Surgery Websites
Department of Surgery »  Faculty »  Vascular Surgery »  Marlene Grenon, M.D., C.M.
Marlene Grenon, M.D., C.M.

Marlene Grenon, M.D., C.M.

Associate Professor
Division of Vascular and Endovascular Surgery

Contact Information

Division of Vascular and Endovascular Surgery, UCSF
400 Parnassus Avenue, A-501
San Francisco, CA 94143-0957
Phone: (415) 353-2357
Fax: (415) 353-2669
Marlene.Grenon@ucsf.edu
Open Popup
  • 1998, International Space University, Diploma in Space Sciences
  • 1995-00, McGill University, Doctorate of Medicine and Masters of Surgery
  • 2002-04, Harvard Medical School, Master in Medical Sciences - Clinical Investigations
  • 2000-02, Dalhousie University, Resident, Cardiac Surgery
  • 2002-06, McGill University, Resident, Cardiac Surgery
  • 2006-07, McGill University, Chief Resident, Cardiac Surgery
  • 2007-09, University of British Columbia, Fellow, Vascular Surgery
  • 2009-10, Arizona Heart Institute, Fellow, Vascular and Endovascular Surgery
  • 2002-04, Harvard Medical School & Massachussetts Institute of Technology, Research Fellow, Cardiovascular Space Medicine

Dr. Marlene Grenon was born in Quebec, Canada. She obtained a diploma in space sciences from the International Space University (ISU) in 1998. She graduated from McGill Medical School in 2000 and obtained a Masters' degree from the Scholars in Clinical Science Program of Harvard Medical School along with a post-doctoral fellowship in cardiovascular space medicine and endocrinology from Brigham and Women's Hospital and the Massachusetts Institute of Technology (MIT) in 2004. She then completed training in cardiac surgery at McGill University in 2007, vascular surgery at the University of British Columbia in 2009 and endovascular surgery at the Arizona Heart Institute in 2010. She is a fellow from the Royal College of Physicians and Surgeons of Canada (RCPSC) and maintains a Certificate of Specialist in both cardiac and vascular surgery from RCPSC.

Dr. Grenon is presently an Associate Professor in the Department of Surgery at UCSF, a Staff surgeon at the VAMC San Francisco and an Adjunct Faculty at the International Space University. She is a member of many professional organizations and has been an invited lecturer at several regional, national and international meetings and conferences. She is the recipient of several awards for research and was one of the finalists in the 2009 Canadian Astronaut selection.

My current research program encompasses two areas:

Lifestyle modifications for peripheral arterial disease (PAD)

It is well known that lifestyle issues including nutrition, physical activity, and stress have a high impact on disease development and readaptation in patients with cardiovascular disease. The evidence for how nutrition, physical activity, and stress affect patients with PAD is less clear. In my research program, we are conducting different clinical studies on how these factors impact PAD.

For example, in one study,"OMEGA-PAD", we are investigating the effects of omega-3 fatty acids (fish oil) in patients with PAD, looking more specifically at endothelial function and inflammation. In another study, the "OMEGA-Bedrest" study we are investigating the effects of physical inactivity on endothelial function, insulin resistance and inflammation, and are also testing a countermeasure (fish oil) for physical inactivity.

These clinical trials parallel research projects in my basic science laboratory studying how fatty acids influence the interactions between monocytes and endothelial cells, two cell lines critical to the development of atherosclerosis. We hope that these studies will help us understand how factors present in everyday life can impact the development of atherosclerotic disease in the lower extremities and how we can target specific therapies or lifestyle modification programs to help with this disease.


Adaptations to the gravitational mechanical unloading environment

What happens during spaceflight is not too different than when people lack physical exercise: the cardiovascular system becomes deconditioned. This part of my research program aims to draw parallels between what we can learn from astronauts flying in space and cardiovascular diseases on earth. Hence, we are conducting studies simulating the effects of microgravity on earth, specifically at the level of the organ ("physiological") and at the level of the cells ("cellular").


 

ResidentYearsGrant or Funding Source
Melinda Schaller, M.D. 7/2015 - 6/2017
 
Most recent publications from a total of 64
  1. Hernandez NV, Ramirez JL, Khetani SA, Spaulding KA, Gasper WJ, Hiramoto J, Lindqvist D, Wolkowitz OM, Hills NK, Grenon SM, Zahner GJ. Depression severity is associated with increased inflammation in veterans with peripheral artery disease. Vasc Med. 2018 Jul 01; 1358863X18787640. View in PubMed
  2. Ramirez JL, Drudi LM, Grenon SM. Review of biologic and behavioral risk factors linking depression and peripheral artery disease. Vasc Med. 2018 May 01; 1358863X18773161. View in PubMed
  3. Arya S, Lee S, Zahner GJ, Cohen BE, Hiramoto J, Wolkowitz OM, Khakharia A, Binney ZO, Grenon SM. The association of comorbid depression with mortality and amputation in veterans with peripheral artery disease. J Vasc Surg. 2018 Mar 24. View in PubMed
  4. Schaller MS, Ramirez JL, Gasper WJ, Zahner GJ, Hills NK, Grenon SM. Frailty Is Associated with an Increased Risk of Major Adverse Cardiac Events in Patients with Stable Claudication. Ann Vasc Surg. 2018 Mar 22. View in PubMed
  5. Zahner GJ, Spaulding KA, Ramirez JL, Schaller MS, Walker SC, Hills NK, Gasper WJ, Grenon SM. Characterizing the relationship between flow-mediated vasodilation and radial artery tonometry in peripheral artery disease. J Surg Res. 2018 Apr; 224:121-131. View in PubMed
  6. Lindqvist D, Mellon SH, Dhabhar FS, Yehuda R, Grenon SM, Flory JD, Bierer LM, Abu-Amara D, Coy M, Makotkine I, Reus VI, Aschbacher K, Bersani FS, Marmar CR, Wolkowitz OM. Increased circulating blood cell counts in combat-related PTSD: Associations with inflammation and PTSD severity. Psychiatry Res. 2017 Dec; 258:330-336. View in PubMed
  7. Zahner GJ, Gruendl MA, Spaulding KA, Schaller MS, Hills NK, Gasper WJ, Grenon SM. Association between arterial stiffness and peripheral artery disease as measured by radial artery tonometry. J Vasc Surg. 2017 Nov; 66(5):1518-1526. View in PubMed
  8. Schaller MS, Zahner GJ, Gasper WJ, Harris WS, Conte MS, Hills NK, Grenon SM. Relationship between the omega-3 index and specialized pro-resolving lipid mediators in patients with peripheral arterial disease taking fish oil supplements. J Clin Lipidol. 2017 Sep - Oct; 11(5):1289-1295. View in PubMed
  9. Drudi LM, Schaller MS, Hiramoto J, Gasper W, Harris WS, Hills NK, Grenon SM. Predictors of change in omega-3 index with fish oil supplementation in peripheral artery disease. J Surg Res. 2017 Apr; 210:124-131. View in PubMed
  10. Lindqvist D, Dhabhar FS, Mellon SH, Yehuda R, Grenon SM, Flory JD, Bierer LM, Abu-Amara D, Coy M, Makotkine I, Reus VI, Bersani FS, Marmar CR, Wolkowitz OM. Increased pro-inflammatory milieu in combat related PTSD - A new cohort replication study. Brain Behav Immun. 2017 Jan; 59:260-264. View in PubMed
  11. View All Publications
Publications provided by UCSF Profiles, powered by CTSI at UCSF. View profile of Marlene Grenon, M.D., C.M.
Please note: UCSF Profiles publications are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact CTSI for help.

Site Directory
    X