Biography
Dr. Andrew Posselt, a bariatric and transplant surgeon, is director of the Pancreatic Islet Transplantation Program at UCSF Medical Center. He specializes in adult and pediatric kidney, liver and pancreas transplantation, laparoscopic and open (traditional) bariatric surgery, robotic surgery and performed the first robotic donor nephrectomy at UCSF in May, 2023.
In addition to caring for patients, Posselt conducts research on pancreatic islet cell transplantation, a procedure that can allow people with type 1 diabetes to discontinue insulin therapy. He also investigates mechanisms by which a transplant recipient's body rejects or tolerates tissue from a donor who isn't genetically identical, and he studies the metabolic and biochemical consequences of bariatric surgery.
Posselt earned his medical degree and a doctorate in immunology from the University of Pennsylvania. He completed residencies in internal medicine and general surgery as well as a transplant fellowship at UCSF, before joining the staff in 2003.
Posselt is a member of several professional and honorary societies, and has given presentations on transplant issues related to patient care and research. At UCSF, he supervises residents and fellows in transplant services and general surgery.
In addition to caring for patients, Posselt conducts research on pancreatic islet cell transplantation, a procedure that can allow people with type 1 diabetes to discontinue insulin therapy. He also investigates mechanisms by which a transplant recipient's body rejects or tolerates tissue from a donor who isn't genetically identical, and he studies the metabolic and biochemical consequences of bariatric surgery.
Posselt earned his medical degree and a doctorate in immunology from the University of Pennsylvania. He completed residencies in internal medicine and general surgery as well as a transplant fellowship at UCSF, before joining the staff in 2003.
Posselt is a member of several professional and honorary societies, and has given presentations on transplant issues related to patient care and research. At UCSF, he supervises residents and fellows in transplant services and general surgery.
Videos
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of Pennsylvania | PhD | Immunology | 1993 |
University of Pennsylvania | M.D. | School of Medicine | 1993 |
University of California, San Francisco | Residency | Internal Medicine |
Board Certifications
- American Board of Internal Medicine, 1996
- American Board of Surgery, 2002
Clinical Expertise
Bariatric Surgery (Laparoscopic and Open)
Bile Duct Injuries
Bile Duct Strictures
Choledochal Cyst Disease
End-Stage Kidney Disease
Fulminant Hepatic Failure
Hepatitis B
Hepatitis C
Hepatocellular Carcinoma (Primary Liver Cancer)
Kidney Transplantation
Laparoscopic Donor Nephrectomy
Liver Cysts
Liver Transplantation
Nonalcoholic Fatty Liver Disease
Pancreas Transplantation
Pediatric Liver Transplantation
Pediatric Kidney Transplantation
Portal Hypertension
Islet Cell Transplantation
Autologous Islet Cell Transplantation
Clinical Trials
- Treatment of Type I Diabetes by Islet Transplantation Into the Gastric Submucosa Study Protocol (NCT02402439)Related Conditions: Diabetes, Diabetes Type 1| Start Date: | End Date:
- Extended Follow-Up After Islet Transplantation in T1D (NCT01369082)Related Conditions: Diabetes, Diabetes Type 1, Islet Transplantation| Start Date: | End Date:
- Related Conditions: Diabetes, Diabetes Type 1| Start Date: | End Date:
- Islet Transplantation in Type 1 Diabetes (NCT00434811)Related Conditions: Diabetes, Diabetes Type 1| Start Date: | End Date:
- Related Conditions: Diabetes, Diabetes Type 1| Start Date: | End Date:
Program Affiliations
Pancreatic Islet Transplantation Program
Bariatric Surgery Center
ABO-Incompatible Kidney Transplant Program
In the News
December, 26, 2017 | UCSF Bariatric Surgery
July, 07, 2014 | UCSF Transplant Surgery
November, 14, 2013 | UCSF Transplant Surgery
March, 15, 2012 | UCSF Transplant Surgery
September, 27, 2011 | UCSF Bariatric Surgery
Grants and Funding
- Vertical Sleeve Gastrectomy for Treatment of NASH: a pilot randomized control | NIH | 2021-07-14 - 2024-05-31 | Role: Co-Principal Investigator
- Treatment of Type I Diabetes by Islet Transplantation into the Gastric Submucosa | NIH | 2014-05-01 - 2021-04-30 | Role: Principal Investigator
- "Advancing Islet Transplant for Type 1 Diabetes Care" | NIH | 2009-09-30 - 2013-07-31 | Role: Principal Investigator
- Effect of Obesity on Long-Term Clinical Outcomes after Kidney Donation | NIH | 2009-09-21 - 2012-06-30 | Role: Principal Investigator
Research Interests
- Transplantation of pancreatic islets as treatment for type 1 diabetes mellitus
- Assessment of long-term clinical outcomes in kidney donors
- Metabolic and biochemical consequences of bariatric surgery
- Clinical outcomes of bariatric surgery in patients with end-stage kidney or liver disease
Publications
MOST RECENT PUBLICATIONS FROM A TOTAL OF 116
- Islet Isolation Outcomes in Patients Undergoing Total Pancreatectomy With Islet Autotransplantation in the POST Consortium.| | View in PubMed
- Skeletal effects of sleeve gastrectomy, by sex and menopausal status and in comparison to Roux-en-Y gastric bypass surgery.| | View in PubMed
- Alteration in the gut microbiome is associated with changes in bone metabolism after laparoscopic sleeve gastrectomy.| | View in PubMed
- Nutritional Risks in Patients Undergoing Total Pancreatectomy Islet AutoTransplantation in the POST Consortium.| | View in PubMed
- A Multi-Modal Approach to Islet and Pancreas Transplantation With Calcineurin-Sparing Immunosuppression Maintains Long-Term Insulin Independence in Patients With Type I Diabetes.| | View in PubMed
- Intestinal Calcium Absorption Decreases After Laparoscopic Sleeve Gastrectomy Despite Optimization of Vitamin D Status.| | View in PubMed
- Characterization of human islet function in a convection-driven intravascular bioartificial pancreas.| | View in PubMed
- Prebiotic to Improve Calcium Absorption in Postmenopausal Women After Gastric Bypass: A Randomized Controlled Trial.| | View in PubMed
- Islets Transplantation at a Crossroads - Need for Urgent Regulatory Update in the United States: Perspective Presented During the Scientific Sessions 2021 at the American Diabetes Association Congress.| | View in PubMed
- Advantages and Limitations of Clinical Scores for Donation After Circulatory Death Liver Transplantation.| | View in PubMed
- Surgical approach and short-term outcomes in adults and children undergoing total pancreatectomy with islet autotransplantation: A report from the Prospective Observational Study of TPIAT.| | View in PubMed
- Bariatric surgery prior to transplantation and risk of early hospital re-admission, graft failure, or death following kidney transplantation.| | View in PubMed
- The Association of Smoking and Alcohol Abuse on Anxiety and Depression in Patients With Recurrent Acute or Chronic Pancreatitis Undergoing Total Pancreatectomy and Islet Autotransplantation: A Report From the Prospective Observational Study of TPIAT Cohor| | View in PubMed
- Arguments against the Requirement of a Biological License Application for Human Pancreatic Islets: The Position Statement of the Islets for US Collaborative Presented during the FDA Advisory Committee Meeting.| | View in PubMed
- Targeting CXCR1/2 in the first multicenter, double-blinded, randomized trial in autologous islet transplant recipients.| | View in PubMed
- Sleeve gastrectomy prior to liver transplantation is superior to medical weight loss in reducing posttransplant metabolic complications.| | View in PubMed
- Anticoagulation practices in total pancreatectomy with autologous islet cell transplant patients: an international survey of clinical programs.| | View in PubMed
- Circulating miRNA in Patients Undergoing Total Pancreatectomy and Islet Autotransplantation.| | View in PubMed
- Preoperative ERCP has no impact on islet yield following total pancreatectomy and islet autotransplantation (TPIAT): Results from the Prospective Observational Study of TPIAT (POST) cohort.| | View in PubMed
- COVID-19 and Abdominal Transplant: A Stepwise Approach to Practice During Pandemic Conditions.| | View in PubMed
- Phase 3 trial of human islet-after-kidney transplantation in type 1 diabetes.| | View in PubMed
- Ampullary stenosis and choledocholithiasis post Roux-En-Y gastric bypass: challenges of biliary access and intervention.| | View in PubMed
- Long-term follow-up of beta cell replacement therapy in 10 HIV-infected patients with renal failure secondary to type 1 diabetes mellitus.| | View in PubMed
- Obesity, transplantation, and bariatric surgery: An evolving solution for a growing epidemic.| | View in PubMed
- Increases in PYY and uncoupling of bone turnover are associated with loss of bone mass after gastric bypass surgery.| | View in PubMed
- A Study on the Effect of Patient Characteristics, Geographical Utilization, and Patient Outcomes for Total Pancreatectomy Alone and Total Pancreatectomy With Islet Autotransplantation in Patients With Pancreatitis in the United States.| | View in PubMed
- Outcomes of Sleeve Gastrectomy in Obese Liver Transplant Candidates.| | View in PubMed
- Changes in Lean Mass, Absolute and Relative Muscle Strength, and Physical Performance After Gastric Bypass Surgery.| | View in PubMed
- Oxygen Perfusion (Persufflation) of Human Pancreata Enhances Insulin Secretion and Attenuates Islet Proinflammatory Signaling.| | View in PubMed
- Effects of Gastric Bypass Surgery on Bone Mass and Microarchitecture Occur Early and Particularly Impact Postmenopausal Women.| | View in PubMed
- Splenic Vein Thrombosis Following Pancreas Transplantation: Identification of Factors That Support Conservative Management.| | View in PubMed
- Bone Marrow Fat Changes After Gastric Bypass Surgery Are Associated With Loss of Bone Mass.| | View in PubMed
- Erratum. National Institutes of Health-Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities. Diabetes 2016;65:3418-3428.| | View in PubMed
- Correction: An intravascular bioartificial pancreas device (iBAP) with silicon nanopore membranes (SNM) for islet encapsulation under convective mass transport.| | View in PubMed
- Pancreas-After-Islet Transplantation in Nonuremic Type 1 Diabetes: A Strategy for Restoring Durable Insulin Independence.| | View in PubMed
- Purified Human Pancreatic Islets, CIT Culture Media with Lisofylline or Exenatide.| | View in PubMed
- An intravascular bioartificial pancreas device (iBAP) with silicon nanopore membranes (SNM) for islet encapsulation under convective mass transport.| | View in PubMed
- Glucose-Stimulated Insulin Response of Silicon Nanopore-Immunoprotected Islets under Convective Transport.| | View in PubMed
- A Single Perioperative Injection of Dexamethasone Decreases Nausea, Vomiting, and Pain after Laparoscopic Donor Nephrectomy.| | View in PubMed
- National Institutes of Health-Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities.| | View in PubMed
- Abnormalities in biomarkers of mineral and bone metabolism in kidney donors.| | View in PubMed
- Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia.| | View in PubMed
- Silicon nanopore membrane (SNM) for islet encapsulation and immunoisolation under convective transport.| | View in PubMed
- Effect of Immigration Status on Outcomes in Pediatric Kidney Transplant Recipients.| | View in PubMed
- A Multicenter Study: North American Islet Donor Score in Donor Pancreas Selection for Human Islet Isolation for Transplantation.| | View in PubMed
- Under Utilization of Pancreas Transplants in Cystic Fibrosis Recipients in the United Network Organ Sharing (UNOS) Data 1987-2014.| | View in PubMed
- A Comparative Analysis of the Safety, Efficacy, and Cost of Islet Versus Pancreas Transplantation in Nonuremic Patients With Type 1 Diabetes.| | View in PubMed
- Expanded indications for bariatric surgery: should patients on chronic steroids be offered bariatric procedures?| | View in PubMed
- Intestinal Calcium Absorption Decreases Dramatically After Gastric Bypass Surgery Despite Optimization of Vitamin D Status.| | View in PubMed
- Autologous islet transplantation with remote islet isolation after pancreas resection for chronic pancreatitis.| | View in PubMed
- Changes in vertebral bone marrow fat and bone mass after gastric bypass surgery: A pilot study.| | View in PubMed
- Islet transplantation for Type 1 diabetes: where are we now?| | View in PubMed
- Islet product characteristics and factors related to successful human islet transplantation from the Collaborative Islet Transplant Registry (CITR) 1999-2010.| | View in PubMed
- Human islet viability and function is maintained during high-density shipment in silicone rubber membrane vessels.| | View in PubMed
- Predictors of hospital stay following laparoscopic gastric bypass: analysis of 9,593 patients from the National Surgical Quality Improvement Program.| | View in PubMed
- Combined pancreatic islet and kidney transplantation in a child with unstable type 1 diabetes and end-stage renal disease.| | View in PubMed
- Laparoscopic sleeve gastrectomy is safe and efficacious for pretransplant candidates.| | View in PubMed
- Improvement in outcomes of clinical islet transplantation: 1999-2010.| | View in PubMed
- Safety and feasibility of sleeve gastrectomy in morbidly obese patients following liver transplantation.| | View in PubMed
- Islet Transplantation & β-Cell Replacement Therapies for Diabetes.| | View in PubMed
- Experience with laparoscopic donor nephrectomy among more than 1000 cases: low complication rates, despite more challenging cases.| | View in PubMed
- Early and late abdominal bleeding after Roux-en-Y gastric bypass: sources and tailored therapeutic strategies.| | View in PubMed
- Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade.| | View in PubMed
- Islet transplantation in type 1 diabetics using an immunosuppressive protocol based on the anti-LFA-1 antibody efalizumab.| | View in PubMed
- Clinical islet transplantation at the University of California, San Francisco.| | View in PubMed
- Successful clinical islet isolation using a GMP-manufactured collagenase and neutral protease.| | View in PubMed
- Portomesenteric venous thrombosis after laparoscopic surgery: a systematic literature review.| | View in PubMed
- Long-term renal function and cardiovascular disease risk in obese kidney donors.| | View in PubMed
- Factors associated with weight loss after gastric bypass.| | View in PubMed
- A clinical scoring system for predicting nonalcoholic steatohepatitis in morbidly obese patients.| | View in PubMed
- Laparoscopic bariatric surgery improves candidacy in morbidly obese patients awaiting transplantation.| | View in PubMed
- Human albumin preserves islet mass and function better than whole serum during pretransplantation islet culture.| | View in PubMed
- The impact of roux limb length on weight loss after gastric bypass.| | View in PubMed
- Catheter-directed therapy for DVT after pancreas transplantation.| | View in PubMed
- Spectrum and risk factors of complications after gastric bypass.| | View in PubMed
- Predictors, treatment, and outcomes of gastrojejunostomy stricture after gastric bypass for morbid obesity.| | View in PubMed
- Routine upper GI series after gastric bypass does not reliably identify anastomotic leaks or predict stricture formation.| | View in PubMed
- Propylthiouracil-associated liver failure presenting as probable autoimmune hepatitis in a child with Graves' disease.| | View in PubMed
- Antibody-mediated rejection of a pancreas allograft.| | View in PubMed
- Pretransplant islet culture: a comparison of four serum-free media using a murine model of islet transplantation.| | View in PubMed
- More than 500 consecutive laparoscopic donor nephrectomies without conversion or repeated surgery.| | View in PubMed
- Laparoscopic procurement of kidneys with multiple renal arteries is associated with increased ureteral complications in the recipient.| | View in PubMed
- BKV in simultaneous pancreas-kidney transplant recipients: a leading cause of renal graft loss in first 2 years post-transplant.| | View in PubMed
- Laparoscopic right donor nephrectomy: a large single-center experience.| | View in PubMed
- Experience with steroid-free maintenance immunosuppression in simultaneous pancreas-kidney transplantation.| | View in PubMed
- Congenital cleft spleen with CT scan appearance of high-grade splenic laceration after blunt abdominal trauma.| | View in PubMed
- CD69 expression on peripheral CD8 T cells correlates with acute rejection in renal transplant recipients.| | View in PubMed
- Longevity of 2328 chairside Cerec inlays and onlays.| | View in PubMed
- Intraportal delivery of immunosuppression to intrahepatic islet allograft recipients.| | View in PubMed
- Prolongation of survival of donor-strain islet xenografts (rat-->mouse) by intrathymic inoculation of xenogeneic islet and bone marrow cells.| | View in PubMed
- Intrathymic transplantation promotes survival of islet xenografts (rat-->mouse).| | View in PubMed
- The failure of intrathymic transplantation of nonimmunogenic islet allografts to promote induction of donor-specific unresponsiveness.| | View in PubMed
- Examination of the mechanisms responsible for tolerance induction after intrathymic inoculation of allogeneic bone marrow.| | View in PubMed
- Promotion of rat cardiac allograft survival by intrathymic inoculation of donor splenocytes.| | View in PubMed
- Prolonged survival of rat orthotopic liver allografts after intrathymic inoculation of donor-strain cells.| | View in PubMed
- Intrathymic inoculation of donor cells promotes survival of rat orthotopic liver allografts.| | View in PubMed
- Intrathymic inoculation of islets at birth prevents autoimmune diabetes and pancreatic insulitis in the BB rat.| | View in PubMed
- Prolonged survival of rat cardiac allografts after intrathymic inoculation of donor thymocytes.| | View in PubMed
- Intrathymic transplantation as a model for tolerance.| | View in PubMed
- Prolongation of rat pancreatic islet allograft survival by anti-CD2 monoclonal antibody treatment.| | View in PubMed
- Pioneering work in immune tolerance.| | View in PubMed
- Microchimerism of the thymus and graft acceptance.| | View in PubMed
- Induction of donor-specific tolerance to rat cardiac allografts by intrathymic inoculation of bone marrow.| | View in PubMed
- Promotion of pancreatic islet allograft survival by intrathymic transplantation of bone marrow.| | View in PubMed
- Successful islet transplantation in the thymus of spontaneously diabetic BB rats.| | View in PubMed
- Prevention of autoimmune diabetes in the BB rat by intrathymic islet transplantation at birth.| | View in PubMed
- Intraportal FK 506 improves intrahepatic islet allograft survival.| | View in PubMed
- Intrathymic islet transplantation in the spontaneously diabetic BB rat.| | View in PubMed
- Major-histocompatibility-complex restricted and nonrestricted autoimmune effector mechanisms in BB rats.| | View in PubMed
- Studies of privileged sites and islet transplantation.| | View in PubMed
- Selective T-cell depletion of recipients in allogeneic small bowel transplantation (SBT) in the rat.| | View in PubMed
- Induction of donor-specific unresponsiveness by intrathymic islet transplantation.| | View in PubMed
- Immunologic consequences of islet MHC antigen modulation in autoimmune diabetes.| | View in PubMed
- The effect of islet cell culture in vitro at 24 degrees C on graft survival and MHC antigen expression.| | View in PubMed
- Suppression of carbon monoxide excretion rate by tin protoporphyrin.| | View in PubMed
- Effect of tin protoporphyrin on the excretion rate of carbon monoxide in newborn rats after hematoma formation.| | View in PubMed