Biography
Awards & Honors
Award | Conferred By | Date |
---|---|---|
Burroughs Wellcome Next Gen Pregnancy Initiative | Burroughs Wellcome Fund | 2023/2027 |
Pew Biomedical Scholar | The Pew Charitable Trusts | 2023/2027 |
Sandler PSSP Grant | UCSF Dean's Office | 2019/2024 |
ASTS-Astellas Fellowship in Transplantation Grant | American Society of Transplant Surgeons | 2017/2019 |
Nusz Achievement Award | UCSF Department of Surgery | 2017/2017 |
Schecter Award for Senior Trauma Fellow | UCSF Division of Trauma and Critical Care | 2016/2016 |
ED Surgical Consultant of the Year | UCSF Emergency Medicine | 2016/2016 |
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of California San Francisco | Clinical Instructor and Fellow | Abdominal Transplant Surgery | 08/2019 |
University of California San Francisco | Chief Resident | General Surgery | 06/2017 |
University of California San Francisco | Resident | General Surgery | 06/2016 |
University of California San Francisco | MD/PhD | Genetics | 06/2012 |
Harvard University | AB | Biochemistry | 06/2002 |
Board Certifications
American Board of Surgery, General Surgery
Clinical Expertise
Ascites
Bile Duct Cancer (Cholangiocarcinoma)
Bile Duct Injuries
Bile Duct Strictures
Bridging Therapies to Downstage HCC in Liver Transplant Setting
Choledochal Cysts
Deceased Donor Organ Utilization
Gallbladder Cancer
Hepatocellular Carcinoma (Primary Liver Cancer)
Kidney Transplantation
Laparoscopic Donor Nephrectomy
Liver Biopsy
Liver Cysts
Liver Metastases (Secondary Liver Cancer)
Liver Resection
Liver Transplantation
Living Donor Kidney Transplantation
Living Donor Liver Transplantation
Normothetic Machine Liver Perfusion
Organ Donation of Cardiovascular Death
Pancreas Transplantation
Pediatric Kidney Transplantation
Pediatric Liver Transplantation
Portal Hypertension
Foreign Languages Spoken
Program Affiliations
UCSF Department of Surgery
UCSF Division of Transplant Surgery
UCSF Diabetes Center
Book Chapters
Gardner JM, Anderson MS. The Mouse Model of Autoimmune Polyglandular Syndrome Type I. Immunoendocrinology: Scientific and Clinical Aspects. 1st edition. Ed. Eisenbarth G. (New York: Humana Press, 2011.)
Gardner et al., American Transplant Congress, 2015. Outcomes in a new category of Pancreas-After-Islet Transplantation.
Gardner et al., UCSF Surgery Resident Research Symposium, 2013-2016. Extrathymic Aire-Expressing Cells in Immune Tolerance and Transplantation.
Gardner et al., International Pancreas and Islet Transplant Association 2013. Outcomes in a new category of Pancreas-After-Islet Transplantation.
Gardner et al., Children?s Diabetes Foundation of the North Bay Annual Retreat, 2010. Novel Approaches for Preventing and Treating Juvenile Diabetes: What?s on the Horizon?
Gardner et al., Kyoto T Cell Conference 2009. Extrathymic Aire-Expressing Cells and the Maintenance of Immunologic Tolerance.
Gardner et al., American Diabetes Association Tour de Cure Donors? Evening, 2008. New approaches to Preventing and Treating Autoimmune Diabetes.
Gardner et al., UCSF/UCB 2008 Immunology Retreat. Phenotypic and Functional Characterization of Extrathymic Aire-Expressing Cells.
In the News
Research Narrative
The Gardner lab studies fundamental mechanisms of immune tolerance -- how the immune system learns to distinguish self from non-self -- and how this understanding can be applied in the context of autoimmunity, transplantation, maternal-fetal tolerance, and cancer immunology.
We have a particular focus on the biology and function of a unique group of cells expressing the Autoimmune Regulator (Aire) gene. Previously the lab identified extra-Thymic Aire-expressing Cells (eTACs), a novel population that plays significant roles in immune homeostasis and immune tolerance. We have since described the fundamental biology and identity of eTACs, as well as defined potential roles for these populations in autoimmune diabetes and in maternal-fetal tolerance.
We utilize multimodal approaches from transgenic engineering to single-cell multiomics to understand the biology and immunology of these unique populations, and more broadly of immune tolerance mechanisms.
The Gardner lab also works closely with the UCSF Transplant community and with the VIable Tissue Acquisition Lab (VITAL) Core, which Dr. Gardner established and directs, to advance groundbreaking research in human immunology and human biology. We work collaboratively with a range of investigators locally and nationally in these efforts.
Research Interests
Immune tolerance
Transplant surgery
Autoimmmune diabetes
Research Pathways
Publications
- Aire in Autoimmunity.| | View in PubMed
- Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.| | View in PubMed
- Circadian clocks drive rhythmic antitumor immune responses mediated by migratory dendritic cells.| | View in PubMed
- Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function.| | View in PubMed
- Successful cryopreservation of functional kidney allografts using vitrification and nanorewarming.| | View in PubMed
- Ikaros is a principal regulator of Aire+ mTEC homeostasis, thymic mimetic cell diversity, and central tolerance.| | View in PubMed
- Epithelial TNF controls cell differentiation and CFTR activity to maintain intestinal mucin homeostasis.| | View in PubMed
- RORγt-lineage APCs: The Aire apparent.| | View in PubMed
- Tissue-specific mitochondrial HIGD1C promotes oxygen sensitivity in carotid body chemoreceptors.| | View in PubMed
- A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation.| | View in PubMed
- A novel microsurgical reconstruction technique in a living-related liver donor hepatic artery dissection using the native hepatic artery.| | View in PubMed
- Nodular Regenerative Hyperplasia After Liver Transplant; It's All in the Presentation.| | View in PubMed
- The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans.| | View in PubMed
- Thymic and extrathymic Aire-expressing cells in maternal-fetal tolerance.| | View in PubMed
- Internal hernia involving the transplant ureter after simultaneous pancreas and kidney transplant - and the atypical management of a consequent transplant ureteral injury.| | View in PubMed
- Procurement of Deceased Donor Parathyroid Glands With the Aid of Near-infrared Autofluorescence Imaging.| | View in PubMed
- Cell types of origin of the cell-free transcriptome.| | View in PubMed
- Advantages and Limitations of Clinical Scores for Donation After Circulatory Death Liver Transplantation.| | View in PubMed
- Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium.| | View in PubMed
- RNA splicing programs define tissue compartments and cell types at single-cell resolution.| | View in PubMed
- Extrathymic Aire-expressing cells support maternal-fetal tolerance.| | View in PubMed
- A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance.| | View in PubMed
- Transplantation From Older Donors: Can Senolytics Turn Back the Clock?| | View in PubMed
- Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla.| | View in PubMed
- Surgical, Interventional, and Medical Palliation of Portal Hypertension.| | View in PubMed
- CON: Portal Vein Thrombosis Does Not Impact Liver Transplantation Outcomes.| | View in PubMed
- COVID-19 and Abdominal Transplant: A Stepwise Approach to Practice During Pandemic Conditions.| | View in PubMed
- Curr Hepatology Rep| | View in PubMed
- Ethical Issues in the COVID Era: Doing the Right Thing Depends on Location, Resources, and Disease Burden.| | View in PubMed
- Pancreas-After-Islet Transplantation in Nonuremic Type 1 Diabetes: A Strategy for Restoring Durable Insulin Independence.| | View in PubMed
- Effect of intratonsillar injection of steroids on the palatine tonsils of rabbits.| | View in PubMed
- Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell population.| | View in PubMed
- Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4⁺ T cells.| | View in PubMed
- Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo.| | View in PubMed
- Immunoendocrinology: Scientific and Clinical Aspects. Eisenbarth, GS (Ed.)| | View in PubMed
- AIRE in the thymus and beyond.| | View in PubMed
- The sickness unto Deaf.| | View in PubMed
- Deletional tolerance mediated by extrathymic Aire-expressing cells.| | View in PubMed
- Mycobacterium tuberculosis-specific CD8+ T cells preferentially recognize heavily infected cells.| | View in PubMed