Biography
Dr. Liang You received his M.D. in 1987 from the Jinzhou Medical College in China and his Ph.D. in pathology from the Medical College of Ohio in 1994. He began work at UCSF in the thoracic oncology laboratory after work at the National Cancer Institute. At UCSF, Dr. You has made a significant impact on lung cancer and mesothelioma research. Most notably, he has been been instrumental in helping Dr. David Jablons mold a fledgling research effort into a thriving molecular genomics laboratory, an integral part of the Comprehensive Cancer Center and nationally recognized.
In November 2007, Dr. You was presented with the David Jablons "Asclepios" Award by the Bonnie J. Addario Lung Cancer Foundation for his pioneering research.
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of California, San Francisco | Clinical Fellowship |
Program Affiliations
- Thoracic Oncology Program
- Thoracic Oncology Laboratory
- UCSF Helen Diller Family Comprehensive Cancer Center
Grants and Funding
- The Role of Cul4A in Genome Stability and Cancer Development | NIH | 2010-07-09 - 2017-05-31 | Role: Principal Investigator
Research Narrative
Dr. You has been a creative and dynamic force in the lab and his work has led to numerous discoveries. He helped demonstrate the relationship of p14ARF tumor suppressor deletions to the p53 pathway in mesothelioma and the effects of oncolytic viruses upon these tumors. He also discovered several novel mechanisms for the activation of upstream WNT pathways.
Dr. You has helped identify several novel biomarkers and therapeutic targets in lung cancer and mesothelioma. He and his colleagues demonstrated overexpression of Dishevelled-3 and silencing of SFRP-2, SOCS-3 and WIF-1 through promoter methylation. Dr. You and chemist Dr. Naoaki Fujii developed a small molecule Wnt pathway inhibitor, FJ9, that disrupts the interaction between the Frizzled receptor and Dishevelled, a Wnt signal transducer.
Dr. You is currently investigating the use of recombinant human WIF-1 protein as a cancer therapy and seeking out new therapeutic targets and novel interventions.
Research Interests
- Human cancer genetics and epigenetics
- Wnt Signaling Pathway
- Akt Signaling Pathway
- Lung cancer and mesothelioma
- Small molecules, antibodies and recombinant proteins
- Molecular analysis on matched normal/tumor tissues
Publications
- A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells.| | View in PubMed
- The Crosstalk between Src and Hippo/YAP Signaling Pathways in Non-Small Cell Lung Cancer (NSCLC).| | View in PubMed
- Inhibition of cyclin-dependent kinase 7 down-regulates yes-associated protein expression in mesothelioma cells.| | View in PubMed
- Epidermal Growth Factor Receptor (EGFR) Pathway, Yes-Associated Protein (YAP) and the Regulation of Programmed Death-Ligand 1 (PD-L1) in Non-Small Cell Lung Cancer (NSCLC).| | View in PubMed
- The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region.| | View in PubMed
- Cucurbitacin E inhibits the Yes‑associated protein signaling pathway and suppresses brain metastasis of human non‑small cell lung cancer in a murine model.| | View in PubMed
- Cul4A Modulates Invasion and Metastasis of Lung Cancer Through Regulation of ANXA10.| | View in PubMed
- The Role of Yes-Associated Protein (YAP) in Regulating Programmed Death-Ligand 1 (PD-L1) in Thoracic Cancer.| | View in PubMed
- Inhibition of yes-associated protein down-regulates PD-L1 (CD274) expression in human malignant pleural mesothelioma.| | View in PubMed
- Inhibition of yes-associated protein suppresses brain metastasis of human lung adenocarcinoma in a murine model.| | View in PubMed
- YAP regulates PD-L1 expression in human NSCLC cells.| | View in PubMed
- Hippo pathway in lung development.| | View in PubMed
- Drug development against the hippo pathway in mesothelioma.| | View in PubMed
- DCLK1 is correlated with MET and ERK5 expression, and associated with prognosis in malignant pleural mesothelioma.| | View in PubMed
- Targeting YAP in malignant pleural mesothelioma.| | View in PubMed
- YAP1 regulates ABCG2 and cancer cell side population in human lung cancer cells.| | View in PubMed
- YAP promotes erlotinib resistance in human non-small cell lung cancer cells.| | View in PubMed
- Knockdown of cullin 4A inhibits growth and increases chemosensitivity in lung cancer cells.| | View in PubMed
- Knockdown of Cul4A increases chemosensitivity to gemcitabine through upregulation of TGFBI in lung cancer cells.| | View in PubMed
- Cul4A overexpression associated with Gli1 expression in malignant pleural mesothelioma.| | View in PubMed
- Analysis of lung tumor initiation and progression in transgenic mice for Cre-inducible overexpression of Cul4A gene.| | View in PubMed
- Genistein Suppresses Growth of Human Uterine Sarcoma Cell Lines via Multiple Mechanisms.| | View in PubMed
- PR-Set7 is Degraded in a Conditional Cul4A Transgenic Mouse Model of Lung Cancer.| | View in PubMed
- Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells.| | View in PubMed
- CK2α, over-expressed in human malignant pleural mesothelioma, regulates the Hedgehog signaling pathway in mesothelioma cells.| | View in PubMed
- An alternative way to initiate Notch1 signaling in non-small cell lung cancer.| | View in PubMed
- Lung tumourigenesis in a conditional Cul4A transgenic mouse model.| | View in PubMed
- CUL4A induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating ZEB1 expression.| | View in PubMed
- Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model.| | View in PubMed
- Coumestrol from the national cancer Institute's natural product library is a novel inhibitor of protein kinase CK2.| | View in PubMed
- Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer.| | View in PubMed
- Inhibition of CK2α down-regulates Notch1 signalling in lung cancer cells.| | View in PubMed
- Inhibition of CK2α down-regulates Hedgehog/Gli signaling leading to a reduction of a stem-like side population in human lung cancer cells.| | View in PubMed
- The expression of Dishevelled-3 and glutamine metabolism in malignant pleural mesothelioma.| | View in PubMed
- Transgenic mice for cre-inducible overexpression of the Cul4A gene.| | View in PubMed
- Cul4A is an oncogene in malignant pleural mesothelioma.| | View in PubMed
- The expression of CXCR4, CXCL12 and CXCR7 in malignant pleural mesothelioma.| | View in PubMed
- Adenovirus-mediated SOCS3 gene transfer inhibits the growth and enhances the radiosensitivity of human non-small cell lung cancer cells.| | View in PubMed
- Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.| | View in PubMed
- Procaine and procainamide inhibit the Wnt canonical pathway by promoter demethylation of WIF-1 in lung cancer cells.| | View in PubMed
- Promoter demethylation of WIF-1 by epigallocatechin-3-gallate in lung cancer cells.| | View in PubMed
- Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library.| | View in PubMed
- Nasopharyngeal carcinoma--review of the molecular mechanisms of tumorigenesis.| | View in PubMed
- Evaluation of a chemical library of small-molecule Dishevelled antagonists that suppress tumor growth by down-regulating T-cell factor-mediated transcription.| | View in PubMed
- Epigenetic alteration of the Wnt inhibitory factor-1 promoter occurs early in the carcinogenesis of Barrett's esophagus.| | View in PubMed
- Targeting the Wnt signaling pathway with dishevelled and cisplatin synergistically suppresses mesothelioma cell growth.| | View in PubMed
- Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells.| | View in PubMed
- Roles of secreted frizzled-related proteins in cancer.| | View in PubMed
- Wnt inhibitory factor-1 gene transfer inhibits melanoma cell growth.| | View in PubMed
- Wnt inhibitory factor inhibits lung cancer cell growth.| | View in PubMed
- An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth.| | View in PubMed
- Stathmin is overexpressed in malignant mesothelioma.| | View in PubMed
- Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma.| | View in PubMed
- Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines.| | View in PubMed
- Wnt-1 signal as a potential cancer therapeutic target.| | View in PubMed
- The role of Wnt signaling in cancer and stem cells.| | View in PubMed
- Wnt2 as a new therapeutic target in malignant pleural mesothelioma.| | View in PubMed
- Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis.| | View in PubMed
- Wnt signaling in stem cells and non-small-cell lung cancer.| | View in PubMed
- Efficacy of Wnt-1 monoclonal antibody in sarcoma cells.| | View in PubMed
- Wnt signaling in lung cancer.| | View in PubMed
- Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations.| | View in PubMed
- Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells.| | View in PubMed
- Dickkopf-1 antagonizes Wnt signaling independent of beta-catenin in human mesothelioma.| | View in PubMed
- Cloning and characterization of the promoter of human Wnt inhibitory factor-1.| | View in PubMed
- Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma.| | View in PubMed
- Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells.| | View in PubMed
- An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth.| | View in PubMed
- Interleukin-4 receptor cytotoxin as therapy for human malignant pleural mesothelioma xenografts.| | View in PubMed
- Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer.| | View in PubMed
- Inhibition of Wnt-1 signaling induces apoptosis in beta-catenin-deficient mesothelioma cells.| | View in PubMed
- Activity of the suppressor of cytokine signaling-3 promoter in human non-small-cell lung cancer.| | View in PubMed
- A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells.| | View in PubMed
- Future directions: oncolytic viruses.| | View in PubMed
- SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer.| | View in PubMed
- Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression.| | View in PubMed
- Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of beta-catenin.| | View in PubMed
- Genomic alterations in human mesothelioma including high resolution mapping of common regions of DNA loss in chromosome arm 6q.| | View in PubMed
- Cloning and characterization of a functional promoter of the human SOCS-3 gene.| | View in PubMed
- A comparison analysis of anti-tumor efficacy of adenoviral gene replacement therapy (p14ARF and p16INK4A) in human mesothelioma cells.| | View in PubMed
- Induction of apoptosis in mesothelioma cells by antisurvivin oligonucleotides.| | View in PubMed
- p14(ARF) modulates the cytolytic effect of ONYX-015 in mesothelioma cells with wild-type p53.| | View in PubMed
- A multicenter evaluation of assays for detection of SV40 DNA and results in masked mesothelioma specimens.| | View in PubMed
- Indomethacin reduces lung adenoma number in A/J mice.| | View in PubMed
- Identification of differentially expressed nucleolar TGF-beta1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily.| | View in PubMed
- Prostaglandin E2 and vasoactive intestinal peptide increase vascular endothelial cell growth factor mRNAs in lung cancer cells.| | View in PubMed
- Stage II (N1) lung cancer.| | View in PubMed
- Adenovirus-mediated p14(ARF) gene transfer in human mesothelioma cells.| | View in PubMed
- ONYX-015 works synergistically with chemotherapy in lung cancer cell lines and primary cultures freshly made from lung cancer patients.| | View in PubMed
- Transforming growth factor-beta expression in mouse lung carcinogenesis.| | View in PubMed
- Reduction in transforming growth factor-beta type II receptor in mouse lung carcinogenesis.| | View in PubMed
- Identification of early growth response gene-1 (Egr-1) as a phorbol myristate acetate-induced gene in lung cancer cells by differential mRNA display.| | View in PubMed
- Differential regulation of protease and extracellular matrix protein expression by transforming growth factor-beta 1 in non-small cell lung cancer cells and normal human bronchial epithelial cells.| | View in PubMed
- Effects of transforming growth factor-beta 1 and phorbol ester on PAI-1 and PA genes in human lung cells.| | View in PubMed
- Carcinogenicity, DNA adduct formation and K-ras activation by 7H-dibenzo[c,g]carbazole in strain A/J mouse lung.| | View in PubMed
- Frameshift mutation in codon 176 of the p53 gene in rat esophageal epithelial cells transformed by benzo[a]pyrene dihydrodiol.| | View in PubMed
- Tumor multiplicity, DNA adducts and K-ras mutation pattern of 5-methylchrysene in strain A/J mouse lung.| | View in PubMed
- Allele-specific activation and expression of the K-ras gene in hybrid mouse lung tumors induced by chemical carcinogens.| | View in PubMed
- Parental bias of Ki-ras oncogenes detected in lung tumors from mouse hybrids.| | View in PubMed
- Activation of protooncogenes in mouse lung tumors.| | View in PubMed