Biography
In his research, Corvera focuses on the mechanisms that underlie inflammation, thickening and scarring in the biliary tract.
Corvera graduated from the University of California, San Diego School of Medicine. He completed a residency in general surgery at UCSF. At Memorial Sloan Kettering Cancer Center in New York City, he completed a clinical fellowship in surgical oncology as well as a fellowship in hepatobiliary surgery.
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Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
Memorial Sloan Kettering Cancer Center, New York | Hepatobiliary Surgery | Surgery | 2002 |
Memorial Sloan Kettering Cancer Center , New York | Surgical Oncology Clinical Fellowship | Surgery | 2001 |
University of California, San Francisco | General Surgery Residency | School of Medicine | 2000 |
University of California San Diego | M.D. | School of Medicine | 1993 |
Board Certifications
- American Board of Surgery
Clinical Expertise
Ascites
Bile Duct Injuries
Bile Duct Strictures
Bile Duct Cancer (Cholangiocarcinoma)
Gastrointestinal Carcinoid Tumor
Gastrointestinal Stromal Tumor (GIST)
Choledochal Cysts
Portal Hypertension
Liver Cancer (Hepatocellular Carcinoma)
Minimally Invasive Liver & Pancreas Surgery
Melanoma
Pancreatic Cancer
Pancreatic Cysts
Soft Tissue Sarcomas
Liver Cysts
Liver Metastases
Gallbladder Cancer
Stomach (Gastric) Cancer
Pancreatic Neuroendocrine (Islet Cell) Tumors
Bridging Therapies to Downstage HCC in Setting of Liver Transplantation
Program Affiliations
Hepatobiliary and Pancreas Surgery Program
UCSF Helen Diller Family Comprehensive Cancer Center
UCSF Department of Surgery at the San Francisco VA
In the News
Research Narrative
Dr. Corvera's scientific research interest is focused on understanding the mechanisms of biliary tract fibrosis and inflammation. More specifically, he is interested in studying the clinical consequences of biliary fibrosis-- mainly cholestatisis. Cholestasis is characterized by impaired bile flow causing a high concentration of bile acids in the liver and the circulation. Prolonged exposure to bile acids in the liver can progress to end-stage liver disease and cirrhosis. In the gastrointestinal tract, the absence of bile flow causes profound local and systemic metabolic disturbances. Dr.Corvera is actively investigating the role of a novel cell surface receptor specific for bile acids that may play a critical role in normal and disease states.
Research Interests
Proteases and Proteinase Activated Receptors in the Biliary Tract
Publications
- ASO Visual Abstract: Long-term Survival Outcomes After Minimally Invasive Surgery for Ileal Neuroendocrie Tumors.| | View in PubMed
- Prognostic implications of margin status in association with systemic treatment in a cohort study of patients with resection of colorectal liver metastases.| | View in PubMed
- Graft choice in pancreatectomy with vascular resection: equivalent safety in selected patients.| | View in PubMed
- Resection versus resection with ablation: Analysis from the colorectal liver operative metastasis international collaborative.| | View in PubMed
- ASO Visual Abstract: Long-Duration Neoadjuvant Therapy with FOLFIRINOX Yields Favorable Outcomes for Patients Who Undergo Surgery for Pancreatic Cancer.| | View in PubMed
- Distinct Indications for Adjuvant Therapy in Resected Invasive Mucinous Cystic Neoplasms of the Pancreas Compared with Pancreatic Ductal Adenocarcinoma.| | View in PubMed
- Long-Duration Neoadjuvant Therapy with FOLFIRINOX Yields Favorable Outcomes for Patients Who Undergo Surgery for Pancreatic Cancer.| | View in PubMed
- Long-Term Survival Outcomes After Minimally Invasive Surgery for Ileal Neuroendocrine Tumors.| | View in PubMed
- National practice patterns in the use of endoscopic ultrasound biopsy for resectable Pancreatic Neuroendocrine Tumors: Insights into the role of DOTATATE PET/CT in diagnosis.| | View in PubMed
- Minimal Residual Disease using a Plasma-Only Circulating Tumor DNA Assay to Predict Recurrence of Metastatic Colorectal Cancer Following Curative Intent Treatment.| | View in PubMed
- Recurrence and tumor-related death after resection of hepatocellular carcinoma in patients with metabolic syndrome.| | View in PubMed
- Metastatic melanoma to small bowel: metastasectomy is supported in the era of immunotherapy and checkpoint inhibitors.| | View in PubMed
- Portal Vein Thrombosis After Transarterial Embolization for Hepatocellular Carcinoma.| | View in PubMed
- Intraoperative hepatic artery infusion pump perfusion testing with indocyanine green near-infrared imaging offers multiple potential advantages.| | View in PubMed
- Improved survival of patients receiving immunotherapy and chemotherapy following curative-intent resection of colorectal liver metastases.| | View in PubMed
- A Machine Learning Approach to Predict Postoperative Pancreatic Fistula After Pancreaticoduodenectomy Using Only Preoperatively Known Data.| | View in PubMed
- ASO Visual Abstract: National Practice Patterns in Malignant Peritoneal Mesothelioma-Updates in Management and Survival.| | View in PubMed
- National Practice Patterns in Malignant Peritoneal Mesothelioma: Updates in Management and Survival.| | View in PubMed
- Metastatic colorectal adenocarcinoma tumor purity assessment from whole exome sequencing data.| | View in PubMed
- Esophageal and Esophagogastric Junction Cancers, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology.| | View in PubMed
- Minimally Invasive Versus Open Liver Resections for Hepatocellular Carcinoma in Patients With Metabolic Syndrome.| | View in PubMed
- Conditional Survival After Hepatectomy for Colorectal Liver Metastasis: Results from the Colorectal Liver Operative Metastasis International Collaborative (COLOMIC).| | View in PubMed
- Survival Outcomes of Optimally Treated Colorectal Metastases: The Importance of R0 Status in Surgical Treatment of Hepatic and Peritoneal Surface Disease.| | View in PubMed
- Machine Learning Models for Predicting the Outcomes of Surgical Treatment of Colorectal Liver Metastases.| | View in PubMed
- Hypertension Requiring Medication Use: a Silent Predictor of Poor Outcomes After Pancreaticoduodenectomy.| | View in PubMed
- Model to predict major complications following liver resection for HCC in patients with metabolic syndrome.| | View in PubMed
- Contemporary Trends in Malignant Peritoneal Mesothelioma: Incidence and Survival in the United States.| | View in PubMed
- Hand-Assisted Versus Pure Minimally-Invasive Distal Pancreatectomy: Is There a Downside to Lending a Hand?| | View in PubMed
- Minimally Invasive Distal Pancreatectomy Techniques: A Contemporary Analysis Exploring Trends, Similarities, and Differences to Open Surgery.| | View in PubMed
- Outcomes after repeat hepatectomy for colorectal liver metastases from the colorectal liver operative metastasis international collaborative (COLOMIC).| | View in PubMed
- Primary Cutaneous Malignant Perivascular Epithelioid Cell Tumor Mimicking Undifferentiated Pleomorphic Sarcoma: A Report of a Rare Entity.| | View in PubMed
- Perioperative chemotherapy for resectable colorectal liver metastases: Analysis from the Colorectal Operative Liver Metastases International Collaborative (COLOMIC).| | View in PubMed
- Association of primary tumor laterality with surgical outcomes for colorectal liver metastases: results from the Colorectal Liver Operative Metastasis International Collaborative (COLOMIC).| | View in PubMed
- ASO Visual Abstract: Determining Hospital Volume Threshold for the Safety of Minimally Invasive Pancreaticoduodenectomy: A Contemporary Cutpoint Analysis.| | View in PubMed
- Determining Hospital Volume Threshold for Safety of Minimally Invasive Pancreaticoduodenectomy: A Contemporary Cutpoint Analysis.| | View in PubMed
- Multifocal pancreatic PPoma in the setting of MEN1: Case report and review of literature.| | View in PubMed
- Burden of Ionizing Radiation in the Diagnosis and Management of Necrotizing Pancreatitis.| | View in PubMed
- Minimally Invasive Surgery for Ileal Neuroendocrine Tumors.| | View in PubMed
- Contemporary Management of Hepatic Cyst Disease: Techniques and Outcomes at a Tertiary Hepatobiliary Center.| | View in PubMed
- Synchronous Versus Metachronous Colorectal Liver Metastasis Yields Similar Survival in Modern Era.| | View in PubMed
- A rare presentation of hepatolithiasis in an adolescent patient: A case report.| | View in PubMed
- Ampullary stenosis and choledocholithiasis post Roux-En-Y gastric bypass: challenges of biliary access and intervention.| | View in PubMed
- A novel stratification of mesenteric mass involvement as a predictor of challenging mesenteric lymph node dissection by minimally invasive approach for ileal neuroendocrine tumors.| | View in PubMed
- Residual tumor volume discriminates prognosis after surgery for neuroendocrine liver metastasis.| | View in PubMed
- Prognostic impact of a large mesenteric mass >2 cm in ileal neuroendocrine tumors.| | View in PubMed
- Esophageal and Esophagogastric Junction Cancers, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.| | View in PubMed
- Comparison of Tumor Regression Grading of Residual Pancreatic Ductal Adenocarcinoma Following Neoadjuvant Chemotherapy Without Radiation: Would Fewer Tier-Stratification Be Favorable Toward Standardization?| | View in PubMed
- Evaluation of an abbreviated screening MRI protocol for patients at risk for hepatocellular carcinoma.| | View in PubMed
- Change in Liver Imaging Reporting and Data System Characterization of Focal Liver Lesions Using Gadoxetate Disodium Magnetic Resonance Imaging Compared With Contrast-Enhanced Computed Tomography.| | View in PubMed
- Multiple arterial phase MRI of arterial hypervascular hepatic lesions: improved arterial phase capture and lesion enhancement.| | View in PubMed
- Imaging Hepatocellular Carcinoma With 68Ga-Citrate PET: First Clinical Experience.| | View in PubMed
- Preoperative FOLFIRINOX for borderline resectable pancreatic cancer: Is radiation necessary in the modern era of chemotherapy?| | View in PubMed
- In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis.| | View in PubMed
- Management of Postoperative Hepatic Failure.| | View in PubMed
- Correcting for respiratory motion in liver PET/MRI: preliminary evaluation of the utility of bellows and navigated hepatobiliary phase imaging.| | View in PubMed
- The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice.| | View in PubMed
- Impact of pre-operative positron emission tomography in gallbladder cancer.| | View in PubMed
- Expanded use of aggressive therapies improves survival in early and intermediate hepatocellular carcinoma.| | View in PubMed
- The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.| | View in PubMed
- The TGR5 receptor mediates bile acid-induced itch and analgesia.| | View in PubMed
- Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway.| | View in PubMed
- The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice.| | View in PubMed
- Localization of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in human gastrointestinal tract.| | View in PubMed
- Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity.| | View in PubMed
- Visual vignette. What is the diagnosis? Insulin-secreting tumor.| | View in PubMed
- Laparoscopic treatment of liver tumours using a two-needle probe bipolar radiofrequency ablation device.| | View in PubMed
- Hepatic surgery at a VA tertiary medical center: lessons learned.| | View in PubMed
- Periprocedural complications by Child-Pugh class in patients undergoing transcatheter arterial embolization or chemoembolization to treat unresectable hepatocellular carcinoma at a VA medical center.| | View in PubMed
- Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATP channels.| | View in PubMed
- Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system.| | View in PubMed
- Hemorrhagic cholecystitis.| | View in PubMed
- Giant mesenteric cystic lymphangioma presenting with abdominal pain and masquerading as a gynecologic malignancy.| | View in PubMed
- Reversible surgical model of biliary inflammation and obstructive jaundice in mice.| | View in PubMed
- Abdominal actinomycosis after laparoscopic cholecystectomy: a rare complication of bile spillage.| | View in PubMed
- Perforated ulcer mimicking a spontaneous pneumothorax in a patient with congenital diaphragmatic hernia.| | View in PubMed
- Caudate split for open and laparoscopic liver resections.| | View in PubMed
- Basal cell carcinoma does metastasize.| | View in PubMed
- Implementation of a multidisciplinary treatment team for hepatocellular cancer at a Veterans Affairs Medical Center improves survival.| | View in PubMed
- 18F-fluorodeoxyglucose positron emission tomography influences management decisions in patients with biliary cancer.| | View in PubMed
- Agonists of protease-activated receptors 1 and 2 stimulate electrolyte secretion from mouse gallbladder.| | View in PubMed
- Role of calcitonin receptor-like receptor in colonic motility and inflammation.| | View in PubMed
- Bipolar pulse coagulation for resection of the cirrhotic liver.| | View in PubMed
- Recurrent invasive intraductal papillary mucinous carcinoma of the pancreas mimicking pott disease: review of the literature.| | View in PubMed
- Clinical and pathologic features of proximal biliary strictures masquerading as hilar cholangiocarcinoma.| | View in PubMed
- The missing thyroid.| | View in PubMed
- Retrocardiac parathyroid tumor: a rare mediastinal site.| | View in PubMed
- Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade.| | View in PubMed
- Role of laparoscopy in the evaluation of biliary tract cancer.| | View in PubMed
- Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase.| | View in PubMed
- Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2.| | View in PubMed
- The relationship between hospital volume and outcomes of hepatic resection for hepatocellular carcinoma.| | View in PubMed
- Desensitization of the neurokinin-1 receptor (NK1-R) in neurons: effects of substance P on the distribution of NK1-R, Galphaq/11, G-protein receptor kinase-2/3, and beta-arrestin-1/2.| | View in PubMed
- Proteinase-activated receptors: novel mechanisms of signaling by serine proteases.| | View in PubMed
- A hospital's annual rate of esophagectomy influences the operative mortality rate.| | View in PubMed
- Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2.| | View in PubMed
- Recent advances. General surgery.| | View in PubMed
- Heterogeneity of P2u- and P2y-purinergic receptor regulation of phospholipases in MDCK cells.| | View in PubMed