Biography
Dr. Roll is a general surgeon specializing in abdominal organ transplantation. He completed both general surgery training and the abdominal organ transplant fellowship at the University of California San Francisco.
During his training, Dr. Roll spent 2 years in Dr. Holger Willenbring's laboratory investigating stem cell biology in the context of liver cell therapy, as well as normal and pathologic liver regeneration. His research concentrated on the use of hepatocyte-like cells derived from stem cells to be used in liver cell therapy. In particular, Dr. Roll investigated the regenerative capabilities of hepatocytes derived from induced pluripotent stem (iPS) cells. They used a genetically deficient mouse model of liver disease as a way to test the functional capabilities of these cells after transplantation. They were able to demonstrate that the profound proliferative capabilities of adult hepatocytes are retained by hepatocytes derived from iPS cells, and transplanting these cells rescued mice with liver failure. Dr. Roll also investigated the role of miRNA in liver regeneration, and the rejection of transplanted hepatocytes and hepatocyte-like cells. The principles of his research will remain valuable in liver and pancreas cell therapy translational science for years.
After fellowship Dr. Roll moved to England to become a Senior International Fellow in Liver Transplant and Multi Organ Procurement at Queen Elizabeth Hospital, Birmingham, one of the busiest liver transplant departments in the United Kingdom. There he gained valuable experience in the blossoming field of normothermic machine liver perfusion prior to returning to UCSF.
Education
Boston College, BS, Finance, 1995-1999
Brandeis University, Post Baccalaureate, Premedical, 1999-2001
Temple University School of Medicine, MD, 2001-2005
University of California, San Francisco, General Surgery, 2005-2012
Board Certifications
American Board of Surgery, General Surgery
Clinical Expertise
Ascites
Bile Duct Cancer (Cholangiocarcinoma)
Bile Duct Injuries
Bile Duct Strictures
Bridging Therapies to Downstage HCC in Liver Transplant Setting
Choledochal Cysts
Deceased Donor Organ Utilization
Gallbladder Cancer
Kidney Transplantation
Laparoscopic Donor Nephrectomy
Liver Biopsy
Hepatocellular Carcinoma (Primary Liver Cancer)
Liver Cysts
Liver Metastases (Secondary Liver Cancer)
Liver Resection
Liver Transplantation
Living Donor Kidney Transplantation
Living Donor Liver Transplantation
Normothetic Machine Liver Perfusion
Organ Donation of Cardiovascular Death
Pancreas Transplantation
Pediatric Kidney Transplantation
Pediatric Liver Transplantation
Portal Hypertension
Clinical Interests
Transplantation
HBP surgery
In the News
Research Interests
Cell therapy with hepatocytes and hepatocyte-like cells derived from stem cells.
Role of miRNA in liver regeneration
Normothetic machine liver perfusion
Research Pathways
Publications
- Living Donor Candidates' Self-reported Health and Health Perceptions and Completion of Donor Evaluation: A Cohort Study.| | PubMed
- Renal Autotransplantation: Association Between Preoperative Disease Duration and Surgical Outcomes.| | PubMed
- Dawn has arrived, illuminating thrilling opportunities and fresh challenges in a new era of United States transplantation.| | PubMed
- The type, duration, and severity of pretransplant kidney injury predict prolonged kidney dysfunction after liver transplantation.| | PubMed
- The future of liver transplantation.| | PubMed
- Chapter 44 Use of living donors for HIV-positive transplant candidates.| | UCSF Research Profile
- Contributors to Volume 2.| | UCSF Research Profile
- Diabetes Insipidus in Deceased Donors and Outcomes in Kidney Transplant Recipients.| | PubMed
- Angiotensin II in liver transplantation (AngLT-1): protocol of a randomised, double-blind, placebo-controlled trial.| | PubMed
- Preserved 2-y Liver Transplant Outcomes Following Simultaneous Thoracoabdominal DCD Organ Procurement Despite Effects on Liver Utilization Rate.| | PubMed
- Cost Saving in the Operating Room: Scoping Review of Surgical Scorecards.| | PubMed
- Expanding Access to Organ Transplant for People Living With HIV: Can Policy Catch Up to Outcomes Data?| | PubMed
- DCD liver transplant in patients with a MELD over 35.| | PubMed
- Normothermic Machine Perfusion of Donor Livers for Transplantation in the United States: A Randomized Controlled Trial.| | PubMed
- Real-world implementation of normothermic machine perfusion: A detailed analysis of intraoperative and early postoperative impact.| | PubMed
- A Multi-Modal Approach to Islet and Pancreas Transplantation With Calcineurin-Sparing Immunosuppression Maintains Long-Term Insulin Independence in Patients With Type I Diabetes.| | PubMed
- Pulmonary Injury Causing a Massive Air Leak During Liver Transplantation: A Case Report and Discussion of Decision-Making.| | PubMed
- Steroid Avoidance After Adult Living Donor Liver Transplant: A Cohort Analysis.| | PubMed
- Advances and innovations in living donor liver transplant techniques, matching and surgical training: Meeting report from the living donor liver transplant consensus conference.| | PubMed
- COVID-19 infection and vaccination rarely impact HLA antibody profile in waitlisted renal transplant candidates- a multicenter cohort.| | PubMed
- Number of Local Regional Therapies for Hepatocellular Carcinoma and Peri-Operative Outcomes after Liver Transplantation.| | PubMed
- Simultaneous thoracic and abdominal donation after circulatory death organ recovery: the abdominal surgeon's perspective.| | PubMed
- Comparison of Biliary Complications Rates After Brain Death, Donation After Circulatory Death, and Living-Donor Liver Transplantation: A Single-Center Cohort Study.| | PubMed
- Diabetes-free survival among living kidney donors and non-donors with obesity: A longitudinal cohort study.| | PubMed
- Which recipient pretransplant factors, such as MELD, renal function, sarcopenia, and recent sepsis influence suitability for and outcome after living donor liver transplantation? A systematic review of the literature and expert panel recommendations.| | PubMed
- 214.1: Strategies to Achieve Long-term Insulin Independence Using a Multimodal Approach to Beta-cell Replacement in Patients With Type I Diabetes.| | UCSF Research Profile
- 335.4: Use of Donation After Circulatory Death Donors for High Model for End-Stage Liver Disease Recipients.| | UCSF Research Profile
- Change in Body Mass Index and Attributable Risk of New-Onset Hypertension Among Obese Living Kidney Donors.| | PubMed
- In quest of the what, when, and where for machine perfusion dynamic liver preservation: Carpe diem!| | PubMed
- Nodular Regenerative Hyperplasia After Liver Transplant; It's All in the Presentation.| | PubMed
- Therapeutic Living Donor Nephrectomy for Proximal Ureteral Pathology: A Longitudinal Case Series.| | PubMed
- Kidney transplant candidacy evaluation and waitlisting practices in the United States and their association with access to transplantation.| | PubMed
- Risk aversion in the use of complex kidneys in paired exchange programs: Opportunities for even more transplants?| | PubMed
- Impact of Portable Normothermic Blood-Based Machine Perfusion on Outcomes of Liver Transplant: The OCS Liver PROTECT Randomized Clinical Trial.| | PubMed
- Toward a more efficient organ placement system (and defeating FOMO).| | PubMed
- Advantages and Limitations of Clinical Scores for Donation After Circulatory Death Liver Transplantation.| | PubMed
- An Analysis of Free-Text Refusals as an Indicator of Readiness to Accept Organ Offers in Liver Transplantation.| | PubMed
- Motivations and outcomes of compatible living donor-recipient pairs in paired exchange.| | PubMed
- Bariatric surgery prior to transplantation and risk of early hospital re-admission, graft failure, or death following kidney transplantation.| | PubMed
- Discrepant subtyping of blood type A2 living kidney donors: Missed opportunities in kidney transplantation.| | PubMed
- With the Proven Tenacity of Waitlist Mortality, Shouldn't We Resist the Urge to Make Mountains Out of Survival Statistic Molehills?| | PubMed
- Navigating in the Dark, Challenges Assessing the Liver-kidney Safety Net.| | PubMed
- Retransplantation After Living Donor Liver Transplantation: Data from the Adult to Adult Living Donor Liver Transplantation Study.| | PubMed
- A case report: anaphylaxis to cefazolin during renal transplant surgery.| | PubMed
- Standardizing Discharge Opioid Prescriptions in Kidney Transplant Patients Decreases Opioid Usage.| | PubMed
- COVID-19 does not impact HLA antibody profile in a series of waitlisted renal transplant candidates.| | PubMed
- Association between Longer Travel Distance for Transplant Care and Access to Kidney Transplantation and Graft Survival in the United States.| | PubMed
- Understanding the Final Disposition of Livers Declined After the Start of Procurement: A Nationwide Organ Procurement Organization Effort.| | PubMed
- Metastatic Donor-derived Malignancies Following Simultaneous Pancreas-kidney Transplant: Three Case Reports and Management Strategies.| | PubMed
- Weighing the waitlist: Weight changes and access to kidney transplantation among obese candidates.| | PubMed
- COVID-19 and Abdominal Transplant: A Stepwise Approach to Practice During Pandemic Conditions.| | PubMed
- The Association Between Vena Cava Implantation Technique and Acute Kidney Injury After Liver Transplantation.| | PubMed
- Longer Distance From Dialysis Facility to Transplant Center Is Associated With Lower Access to Kidney Transplantation.| | PubMed
- PROPENSITY SCORE MATCHED RISK OF BILIARY COMPLICATIONS AFTER LIVER TRANSPLANT AND OUTCOME BY DONOR TYPE.| | UCSF Research Profile
- Donation After Circulatory Death Is Associated With Similar Posttransplant Survival in All but the Highest-Risk Hepatocellular Carcinoma Patients.| | PubMed
- Racial and Ethnic Disparities in Kidney Transplant Access Within a Theoretical Context of Medical Eligibility.| | PubMed
- Trends in Living Donation by Race and Ethnicity Among Children With End-stage Renal Disease in the United States, 1995-2015.| | PubMed
- A Virtual Crossmatch-based Strategy Facilitates Sharing of Deceased Donor Kidneys for Highly Sensitized Recipients.| | PubMed
- Ingenol mebutate 0·015% gel is safe for short-term treatment of actinic keratoses on the face in solid organ transplant recipients.| | PubMed
- Donation after circulatory death liver transplantation: What are the limits for an acceptable DCD graft?| | PubMed
- Long-term follow-up of beta cell replacement therapy in 10 HIV-infected patients with renal failure secondary to type 1 diabetes mellitus.| | PubMed
- Living Donor Liver Transplant for Alcoholic Liver Disease: Data from the Adult-to-adult Living Donor Liver Transplantation Study.| | PubMed
- An Update on Machine Preservation of the Liver.| | PubMed
- Initial skin cancer screening for solid organ transplant recipients in the United States: Delphi method development of expert consensus guidelines.| | PubMed
- The effect of an organ procurement experience on preclinical medical student perceptions of transplant surgery.| | PubMed
- Association of HLA Antigen Mismatch With Risk of Developing Skin Cancer After Solid-Organ Transplant.| | PubMed
- Split Liver Transplantation and Pediatric Waitlist Mortality in the United States: Potential for Improvement.| | PubMed
- Chapter 132 Hepatocellular Carcinoma.| | UCSF Research Profile
- The Impact of Deceased Donor Liver Extraction Time on Early Allograft Function in Adult Liver Transplant Recipients.| | PubMed
- Potential for overlooked melanoma in solid organ donors with a severely dysplastic nevus.| | PubMed
- Adult Living-Donor Liver Transplantation: Left Lobe.| | UCSF Research Profile
- Living Donor Liver Transplantation for Alcoholic Liver Disease.| | UCSF Research Profile
- Retransplantation after Living Donor Liver Transplantation.| | UCSF Research Profile
- Successful Deceased Donor Kidney Transplantation of Highly Sensitized Candidates Across Positive Cross Match and Strong Donor-Specific HLA-DP Antibodies without Desensitization.| | UCSF Research Profile
- Virtual Crossmatch Permits Kidney Sharing; Avoiding Transplant into Unintended Recipients.| | UCSF Research Profile
- Intraoperative Management of Liver Transplant Patients Without the Routine Use of Renal Replacement Therapy.| | PubMed
- Central venous pressure monitoring in living donor kidney recipients does not affect immediate graft function: A propensity score analysis.| | PubMed
- Normothermic machine perfusion of the liver.| | PubMed
- Surgical Options in Liver Cancers.| | UCSF Research Profile
- Splenic Vein Thrombosis Following Pancreas Transplantation: Identification of Factors That Support Conservative Management.| | PubMed
- Pancreas-After-Islet Transplantation in Nonuremic Type 1 Diabetes: A Strategy for Restoring Durable Insulin Independence.| | PubMed
- Intention to Split Policy: A Successful Strategy in a Combined Pediatric and Adult Liver Transplant Center.| | PubMed
- Chapter 115A Liver transplantation for hepatocellular carcinoma.| | UCSF Research Profile
- Preoperative Thromboelastography as a Sensitive Tool Predicting Those at Risk of Developing Early Hepatic Artery Thrombosis After Adult Liver Transplantation.| | PubMed
- Kidney transplantation of highly sensitized recipients under the new kidney allocation system: A reflection from five different transplant centers across the United States.| | PubMed
- Effect of moderately intense perioperative glucose control on renal allograft function: a pilot randomized controlled trial in renal transplantation.| | PubMed
- Long-term follow-up after endovascular treatment of hepatic venous outflow obstruction following liver transplantation.| | PubMed
- Strategies to improve outcomes for hepatitis C virus/human immunodeficiency virus coinfected liver transplant candidates.| | PubMed
- Biliary complications following living donor hepatectomy.| | PubMed
- Impact of Graft Selection on Donor and Recipient Outcomes After Living Donor Liver Transplantation.| | PubMed
- Accepting multiple simultaneous liver offers does not negatively impact transplant outcomes.| | PubMed
- First human liver transplantation using a marginal allograft resuscitated by normothermic machine perfusion.| | PubMed
- The safety and efficacy of proximal splenic artery embolization after liver transplantation are still not clearly defined.| | PubMed
- Brief report: Parthenogenetic embryonic stem cells are an effective cell source for therapeutic liver repopulation.| | PubMed
- Emesis following laparoscopic left donor nephrectomy.| | PubMed
- Failure to achieve normal metabolic response in non-obese diabetic mice and streptozotocin-induced diabetic mice after transplantation of primary murine hepatocytes electroporated with the human proinsulin gene (p3MTChins).| | PubMed
- Case report of intestinal tuberculosis 6 years after simultaneous pancreas and kidney transplant.| | PubMed
- Left versus right lobe liver donation.| | PubMed
- Peri-operative hyperglycemia is associated with delayed graft function in deceased donor renal transplantation.| | PubMed
- Highly efficient differentiation of functional hepatocytes from human induced pluripotent stem cells.| | PubMed
- Left hepatectomy versus right hepatectomy for living donor liver transplantation: shifting the risk from the donor to the recipient.| | PubMed
- A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration.| | PubMed
- Chapter 97D Liver transplantation for hepatocellular carcinoma.| | UCSF Research Profile
- Predictors of long-term outcome after laparoscopic esophagomyotomy and Dor fundoplication for achalasia.| | PubMed
- Better weight loss, resolution of diabetes, and quality of life for laparoscopic gastric bypass vs banding: results of a 2-cohort pair-matched study.| | PubMed
- Acquired A amyloidosis from injection drug use presenting with atraumatic splenic rupture in a hospitalized patient: a case report.| | PubMed
- Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice.| | PubMed
- Transplanted nonviable human hepatocytes produce appreciable serum albumin levels in mice.| | PubMed
- BETA CELL REPLACEMENT THERAPY IN FIVE HIV INFECTED PATIENTS WITH RENAL FAILURE SECONDARY TO TYPE I DIABETES MELLITUS.| | UCSF Research Profile
- MicroRNAs control hepatocyte proliferation during liver regeneration.| | PubMed
- Excellent outcomes of laparoscopic esophagomyotomy for achalasia in patients older than 60 years of age.| | PubMed
- A controversy that has been tough to swallow: is the treatment of achalasia now digested?| | PubMed
- W1516 A Safe and Reproducible Anastomotic Technique for Minimally Invasive Ivor Lewis Esophagectomy – the Circular Stapled Anastomosis with the Transoral Anvil.| | UCSF Research Profile
- Bilateral renal vein thrombosis secondary to membraneous glomerulonephritis: successful treatment with thrombolytic therapy.| | PubMed