University of California San Francisco

Julius M. Guccione - 144x
Julius M. Guccione Jr., PhD

Professor of Surgery
Division of Cardiothoracic Surgery
Co-Director, Cardiac Biomechanics Lab
Core Member, UC Berkeley & UCSF Graduate Program in Bioengineering

Address

533 Parnassus Avenue, #158
San Francisco, CA 94117
United States

Email: [email protected]
Phone: 415-680-6285
Fax: 415-750-2181

Biography

Julius M. Guccione, Ph.D. is Professor Emeritus in the UCSF Department of Surgery, specializing in realistic simulation of the efficacy of novel surgical procedures and devices for treating ischemic cardiomyopathy. He graduated with a B.S. in Biomedical Engineering from Tulane University. He obtained his M.S. and Ph.D. in Bioengineering from UCSD. He completed a research fellowship in Biomedical Engineering at The Johns Hopkins University. Dr. Guccione's research interests include the development and validation of a non-invasive method for estimating regional myocardial contractility in vivo. Such a method would be of great value in the design and evaluation of new surgical and medical strategies to treat and/or prevent infarction-induced heart failure. In 2012, he published the first evidence of depressed contractility in the border zone of a human myocardial infarction. Dr. Guccione's research is focused on optimizing the design of medical devices for treating heart failure, especially polymeric injection. Large animal models and computer simulations indicate that adding non-contractile material to the damaged left ventricular wall can potentially reduce myofiber stress. Recent results from a clinical trial support the novel concept that polymeric injection plus coronary artery bypass grafting leads to decreased myofiber stress, restored left ventricular geometry and improved function. Dr. Guccione also is CTO at 3DT HOLDINGS, LLC

Awards & Honors

Award Conferred By Date
AIMBE Fellow American Institute for Medical and Biological Engineering (AIMBE) College of Fellows 2019
Richard Skalak Best Paper Award of the ASME Bioengineering Division 1999
Individual National Research Service Award of the NIH 1991/1993
Institutional National Research Service Award Johns Hopkins University, Baltimore, MD 1990/1991
Institutional National Research Service Award University of California, San Diego, CA 1985/1990

Education

Institution Degree Dept or School End Date
Johns Hopkins University Postdoctoral Training Biomedical Engineering 07/1993
UCSD Ph.D. Engineering Sciences (Bioengineering) 06/1990
UCSD M.S. Engineering Sciences (Bioengineering) 06/1987
Tulane University B.S. Biomedical Engineering 05/1985

Program Affiliations

Member, UCB/UCSF Graduate Bioengineering Program

In the News

Julius Guccione, Jr., PhD Inducted into American Institute for Medical and Biological Engineering (AIMBE) College of Fellows
March, 27, 2019 | UCSF Surgical Innovations and Cardiac Biomechanics Lab
Mission in a Minute: 3D Modeling to Help Treat Cardiovascular Disease
December, 01, 2014 | Cardiac Biomechanics Lab
Julius Guccione "Mesmerized" by Virtual 3D Image of Beating Heart
January, 16, 2014 | Cardiac Biomechanics Lab

Grants and Funding

  • Software-guided Operative Planning of MitraClip Placement | NIH/NHLBI | 2023-12-01 - 2026-05-31 | Role: Principal Investigator
  • Software Tool for Optimization of CRT | NIH/NHLBI | 2024-04-01 - 2024-12-31 | Role: Principal Investigator
  • Real-Time Virtual Assessment of MitraClip Placement | NIH/NHLBI | 2019-08-15 - 2022-07-31 | Role: Consultant (Initiator)
  • Quantitative analysis of left ventriculoplasty: CHF | NIH | 2000-04-17 - 2020-04-30 | Role: Co-Investigator
  • Multi-Scale Laws of Myocardial Growth and Remodeling | NIH | 2014-07-25 - 2019-06-30 | Role: Principal Investigator
  • Minimally Invasive Ventricular Polymeric Injection for Treatment of Heart Failure | NIH | 2013-09-01 - 2019-06-30 | Role: Principal Investigator
  • VIRTUAL TOOLS FOR CARDIAC VENTRICULAR REMODELING SURGERY | NIH | 2006-04-15 - 2018-07-31 | Role: Principal Investigator
  • Simulation of Coronary Artery Bypass Graft and Surgical Ventricular Restoration | NIH | 2009-08-15 - 2011-07-31 | Role: Principal Investigator
  • REGIONAL MECHANICS OF LEFT VENTRICULAR ANEURYSM | NIH | 1997-09-01 - 2001-08-31 | Role: Principal Investigator
  • Regional Mechanical Properties of Intact Ventricular Muscle | The Whitaker Foundation | 1994-08-01 - 1997-07-31 | Role: Principal Investigator
  • VENTRICULAR MUSCLE MECHANICS UNDER PHYSIOLOGICAL LOADING | NIH | 1991-12-20 - 1900-01-01 | Role: Principal Investigator

Research Narrative

Dr. Guccione's research interests include the development and validation of a non-invasive method for estimating regional myocardial contractility in vivo. Such a method would be of great value in the design and evaluation of new surgical and medical strategies to treat and/or prevent infarction-induced heart failure. Recently, he published the first evidence of depressed contractility in the border zone of a human myocardial infarction.

Dr. Guccione's research is focused on optimizing the design of medical devices for treating heart failure, especially polymeric injection. Large animal models and computer simulations indicate that adding non-contractile material to the damaged left ventricular wall can potentially reduce myofiber stress. Recent results from a clinical trial support the novel concept that polymeric injection plus coronary artery bypass grafting leads to decreased myofiber stress, restored left ventricular geometry and improved function.

See also: The 3D Living Heart Project Overview

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 155
  1. Height and body surface area versus wall stress for stratification of mid-term outcomes in ascending aortic aneurysm.
    Zamirpour S, Xuan Y, Wang Z, Gomez A, Leach JR, Mitsouras D, Saloner DA, Guccione JM, Ge L, Tseng EE| | View in PubMed
  2. A Simulation Study of the Effects of Number and Location of MitraClips on Mitral Regurgitation
    Dabiri Y, Mahadevan V, Guccione JM, Kassab GS| | View in PubMed
  3. Imaging and Computational Modeling of Tricuspid Regurgitation and Repair
    Morgan AE, Howell K, Chen S, Serrone RO, Zhang Y, Wang VY, Kim JJ, Grossi E, Selzman CH, Guccione JM, Sharma V, MacLeod R; Ratcliffe MB| | View in PubMed
  4. On the Role of Ionic Model in the Signature of Cardiac Arrhythmias for Healthy and Diseased Hearts
    Ramirez WA, Gizzi A, Sack KL, Filippi S, Guccione JM, Hurtado DE| | View in PubMed
  5. On the Severity of Aortic Stenosis in Ascending Aortic Aneurysm A Computational Tool
    to Examine Ventricular-Arterial Interaction and Aortic Wall Stress
    Cosentino F, Giuseppe M, Agnese V, Gentile G, Raffa GM, Wisneski A, Guccione J, Pilato M, Pasta S| | View in PubMed
  6. Aortic area/height ratio, peak wall stresses, and outcomes in veterans with tricuspid versus bicuspid aortic valve-associated ascending thoracic aortic aneurysms.
    Zamirpour S, Xuan Y, Wang Z, Gomez A, Leach J, Mitsouras D, Saloner DA, Guccione JM, Ge L, Tseng EE| | View in PubMed
  7. Ascending thoracic aortic aneurysm elongation occurs in parallel with dilatation in a nonsurgical population.
    Gulati A, Zamirpour S, Leach J, Khan A, Wang Z, Xuan Y, Hope MD, Saloner DA, Guccione JM, Ge L, Tseng EE| | View in PubMed
  8. Looking towards the future: patient-specific computational modeling to optimize outcomes for transcatheter mitral valve repair.
    Wong P, Wisneski AD, Sandhu A, Wang Z, Mahadevan VS, Nguyen TC, Guccione JM| | View in PubMed
  9. Machine learning used for simulation of MitraClip intervention: A proof-of-concept study.
    Dabiri Y, Mahadevan VS, Guccione JM, Kassab GS| | View in PubMed
  10. Computational analysis of ventricular mechanics in hypertrophic cardiomyopathy patients.
    Mojumder J, Fan L, Nguyen T, Campbell KS, Wenk JF, Guccione JM, Abraham T, Lee LC| | View in PubMed
  11. Regional and directional delamination properties of healthy human ascending aorta and sinotubular junction.
    Xuan Y, Wang Z, Guccione JM, Tseng EE, Ge L| | View in PubMed
  12. Numerical simulation of transcatheter mitral valve replacement: The dynamic implication of LVOT obstruction in the valve-in-ring case.
    Pasta S, Catalano C, Cannata S, Guccione JM, Gandolfo C| | View in PubMed
  13. A Computationally Efficient Approach to Simulate Heart Rate Effects Using a Whole Human Heart Model.
    Yao J, Chen S, Guccione JM| | View in PubMed
  14. Association of 3-Year All-Cause Mortality and Peak Wall Stresses of Ascending Thoracic Aortic Aneurysms in Veterans.
    Zamirpour S, Xuan Y, Wang Z, Gomez A, Hope MD, Leach J, Mitsouras D, Saloner DA, Guccione JM, Ge L, Tseng EE| | View in PubMed
  15. Regional wall stress differences on tricuspid aortic valve-associated ascending aortic aneurysms.
    Gomez A, Wang Z, Xuan Y, Hope MD, Saloner DA, Guccione JM, Ge L, Tseng EE| | View in PubMed
  16. Inversion of Left Atrial Appendage Will Cause Compressive Stresses in the Tissue: Simulation Study of Potential Therapy.
    Pasta S, Guccione JM, Kassab GS| | View in PubMed
  17. Left Ventricle Biomechanics of Low-Flow, Low-Gradient Aortic Stenosis: A Patient-Specific Computational Model.
    Wisneski AD, Wang Y, Cutugno S, Pasta S, Stroh A, Yao J, Nguyen TC, Mahadevan VS, Guccione JM| | View in PubMed
  18. Mitral Valve Atlas for Artificial Intelligence Predictions of MitraClip Intervention Outcomes.
    Dabiri Y, Yao J, Mahadevan VS, Gruber D, Arnaout R, Gentzsch W, Guccione JM, Kassab GS| | View in PubMed
  19. Patient-Specific Analysis of Ascending Thoracic Aortic Aneurysm with the Living Heart Human Model.
    Cutugno S, Agnese V, Gentile G, Raffa GM, Wisneski AD, Guccione JM, Pilato M, Pasta S| | View in PubMed
  20. Regional biomechanical and failure properties of healthy human ascending aorta and root.
    Xuan Y, Wisneski AD, Wang Z, Lum M, Kumar S, Pallone J, Flores N, Inman J, Lai L, Lin J, Guccione JM, Tseng EE, Ge L| | View in PubMed
  21. Association of diameter and wall stresses of tricuspid aortic valve ascending thoracic aortic aneurysms.
    Gomez A, Wang Z, Xuan Y, Hope MD, Saloner DA, Guccione JM, Ge L, Tseng EE| | View in PubMed
  22. A kinematic model-based analysis framework for 3D Cine-DENSE-validation with an axially compressed gel phantom and application in sheep before and after antero-apical myocardial infarction.
    Wang VY, Tartibi M, Zhang Y, Selvaganesan K, Haraldsson H, Auger DA, Faraji F, Spaulding K, Takaba K, Collins A, Aguayo E, Saloner D, Wallace AW, Weinsaft JW, Epstein FH, Guccione J, Ge L, Ratcliffe MB| | View in PubMed
  23. Computational Modeling Studies of the Roles of Left Ventricular Geometry, Afterload, and Muscle Contractility on Myocardial Strains in Heart Failure with Preserved Ejection Fraction.
    Shavik SM, Wall S, Sundnes J, Guccione JM, Sengupta P, Solomon SD, Burkhoff D, Lee LC| | View in PubMed
  24. Finite-element based optimization of left ventricular passive stiffness in normal volunteers and patients after myocardial infarction: Utility of an inverse deformation gradient calculation of regional diastolic strain.
    Zhang Y, Wang VY, Morgan AE, Kim J, Tafreshi R, Wallace AW, Guccione JM, Weinsaft JW, Ge L, Ratcliffe MB| | View in PubMed
  25. Precision medicine in human heart modeling : Perspectives, challenges, and opportunities.
    Peirlinck M, Costabal FS, Yao J, Guccione JM, Tripathy S, Wang Y, Ozturk D, Segars P, Morrison TM, Levine S, Kuhl E| | View in PubMed
  26. Application of feed forward and recurrent neural networks in simulation of left ventricular mechanics.
    Dabiri Y, Van der Velden A, Sack KL, Choy JS, Guccione JM, Kassab GS| | View in PubMed
  27. Impact of Transcatheter Aortic Valve Size on Leaflet Stresses: Implications for Durability and Optimal Grey Zone Sizing.
    Xuan Y, Dvir D, Wisneski AD, Wang Z, Ye J, Guccione JM, Ge L, Tseng EE| | View in PubMed
  28. Commentary: Fast and accurate surrogate of finite-element analysis: For bench to bedside, we need it now!
    Wisneski AD, Guccione JM| | View in PubMed
  29. Impact of Aortic Stenosis on Myofiber Stress: Translational Application of Left Ventricle-Aortic Coupling Simulation.
    Wisneski AD, Wang Y, Deuse T, Hill AC, Pasta S, Sack KL, Yao J, Guccione JM| | View in PubMed
  30. In-silico study of the cardiac arrhythmogenic potential of biomaterial injection therapy.
    Ramírez WA, Gizzi A, Sack KL, Guccione JM, Hurtado DE| | View in PubMed
  31. Left ventricular geometry during unloading and the end-systolic pressure volume relationship: Measurement with a modified real-time MRI-based method in normal sheep.
    Giao DM, Wang Y, Rojas R, Takaba K, Badathala A, Spaulding KA, Soon G, Zhang Y, Wang VY, Haraldsson H, Liu J, Saloner D, Guccione JM, Ge L, Wallace AW, Ratcliffe MB| | View in PubMed
  32. Stent and leaflet stresses across generations of balloon-expandable transcatheter aortic valves.
    Xuan Y, Dvir D, Wang Z, Ye J, Guccione JM, Ge L, Tseng EE| | View in PubMed
  33. Intra-myocardial alginate hydrogel injection acts as a left ventricular mid-wall constraint in swine.
    Sack KL, Aliotta E, Choy JS, Ennis DB, Davies NH, Franz T, Kassab GS, Guccione JM| | View in PubMed
  34. A Novel MRI-Based Finite Element Modeling Method for Calculation of Myocardial Ischemia Effect in Patients With Functional Mitral Regurgitation.
    Zhang Y, Wang VY, Morgan AE, Kim J, Ge L, Guccione JM, Weinsaft JW, Ratcliffe MB| | View in PubMed
  35. Wall Stress Distribution in Bicuspid Aortic Valve-Associated Ascending Thoracic Aortic Aneurysms.
    Gomez A, Wang Z, Xuan Y, Wisneski AD, Hope MD, Saloner DA, Guccione JM, Ge L, Tseng EE| | View in PubMed
  36. Wall stress analyses in patients with ≥5 cm versus <5 cm ascending thoracic aortic aneurysm.
    Wang Z, Flores N, Lum M, Wisneski AD, Xuan Y, Inman J, Hope MD, Saloner DA, Guccione JM, Ge L, Tseng EE| | View in PubMed
  37. Numerical Simulations of MitraClip Placement: Clinical Implications.
    Kamakoti R, Dabiri Y, Wang DD, Guccione J, Kassab GS| | View in PubMed
  38. Mechanical effects of MitraClip on leaflet stress and myocardial strain in functional mitral regurgitation - A finite element modeling study.
    Zhang Y, Wang VY, Morgan AE, Kim J, Handschumacher MD, Moskowitz CS, Levine RA, Ge L, Guccione JM, Weinsaft JW, Ratcliffe MB| | View in PubMed
  39. Editorial: Mathematical Modeling of Cardiovascular Systems: From Physiology to the Clinic.
    Kassab G, Guccione J| | View in PubMed
  40. Prediction of Left Ventricular Mechanics Using Machine Learning.
    Dabiri Y, Van der Velden A, Sack KL, Choy JS, Kassab GS, Guccione JM| | View in PubMed
  41. Method for Calibration of Left Ventricle Material Properties Using Three-Dimensional Echocardiography Endocardial Strains.
    Dabiri Y, Sack KL, Rebelo N, Wang P, Wang Y, Choy JS, Kassab GS, Guccione JM| | View in PubMed
  42. Finite elastic wrinkling deformations of incompressible fiber-reinforced plates.
    Taylor M, Shirani M, Dabiri Y, Guccione JM, Steigmann DJ| | View in PubMed
  43. Using machine learning to characterize heart failure across the scales.
    Peirlinck M, Sahli Costabal F, Sack KL, Choy JS, Kassab GS, Guccione JM, De Beule M, Segers P, Kuhl E| | View in PubMed
  44. Tricuspid Valve Regurgitation Decreases after MitraClip Implantation: Fluid Structure Interaction Simulation.
    Dabiri Y, Yao J, Sack KL, Kassab GS, Guccione JM| | View in PubMed
  45. Reply to Letter to Editor by S Tong, L Zhang, J Joseph, and X Jiang "A potential and novel therapeutic approach to ischemic heart failure: Algisyl-LVR".
    Kassab GS, Choy JS, Guccione JM| | View in PubMed
  46. Multiscale characterization of heart failure.
    Sahli Costabal F, Choy JS, Sack KL, Guccione JM, Kassab GS, Kuhl E| | View in PubMed
  47. Intramyocardial Injections to De-Stiffen the Heart: A Subject-Specific in Silico Approach.
    Dabiri Y, Sack KL, Shaul S, Acevedo-Bolton G, Choy JS, Kassab GS, Guccione JM| | View in PubMed
  48. Range of Pulmonary Autograft Responses to Systemic Pressure Immediately After Ross Procedure.
    Wisneski AD, Wang Z, Xuan Y, Guccione JM, Ge L, Tseng EE| | View in PubMed
  49. Diffusion and swelling in a bio-elastic cylinder.
    Tartibi M, Guccione JM, Steigmann DJ| | View in PubMed
  50. Relationship of Transmural Variations in Myofiber Contractility to Left Ventricular Ejection Fraction: Implications for Modeling Heart Failure Phenotype With Preserved Ejection Fraction.
    Dabiri Y, Sack KL, Shaul S, Sengupta PP, Guccione JM| | View in PubMed
  51. Effect of intra-myocardial Algisyl-LVRâ„¢ injectates on fibre structure in porcine heart failure.
    Sack KL, Aliotta E, Choy JS, Ennis DB, Davies NH, Franz T, Kassab GS, Guccione JM| | View in PubMed
  52. Construction and Validation of Subject-Specific Biventricular Finite-Element Models of Healthy and Failing Swine Hearts From High-Resolution DT-MRI.
    Sack KL, Aliotta E, Ennis DB, Choy JS, Kassab GS, Guccione JM, Franz T| | View in PubMed
  53. Stent and leaflet stresses in 26-mm, third-generation, balloon-expandable transcatheter aortic valve.
    Xuan Y, Dvir D, Wang Z, Mizoguchi T, Ye J, Guccione JM, Ge L, Tseng EE| | View in PubMed
  54. Investigating the Role of Interventricular Interdependence in Development of Right Heart Dysfunction During LVAD Support: A Patient-Specific Methods-Based Approach.
    Sack KL, Dabiri Y, Franz T, Solomon SD, Burkhoff D, Guccione JM| | View in PubMed
  55. Efficacy of intramyocardial injection of Algisyl-LVR for the treatment of ischemic heart failure in swine.
    Choy JS, Leng S, Acevedo-Bolton G, Shaul S, Fu L, Guo X, Zhong L, Guccione JM, Kassab GS| | View in PubMed
  56. Wall stress on ascending thoracic aortic aneurysms with bicuspid compared with tricuspid aortic valve.
    Xuan Y, Wang Z, Liu R, Haraldsson H, Hope MD, Saloner DA, Guccione JM, Ge L, Tseng E| | View in PubMed
  57. Ischemic Mitral Regurgitation: Abnormal Strain Overestimates Nonviable Myocardium.
    Morgan AE, Zhang Y, Tartibi M, Goldburg S, Kim JJ, Nguyen TD, Guccione J, Ge L, Weinsaft JW, Ratcliffe MB| | View in PubMed
  58. Impact of Patient-Specific Material Properties on Aneurysm Wall Stress: Finite Element Study.
    Wang Z, Xuan Y, Guccione JM, Tseng EE, Ge L| | View in PubMed
  59. Stent and Leaflet Stresses in 29-mm Second-Generation Balloon-Expandable Transcatheter Aortic Valve.
    Xuan Y, Krishnan K, Ye J, Dvir D, Guccione JM, Ge L, Tseng EE| | View in PubMed
  60. Leaflet Mechanical Properties of Carpentier-Edwards Perimount Magna Pericardial Aortic Bioprostheses.
    Kuang H, Xuan Y, Lu M, Mookhoek A, Wisneski AD, Guccione JM, Ge L, Tseng EE| | View in PubMed
  61. Stent and leaflet stresses in a 26-mm first-generation balloon-expandable transcatheter aortic valve.
    Xuan Y, Krishnan K, Ye J, Dvir D, Guccione JM, Ge L, Tseng EE| | View in PubMed
  62. Personalised computational cardiology: Patient-specific modelling in cardiac mechanics and biomaterial injection therapies for myocardial infarction.
    Sack KL, Davies NH, Guccione JM, Franz T| | View in PubMed
  63. Partial LVAD restores ventricular outputs and normalizes LV but not RV stress distributions in the acutely failing heart in silico.
    Sack KL, Baillargeon B, Acevedo-Bolton G, Genet M, Rebelo N, Kuhl E, Klein L, Weiselthaler GM, Burkhoff D, Franz T, Guccione JM| | View in PubMed
  64. Suture Forces for Closure of Transapical Transcatheter Aortic Valve Replacement: A Mathematical Model.
    Ge L, Haraldsson H, Hope MD, Saloner D, Guccione JM, Ratcliffe MB, Tseng EE| | View in PubMed
  65. A New Twist on Mitral Regurgitation.
    Burkhoff D, Guccione J| | View in PubMed
  66. Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective.
    Kassab GS, An G, Sander EA, Miga MI, Guccione JM, Ji S, Vodovotz Y| | View in PubMed
  67. Mathematical modeling of cardiac growth and remodeling.
    Lee LC, Kassab GS, Guccione JM| | View in PubMed
  68. Moderate Ischemic Mitral Regurgitation After Posterolateral Myocardial Infarction in Sheep Alters Left Ventricular Shear but Not Normal Strain in the Infarct and Infarct Borderzone.
    Ge L, Wu Y, Soleimani M, Khazalpour M, Takaba K, Tartibi M, Zhang Z, Acevedo-Bolton G, Saloner DA, Wallace AW, Mishra R, Grossi EA, Guccione JM, Ratcliffe MB| | View in PubMed
  69. Finite Element Modeling of Mitral Valve Repair.
    Morgan AE, Pantoja JL, Weinsaft J, Grossi E, Guccione JM, Ge L, Ratcliffe M| | View in PubMed
  70. Measuring cardiac efficiency using PET/MRI.
    Gullberg G, Aparici CM, Brooks G, Liu J, Guccione J, Saloner D, Seo AY, Ordovas KG| | View in PubMed
  71. Bicuspid Aortic Valve-Associated Ascending Thoracic Aortic Aneurysm: Patient-Specific Finite Element Analysis.
    Wisneski AD, Mookhoek A, Chitsaz S, Hope MD, Guccione JM, Ge L, Tseng EE| | View in PubMed
  72. Residual Stress Impairs Pump Function After Surgical Ventricular Remodeling: A Finite Element Analysis.
    Pantoja JL, Zhang Z, Tartibi M, Sun K, Macmillan W, Guccione JM, Ge L, Ratcliffe MB| | View in PubMed
  73. Ascending thoracic aortic aneurysm wall stress analysis using patient-specific finite element modeling of in vivo magnetic resonance imaging.
    Krishnan K, Ge L, Haraldsson H, Hope MD, Saloner DA, Guccione JM, Tseng EE| | View in PubMed
  74. A Novel Method for Quantifying Smooth Regional Variations in Myocardial Contractility Within an Infarcted Human Left Ventricle Based on Delay-Enhanced Magnetic Resonance Imaging.
    Genet M, Chuan Lee L, Ge L, Acevedo-Bolton G, Jeung N, Martin A, Cambronero N, Boyle A, Yeghiazarians Y, Kozerke S, Guccione JM| | View in PubMed
  75. Modeling Pathologies of Diastolic and Systolic Heart Failure.
    Genet M, Lee LC, Baillargeon B, Guccione JM, Kuhl E| | View in PubMed
  76. Heterogeneous growth-induced prestrain in the heart.
    Genet M, Rausch MK, Lee LC, Choy S, Zhao X, Kassab GS, Kozerke S, Guccione JM, Kuhl E| | View in PubMed
  77. Human Cardiac Function Simulator for the Optimal Design of a Novel Annuloplasty Ring with a Sub-valvular Element for Correction of Ischemic Mitral Regurgitation.
    Baillargeon B, Costa I, Leach JR, Lee LC, Genet M, Toutain A, Wenk JF, Rausch MK, Rebelo N, Acevedo-Bolton G, Kuhl E, Navia JL, Guccione JM| | View in PubMed
  78. Effect of mitral annuloplasty device shape and size on leaflet and myofiber stress following repair of posterior leaflet prolapse: a patient-specific finite element simulation.
    Morrel WG, Ge L, Zhang Z, Grossi EA, Guccione JM, Ratcliffe MB| | View in PubMed
  79. Patient-specific finite element analysis of ascending thoracic aortic aneurysm.
    Wisneski AD, Mookhoek A, Chitsaz S, Hope MD, Guccione JM, Ge L, Tseng EE| | View in PubMed
  80. Posterior papillary muscle anchoring affects remote myofiber stress and pump function: finite element analysis.
    Pantoja JL, Ge L, Zhang Z, Morrel WG, Guccione JM, Grossi EA, Ratcliffe MB| | View in PubMed
  81. Invited commentary.
    Lee LC, Genet M, Guccione JM| | View in PubMed
  82. Bioinjection treatment: effects of post-injection residual stress on left ventricular wall stress.
    Lee LC, Wall ST, Genet M, Hinson A, Guccione JM| | View in PubMed
  83. A computational model that predicts reverse growth in response to mechanical unloading.
    Lee LC, Genet M, Acevedo-Bolton G, Ordovas K, Guccione JM, Kuhl E| | View in PubMed
  84. Distribution of normal human left ventricular myofiber stress at end diastole and end systole: a target for in silico design of heart failure treatments.
    Genet M, Lee LC, Nguyen R, Haraldsson H, Acevedo-Bolton G, Zhang Z, Ge L, Ordovas K, Kozerke S, Guccione JM| | View in PubMed
  85. Patient-specific finite element modeling of the Cardiokinetix Parachute(®) device: effects on left ventricular wall stress and function.
    Lee LC, Ge L, Zhang Z, Pease M, Nikolic SD, Mishra R, Ratcliffe MB, Guccione JM| | View in PubMed
  86. Human pulmonary autograft wall stress at systemic pressures prior to remodeling after the Ross procedure.
    Wisneski AD, Matthews PB, Azadani AN, Mookhoek A, Chitsaz S, Guccione JM, Ge L, Tseng EE| | View in PubMed
  87. Applications of computational modeling in cardiac surgery.
    Lee LC, Genet M, Dang AB, Ge L, Guccione JM, Ratcliffe MB| | View in PubMed
  88. Measurement of mitral leaflet and annular geometry and stress after repair of posterior leaflet prolapse: virtual repair using a patient-specific finite element simulation.
    Ge L, Morrel WG, Ward A, Mishra R, Zhang Z, Guccione JM, Grossi EA, Ratcliffe MB| | View in PubMed
  89. Mild anastomotic stenosis in patient-specific CABG model may enhance graft patency: a new hypothesis.
    Huo Y, Luo T, Guccione JM, Teague SD, Tan W, Navia JA, Kassab GS| | View in PubMed
  90. Biomechanical properties of human ascending thoracic aortic aneurysms.
    Azadani AN, Chitsaz S, Mannion A, Mookhoek A, Wisneski A, Guccione JM, Hope MD, Ge L, Tseng EE| | View in PubMed
  91. Analysis of patient-specific surgical ventricular restoration: importance of an ellipsoidal left ventricular geometry for diastolic and systolic function.
    Lee LC, Wenk JF, Zhong L, Klepach D, Zhang Z, Ge L, Ratcliffe MB, Zohdi TI, Hsu E, Navia JL, Kassab GS, Guccione JM| | View in PubMed
  92. Biventricular finite element modeling of the Acorn CorCap Cardiac Support Device on a failing heart.
    Wenk JF, Ge L, Zhang Z, Mojsejenko D, Potter DD, Tseng EE, Guccione JM, Ratcliffe MB| | View in PubMed
  93. Reduction in left ventricular wall stress and improvement in function in failing hearts using Algisyl-LVR.
    Lee LC, Zhihong Z, Hinson A, Guccione JM| | View in PubMed
  94. Left ventricular myocardial contractility is depressed in the borderzone after posterolateral myocardial infarction.
    Shimkunas R, Zhang Z, Wenk JF, Soleimani M, Khazalpour M, Acevedo-Bolton G, Wang G, Saloner D, Mishra R, Wallace AW, Ge L, Baker AJ, Guccione JM, Ratcliffe MB| | View in PubMed
  95. Left ventricular pressure gating in ovine cardiac studies: a software-based method.
    Acevedo-Bolton G, Suzuki T, Malhotra D, Zhang Z, Wallace AW, Guccione JM, Saloner DA, Ratcliffe MB| | View in PubMed
  96. Algisyl-LVRâ„¢ with coronary artery bypass grafting reduces left ventricular wall stress and improves function in the failing human heart.
    Lee LC, Wall ST, Klepach D, Ge L, Zhang Z, Lee RJ, Hinson A, Gorman JH, Gorman RC, Guccione JM| | View in PubMed
  97. Finite element modeling of mitral leaflet tissue using a layered shell approximation.
    Wenk JF, Ratcliffe MB, Guccione JM| | View in PubMed
  98. Material properties of CorCap passive cardiac support device.
    Chitsaz S, Wenk JF, Ge L, Wisneski A, Mookhoek A, Ratcliffe MB, Guccione JM, Tseng EE| | View in PubMed
  99. Patient-specific finite element-based analysis of ventricular myofiber stress after Coapsys: importance of residual stress.
    Carrick R, Ge L, Lee LC, Zhang Z, Mishra R, Axel L, Guccione JM, Grossi EA, Ratcliffe MB| | View in PubMed
  100. Patient-specific multiscale modeling of blood flow for coronary artery bypass graft surgery.
    Sankaran S, Esmaily Moghadam M, Kahn AM, Tseng EE, Guccione JM, Marsden AL| | View in PubMed
  101. The benefit of enhanced contractility in the infarct borderzone: a virtual experiment.
    Zhang Z, Sun K, Saloner DA, Wallace AW, Ge L, Baker AJ, Guccione JM, Ratcliffe MB| | View in PubMed
  102. Growth and remodeling of the left ventricle: A case study of myocardial infarction and surgical ventricular restoration.
    Klepach D, Lee LC, Wenk JF, Ratcliffe MB, Zohdi TI, Navia JA, Kassab GS, Kuhl E, Guccione JM| | View in PubMed
  103. First evidence of depressed contractility in the border zone of a human myocardial infarction.
    Wenk JF, Klepach D, Lee LC, Zhang Z, Ge L, Tseng EE, Martin A, Kozerke S, Gorman JH, Gorman RC, Guccione JM| | View in PubMed
  104. A coupled biventricular finite element and lumped-parameter circulatory system model of heart failure.
    Wenk JF, Ge L, Zhang Z, Soleimani M, Potter DD, Wallace AW, Tseng E, Ratcliffe MB, Guccione JM| | View in PubMed
  105. The effect of mitral annuloplasty shape in ischemic mitral regurgitation: a finite element simulation.
    Wong VM, Wenk JF, Zhang Z, Cheng G, Acevedo-Bolton G, Burger M, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB, Ge L| | View in PubMed
  106. Electromechanical feedback with reduced cellular connectivity alters electrical activity in an infarct injured left ventricle: a finite element model study.
    Wall ST, Guccione JM, Ratcliffe MB, Sundnes JS| | View in PubMed
  107. Invited commentary.
    Wenk J, Guccione J, Ratcliffe M| | View in PubMed
  108. Moderate mitral regurgitation accelerates left ventricular remodeling after posterolateral myocardial infarction.
    Soleimani M, Khazalpour M, Cheng G, Zhang Z, Acevedo-Bolton G, Saloner DA, Mishra R, Wallace AW, Guccione JM, Ge L, Ratcliffe MB| | View in PubMed
  109. A novel method for quantifying in-vivo regional left ventricular myocardial contractility in the border zone of a myocardial infarction.
    Lee LC, Wenk JF, Klepach D, Zhang Z, Saloner D, Wallace AW, Ge L, Ratcliffe MB, Guccione JM| | View in PubMed
  110. A novel method for quantifying the in-vivo mechanical effect of material injected into a myocardial infarction.
    Wenk JF, Eslami P, Zhang Z, Xu C, Kuhl E, Gorman JH, Robb JD, Ratcliffe MB, Gorman RC, Guccione JM| | View in PubMed
  111. Simulation of mechanical environment in active lead fixation: effect of fixation helix size.
    Zhao X, Wenk JF, Burger M, Liu Y, Das MK, Combs W, Ge L, Guccione JM, Kassab GS| | View in PubMed
  112. Regional left ventricular myocardial contractility and stress in a finite element model of posterobasal myocardial infarction.
    Wenk JF, Sun K, Zhang Z, Soleimani M, Ge L, Saloner D, Wallace AW, Ratcliffe MB, Guccione JM| | View in PubMed
  113. Simulation of LV pacemaker lead in marginal vein: potential risk factors for acute dislodgement.
    Zhao X, Burger M, Liu Y, Das MK, Combs W, Wenk JF, Guccione JM, Kassab GS| | View in PubMed
  114. Impact of surgical ventricular restoration on ventricular shape, wall stress, and function in heart failure patients.
    Zhong L, Su Y, Gobeawan L, Sola S, Tan RS, Navia JL, Ghista DN, Chua T, Guccione J, Kassab GS| | View in PubMed
  115. Comparison of the Young-Laplace law and finite element based calculation of ventricular wall stress: implications for postinfarct and surgical ventricular remodeling.
    Zhang Z, Tendulkar A, Sun K, Saloner DA, Wallace AW, Ge L, Guccione JM, Ratcliffe MB| | View in PubMed
  116. Finite element modeling of the pulmonary autograft at systemic pressure before remodeling.
    Matthews PB, Jhun CS, Yaung S, Azadani AN, Guccione JM, Ge L, Tseng EE| | View in PubMed
  117. Comparison of porcine pulmonary and aortic root material properties.
    Matthews PB, Azadani AN, Jhun CS, Ge L, Guy TS, Guccione JM, Tseng EE| | View in PubMed
  118. First finite element model of the left ventricle with mitral valve: insights into ischemic mitral regurgitation.
    Wenk JF, Zhang Z, Cheng G, Malhotra D, Acevedo-Bolton G, Burger M, Suzuki T, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB| | View in PubMed
  119. Dor procedure for dyskinetic anteroapical myocardial infarction fails to improve contractility in the border zone.
    Sun K, Zhang Z, Suzuki T, Wenk JF, Stander N, Einstein DR, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB| | View in PubMed
  120. Fluid-Structure Interactions of the Mitral Valve and Left Heart: Comprehensive Strategies, Past, Present and Future.
    Einstein DR, Del Pin F, Jiao X, Kuprat AP, Carson JP, Kunzelman KS, Cochran RP, Guccione JM, Ratcliffe MB| | View in PubMed
  121. Effect of adjustable passive constraint on the failing left ventricle: a finite-element model study.
    Jhun CS, Wenk JF, Zhang Z, Wall ST, Sun K, Sabbah HN, Ratcliffe MB, Guccione JM| | View in PubMed
  122. A method for automatically optimizing medical devices for treating heart failure: designing polymeric injection patterns.
    Wenk JF, Wall ST, Peterson RC, Helgerson SL, Sabbah HN, Burger M, Stander N, Ratcliffe MB, Guccione JM| | View in PubMed
  123. A computationally efficient formal optimization of regional myocardial contractility in a sheep with left ventricular aneurysm.
    Sun K, Stander N, Jhun CS, Zhang Z, Suzuki T, Wang GY, Saeed M, Wallace AW, Tseng EE, Baker AJ, Saloner D, Einstein DR, Ratcliffe MB, Guccione JM| | View in PubMed
  124. Biomechanical perspective on the porcine pulmonary root prior to Ross remodeling.
    Matthews PB, Kim B, Azadani AN, Guy TS, Guccione JM, Ge L, Tseng EE| | View in PubMed
  125. Adaptive generation of multimaterial grids from imaging data for biomedical Lagrangian fluid-structure simulations.
    Carson JP, Kuprat AP, Jiao X, Dyedov V, Del Pin F, Guccione JM, Ratcliffe MB, Einstein DR| | View in PubMed
  126. Aortic valve-in-valve implantation: impact of transcatheter- bioprosthesis size mismatch.
    Azadani AN, Jaussaud N, Matthews PB, Chuter TA, Ge L, Guy TS, Guccione J, Tseng EE| | View in PubMed
  127. Significant material property differences between the porcine ascending aorta and aortic sinuses.
    Gundiah N, Matthews PB, Karimi R, Azadani A, Guccione J, Guy TS, Saloner D, Tseng EE| | View in PubMed
  128. Asymmetric mechanical properties of porcine aortic sinuses.
    Gundiah N, Kam K, Matthews PB, Guccione J, Dwyer HA, Saloner D, Chuter TA, Guy TS, Ratcliffe MB, Tseng EE| | View in PubMed
  129. Magnetic resonance imaging-based finite element stress analysis after linear repair of left ventricular aneurysm.
    Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Hsu EW, Saloner DA, Guccione JM| | View in PubMed
  130. Endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm increases systolic circumferential shortening in sheep.
    Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A, Acevedo-Bolton G, Guttman MA, Ozturk C, McVeigh ER, Saloner DA, Wallace AW, Ratcliffe MB| | View in PubMed
  131. Transmural heterogeneity of diffusion anisotropy in the sheep myocardium characterized by MR diffusion tensor imaging.
    Jiang Y, Guccione JM, Ratcliffe MB, Hsu EW| | View in PubMed
  132. Theoretical impact of the injection of material into the myocardium: a finite element model simulation.
    Wall ST, Walker JC, Healy KE, Ratcliffe MB, Guccione JM| | View in PubMed
  133. The effect of anteroapical aneurysm plication on end-systolic three-dimensional strain in the sheep: a magnetic resonance imaging tagging study.
    Guccione JM, Walker JC, Beitler JR, Moonly SM, Zhang P, Guttman MA, Ozturk C, McVeigh ER, Wallace AW, Saloner DA, Ratcliffe MB| | View in PubMed
  134. Left ventricular volume and function after endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm in sheep.
    Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A, Saloner DA, Wallace AW, Ratcliffe MB| | View in PubMed
  135. MRI-based finite-element analysis of left ventricular aneurysm.
    Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Fata B, Hsu EW, Saloner D, Guccione JM| | View in PubMed
  136. Helical myofiber orientation after myocardial infarction and left ventricular surgical restoration in sheep.
    Walker JC, Guccione JM, Jiang Y, Zhang P, Wallace AW, Hsu EW, Ratcliffe MB| | View in PubMed
  137. Effect of ventricular size and patch stiffness in surgical anterior ventricular restoration: a finite element model study.
    Dang AB, Guccione JM, Zhang P, Wallace AW, Gorman RC, Gorman JH, Ratcliffe MB| | View in PubMed
  138. Akinetic myocardial infarcts must contain contracting myocytes: finite-element model study.
    Dang AB, Guccione JM, Mishell JM, Zhang P, Wallace AW, Gorman RC, Gorman JH, Ratcliffe MB| | View in PubMed
  139. Myosplint decreases wall stress without depressing function in the failing heart: a finite element model study.
    Guccione JM, Salahieh A, Moonly SM, Kortsmit J, Wallace AW, Ratcliffe MB| | View in PubMed
  140. Altered left ventricular geometry changes the border zone temporal distribution of stress in an experimental model of left ventricular aneurysm: a finite element model study.
    Moustakidis P, Maniar HS, Cupps BP, Absi T, Zheng J, Guccione JM, Sundt TM, Pasque MK| | View in PubMed
  141. A finite element model of left ventricular cellular transplantation in dilated cardiomyopathy.
    Quarterman RL, Moonly S, Wallace AW, Guccione J, Ratcliffe MB| | View in PubMed
  142. Residual stress produced by ventricular volume reduction surgery has little effect on ventricular function and mechanics: a finite element model study.
    Guccione JM, Moonly SM, Wallace AW, Ratcliffe MB| | View in PubMed
  143. Mechanism underlying mechanical dysfunction in the border zone of left ventricular aneurysm: a finite element model study.
    Guccione JM, Moonly SM, Moustakidis P, Costa KD, Moulton MJ, Ratcliffe MB, Pasque MK| | View in PubMed
  144. Epicardial suction: a new approach to mechanical testing of the passive ventricular wall.
    Okamoto RJ, Moulton MJ, Peterson SJ, Li D, Pasque MK, Guccione JM| | View in PubMed
  145. The effects of cross-fiber deformation on axial fiber stress in myocardium.
    Zahalak GI, de Laborderie V, Guccione JM| | View in PubMed
  146. A distribution-moment model of deactivation in cardiac muscle.
    Guccione JM, Motabarzadeh I, Zahalak GI| | View in PubMed
  147. Measurements of active myocardial tension under a wide range of physiological loading conditions.
    Guccione JM, Le Prell GS, de Tombe PP, Hunter WC| | View in PubMed
  148. Anterior and posterior left ventricular sarcomere lengths behave similarly during ejection.
    Guccione JM, O'Dell WG, McCulloch AD, Hunter WC| | View in PubMed
  149. A three-dimensional finite element method for large elastic deformations of ventricular myocardium: I--Cylindrical and spherical polar coordinates.
    Costa KD, Hunter PJ, Rogers JM, Guccione JM, Waldman LK, McCulloch AD| | View in PubMed
  150. A three-dimensional finite element method for large elastic deformations of ventricular myocardium: II--Prolate spheroidal coordinates.
    Costa KD, Hunter PJ, Wayne JS, Waldman LK, Guccione JM, McCulloch AD| | View in PubMed
  151. Finite element stress analysis of left ventricular mechanics in the beating dog heart.
    Guccione JM, Costa KD, McCulloch AD| | View in PubMed
  152. Mechanics of active contraction in cardiac muscle: Part I--Constitutive relations for fiber stress that describe deactivation.
    Guccione JM, McCulloch AD| | View in PubMed
  153. Mechanics of active contraction in cardiac muscle: Part II--Cylindrical models of the systolic left ventricle.
    Guccione JM, Waldman LK, McCulloch AD| | View in PubMed
  154. Large-scale finite element analysis of the beating heart.
    McCulloch A, Waldman L, Rogers J, Guccione J| | View in PubMed
  155. Passive material properties of intact ventricular myocardium determined from a cylindrical model.
    Guccione JM, McCulloch AD, Waldman LK| | View in PubMed