Department of Surgery »  Faculty »  Rajalingam Raja, Ph.D., D(ABHI)
Rajalingam Raja, Ph.D., D(ABHI)

Rajalingam Raja, Ph.D., D(ABHI)

Clinical Professor of Surgery
Director, Immunogenetics and Transplantation Laboratory

Contact Information

Immunogenetics and Transplantation Laboratory
University of California at San Francisco
Main Hospital Level B, CPMC Davis Campus
45 Castro Street
San Francisco, CA 94114
Phone: (415) 476-0647
Fax: (415) 476-0379
Rajalingam.Raja@ucsf.edu
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  • University of Madras, India. B.Sc., 1984
  • Bharathiyar University, India. M.Sc., 1988
  • University of Madras, India. M.Phil., 1989
  • All India Institute of Medical Sciences, India. Ph.D., 1996
  • Postdoctoral Fellow, Stanford University, Stanford 1997-2002

Rajalingam Raja, Ph.D., D(ABHI) is a Clinical Professor in the Department of Surgery and the Director of Immunogenetics and Transplantation Laboratory (ITL) at UCSF. ITL provides cutting edge histocompatibility testing service for solid organ and hematopoietic stem cell transplantation.

Dr. Raja earned his Ph.D. in Immunogenetics at the All India Institute of Medical Sciences, New Delhi in 1997. He was a postdoctoral fellow at Stanford University. Dr. Raja's current research centers on understanding the complex relationship between polymorphic NK cell receptors and HLA class I ligands in human health and disease.

Natural killer (NK) have been implicated in control and clearance of malignant and virally infected cells, regulation of adaptive immune responses, rejection of bone marrow transplants, autoimmunity and the maintenance of pregnancy. Human NK cells largely use a family of Human Leukocyte Antigen (HLA)-specific Killer cell Immunoglobulin-like Receptors (KIR) to recognize and respond to the unhealthy target cells. KIR and HLA loci are both polygenic and substantially polymorphic, and they map to distinct human chromosomes (Chromosomes 19 and 6, respectively).

KIR and HLA gene families segregate independently, yielding many individuals who express KIR receptors for which they lack HLA class I ligands, and vice versa, thus creating human diversity in the number and type of KIR-HLA inherited gene pairs, which potentially could influence the health and disease status of a given individual. The overall goal of our research is to understand the diversity of KIR receptors, HLA ligands, and KIR-HLA gene combinations in populations and their relevance in human health and disease.

Most recent publications from a total of 67
  1. Heaney AP, Sumerel B, Rajalingam R, Bergsneider M, Yong WH, Liau LM. HLA Markers DQ8 and DR53 Are Associated With Lymphocytic Hypophysitis and May Aid in Differential Diagnosis. J Clin Endocrinol Metab. 2015 Nov; 100(11):4092-7. View in PubMed
  2. Lin L, Ma C, Wei B, Aziz N, Rajalingam R, Yusung S, Erlich HA, Trachtenberg EA, Targan SR, McGovern DP, Heath JR, Braun J. Human NK cells licensed by killer Ig receptor genes have an altered cytokine program that modifies CD4+ T cell function. J Immunol. 2014 Jul 15; 193(2):940-9. View in PubMed
  3. Osman AE, Mubasher M, ElSheikh NE, AlHarthi H, Al Yami AS, Rajalingam R, Al-Dehaimi A, Middleton D, ElGhazali G. Characterization of human killer immunoglobulin-like receptors (KIRs) among healthy Saudis. Hum Immunol. 2014 Jun; 75(6):536-40. View in PubMed
  4. Rajalingam R, Ashouri E. Gene-specific PCR typing of killer cell immunoglobulin-like receptors. Methods Mol Biol. 2013; 1034:239-55. View in PubMed
  5. Vierra-Green C, Roe D, Hou L, Hurley CK, Rajalingam R, Reed E, Lebedeva T, Yu N, Stewart M, Noreen H, Hollenbach JA, Guethlein LA, Wang T, Spellman S, Maiers M. Allele-level haplotype frequencies and pairwise linkage disequilibrium for 14 KIR loci in 506 European-American individuals. PLoS One. 2012; 7(11):e47491. View in PubMed
  6. Sauna ZE, Ameri A, Kim B, Yanover C, Viel KR, Rajalingam R, Cole SA, Howard TE. Observations regarding the immunogenicity of BDD-rFVIII derived from a mechanistic personalized medicine perspective. J Thromb Haemost. 2012 Sep; 10(9):1961-5. View in PubMed
  7. Rajalingam R. Overview of the killer cell immunoglobulin-like receptor system. Methods Mol Biol. 2012; 882:391-414. View in PubMed
  8. Rajalingam R. Human diversity of killer cell immunoglobulin-like receptors and disease. Korean J Hematol. 2011 Dec; 46(4):216-28. View in PubMed
  9. Abi-Rached L, Jobin MJ, Kulkarni S, McWhinnie A, Dalva K, Gragert L, Babrzadeh F, Gharizadeh B, Luo M, Plummer FA, Kimani J, Carrington M, Middleton D, Rajalingam R, Beksac M, Marsh SG, Maiers M, Guethlein LA, Tavoularis S, Little AM, Green RE, Norman PJ, Parham P. The shaping of modern human immune systems by multiregional admixture with archaic humans. Science. 2011 Oct 7; 334(6052):89-94. View in PubMed
  10. Solgi G, Ghafari H, Ashouri E, Alimoghdam K, Rajalingam R, Amirzargar A. Comparison of KIR gene content profiles revealed a difference between northern and southern Persians in the distribution of KIR2DS5 and its linked loci. Hum Immunol. 2011 Nov; 72(11):1079-83. View in PubMed
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