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Department of Surgery »  Faculty »  Transplant Surgery  »  Garrett R. Roll, M.D.
Garrett R. Roll, M.D., FACS

Garrett R. Roll, M.D., FACS

  • Associate Professor of Surgery
  • Division of Transplant Surgery

Contact Information

Academic Office
(415) 353-8725
garrett.roll@ucsf.edu
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Boston College, BS, Finance, 1995-1999
Brandeis University, Post Baccalaureate, Premedical, 1999-2001
Temple University School of Medicine, MD, 2001-2005

  • University of California, San Francisco, General Surgery, 2005-2012
  • UCSF Department of GI Hepatology Research Fellowship
  • University of California, San Francisco, Abdominal Transplant Surgery, 2012-2014
  • Senior international Fellow in liver transplant and retrieval, Queen Elizabeth Hospital, Birmingham, England
  • American Board of Surgery, General Surgery
  • Transplantation
  • HBP surgery
  • Cell therapy with hepatocytes and hepatocyte-like cells derived from stem cells.
  • Normothetic machine liver perfusion
  • Role of miRNA in liver regeneration

Dr. Roll is a general surgeon specializing in abdominal organ transplantation. He completed both general surgery training and the abdominal organ transplant fellowship at the University of California San Francisco. 

During his training, Dr. Roll spent 2 years in Dr. Holger Willenbring's laboratory investigating stem cell biology in the context of liver cell therapy, as well as normal and pathologic liver regeneration. His research concentrated on the use of hepatocyte-like cells derived from stem cells to be used in liver cell therapy. In particular, Dr. Roll investigated the regenerative capabilities of hepatocytes derived from induced pluripotent stem (iPS) cells. They used a genetically deficient mouse model of liver disease as a way to test the functional capabilities of these cells after transplantation. They were able to demonstrate that the profound proliferative capabilities of adult hepatocytes are retained by hepatocytes derived from iPS cells, and transplanting these cells rescued mice with liver failure. Dr. Roll also investigated the role of miRNA in liver regeneration, and the rejection of transplanted hepatocytes and hepatocyte-like cells. The principles of his research will remain valuable in liver and pancreas cell therapy translational science for years.

After fellowship Dr. Roll moved to England to become a Senior International Fellow in Liver Transplant and Multi Organ Procurement at Queen Elizabeth Hospital, Birmingham, one of the busiest liver transplant departments in the United Kingdom. There he gained valuable experience in the blossoming field of normothermic machine liver perfusion prior to returning to UCSF. 

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MOST RECENT PUBLICATIONS FROM A TOTAL OF 96
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  1. Steven Wisel, Miguel Nunez, James M Gardner, Giulia Worner, Garrett R Roll, Shareef M Syed, Gregory Szot, Medhi Tokhol, Kristina Johnson, Umesh Masharani, Andrew M Posselt, Peter G Stock. 214.1: Strategies to Achieve Long-term Insulin Independence Using a Multimodal Approach to Beta-cell Replacement in Patients With Type I Diabetes. Transplantation. 2022 Sep 13; 106(9S):s34-s34. View in PubMed
  2. Raphael Meier, Miguel Nunez, Shareef Syed, Chris Freise, John Roberts, Nancy Ascher, Ryutaro Hirose, Garrett Roll. 335.4: Use of Donation After Circulatory Death Donors for High Model for End-Stage Liver Disease Recipients. Transplantation. 2022 Sep 13; 106(9S):s294-s294. View in PubMed
  3. Roll GR, Quintini C, Reich DJ. In quest of the what, when, and where for machine perfusion dynamic liver preservation: Carpe diem! Liver Transpl. 2022 Jul 18. View in PubMed
  4. Chen AK, Lunow-Luke T, Yamaguchi S, Praglin C, Agudelo E, Mehta N, Dirks R, Braun HJ, Gardner JM, Roberts JP, Syed SM, Roll GR. Nodular Regenerative Hyperplasia After Liver Transplant; It's All in the Presentation. Front Surg. 2022; 9:876818. View in PubMed
  5. Freise J, Nunez M, Chi T, Stoller M, Freise C, Roll GR. Therapeutic Living Donor Nephrectomy for Proximal Ureteral Pathology: A Longitudinal Case Series. Urology. 2022 Aug; 166:277-282. View in PubMed
  6. View All Publications

 

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