19 epidemic-An interrupted time-series analysis.| | View in PubMed
- Good Platelets Gone Bad: The Effects of Trauma Patient Plasma on Healthy Platelet Aggregation.| | View in PubMed
- Internal and External Validation of an Alcohol Biomarker for Screening in Trauma.| | View in PubMed
- Dynamic effects of calcium on in vivo and ex vivo platelet behavior after trauma.| | View in PubMed
- Platelets.| | View in PubMed
- Dynamic impact of transfusion ratios on outcomes in severely injured patients: Targeted machine learning analysis of the Pragmatic, Randomized Optimal Platelet and Plasma Ratios randomized clinical trial.| | View in PubMed
- Repeat computed tomography head scan is not indicated in trauma patients taking novel anticoagulation: A multicenter study.| | View in PubMed
- Identification of injury and shock driven effects on ex vivo platelet aggregometry: A cautionary tale of phenotyping.| | View in PubMed
- Cigarette Smoking and ARDS After Blunt Trauma: The Influence of Changing Smoking Patterns and Resuscitation Practices.| | View in PubMed
- A journey upstream: Fluctuating platelet-specific genes in cell-free plasma as proof-of-concept for using ribonucleic acid sequencing to improve understanding of postinjury platelet biology.| | View in PubMed
- Von Willebrand factor as a thrombotic and inflammatory mediator in critical illness.| | View in PubMed
- A case of unexplained duodenal ulcer and massive gastrointestinal bleed.| | View in PubMed
- A comparison between the TEG 6s and TEG 5000 analyzers to assess coagulation in trauma patients.| | View in PubMed
- Alterations in platelet behavior after major trauma: adaptive or maladaptive?| | View in PubMed
- Platelet Contributions to Trauma-Induced Coagulopathy: Updates in Post-injury Platelet Biology, Platelet Transfusions, and Emerging Platelet-Based Hemostatic Agents.| | View in PubMed
- It's About Time: Transfusion effects on postinjury platelet aggregation over time.| | View in PubMed
- Do Plasma Biomarkers Have Value in Identifying Hypoxemic Trauma Patients Who Will Develop ARDS?.| | View in PubMed
- Effect of mass shootings on gun sales-A 20-year perspective.| | View in PubMed
- Fibrinolysis Shutdown in Trauma: Historical Review and Clinical Implications.| | View in PubMed
- Response to Letter to the Editor submitted by Dr. Gando and Dr. Otomo re: Trauma-induced coagulopathy: The past, present, and future.| | View in PubMed
- Response to Letter to the Editor submitted by Dr. Wada and Dr. Yamakawa re: Trauma-induced coagulopathy: The past, present, and future.| | View in PubMed
- Predictors of postinjury acute respiratory distress syndrome: Lung injury persists in the era of hemostatic resuscitation.| | View in PubMed
- Regulation of endothelial cell permeability by platelet-derived extracellular vesicles.| | View in PubMed
- Trauma-induced coagulopathy: The past, present, and future.| | View in PubMed
- The why and how our trauma patients die: A prospective Multicenter Western Trauma Association study.| | View in PubMed
- Discrepancies between conventional and viscoelastic assays in identifying trauma-induced coagulopathy.| | View in PubMed
- Dynamic coagulability after injury: Is delaying venous thromboembolism chemoprophylaxis worth the wait?| | View in PubMed
- Perhaps it's not the platelet: Ristocetin uncovers the potential role of von Willebrand factor in impaired platelet aggregation following traumatic brain injury.| | View in PubMed
- Age-Related Alteration of the Fibrin Platelet Balance: The Impact of Age on Coagulation after Injury.| | View in PubMed
- Citrated kaolin thrombelastography (TEG) thresholds for goal-directed therapy in injured patients receiving massive transfusion.| | View in PubMed
- Health care utilization and the cost of posttraumatic acute respiratory distress syndrome care.| | View in PubMed
- Trauma Early Mortality Prediction Tool (TEMPT) for assessing 28-day mortality.| | View in PubMed
- Exposing the bidirectional effects of alcohol on coagulation in trauma: Impaired clot formation and decreased fibrinolysis in rotational thromboelastometry.| | View in PubMed
- Characterizing the gut microbiome in trauma: significant changes in microbial diversity occur early after severe injury.| | View in PubMed
- Post-Traumatic Complications as Preventable Events… Yes, No, or Maybe So?.| | View in PubMed
- Tired Platelet: Functional Anergy after Injury.| | View in PubMed
- Characterization of distinct coagulopathic phenotypes in injury: Pathway-specific drivers and implications for individualized treatment.| | View in PubMed
- Correlation between factor (F)XIa, FIXa and tissue factor and trauma severity.| | View in PubMed
- Individual clotting factor contributions to mortality following trauma.| | View in PubMed
- The acute respiratory distress syndrome following isolated severe traumatic brain injury.| | View in PubMed
- Inducing Acute Traumatic Coagulopathy In Vitro: The Effects of Activated Protein C on Healthy Human Whole Blood.| | View in PubMed
- Discovering the truth about life after discharge: Long-term trauma-related mortality.| | View in PubMed
- Correlation between Factor (F)XIa, FIXa and Tissue Factor and Trauma Severity.| | View in PubMed
- The found down patient: A Western Trauma Association multicenter study.| | View in PubMed
- Differences in degree, differences in kind: characterizing lung injury in trauma.| | View in PubMed
- Obesity and clotting: Body mass index independently contributes to hypercoagulability after injury.| | View in PubMed
- Response: the whole is greater than the sum of its parts: hemostatic profiles of whole-blood variants.| | View in PubMed
- The effects of alcohol on coagulation in trauma patients: interpreting thrombelastography with caution.| | View in PubMed
- The natural history and effect of resuscitation ratio on coagulation after trauma: a prospective cohort study.| | View in PubMed
- The whole is greater than the sum of its parts: hemostatic profiles of whole blood variants.| | View in PubMed
- Predictors of the necessity for early tracheostomy in patients with acute cervical spinal cord injury: a 15-year experience.| | View in PubMed
- Exposing the Bidirectional Effects of Alcohol on Coagulation after Injury.| | View in PubMed
- Prothrombin Function: Critical Role in Hemostasis after Injury.| | View in PubMed
- Fibrinogen and platelet contributions to clot formation: implications for trauma resuscitation and thromboprophylaxis.| | View in PubMed
- Mechanical ventilation weaning and extubation after spinal cord injury: a Western Trauma Association multicenter study.| | View in PubMed
- A paradigm shift in trauma resuscitation: evaluation of evolving massive transfusion practices.| | View in PubMed
- Functional fibrinogen in coagulopathy, transfusion, and mortality after injury.| | View in PubMed
- Normalization of coagulation after traumatic brain injury: When to initiate deep venous thrombosis prophylaxis.| | View in PubMed
- The "found down" patient: a diagnostic dilemma.| | View in PubMed
- Blunt trauma induced splenic blushes are not created equal.| | View in PubMed
- Future of acute care surgery: a perspective from the next generation.| | View in PubMed
- Blunt cerebrovascular injuries in the child.| | View in PubMed
- One thousand bedside percutaneous tracheostomies in the surgical intensive care unit: time to change the gold standard.| | View in PubMed
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