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Department of Surgery »  Faculty »  Vascular Surgery »  Marlene Grenon, M.D., C.M.
Marlene Grenon, M.D., C.M.

Marlene Grenon, M.D., C.M.

Associate Professor
Division of Vascular and Endovascular Surgery

Contact Information

Division of Vascular and Endovascular Surgery, UCSF
400 Parnassus Avenue, A-501
San Francisco, CA 94143-0957
Phone: (415) 353-2357
Fax: (415) 353-2669
Marlene.Grenon@ucsf.edu
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  • 1998, International Space University, Diploma in Space Sciences
  • 1995-00, McGill University, Doctorate of Medicine and Masters of Surgery
  • 2002-04, Harvard Medical School, Master in Medical Sciences - Clinical Investigations
  • 2000-02, Dalhousie University, Resident, Cardiac Surgery
  • 2002-06, McGill University, Resident, Cardiac Surgery
  • 2006-07, McGill University, Chief Resident, Cardiac Surgery
  • 2007-09, University of British Columbia, Fellow, Vascular Surgery
  • 2009-10, Arizona Heart Institute, Fellow, Vascular and Endovascular Surgery
  • 2002-04, Harvard Medical School & Massachussetts Institute of Technology, Research Fellow, Cardiovascular Space Medicine
  • Abdominal Aortic Aneurysm
  • Carotid Artery Disease
  • Chronic Venous Insufficiency
  • Complex Limb Revascularization
  • Critical Limb Ischemia
  • Deep Vein Thrombosis
  • Diabetic Vascular Disease
  • Dialysis Access
  • Endovascular Aneurysm Repair
  • Mesenteric Artery Disease
  • Peripheral Artery Disease
  • Thoracic Aortic Aneurysm
  • Varicose Veins
  • Vascular Malformations

Dr. Marlene Grenon was born in Quebec, Canada. She obtained a diploma in space sciences from the International Space University (ISU) in 1998. She graduated from McGill Medical School in 2000 and obtained a Masters' degree from the Scholars in Clinical Science Program of Harvard Medical School along with a post-doctoral fellowship in cardiovascular space medicine and endocrinology from Brigham and Women's Hospital and the Massachusetts Institute of Technology (MIT) in 2004. She then completed training in cardiac surgery at McGill University in 2007, vascular surgery at the University of British Columbia in 2009 and endovascular surgery at the Arizona Heart Institute in 2010. She is a fellow from the Royal College of Physicians and Surgeons of Canada (RCPSC) and maintains a Certificate of Specialist in both cardiac and vascular surgery from RCPSC.

Dr. Grenon is presently an Associate Professor in the Department of Surgery at UCSF, a Staff surgeon at the VAMC San Francisco and an Adjunct Faculty at the International Space University. She is a member of many professional organizations and has been an invited lecturer at several regional, national and international meetings and conferences. She is the recipient of several awards for research and was one of the finalists in the 2009 Canadian Astronaut selection.

My current research program encompasses two areas:

Lifestyle modifications for peripheral arterial disease (PAD)

It is well known that lifestyle issues including nutrition, physical activity, and stress have a high impact on disease development and readaptation in patients with cardiovascular disease. The evidence for how nutrition, physical activity, and stress affect patients with PAD is less clear. In my research program, we are conducting different clinical studies on how these factors impact PAD.

For example, in one study,"OMEGA-PAD", we are investigating the effects of omega-3 fatty acids (fish oil) in patients with PAD, looking more specifically at endothelial function and inflammation. In another study, the "OMEGA-Bedrest" study we are investigating the effects of physical inactivity on endothelial function, insulin resistance and inflammation, and are also testing a countermeasure (fish oil) for physical inactivity.

These clinical trials parallel research projects in my basic science laboratory studying how fatty acids influence the interactions between monocytes and endothelial cells, two cell lines critical to the development of atherosclerosis. We hope that these studies will help us understand how factors present in everyday life can impact the development of atherosclerotic disease in the lower extremities and how we can target specific therapies or lifestyle modification programs to help with this disease.


Adaptations to the gravitational mechanical unloading environment

What happens during spaceflight is not too different than when people lack physical exercise: the cardiovascular system becomes deconditioned. This part of my research program aims to draw parallels between what we can learn from astronauts flying in space and cardiovascular diseases on earth. Hence, we are conducting studies simulating the effects of microgravity on earth, specifically at the level of the organ ("physiological") and at the level of the cells ("cellular").


 

Most recent publications from a total of 70
  1. Walker RE, Jackson KH, Tintle NL, Shearer GC, Bernasconi A, Masson S, Latini R, Heydari B, Kwong RY, Flock M, Kris-Etherton PM, Hedengran A, Carney RM, Skulas-Ray A, Gidding SS, Dewell A, Gardner CD, Grenon SM, Sarter B, Newman JW, Pedersen TL, Larson MK, Harris WS. Predicting the effects of supplemental EPA and DHA on the omega-3 index. Am J Clin Nutr. 2019 Oct 01; 110(4):1034-1040. View in PubMed
  2. Ramirez JL, Zahner GJ, Spaulding KA, Khetani SA, Hills NK, Gasper WJ, Harris WS, Cohen BE, Grenon SM. Peripheral Artery Disease Is Associated with a Deficiency of Erythrocyte Membrane n-3 Polyunsaturated Fatty Acids. Lipids. 2019 04; 54(4):211-219. View in PubMed
  3. Ramirez JL, Gasper WJ, Khetani SA, Zahner GJ, Hills NK, Mitchell PT, Sansbury BE, Conte MS, Spite M, Grenon SM. Fish Oil Increases Specialized Pro-resolving Lipid Mediators in PAD (The OMEGA-PAD II Trial). J Surg Res. 2019 Jun; 238:164-174. View in PubMed
  4. Zahner GJ, Ramirez JL, Spaulding KA, Khetani SA, Gasper WJ, Grunfeld C, Hills NK, Schafer AL, Grenon SM. Leptinemia is Associated With Peripheral Artery Disease. J Surg Res. 2019 Jun; 238:48-56. View in PubMed
  5. Drudi LM, Ades M, Landry T, Gill HL, Grenon SM, Steinmetz OK, Afilalo J. Scoping review of frailty in vascular surgery. J Vasc Surg. 2019 Jun; 69(6):1989-1998.e2. View in PubMed
  6. Ramirez JL, Khetani SA, Zahner GJ, Spaulding KA, Schaller MS, Gasper WJ, Hills NK, Schafer AL, Grenon SM. Serum resistin is associated with impaired endothelial function and a higher rate of adverse cardiac events in patients with peripheral artery disease. J Vasc Surg. 2019 02; 69(2):497-506. View in PubMed
  7. Ramirez JL, Grenon SM. Depression and peripheral artery disease: why we should care and what we can do. CVIR Endovasc. 2018; 1(1):14. View in PubMed
  8. Hernandez NV, Ramirez JL, Khetani SA, Spaulding KA, Gasper WJ, Hiramoto J, Lindqvist D, Wolkowitz OM, Hills NK, Grenon SM, Zahner GJ. Depression severity is associated with increased inflammation in veterans with peripheral artery disease. Vasc Med. 2018 10; 23(5):445-453. View in PubMed
  9. Ramirez JL, Drudi LM, Grenon SM. Review of biologic and behavioral risk factors linking depression and peripheral artery disease. Vasc Med. 2018 10; 23(5):478-488. View in PubMed
  10. Schaller MS, Ramirez JL, Gasper WJ, Zahner GJ, Hills NK, Grenon SM. Frailty Is Associated with an Increased Risk of Major Adverse Cardiac Events in Patients with Stable Claudication. Ann Vasc Surg. 2018 Jul; 50:38-45. View in PubMed
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