University of California San Francisco

Jason Smith, MD

Professor of Surgery
Division of Cardiothoracic Surgery
Surgical Director, Heart Transplant and Mechanical Circulatory Support

Academic Office: 
513 Parnassus Avenue, Suite 309F, Box 0118
San Francisco, CA 94143
Phone: 415-353-8890
Email: [email protected] 
Assistant: [email protected]

Cardiac Surgery Program
400 Parnassus Avenue, Suite 501, Box 0957
San Francisco, CA, 94143
Tel: 415-353-1606
Fax: 415-353-1312

Heart Transplant Program
400 Parnassus Avenue, Suite 501, Box 0115
San Francisco, CA 94143
Tel: 415-502-4243


    Dr. Jason W. Smith is a cardiac and transplant surgeon who specializes in heart transplantation and the use of mechanical circulatory support, such as artificial heart pumps and left ventricular assist devices. He has expertise in complex cardiac procedures that include mitral valve repair and replacement, aortic valve surgery, transcatheter aortic valve procedures (minimally invasive techniques to replace a failing valve), surgeries to treat the ascending aorta and aortic arch, treatment of endocarditis (infections of the heart's inner lining), operations to correct atrial fibrillation (irregular and often rapid heartbeats), and sternal repair and reconstruction. He also manages extracorporeal membrane oxygenation (ECMO), which supports the heart and lungs by using a machine to oxygenate blood outside of the body. He is the surgical director of UCSF's heart transplantation and mechanical circulatory support programs. Smith has been active in a national effort to increase access to heart transplantation by improving the use of donor organs. He served as a primary investigator for a nationwide clinical trial on donation after cardiac death. Smith earned his medical degree from the Stritch School of Medicine at Loyola University Chicago, then completed a residency in general surgery and a fellowship in cardiothoracic surgery at Loyola University Medical Center. He completed a fellowship in heart and lung transplantation at Stanford Medicine. Upon completing his training, he joined the surgical faculty at the University of Washington. Prior to joining UCSF, he served as surgical director of transplant and mechanical circulatory support at the University of Wisconsin – Madison. Smith serves on the membership and professional standards committee of the national Organ Procurement and Transplantation Network. He frequently makes presentations on issues related to organ transplantation and utilization and belongs to numerous professional and honorary societies. He is a San Francisco native.


    Institution Degree Dept or School End Date
    Stanford University Hospital and Clinics Heart and Lung Transplant and Mechanical Circulatory Support 06/2012
    Loyola University Medical Center Cardiothoracic Surgery 06/2011
    Loyola University Medical Center General Surgery 06/2009
    Loyola University Medical Center, Burn Shock Trauma Center Research Fellowship 06/2005
    Loyola University Medical School MD Medicine 06/2002
    Baylor University BA University Scholar 12/1993

    Board Certifications

    American Board of Thoracic Surgery, Thoracic and Cardiac Surgery

    Clinical Expertise

    Heart Transplant

    Total Artificial Heart support

    left ventricular assist devices

    minimally invasive LVAD surgery

    Acute heart support

    Extra Corporeal membrane oxygenator support (ECMO)

    aortic valve repair and replacement

    transcatheter aortic valve procedures

    mitral valve replacement

    mitral valve repair

    tricuspid valve repair and replacement


    ascending aortic aneurysm

    aortic arch aneurysm

    reoperative heart surgery

    atrial fibrillation surgery

    cardiac tumors

    In the News

    May, 16, 2022 | UCSF Department of Surgery

    Research Interests

    Organ donor utilization

    DCD heart donation

    ex-vivo heart perfusion

    normothermic regional perfusion


    1. Author Reply: "What do we mean by source control and what are we trying to accomplish with an open abdomen in severe complicated intra-abdominal sepsis?"
      Risinger WB, Smith JW| | View in PubMed
    2. Applying the antecedent, behaviour, and consequence taxonomy to unintentional firearm injury as determined by a collaborative firearm injury database.
      Risinger WB, Nickols AK, Harris AN, Benns MV, Nash NA, Bozeman MC, Pera SJ, Coleman JC, Franklin GA, Smith JW, Harbrecht BG, Miller KR| | View in PubMed
    3. Increasing Utilization of Extended Criteria Donor Hearts for Transplantation: The OCS Heart EXPAND Trial.
      Schroder JN, Patel CB, DeVore AD, Casalinova S, Koomalsingh KJ, Shah AS, Anyanwu AC, D'Alessandro DA, Mudy K, Sun B, Strueber M, Khaghani A, Shudo Y, Esmailian F, Liao K, Pagani FD, Silvestry S, Wang IW, Salerno CT, Absi TS, Madsen JC, Mancini D, Fiedler AG, Milano CA, Smith JW| | View in PubMed
    4. A Decade of Analysis of Unplanned Extubation Etiology in Trauma Patients Including the Impact of the COVID Pandemic.
      Harbrecht BG, Miller KR, Egger ME, Nash NA, Doan R, Georgel J, Franklin GA, Smith JW, Bozeman MC, Benns MV| | View in PubMed
    5. Expanding the Donation After Circulatory Death Transplant Pool in the United States.
      Fiedler A, Miller PN, Smith JW| | View in PubMed
    6. Plasma resuscitation improves and restores intestinal microcirculatory physiology following haemorrhagic shock.
      Schucht JE, Harbrecht BG, Bond LM, Risinger WB, Matheson PJ, Smith JW| | View in PubMed
    7. Damage control surgery in emergency general surgery: What you need to know.
      Risinger WB, Smith JW| | View in PubMed
    8. Establishing a core outcome set for blunt cerebrovascular injury: an EAST modified Delphi method consensus study.
      Ziesmann M, Byerly S, Yeh DD, Boltz M, Gelbard R, Haut ER, Smith JW, Stein DM, Zarzaur BL, Bensard DD, Biffl WL, Boyd A, Brommeland T, Cothren Burlew C, Fabian T, Lauerman M, Leichtle S, Moore EE, Timmons S, Vogt K, Nahmias J| | View in PubMed
    9. Transplantation Outcomes with Donor Hearts after Circulatory Death.
      Schroder JN, Patel CB, DeVore AD, Bryner BS, Casalinova S, Shah A, Smith JW, Fiedler AG, Daneshmand M, Silvestry S, Geirsson A, Pretorius V, Joyce DL, Um JY, Esmailian F, Takeda K, Mudy K, Shudo Y, Salerno CT, Pham SM, Goldstein DJ, Philpott J, Dunning J, Lozonschi L, Couper GS, Mallidi HR, Givertz MM, Pham DT, Shaffer AW, Kai M, Quader MA, Absi T, Attia TS, Shukrallah B, Sun BC, Farr M, Mehra MR, Madsen JC, Milano CA, D'Alessandro DA| | View in PubMed
    10. Comment on: Detection and management of HLA sensitization in candidates for adult heart transplantation.
      Fiedler AG, Klein L, DeMarco T, Kouretas P, Smith JW| | View in PubMed
    11. Establishing a core outcomes set for massive transfusion: An Eastern Association for the Surgery of Trauma modified Delphi method consensus study.
      Gelbard RB, Nahmias J, Byerly S, Ziesmann M, Stein D, Haut ER, Smith JW, Boltz M, Zarzaur B, Callum J, Cotton BA, Cripps M, Gunter OL, Holcomb JB, Kerby J, Kornblith LZ, Moore EE, Riojas CM, Schreiber M, Sperry JL, Yeh DD| | View in PubMed
    12. Molecules, Machines, and the Perfusate Milieu: Organ Preservation and Emerging Concepts for Heart Transplant.
      Wisneski A, Smith JW, Nguyen TC, Fiedler AG| | View in PubMed
    13. Effect of Plasma Resuscitation with Adjunctive Peritoneal Resuscitation on Hepatic Blood Flow and End-Organ Damage after Hemorrhagic Shock.
      Smith JW, Schucht JE, Harbrecht BG, Bond LM, Matheson PJ| | View in PubMed
    14. Direct Peritoneal Resuscitation for Trauma.
      Pera SJ, Schucht J, Smith JW| | View in PubMed
    15. A new pandemic and an old epidemic: The impact of COVID-19 and gun violence as measured by years of potential life lost in a US city.
      Risinger WB, Pera SJ, Bhutiani N, Ruther M, Harbrecht BG, Smith JW, Benns MV, Miller KR| | View in PubMed
    16. Normothermic regional perfusion surgical technique for the procurement of cardiac donors after circulatory death.
      Fiedler AG, DeVries S, Czekajlo C, Smith JW| | View in PubMed
    17. Unconventional use of total artificial heart in a patient with severe, destructive prosthetic valve endocarditis.
      Johnstad C, Bomareddi S, Hermsen JL, Smith JW, Fiedler AG| | View in PubMed
    18. Survival after orthotopic heart transplantation in patients with BMI > = 35 with and without diabetes.
      Fiedler AG, Stalter L, Marka N, Dhingra R, Hermsen JL, Smith JW| | View in PubMed
    19. Left ventricular assist device implantation by bi-thoracotomy technique: A single-center perspective.
      Stoeckl EM, Smith JW, Dhingra R, Fiedler AG| | View in PubMed
    20. Risk factors and outcomes for delayed kidney graft function in simultaneous heart and kidney transplant recipients: A UNOS/OPTN database analysis.
      Parajuli S, Karim AS, Muth BL, Leverson GE, Yang Q, Dhingra R, Smith JW, Foley DP, Mandelbrot DA| | View in PubMed
    21. Successful heart transplantation in a patient who recovered from COVID-19.
      Johnstad CM, Murray D, Dhingra R, Smith JW, Fiedler AG| | View in PubMed
    22. Orthotopic Heart Transplant: How I Teach It.
      Fiedler AG, Hermsen JL, Bommareddi S, Smith JW| | View in PubMed
    23. Amiodarone Use Prior to Cardiac Transplant Impacts Early Post-Transplant Survival.
      Allana SS, Rajput FA, Smith JW, Lozonschi L, Liou JI, Johnson M, Kohmoto T, Dhingra R| | View in PubMed
    24. 2020 ACC/HFSA/ISHLT Lifelong Learning Statement for Advanced Heart Failure and Transplant Cardiology Specialists: A Report of the ACC Competency Management Committee.
      Writing Committee Members, Yancy CW, Drazner MH, Coffin ST, Cornwell W, Desai S, Erwin JP, Ginwalla M, Harshaw-Ellis KS, Horwich T, Kittleson M, Lala A, Lewsey SC, Marine JE, Martin C, Meehan K, Morrow DA, Schlendorf K, Smith JW, Stevens GR, ACC Competency Management Committee, Arrighi JA, Mendes LA, Adams JE, Brush JE, Dec GW, Denktas A, Fernandes S, Freeman R, Francis SA, Hahn RT, Halperin JL, Housholder-Hughes SD, Khan SS, Klarich K, Lin CH, Marine JE, McPherson JA, Niazi K, Ryan T, Solomon MA, Spicer RL, Tam M, Wang A, Weissman G, Weitz HH, Williams ES| | View in PubMed
    25. 2020 ACC/HFSA/ISHLT Lifelong Learning Statement for Advanced Heart Failure and Transplant Cardiology Specialists: A Report of the ACC Competency Management Committee.
      Yancy CW, Drazner MH, Coffin ST, Cornwell W, Desai S, Erwin JP, Ginwalla M, Harshaw-Ellis KS, Horwich T, Kittleson M, Lala A, Lewsey SC, Marine JE, Martin CM, Meehan K, Morrow DA, Schlendorf K, Smith JW, Stevens GR| | View in PubMed
    26. Long-term discontinuation of warfarin in a patient with HeartMate 3 left ventricular assist device without complication.
      Fiedler AG, Hermsen JL, Smith JW, Dhingra R| | View in PubMed
    27. Small Left Ventricular Size Is an Independent Risk Factor for Ventricular Assist Device Thrombosis.
      Chivukula VK, Beckman JA, Prisco AR, Lin S, Dardas TF, Cheng RK, Farris SD, Smith JW, Mokadam NA, Mahr C, Aliseda A| | View in PubMed
    28. Left Ventricular Assist Device Inflow Cannula Angle and Thrombosis Risk.
      Chivukula VK, Beckman JA, Prisco AR, Dardas T, Lin S, Smith JW, Mokadam NA, Aliseda A, Mahr C| | View in PubMed
    29. Dilemmas in Dual Disease: Complexity and Futility in Prosthetic Valve Endocarditis and Substance Use Disorder.
      Kirkpatrick JN, Smith JW| | View in PubMed
    30. Invited Commentary.
      Smith JW, Mokadam NA| | View in PubMed
    31. Pulmonary function tests do not predict mortality in patients undergoing continuous-flow left ventricular assist device implantation.
      Bedzra EKS, Dardas TF, Cheng RK, Pal JD, Mahr C, Smith JW, Shively K, Masri SC, Levy WC, Mokadam NA| | View in PubMed
    32. The Benefit of Donor-Recipient Matching for Patients Undergoing Heart Transplantation.
      Nguyen VP, Mahr C, Mokadam NA, Pal J, Smith JW, Dardas TF| | View in PubMed
    33. Outflow Graft Obstruction Treated With Transcatheter Management: A Novel Therapy for a New Diagnosis.
      Bhamidipati CM, Pal JD, Jones TK, McCabe JM, Reisman M, Smith JW, Mahr C, Mokadam NA| | View in PubMed
    34. Successful Repair of Acute Type A Aortic Dissection 15 Years Following Bilateral Lung Transplantation.
      Hermsen JL, Madathil R, Berfield KS, Li K, Smith JW, Mulligan MS| | View in PubMed
    35. Endovascular Repair for Type A Aortic Dissection After Transcatheter Aortic Valve Replacement With a Medtronic CoreValve.
      Berfield KK, Sweet MP, McCabe JM, Reisman M, Mackensen GB, Mokadam NA, Dean LS, Smith JW| | View in PubMed
    36. Systematic donor selection review process improves cardiac transplant volumes and outcomes.
      Smith JW, O'Brien KD, Dardas T, Pal JD, Fishbein DP, Levy WC, Mahr C, Masri SC, Cheng RK, Stempien-Otero A, Mokadam NA| | View in PubMed
    37. Periportal fibrosis without cirrhosis does not affect outcomes after continuous flow ventricular assist device implantation.
      Sargent JE, Dardas TF, Smith JW, Pal JD, Cheng RK, Masri SC, Shively KR, Colyer LM, Mahr C, Mokadam NA| | View in PubMed
    38. Late Surgical Bleeding Following Total Artificial Heart Implantation.
      Hermsen JL, Smith JW, Pal JD, Mahr C, Masri SC, Dardas TF, Cheng RK, Mokadam NA| | View in PubMed
    39. Self-administration education and polypharmacy in mechanical circulatory support patients.
      Hermsen JL, Smith JW, Mokadam NA| | View in PubMed
    40. The influence of (18)flourodeoxyglucose positron emission tomography on the management of gastroesophageal junction carcinoma.
      Smith JW, Moreira J, Abood G, Aranha GV, Nagda S, Wagner RH, Shoup M| | View in PubMed
    41. Immunologic responses to critical injury and sepsis.
      Smith JW, Gamelli RL, Jones SB, Shankar R| | View in PubMed
    42. New perspectives for a new century: implications of pathogen responses for the future of antimicrobial therapy.
      Melstrom KA, Smith JW, Gamelli RL, Shankar R| | View in PubMed