Biography
Dr. Elaine Tseng is Professor of Surgery in the Division of Cardiothoracic Surgery at University of California San Francisco Medical Center. Her clinical expertise includes minimally invasive aortic valve replacement with Y-root enlargement, Ross operation, aortic surgery including ascending thoracic aortic aneurysm repairs, valve sparing aortic root replacements, structural heart disease—transcatheter aortic valve replacement and transcatheter edge-to-edge repair, and multi-arterial coronary artery bypass grafting.
Dr. Tseng grew up in North Carolina where she attended the North Carolina School of Science and Mathematics. She was a National Merit Scholar. She completed her undergraduate Bachelor of Science at the Massachusetts Institute of Technology where she graduated Phi Beta Kappa with a GPA 5.0. She earned her medical degree at Harvard Medical School and was one of three recipients per year of the Virginia A. Linnane Scholarship. Dr. Tseng underwent her general surgery training at The Johns Hopkins Hospital, where she received the George D. Zeidema Surgery Award and the Vincent L. Gott Cardiac Surgery Award. She was inducted into the Alpha Omega Alpha Honor Society and was awarded the Nina Braunwald Research Fellowship Award from The Thoracic Surgery Foundation for Research and Education. She also received the Hawley H. Seiler MD Award from the Southern Thoracic Surgical Association. Dr. Tseng underwent her clinical and advanced training in cardiothoracic surgery at The Johns Hopkins Hospital.
After completing her education and training, she joined the cardiac surgery staff at the UCSF and SFVA Medical Centers in 2002. Her academic research interests over the past 20 years have involved biomechanics, fluid dynamics, and computational simulations of aortic root surgery, including aortic stenosis, transcatheter aortic valves, Ross operation, ascending thoracic aortic aneurysm (aTAA) and dissection. She has been NIH R01 funded surgeon-scientist investigating the biomechanics of ascending thoracic aortic aneurysms to determine better predictors of type A dissection than maximum diameter. She is currently funded through a VA Merit award to investigate the impact of aTAA biomechanics on dissection, rupture, and all-cause mortality. She is the UCSF/SFVA site-principal investigator for the multi-institutional international randomized trial of treatment of ascending thoracic aortic aneurysms, TITAN trial, early surgery vs surveillance for 5.0-5.4cm aneurysms. She has published >100 scientific papers and book chapters. Dr. Tseng serves on the Society of Thoracic Surgeons (STS) Workforce on New Technology, American Association for Thoracic Surgery (AATS) Clinical Practice Standards Committee. She is on the Board of Directors of the Heart Valve Society, and the Thoracic Surgery Foundation. She is the Vice-Chair of the Cardiovascular Surgery and Anesthesia Council of the American Heart Association and is Senior Editor in the Editorial Board of Annals of Thoracic Surgery. She is a fellow of the American College of Surgeons and the American Heart Association and is certified by the American Board of Surgery and the American Board of Thoracic Surgery.
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of California | Diversity, Equity, and Inclusion Champion Training | 2018 | |
Lenox Hill Hospital | Fellowship | Endovascular/Interventional Cardiology | 2006 |
Johns Hopkins Hospital | Fellowship | Cardiac Surgery | 2000 |
Johns Hopkins Hospital | Research Fellowship | Cardiac Surgery | 1997 |
Johns Hopkins Hospital | Residency | General Surgery | 1995 |
Johns Hopkins Hospital | Internship | General Surgery | 1994 |
Harvard Medical School | M.D. | Health Sciences and Technology (HST) Division | 1993 |
Massachusetts Institute of Technology | B.S. | 1989 |
Board Certifications
American Board of Surgery, 2000
American Board of Thoracic Surgery, 2003
Clinical Expertise
Acute and chronic type B aortic dissections
Aortic arch aneurysms
Aortic valve surgery
Ascending aortic and arch surgery
Endovascular repair of descending thoracic aortic aneurysm
Hypothermic circulatory arrest (HCA)
Marfan syndrome
Maze procedure for atrial fibrillation
Maze procedure for atrial fibrillation
Minimally invasive valve surgery
Off-pump coronary artery bypass
Reoperative cardiac surgery
Robotic cardiac surgery
Clinical Trials
- Related Conditions: Aneurysm| Start Date: | End Date:
Grants and Funding
- Developing Biomechanical Predictors of Ascending Thoracic Aortic Aneurysm Growth and Dissection | Veteran Affairs | 2022-04-01 - 2026-04-01 | Role: Principal Investigator
- Development of a System to Remove and Replace Transcatheter Heart Valves Percutaneously | Veterans Affairs | 2023-04-01 - 2024-03-31 | Role: Principal Investigator
- Improved Rupture Risk Assessment of Ascending Thoracic Aortic Aneurysms: Application of Patient-specific Modeling and Biomechanics | Marfan Fundation | 2020-02-15 - 2023-06-30 | Role: Principal Investigator
- Biomechanical Understanding of Ascending Thoracic Aortic Aneurysms | NIH | 2015-04-01 - 2021-03-31 | Role: Principal Investigator
Research Interests
Publications
- Height and body surface area versus wall stress for stratification of mid-term outcomes in ascending aortic aneurysm.| | View in PubMed
- Impact of Oral Anticoagulation on Clinical Outcomes in Postoperative Atrial Fibrillation.| | View in PubMed
- Sex differences in ascending aortic size reporting and growth on chest computed tomography and magnetic resonance imaging.| | View in PubMed
- Navigating Promotion in Thoracic Surgery.| | View in PubMed
- Ascending thoracic aortic aneurysm size at presentation and growth by diameter.| | View in PubMed
- Reimplantation vs Remodeling: End of the Debate?| | View in PubMed
- Perspectives on the 2022 joint guidelines on the diagnosis and management of aortic disease.| | View in PubMed
- 2022 ACC/AHA guideline for the diagnosis and management of aortic disease: A report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.| | View in PubMed
- Aortic area/height ratio, peak wall stresses, and outcomes in veterans with tricuspid versus bicuspid aortic valve-associated ascending thoracic aortic aneurysms.| | View in PubMed
- Ascending thoracic aortic aneurysm elongation occurs in parallel with dilatation in a nonsurgical population.| | View in PubMed
- Formal consensus study on surgery to replace the aortic valve in adults aged 18-60 years.| | View in PubMed
- Regional and directional delamination properties of healthy human ascending aorta and sinotubular junction.| | View in PubMed
- 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.| | View in PubMed
- 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.| | View in PubMed
- Midterm Durability and Structural Valve Degeneration of Transcatheter Aortic Valve Replacement in a Federal Facility.| | View in PubMed
- Proximal Aortic Surgery in Women-We Need to Do Better.| | View in PubMed
- Association of 3-Year All-Cause Mortality and Peak Wall Stresses of Ascending Thoracic Aortic Aneurysms in Veterans.| | View in PubMed
- Regional wall stress differences on tricuspid aortic valve-associated ascending aortic aneurysms.| | View in PubMed
- Eptifibatide bridging therapy for staged carotid artery stenting and cardiac surgery: Safety and feasibility.| | View in PubMed
- Under Pressure-To See or Not To See.| | View in PubMed
- Ascending thoracic aortic aneurysm growth is minimal at sizes that do not meet criteria for surgical repair.| | View in PubMed
- Restrictive versus liberal transfusion in patients with diabetes undergoing cardiac surgery: An open-label, randomized, blinded outcome evaluation trial.| | View in PubMed
- Time to Remove the Left Atrial Appendage at Surgery: LAAOS III in Perspective.| | View in PubMed
- Wall stresses of early remodeled pulmonary autografts.| | View in PubMed
- Patient-Specific Biomechanics in Marfan Ascending Thoracic Aortic Aneurysms.| | View in PubMed
- Regional biomechanical and failure properties of healthy human ascending aorta and root.| | View in PubMed
- Discussion.| | View in PubMed
- Minimally invasive surgical aortic valve replacement in setting of pseudoxanthoma elasticum.| | View in PubMed
- Association of diameter and wall stresses of tricuspid aortic valve ascending thoracic aortic aneurysms.| | View in PubMed
- Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer.| | View in PubMed
- Development of the Minimalist Approach for Transcatheter Aortic Valve Replacement at a Veterans Affairs Medical Center.| | View in PubMed
- Impact of Transcatheter Aortic Valve Size on Leaflet Stresses: Implications for Durability and Optimal Grey Zone Sizing.| | View in PubMed
- Commentary: Virtual thoracic endovascular aortic repair for type A aortic dissection: Engineering transforms clinical reality.| | View in PubMed
- Long-term outcomes after transcatheter aortic valve implantation in failed bioprosthetic valves.| | View in PubMed
- Reply from authors: Aortic aneurysm biomechanics: Perfect is the enemy of good.| | View in PubMed
- Stent and leaflet stresses across generations of balloon-expandable transcatheter aortic valves.| | View in PubMed
- Wall Stress Distribution in Bicuspid Aortic Valve-Associated Ascending Thoracic Aortic Aneurysms.| | View in PubMed
- Wall stress analyses in patients with ≥5 cm versus <5 cm ascending thoracic aortic aneurysm.| | View in PubMed
- Outcomes of Veterans Undergoing TAVR Within Veterans Affairs Medical Centers: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program.| | View in PubMed
- Veterans Affairs Heart Team Experience With Transcatheter Aortic Valve Replacement and Minimally Invasive Surgical Aortic Valve Replacement.| | View in PubMed
- Evolution of Minimally Invasive Surgical Aortic Valve Replacement at a Veterans Affairs Medical Center.| | View in PubMed
- Evolution of Bilateral Mammary Arterial Grafting Program in Veterans Affairs Medical Center.| | View in PubMed
- Range of Pulmonary Autograft Responses to Systemic Pressure Immediately After Ross Procedure.| | View in PubMed
- Randomized Trial of Endoscopic or Open Vein-Graft Harvesting for Coronary-Artery Bypass.| | View in PubMed
- Factors associated with early dropout in an employer-based commercial weight-loss program.| | View in PubMed
- Long-term retention in an employer-based, commercial weight-loss programme.| | View in PubMed
- Stent and leaflet stresses in 26-mm, third-generation, balloon-expandable transcatheter aortic valve.| | View in PubMed
- Wall stress on ascending thoracic aortic aneurysms with bicuspid compared with tricuspid aortic valve.| | View in PubMed
- Evolution of Veterans Affairs Transcatheter Aortic Valve Replacement Program: The First 100 Patients.| | View in PubMed
- Impact of Patient-Specific Material Properties on Aneurysm Wall Stress: Finite Element Study.| | View in PubMed
- Gated thoracic magnetic resonance angiography at 3T: noncontrast versus blood pool contrast.| | View in PubMed
- Stent and Leaflet Stresses in 29-mm Second-Generation Balloon-Expandable Transcatheter Aortic Valve.| | View in PubMed
- Leaflet Mechanical Properties of Carpentier-Edwards Perimount Magna Pericardial Aortic Bioprostheses.| | View in PubMed
- Ferumoxytol MRA for transcatheter aortic valve replacement planning with renal insufficiency.| | View in PubMed
- Stent and leaflet stresses in a 26-mm first-generation balloon-expandable transcatheter aortic valve.| | View in PubMed
- Biomechanics of Failed Pulmonary Autografts Compared to Native Aortic Roots.| | View in PubMed
- In vitro evaluation of implantation depth in valve-in-valve using different transcatheter heart valves.| | View in PubMed
- Biomechanics of Failed Pulmonary Autografts Compared With Normal Pulmonary Roots.| | View in PubMed
- Suture Forces for Closure of Transapical Transcatheter Aortic Valve Replacement: A Mathematical Model.| | View in PubMed
- Vascular Operations Performed by Cardiothoracic Surgeons: The Society of Thoracic Surgeons Survey.| | View in PubMed
- When valve-in-valve implantation is not sufficient: Bioprosthetic Russian dolls.| | View in PubMed
- Flow-Induced Damage to Blood Cells in Aortic Valve Stenosis.| | View in PubMed
- Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.| | View in PubMed
- Bicuspid Aortic Valve-Associated Ascending Thoracic Aortic Aneurysm: Patient-Specific Finite Element Analysis.| | View in PubMed
- In Vitro Kinetic Characterization of Axitinib Metabolism.| | View in PubMed
- Proof of concept of FOLDAVALVE, a novel 14 Fr totally repositionable and retrievable transcatheter aortic valve.| | View in PubMed
- Ascending thoracic aortic aneurysm wall stress analysis using patient-specific finite element modeling of in vivo magnetic resonance imaging.| | View in PubMed
- Development of a Veterans Affairs hybrid operating room for transcatheter aortic valve replacement in the cardiac catheterization laboratory.| | View in PubMed
- Extended 3D approach for quantification of abnormal ascending aortic flow.| | View in PubMed
- Patient-specific finite element analysis of ascending thoracic aortic aneurysm.| | View in PubMed
- Successful percutaneous management of partial avulsion of the native aortic valve complex complicating transcatheter aortic valve replacement.| | View in PubMed
- Systolic flow displacement correlates with future ascending aortic growth in patients with bicuspid aortic valves undergoing magnetic resonance surveillance.| | View in PubMed
- Human pulmonary autograft wall stress at systemic pressures prior to remodeling after the Ross procedure.| | View in PubMed
- Feasibility of asymmetric stretch assessment in the ascending aortic wall with DENSE cardiovascular magnetic resonance.| | View in PubMed
- Invited commentary.| | View in PubMed
- Biomechanical properties of human ascending thoracic aortic aneurysms.| | View in PubMed
- Biventricular finite element modeling of the Acorn CorCap Cardiac Support Device on a failing heart.| | View in PubMed
- Magnetic resonance measurement of turbulent kinetic energy for the estimation of irreversible pressure loss in aortic stenosis.| | View in PubMed
- Identification of multiple 5-HT₄ partial agonist clinical candidates for the treatment of Alzheimer's disease.| | View in PubMed
- Improved preclinical cardiovascular therapeutic indices with long-term inhibition of norepinephrine reuptake using reboxetine.| | View in PubMed
- Material properties of CorCap passive cardiac support device.| | View in PubMed
- Imaging biomarkers of aortic disease: increased growth rates with eccentric systolic flow.| | View in PubMed
- Acute type A aortic dissection intimal tears by 64-slice computed tomography: a role for endovascular stent-grafting?| | View in PubMed
- Hemodynamic determinants of aortic dissection propagation by 2D computational modeling: implications for endovascular stent-grafting.| | View in PubMed
- Regional mechanical properties of human pulmonary root used for the Ross operation.| | View in PubMed
- Cerebrospinal fluid amyloid-β (Aβ) as an effect biomarker for brain Aβ lowering verified by quantitative preclinical analyses.| | View in PubMed
- Correlation of calcification on excised aortic valves by micro-computed tomography with severity of aortic stenosis.| | View in PubMed
- Patient-specific multiscale modeling of blood flow for coronary artery bypass graft surgery.| | View in PubMed
- The 5-hydroxytryptamine4 receptor agonists prucalopride and PRX-03140 increase acetylcholine and histamine levels in the rat prefrontal cortex and the power of stimulated hippocampal θ oscillations.| | View in PubMed
- First evidence of depressed contractility in the border zone of a human myocardial infarction.| | View in PubMed
- A coupled biventricular finite element and lumped-parameter circulatory system model of heart failure.| | View in PubMed
- Biomechanical comparison of human pulmonary and aortic roots.| | View in PubMed
- Transcatheter heart valves for failing bioprostheses: state-of-the-art review of valve-in-valve implantation.| | View in PubMed
- Incidental aortic valve calcification on CT scans: significance for bicuspid and tricuspid valve disease.| | View in PubMed
- Echo rounds: aneurysm of the anterior mitral valve.| | View in PubMed
- Comparison of mechanical properties of human ascending aorta and aortic sinuses.| | View in PubMed
- Post-stenotic dilation: evaluation of ascending aortic dilation with 4D flow MR imaging.| | View in PubMed
- Operative risks and survival in veterans with severe aortic stenosis: surgery versus medical therapy.| | View in PubMed
- Valve-in-valve hemodynamics of 20-mm transcatheter aortic valves in small bioprostheses.| | View in PubMed
- Finite element modeling of the pulmonary autograft at systemic pressure before remodeling.| | View in PubMed
- Closure of aortic paravalvular leak under intravascular ultrasound and intracardiac echocardiography guidance.| | View in PubMed
- Transcatheter valve-in-valve implantation for failing bioprosthetic valves.| | View in PubMed
- Live transference of surgical subspecialty skills using telerobotic proctoring to remote general surgeons.| | View in PubMed
- Comparison of porcine pulmonary and aortic root material properties.| | View in PubMed
- Transcatheter aortic valves inadequately relieve stenosis in small degenerated bioprostheses.| | View in PubMed
- Glutamate excitotoxicity mediates neuronal apoptosis after hypothermic circulatory arrest.| | View in PubMed
- Energy loss due to paravalvular leak with transcatheter aortic valve implantation.| | View in PubMed
- Valve-in-valve implantation using a novel supravalvular transcatheter aortic valve: proof of concept.| | View in PubMed
- A computationally efficient formal optimization of regional myocardial contractility in a sheep with left ventricular aneurysm.| | View in PubMed
- Biomechanical perspective on the porcine pulmonary root prior to Ross remodeling.| | View in PubMed
- Migration forces of transcatheter aortic valves in patients with noncalcific aortic insufficiency.| | View in PubMed
- Aortic valve-in-valve implantation: impact of transcatheter- bioprosthesis size mismatch.| | View in PubMed
- Usability of robotic platforms for remote surgical teleproctoring.| | View in PubMed
- Computational fluid dynamics simulation of transcatheter aortic valve degeneration.| | View in PubMed
- Mechanical properties of surgical glues used in aortic root replacement.| | View in PubMed
- Retrograde cerebral perfusion and delayed hyperbaric oxygen for massive air embolism during cardiac surgery.| | View in PubMed
- Significant material property differences between the porcine ascending aorta and aortic sinuses.| | View in PubMed
- Robotic mammary artery harvest and anastomotic device allows minimally invasive mitral valve repair and coronary bypass.| | View in PubMed
- A simple correction for anomalous coronary arteries in adults.| | View in PubMed
- Robotic cardiac surgery: give it more time!| | View in PubMed
- Invited commentary.| | View in PubMed
- Asymmetric mechanical properties of porcine aortic sinuses.| | View in PubMed
- Central nervous system pharmacokinetics of the Mdr1 P-glycoprotein substrate CP-615,003: intersite differences and implications for human receptor occupancy projections from cerebrospinal fluid exposures.| | View in PubMed
- Percutaneous technique for creation of tricuspid regurgitation in an ovine model.| | View in PubMed
- Use of bivalirudin, a direct thrombin inhibitor, and its reversal with modified ultrafiltration during heart transplantation in a patient with heparin-induced thrombocytopenia.| | View in PubMed
- Reversal of direct thrombin inhibition after cardiopulmonary bypass in a patient with heparin-induced thrombocytopenia.| | View in PubMed
- Profound hypoxemia resulting from shunting across an inadvertent atrial septal tear after left ventricular assist device placement.| | View in PubMed
- Barrett's esophagus with high grade dysplasia: surgical results and long-term outcome--an update.| | View in PubMed
- Cerebral hemodynamics changes during retrograde brain perfusion in dogs.| | View in PubMed
- Training women surgeons and their academic advancement.| | View in PubMed
- Laparoscopic nephrectomy for autotransplantation.| | View in PubMed
- Prevalence of aspiration and laryngeal penetration in patients with unilateral vocal fold motion impairment.| | View in PubMed
- Apoptosis detection in brain using low-magnification dark-field microscopy.| | View in PubMed
- Assessing the impact of cerebral injury after cardiac surgery: will determining the mechanism reduce this injury?| | View in PubMed
- Increased intracerebral excitatory amino acids and nitric oxide after hypothermic circulatory arrest.| | View in PubMed
- Nitric oxide mediates neurologic injury after hypothermic circulatory arrest.| | View in PubMed
- Relationship of the long thoracic nerve to the scapular tip: an aid to prevention of proximal nerve injury.| | View in PubMed
- Monosialoganglioside GM1 inhibits neurotoxicity after hypothermic circulatory arrest.| | View in PubMed
- The role of the monosialoganglioside, GM1 as a neuroprotectant in an experimental model of cardiopulmonary bypass and hypothermic circulatory arrest.| | View in PubMed
- Neuronal nitric oxide synthase inhibition reduces neuronal apoptosis after hypothermic circulatory arrest.| | View in PubMed
- Aortic valve replacement in the elderly. Risk factors and long-term results.| | View in PubMed
- Selective endothelial dysfunction in conscious dogs after cardiopulmonary bypass.| | View in PubMed
- Pathophysiology of cerebral injury and future management.| | View in PubMed
- Overcoming rejection in pig-to-primate cardiac xenotransplantation.| | View in PubMed