UCSF Begins Clinical Trial of Incision-free Obesity Treatment
UCSF News reports on the "TOGA" study led by Stanley Rogers, MD, FACS, Associate Clinical Professor of Surgery and Co-Director of the UCSF Bariatric Surgery Center, and John Cello, MD, Professor of Medicine and Surgery, and Medical Director of Bariatric Surgery Center. The investigational procedure, transoral gastroplasty, or "TOGA" for short, is being tested in a clinical trial. UCSF is one of nine U.S. trial sites. Drs. Rogers and Cello are principal investigators on the study.
A team of specialists at UCSF Medical Center has treated its first patients as part of a multi-center clinical study to evaluate an incision-free procedure for the treatment of obesity.
Like other obesity procedures, this investigational treatment is designed to modify stomach anatomy to give the patient a feeling of fullness after a small meal, therefore decreasing calorie intake.
The new treatment differs from standard procedures, such as the gastric bypass, because it is performed through the mouth, without incisions. In gastric bypass, which is surgical stomach stapling to treat obesity, incisions are made in the abdominal wall, a surgical approach that has been used for over 30 years. This new incision-free technique represents the next generation of bariatric surgery, according to the UCSF team.
The medical name for the investigational procedure is transoral gastroplasty, which is known informally as TOGA. The surgeon introduces a set of flexible stapling devices through the mouth into the stomach and, with endoscopic imaging, uses the devices to create a restrictive pouch. The pouch is intended to retain food as it enters the stomach, giving patients a feeling of fullness and reducing caloric intake........
Stanley Rogers, MD, FACS, associate clinical professor of surgery and co-director of the UCSF Bariatric Surgery Center, and John Cello, MD, professor of medicine and surgery and a member of the gastroenterology division, are principal investigators of the UCSF clinical trial. In late January, they headed a multidisciplinary team that performed the first two of 30 procedures currently scheduled at UCSF Medical Center. UCSF is one of nine TOGA trial sites in the U.S., and there is one site in Belgium.
“Current results from studies performed in humans show weight loss outcomes similar to that achieved with the more invasive surgical procedures, including gastric banding,” said Rogers. The TOGA procedure typically takes just over an hour to perform, he said, and the short procedure time means patients are under anesthesia for less time than during the standard gastroplasty surgery. This, in addition to the absence of abdominal wall incisions, will allow the TOGA procedure ultimately to be performed on an outpatient basis, he added. This contrasts with laparoscopic procedures, which involve an incision in the abdominal wall and a hospital stay of usually 24 to 48 hours.