University of California San Francisco

Schrepfer 300Dpi
Sonja
Schrepfer
MD, PhD

Professor of Surgery
Division of Cardiothoracic Surgery
Co-Director, Transplant and Stem Cell Immunobiology (TSI) Lab

Address

513 Parnassus Ave, MSB, #1268B
San Francisco, CA 94117
United States

Email: [email protected]
Phone: 415-502-8742

Biography

Sonja Schrepfer, M.D., Ph.D., Professor of Surgery, founded the Transplant and Stem Cell Immunobiology (TSI) Lab in 2009 in Germany. In 2016, she joined the faculty of the Department of Surgery at the University of California San Francisco. She is also Co-Director of the TSI Lab at UCSF.

Dr. Schrepfer's research career has been dedicated to making fundamental discovers in stem cell immunology, transplant and cardiovascular immunobiology. Her lab currently works on immunobiological mechanisms of pluripotent stem cells (mouse and human). One project uses e.g. a combination of molecular/cellular biology, genomic/epigenomic profiling, tissue engineering, and molecular imaging technologies to better understand stem cell biology in vitro and in vivo. She has made significant contributions in the field of immunological barriers in regenerative medicine and in identifying novel immunobiological targets involved in cardiovascular diseases.

The TSI Lab is also investigating the vascular biology of “mice from space”; that is mice that have spent time at the international space station (ISS). This research will provide insight into what physiological effects time in outer space might have on astronauts, with potentially important implications for future longer-term missions, and has the possibility to open the door to fascinating new discoveries that could be used in earth-bound cardiovascular research.

Education

Education

University of Wuerzburg and Munich, Germany MD 10/2001 Medicine, Immunology

University of Wuerzburg, Germany Doctoral Thesis 05/2002 Medicine, Immunology

University of Hamburg, Germany and Stanford University, Stanford, CA PhD 01/2007 Experimental Cardiac Surgery, Transplant Immunobiology

Stanford University, Stanford, CA Postdoctoral Training and Instructor 02/2009 Cardiothoracic Surgery, Transplant Immunobiology

Fellowships

2005 - 2007 Postdoctoral Fellow, Transplant Immunology Laboratory, Stanford University, School of Medicine, CT Surgery. Advisor: Dr. Robert C. Robbins

Postdoctoral Training

2007 - 2009 Instructor, Transplant Immunology Laboratory, Stanford University, School of Medicine, CT Surgery

2009-2015 Professor and Founder, Transplant and Stem Cell Immunobiology (TSI) Laboratory, University Heart Center Hamburg, Germany

Foreign Languages Spoken

German, French

Grants and Funding

  • Hypo-immunogenic cardiomyocytes for myocardial repair | NIH | 2018-08-01 - 2022-06-30 | Role: Co-Principal Investigator
  • Microgravity as model for immunological senescence and its impact on tissue stem cells and regeneration | NIH | 2017-06-15 - 2022-06-30 | Role: Principal Investigator
  • Microgravity as model for immunological senescence and its impact on tissue stem cells and regeneration | NIH | 2017-06-15 - 2020-02-29 | Role: Principal Investigator

Research Narrative

Dr. Schrepfer's research aims to understand the critical immunological barrier that presently precludes the successful application of cell-based regenerative therapy Her TSI Lab has made seminal contributions to the field, including the first description of the antigenicity of mitochondria in embryonic stem cells derived by somatic cell nucleus transfer (SCNT). Currently, her group is interested in understanding the molecular, cellular, and epigenetic landscape changes after transplantation of stem cells and their derivates and we are aiming to decrease the immunogenic potential of PSCs.

The lab has also discovered novel pathways involved in the development of vascular intimal hyperplasia. Myointimal hyperplasia is a pathological process of the vascular system characterized by abnormal proliferation of smooth muscle cells of the vascular wall that leads to luminal obliteration and subsequent ischemia. Myointimal hyperplasia may occur in patients after vessel injury during medical procedures (e.g. after balloon dilation or stent placement) or after pathological injury of the blood vessel (e.g. due to inflammation or toxic exposure). It can cause graft failure and in-stent restenosis. To help prevent this and increase the success of treatments for coronary heart disease, Dr. Schrepfer's   lab has also developed novel humanized models to study the development of intimal hyperplasia.

Transplant immunology after heart and lung transplantation is another area the lab is exploring with particular focus on translational research and investigation of underlying mechanisms of acute and chronic graft rejection. Novel drug discoveries will benefit our patients tremendously.

Research Interests

Pluripotent Stem Cell Immunobiology

Cardiovascular MechanismsiInvolved in Vessel Stenosis

Transplant Immunology

Vascular Biology of Mice During Space Travel

Research Pathways

Basic Biomedical & Translational Research

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 98
  1. Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate.
    Hu X, White K, Young C, Olroyd AG, Kievit P, Connolly AJ, Deuse T, Schrepfer S| | View in PubMed
  2. Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity.
    Gravina A, Tediashvili G, Zheng Y, Iwabuchi KA, Peyrot SM, Roodsari SZ, Gargiulo L, Kaneko S, Osawa M, Schrepfer S, Deuse T| | View in PubMed
  3. Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques.
    Hu X, White K, Olroyd AG, DeJesus R, Dominguez AA, Dowdle WE, Friera AM, Young C, Wells F, Chu EY, Ito CE, Krishnapura H, Jain S, Ankala R, McGill TJ, Lin A, Egenberger K, Gagnon A, Michael Rukstalis J, Hogrebe NJ, Gattis C, Basco R, Millman JR, Kievit P, Davis MM, Lanier LL, Connolly AJ, Deuse T, Schrepfer S| | View in PubMed
  4. Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice.
    Hu X, Gattis C, Olroyd AG, Friera AM, White K, Young C, Basco R, Lamba M, Wells F, Ankala R, Dowdle WE, Lin A, Egenberger K, Rukstalis JM, Millman JR, Connolly AJ, Deuse T, Schrepfer S| | View in PubMed
  5. Hypoimmune anti-CD19 chimeric antigen receptor T cells provide lasting tumor control in fully immunocompetent allogeneic humanized mice.
    Hu X, Manner K, DeJesus R, White K, Gattis C, Ngo P, Bandoro C, Tham E, Chu EY, Young C, Wells F, Basco R, Friera A, Kangeyan D, Beauchesne P, Dowdle WE, Deuse T, Fry TJ, Foster AE, Schrepfer S| | View in PubMed
  6. Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression.
    Gravina A, Tediashvili G, Rajalingam R, Quandt Z, Deisenroth C, Schrepfer S, Deuse T| | View in PubMed
  7. Author Correction: Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients.
    Deuse T, Hu X, Gravina A, Wang D, Tediashvili G, De C, Thayer WO, Wahl A, Garcia JV, Reichenspurner H, Davis MM, Lanier LL, Schrepfer S| | View in PubMed
  8. Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice.
    Deuse T, Tediashvili G, Hu X, Gravina A, Tamenang A, Wang D, Connolly A, Mueller C, Mallavia B, Looney MR, Alawi M, Lanier LL, Schrepfer S| | View in PubMed
  9. Immunomodulation Therapy Using Tolerogenic Macrophages in a Rodent Model of Pulmonary Hypertension.
    Guihaire J, Deuse T, Wang D, Spin JM, Blankenberg FG, Fadel E, Reichenspurner H, Schrepfer S| | View in PubMed
  10. The SIRPα-CD47 immune checkpoint in NK cells.
    Deuse T, Hu X, Agbor-Enoh S, Jang MK, Alawi M, Saygi C, Gravina A, Tediashvili G, Nguyen VQ, Liu Y, Valantine H, Lanier LL, Schrepfer S| | View in PubMed
  11. Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact.
    da Silveira WA, Fazelinia H, Rosenthal SB, Laiakis EC, Kim MS, Meydan C, Kidane Y, Rathi KS, Smith SM, Stear B, Ying Y, Zhang Y, Foox J, Zanello S, Crucian B, Wang D, Nugent A, Costa HA, Zwart SR, Schrepfer S, Elworth RAL, Sapoval N, Treangen T, MacKay M, Gokhale NS, Horner SM, Singh LN, Wallace DC, Willey JS, Schisler JC, Meller R, McDonald JT, Fisch KM, Hardiman G, Taylor D, Mason CE, Costes SV, Beheshti A| | View in PubMed
  12. The H-Y Antigen in Embryonic Stem Cells Causes Rejection in Syngeneic Female Recipients.
    Hu X, Kueppers ST, Kooreman NG, Gravina A, Wang D, Tediashvili G, Schlickeiser S, Frentsch M, Nikolaou C, Thiel A, Marcus S, Fuchs S, Velden J, Reichenspurner H, Volk HD, Deuse T, Schrepfer S| | View in PubMed
  13. A Cryoinjury Model to Study Myocardial Infarction in the Mouse.
    Wang D, Tediashvili G, Hu X, Gravina A, Marcus SG, Zhang H, Olgin JE, Deuse T, Schrepfer S| | View in PubMed
  14. De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans.
    Deuse T, Hu X, Agbor-Enoh S, Koch M, Spitzer MH, Gravina A, Alawi M, Marishta A, Peters B, Kosaloglu-Yalcin Z, Yang Y, Rajalingam R, Wang D, Nashan B, Kiefmann R, Reichenspurner H, Valantine H, Weissman IL, Schrepfer S| | View in PubMed
  15. Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients.
    Deuse T, Hu X, Gravina A, Wang D, Tediashvili G, De C, Thayer WO, Wahl A, Garcia JV, Reichenspurner H, Davis MM, Lanier LL, Schrepfer S| | View in PubMed
  16. Dead space ventilation promotes alveolar hypocapnia reducing surfactant secretion by altering mitochondrial function.
    Kiefmann M, Tank S, Tritt MO, Keller P, Heckel K, Schulte-Uentrop L, Olotu C, Schrepfer S, Goetz AE, Kiefmann R| | View in PubMed
  17. Exosomal profiling in cardiac allograft rejection: Best basic science article in 2018.
    Kulkarni HS, Diamond JM, Schrepfer S, Cantu E| | View in PubMed
  18. No effect of thymosin beta-4 on the expression of the transcription factor Islet-1 in the adult murine heart.
    Weinberger F, Nicol P, Starbatty J, Stubbendorff M, Becher PM, Schrepfer S, Eschenhagen T| | View in PubMed
  19. Sphingosine-1-phosphate receptor 1 regulates neointimal growth in a humanized model for restenosis.
    Braetz J, Becker A, Geissen M, Larena-Avellaneda A, Schrepfer S, Daum G| | View in PubMed
  20. Optimization of oxygenation during ex vivo lung perfusion-Best basic science article in 2017.
    Shaver CM, Diamond JM, Schrepfer S, Cantu E| | View in PubMed
  21. Balloon-based Injury to Induce Myointimal Hyperplasia in the Mouse Abdominal Aorta.
    Tediashvili G, Wang D, Reichenspurner H, Deuse T, Schrepfer S| | View in PubMed
  22. Opportunities for Lung Repair and Regeneration: An Overview.
    Schrepfer S| | View in PubMed
  23. Thalidomide treatment prevents chronic graft rejection after aortic transplantation in rats - an experimental study.
    Miller KK, Wang D, Hu X, Hua X, Deuse T, Neofytou E, Renne T, Velden J, Reichenspurner H, Schrepfer S, Bernstein D| | View in PubMed
  24. Differences in Vascular Response between Balloon Overstretch and Stent Overexpansion in Nonatherosclerotic Porcine Coronary Arteries.
    Mitsutake Y, Reifart J, Pyun WB, Lyons JK, Deuse T, Schrepfer S, Ikeno F| | View in PubMed
  25. The ubiquitin-proteasome system: A potential therapeutic target for heart failure.
    Barac YD, Emrich F, Krutzwakd-Josefson E, Schrepfer S, Sampaio LC, Willerson JT, Robbins RC, Ciechanover A, Mohr FW, Aravot D, Taylor DA| | View in PubMed
  26. Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency.
    Wang D, Tediashvili G, Pecha S, Reichenspurner H, Deuse T, Schrepfer S| | View in PubMed
  27. Orthotopic tracheal transplantation using human bronchus: an original xenotransplant model of obliterative airway disorder.
    Guihaire J, Itagaki R, Stubbendorff M, Hua X, Deuse T, Ullrich S, Fadel E, Dorfmüller P, Robbins RC, Reichenspurner H, Schumacher U, Schrepfer S| | View in PubMed
  28. miR-126: a potential new key player in hypoxia and reperfusion?
    Guenther SP, Schrepfer S| | View in PubMed
  29. The Selective JAK1/3-Inhibitor R507 Mitigates Obliterative Airway Disease Both With Systemic Administration and Aerosol Inhalation.
    Deuse T, Hua X, Stubbendorff M, Spin JM, Neofytou E, Taylor V, Chen Y, Park G, Fink JB, Renne T, Kiefmann M, Kiefmann R, Reichenspurner H, Robbins RC, Schrepfer S| | View in PubMed
  30. "Bioengineered lungs" Best science paper in JHLT 2014-2015.
    Schrepfer S, Cantu E, Gandy K, Baan CC, West LJ| | View in PubMed
  31. miR-21 promotes fibrosis in an acute cardiac allograft transplantation model.
    Gupta SK, Itagaki R, Zheng X, Batkai S, Thum S, Ahmad F, Van Aelst LN, Sharma A, Piccoli MT, Weinberger F, Fiedler J, Heuser M, Heymans S, Falk CS, Förster R, Schrepfer S, Thum T| | View in PubMed
  32. Sex Differences in Immunology: More Severe Development of Experimental Pulmonary Hypertension in Male Rats Exposed to Vascular Endothelial Growth Factor Receptor Blockade.
    Guihaire J, Deuse T, Wang D, Fadel E, Reichenspurner H, Schrepfer S| | View in PubMed
  33. Alagebrium inhibits neointimal hyperplasia and restores distributions of wall shear stress by reducing downstream vascular resistance in obese and diabetic rats.
    Wang H, Weihrauch D, Kersten JR, Toth JM, Passerini AG, Rajamani A, Schrepfer S, LaDisa JF| | View in PubMed
  34. Distal Airway Stem Cells are Essential for Lung Regeneration.
    Deuse T, Schrepfer S| | View in PubMed
  35. Local MicroRNA Modulation Using a Novel Anti-miR-21-Eluting Stent Effectively Prevents Experimental In-Stent Restenosis.
    Wang D, Deuse T, Stubbendorff M, Chernogubova E, Erben RG, Eken SM, Jin H, Li Y, Busch A, Heeger CH, Behnisch B, Reichenspurner H, Robbins RC, Spin JM, Tsao PS, Schrepfer S, Maegdefessel L| | View in PubMed
  36. Advancing knowledge of right ventricular pathophysiology in chronic pressure overload: Insights from experimental studies.
    Guihaire J, Noly PE, Schrepfer S, Mercier O| | View in PubMed
  37. Effective Apical Infection of Differentiated Human Bronchial Epithelial Cells and Induction of Proinflammatory Chemokines by the Highly Pneumotropic Human Adenovirus Type 14p1.
    Lam E, Ramke M, Warnecke G, Schrepfer S, Kopfnagel V, Dobner T, Heim A| | View in PubMed
  38. Mesenchymal stromal cell therapy: different sources exhibit different immunobiological properties.
    Neofytou E, Deuse T, Beygui RE, Schrepfer S| | View in PubMed
  39. Immunobiology of fibrin-based engineered heart tissue.
    Conradi L, Schmidt S, Neofytou E, Deuse T, Peters L, Eder A, Hua X, Hansen A, Robbins RC, Beygui RE, Reichenspurner H, Eschenhagen T, Schrepfer S| | View in PubMed
  40. Impaired Endothelial Regeneration Through Human Parvovirus B19-Infected Circulating Angiogenic Cells in Patients With Cardiomyopathy.
    Schmidt-Lucke C, Zobel T, Schrepfer S, Kuhl U, Wang D, Klingel K, Becher PM, Fechner H, Pozzuto T, Van Linthout S, Lassner D, Spillmann F, Escher F, Holinski S, Volk HD, Schultheiss HP, Tschope C| | View in PubMed
  41. Erratum: miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development.
    Maegdefessel L, Spin JM, Raaz U, Eken SM, Toh R, Azuma J, Adam M, Nakagami F, Heymann HM, Chernogubova E, Jin H, Roy J, Hultgren R, Caidahl K, Schrepfer S, Hamsten A, Eriksson P, McConnell MV, Dalman RL, Tsao PS| | View in PubMed
  42. SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts.
    Deuse T, Wang D, Stubbendorff M, Itagaki R, Grabosch A, Greaves LC, Alawi M, Grünewald A, Hu X, Hua X, Velden J, Reichenspurner H, Robbins RC, Jaenisch R, Weissman IL, Schrepfer S| | View in PubMed
  43. miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development.
    Maegdefessel L, Spin JM, Raaz U, Eken SM, Toh R, Azuma J, Adam M, Nakagami F, Nagakami F, Heymann HM, Chernogubova E, Chernugobova E, Jin H, Roy J, Hultgren R, Caidahl K, Schrepfer S, Hamsten A, Eriksson P, McConnell MV, Dalman RL, Tsao PS| | View in PubMed
  44. Inducing myointimal hyperplasia versus atherosclerosis in mice: an introduction of two valid models.
    Stubbendorff M, Hua X, Deuse T, Ali Z, Reichenspurner H, Maegdefessel L, Robbins RC, Schrepfer S| | View in PubMed
  45. Dichloroacetate prevents restenosis in preclinical animal models of vessel injury.
    Deuse T, Hua X, Wang D, Maegdefessel L, Heeren J, Scheja L, Bolaños JP, Rakovic A, Spin JM, Stubbendorff M, Ikeno F, Länger F, Zeller T, Schulte-Uentrop L, Stoehr A, Itagaki R, Haddad F, Eschenhagen T, Blankenberg S, Kiefmann R, Reichenspurner H, Velden J, Klein C, Yeung A, Robbins RC, Tsao PS, Schrepfer S| | View in PubMed
  46. The Ca²⁺-activated K⁺ channel KCa3.1 as a potential new target for the prevention of allograft vasculopathy.
    Chen YJ, Lam J, Gregory CR, Schrepfer S, Wulff H| | View in PubMed
  47. Immunological properties of extraembryonic human mesenchymal stromal cells derived from gestational tissue.
    Stubbendorff M, Deuse T, Hua X, Phan TT, Bieback K, Atkinson K, Eiermann TH, Velden J, Schröder C, Reichenspurner H, Robbins RC, Volk HD, Schrepfer S| | View in PubMed
  48. Small animal models of experimental obliterative bronchiolitis.
    Jungraithmayr W, Jang JH, Schrepfer S, Inci I, Weder W| | View in PubMed
  49. The potassium channel KCa3.1 as new therapeutic target for the prevention of obliterative airway disease.
    Hua X, Deuse T, Chen YJ, Wulff H, Stubbendorff M, Köhler R, Miura H, Länger F, Reichenspurner H, Robbins RC, Schrepfer S| | View in PubMed
  50. Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545.
    Deuse T, Hua X, Taylor V, Stubbendorff M, Baluom M, Chen Y, Park G, Velden J, Streichert T, Reichenspurner H, Robbins RC, Schrepfer S| | View in PubMed
  51. Effects of intracoronary CD34+ stem cell transplantation in nonischemic dilated cardiomyopathy patients: 5-year follow-up.
    Vrtovec B, Poglajen G, Lezaic L, Sever M, Domanovic D, Cernelc P, Socan A, Schrepfer S, Torre-Amione G, Haddad F, Wu JC| | View in PubMed
  52. Human internal mammary artery (IMA) transplantation and stenting: a human model to study the development of in-stent restenosis.
    Hua X, Deuse T, Michelakis ED, Haromy A, Tsao PS, Maegdefessel L, Erben RG, Bergow C, Behnisch BB, Reichenspurner H, Robbins RC, Schrepfer S| | View in PubMed
  53. Localization of Islet-1-positive cells in the healthy and infarcted adult murine heart.
    Weinberger F, Mehrkens D, Friedrich FW, Stubbendorff M, Hua X, Müller JC, Schrepfer S, Evans SM, Carrier L, Eschenhagen T| | View in PubMed
  54. Human leukocyte antigen I knockdown human embryonic stem cells induce host ignorance and achieve prolonged xenogeneic survival.
    Deuse T, Seifert M, Phillips N, Fire A, Tyan D, Kay M, Tsao PS, Hua X, Velden J, Eiermann T, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S| | View in PubMed
  55. Immunobiology of naïve and genetically modified HLA-class-I-knockdown human embryonic stem cells.
    Deuse T, Seifert M, Phillips N, Fire A, Tyan D, Kay M, Tsao PS, Hua X, Velden J, Eiermann T, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S| | View in PubMed
  56. Assessment of physiologic natural killer cell cytotoxicity in vitro.
    Duske H, Sputtek A, Binder T, Kröger N, Schrepfer S, Eiermann T| | View in PubMed
  57. Peptide ligands incorporated into the threefold spike capsid domain to re-direct gene transduction of AAV8 and AAV9 in vivo.
    Michelfelder S, Varadi K, Raupp C, Hunger A, Körbelin J, Pahrmann C, Schrepfer S, Müller OJ, Kleinschmidt JA, Trepel M| | View in PubMed
  58. Bioluminescence imaging for assessment of immune responses following implantation of engineered heart tissue (EHT).
    Conradi L, Pahrmann C, Schmidt S, Deuse T, Hansen A, Eder A, Reichenspurner H, Robbins RC, Eschenhagen T, Schrepfer S| | View in PubMed
  59. Prevention of transplant coronary artery disease by prenylation inhibitors.
    Stein W, Schrepfer S, Itoh S, Kimura N, Velotta J, Palmer O, Bartos J, Wang X, Robbins RC, Fischbein MP| | View in PubMed
  60. Orthotopic aortic transplantation: a rat model to study the development of chronic vasculopathy.
    Stubbendorff M, Deuse T, Hammel A, Robbins RC, Reichenspurner H, Schrepfer S| | View in PubMed
  61. Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells.
    Deuse T, Stubbendorff M, Tang-Quan K, Phillips N, Kay MA, Eiermann T, Phan TT, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S| | View in PubMed
  62. Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting.
    Deuse T, Koyanagi T, Erben RG, Hua X, Velden J, Ikeno F, Reichenspurner H, Robbins RC, Mochly-Rosen D, Schrepfer S| | View in PubMed
  63. Non-volume-loaded heart provides a more relevant heterotopic transplantation model.
    Tang-Quan KR, Bartos J, Deuse T, Churchill E, Schäfer H, Reichenspurner H, Mochly-Rosen D, Robbins RC, Schrepfer S| | View in PubMed
  64. Heterotopic and orthotopic tracheal transplantation in mice used as models to study the development of obliterative airway disease.
    Hua X, Deuse T, Tang-Quan KR, Robbins RC, Reichenspurner H, Schrepfer S| | View in PubMed
  65. Mechanisms behind local immunosuppression using inhaled tacrolimus in preclinical models of lung transplantation.
    Deuse T, Blankenberg F, Haddad M, Reichenspurner H, Phillips N, Robbins RC, Schrepfer S| | View in PubMed
  66. LAD-ligation: a murine model of myocardial infarction.
    Kolk MV, Meyberg D, Deuse T, Tang-Quan KR, Robbins RC, Reichenspurner H, Schrepfer S| | View in PubMed
  67. Poor functional recovery after transplantation of diabetic bone marrow stem cells in ischemic myocardium.
    Govaert JA, Swijnenburg RJ, Schrepfer S, Xie X, van der Bogt KE, Hoyt G, Stein W, Ransohoff KJ, Robbins RC, Wu JC| | View in PubMed
  68. Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction.
    Deuse T, Peter C, Fedak PW, Doyle T, Reichenspurner H, Zimmermann WH, Eschenhagen T, Stein W, Wu JC, Robbins RC, Schrepfer S| | View in PubMed
  69. Imaging in-stent restenosis: an inexpensive, reliable, and rapid preclinical model.
    Deuse T, Ikeno F, Robbins RC, Schrepfer S| | View in PubMed
  70. A novel JAK3 inhibitor, R348, attenuates chronic airway allograft rejection.
    Velotta JB, Deuse T, Haddad M, Masuda E, Park G, Carroll D, Taylor V, Robbins RC, Schrepfer S| | View in PubMed
  71. Comparison of transplantation of adipose tissue- and bone marrow-derived mesenchymal stem cells in the infarcted heart.
    van der Bogt KE, Schrepfer S, Yu J, Sheikh AY, Hoyt G, Govaert JA, Velotta JB, Contag CH, Robbins RC, Wu JC| | View in PubMed
  72. In vivo imaging of embryonic stem cells reveals patterns of survival and immune rejection following transplantation.
    Swijnenburg RJ, Schrepfer S, Cao F, Pearl JI, Xie X, Connolly AJ, Robbins RC, Wu JC| | View in PubMed
  73. Comparison of different adult stem cell types for treatment of myocardial ischemia.
    van der Bogt KE, Sheikh AY, Schrepfer S, Hoyt G, Cao F, Ransohoff KJ, Swijnenburg RJ, Pearl J, Lee A, Fischbein M, Contag CH, Robbins RC, Wu JC| | View in PubMed
  74. Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts.
    Swijnenburg RJ, Schrepfer S, Govaert JA, Cao F, Ransohoff K, Sheikh AY, Haddad M, Connolly AJ, Davis MM, Robbins RC, Wu JC| | View in PubMed
  75. Novel immunosuppression: R348, a JAK3- and Syk-inhibitor attenuates acute cardiac allograft rejection.
    Deuse T, Velotta JB, Hoyt G, Govaert JA, Taylor V, Masuda E, Herlaar E, Park G, Carroll D, Pelletier MP, Robbins RC, Schrepfer S| | View in PubMed
  76. Prevention and inhibition but not reversion of chronic allograft vasculopathy by FK778.
    Deuse T, Hoyt G, Koyanagi T, Robbins RC, Schrepfer S| | View in PubMed
  77. Introducing the first polymer-free leflunomide eluting stent.
    Deuse T, Erben RG, Ikeno F, Behnisch B, Boeger R, Connolly AJ, Reichenspurner H, Bergow C, Pelletier MP, Robbins RC, Schrepfer S| | View in PubMed
  78. Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins.
    Huellner MW, Schrepfer S, Weyand M, Weiner H, Wimplinger I, Eschenhagen T, Rau T| | View in PubMed
  79. Failed induction of heme oxygenase 1 in endothelial cells exposed to the hemoglobin based oxygen carrier Oxyglobin.
    Rempf C, Ritter A, Schrepfer S, Freitag M, Standl T, Gottschalk A| | View in PubMed
  80. Right atrial mass after primary repair of an atrial septal defect: thrombus masquerading as a myxoma.
    Sheikh AY, Schrepfer S, Stein W, West J, Lombard J, Burdon T, Pinsker B, Pelletier MP| | View in PubMed
  81. Techniques for experimental heterotopic and orthotopic tracheal transplantations - When to use which model?
    Deuse T, Schrepfer S, Reichenspurner H, Hoyt G, Fischbein MP, Robbins RC, Pelletier MP| | View in PubMed
  82. Coincidence of aortic valve stenosis and regurgitation and multiple cardiac papillary fibroelastomas in a young male adult.
    Sydow K, Schrepfer S, Franzen O, Detter C, Willems S, Meinertz T, Reichenspurner H| | View in PubMed
  83. Simplified protocol to isolate, purify, and culture expand mesenchymal stem cells.
    Schrepfer S, Deuse T, Lange C, Katzenberg R, Reichenspurner H, Robbins RC, Pelletier MP| | View in PubMed
  84. Experimental orthotopic tracheal transplantation: The Stanford technique.
    Schrepfer S, Deuse T, Hoyt G, Sheikh AY, Hoffmann J, Reichenspurner H, Robbins RC, Pelletier MP| | View in PubMed
  85. FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy.
    Schrepfer S, Deuse T, Koch-Nolte F, Krieger T, Haddad M, Schäfer H, Pelletier MP, Robbins RC, Reichenspurner H| | View in PubMed
  86. Inhibition of restenosis development after mechanical injury: a new field of application for malononitrilamides?
    Schrepfer S, Deuse T, Sultan KR, Haddad M, Böger R, Münzel T, Schäfer H, Pelletier MP, Robbins RC, Reichenspurner H| | View in PubMed
  87. The selective estrogen receptor-beta agonist biochanin A shows vasculoprotective effects without uterotrophic activity.
    Schrepfer S, Deuse T, Münzel T, Schäfer H, Braendle W, Reichenspurner H| | View in PubMed
  88. Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase.
    Baldus S, Rudolph V, Roiss M, Ito WD, Rudolph TK, Eiserich JP, Sydow K, Lau D, Szöcs K, Klinke A, Kubala L, Berglund L, Schrepfer S, Deuse T, Haddad M, Risius T, Klemm H, Reichenspurner HC, Meinertz T, Heitzer T| | View in PubMed
  89. Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease.
    Deuse T, Schrepfer S, Koch-Nolte F, Haddad M, Schäfer H, Detter C, Reichenspurner H| | View in PubMed
  90. The phytoestrogen biochaninA weakens acute cardiac allograft rejection without affecting the reproductive system.
    Schrepfer S, Deuse T, Schäfer H, Koch-Nolte F, Braendle W, Reichenspurner H| | View in PubMed
  91. FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation.
    Deuse T, Schrepfer S, Koch-Nolte F, Haddad M, Schwedhelm E, Böger R, Schäfer H, Detter C, Reichenspurner H| | View in PubMed
  92. FK778, a novel immunosuppressive agent, reduces early adhesion molecule up-regulation and prolongs cardiac allograft survival.
    Schrepfer S, Deuse T, Schäfer H, Reichenspurner H| | View in PubMed
  93. FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies.
    Deuse T, Schrepfer S, Schäfer H, Koch-Nolte F, Schwedhelm E, Böger RH, Reichenspurner H| | View in PubMed
  94. The interaction between FK778 and tacrolimus in the prevention of rat cardiac allograft rejection is dose dependent.
    Deuse T, Schrepfer S, Reichenspurner H| | View in PubMed
  95. Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model.
    Deuse T, Schrepfer S, Reichenspurner H| | View in PubMed
  96. Successful resection of a symptomatic right ventricular lipoma.
    Schrepfer S, Deuse T, Detter C, Treede H, Koops A, Boehm DH, Willems S, Lacour-Gayet F, Reichenspurner H| | View in PubMed
  97. New technique for chest opening in mice: U-sternotomy.
    Schrepfer S, Deuse T, Reichenspurner H| | View in PubMed
  98. Myoblasts survive intracardiac transfer and divide further after transplantation.
    Gulbins H, Schrepfer S, Uhlig A, Goldemund A, Oberhoffer M, Reichenspurner H, Meiser B, Reichart B| | View in PubMed