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Department of Surgery »  Faculty »  Pediatric Surgery »  Tippi MacKenzie, M.D.

Tippi MacKenzie, M.D.

Professor of Surgery
Division of Pediatric Surgery
Co-director, UCSF Center for Maternal-Fetal Precision Medicine
UCSF Benioff Children's Hospital, San Francisco



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  • 1987-91, Harvard University, B.A., Biochemistry
  • 1992-97, Stanford University School of Medicine, M.D., Medicine
  • 1998-99, Brigham and Women's Hospital, Resident, Surgery
  • 2002-04, Brigham and Women's Hospital, Resident, Surgery
  • 2004-05, Brigham and Women's Hospital, Chief Resident, Surgery
  • 1999-02, Children's Hospital of Philadelphia, Fellow, Fetal Therapy
  • 2005-07, Children's Hospital of Philadelphia, Fellow, Pediatric Surgery
  • American Board of Surgery, 2006
  • Fetal Treatment Center
  • Biomedical Sciences Program
  • Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
  • Center for Maternal-Fetal Precision Medicine
  • Advanced Laparoscopy
  • Birth Defects
  • Endocrine and Biliary Surgery
  • Fetal Surgery
  • Pediatric Surgery
  • In-Utero Stem Cell Transplantation

Dr. Tippi MacKenzie is Professor of Surgery at the UCSF Division of Pediatric Surgery and the Fetal Treatment Center. Dr. MacKenzie obtained her undergraduate degree in Biochemistry at Harvard, then came to the Bay Area for medical school at Stanford. She did her surgical residency at Brigham and Women's Hospital in Boston. During this time, she took three years to do research on fetal surgery and in utero stem cell transplantation at the Children's Hospital of Philadelphia. Following residency, she returned to CHOP for her clinical pediatric surgery fellowship.

Dr. MacKenzie's clinical interests include fetal surgery, advanced laparoscopy, and endocrine and biliary surgery.

Dr. MacKenzie has an active laboratory and is a member of the Biomedical Sciences Program and the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research. Her research focus is on mechanisms of tolerance induction following in utero stem cell transplantation  and the pathophysiology of prenatally diagnosed diseases, such as congenital diaphragmatic hernia and gastroschisis, to identify biomarkers that predict prognosis and molecular pathways that may be targets for prenatal intervention.

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  • Autoimmune Regulator gene (Aire)-mediated tolerance to pregnancy-associated self-antigens
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    Aug 2019
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    Jul 2024
    Principal Investigator
  • In utero hematopoietic stem cell transplantation for the treatment of fetuses with alpha thalassemia major (phase I clinical trial)
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    Aug 2017
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    Jul 2022
    Principal Investigator
  • A precision medicine approach to detect dysbiosis and immune activation in preterm labor
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    Jul 2017
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    Jun 2021
    Principal Investigator
  • T cell activation and the breakdown of maternal-fetal tolerance in preterm labor
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    Jun 2015
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    May 2020
    Principal Investigator
  • Maternal and fetal immune responses to in utero HSC transplantation
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    Jul 2010
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    May 2015
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  • IN UTERO MESENCHYMAL STEM CELL TRANSPLANTATION
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    Jan 2000
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    Jan 0001
    Principal Investigator
Data provided by UCSF Profiles, powered by CTSI
MOST RECENT PUBLICATIONS FROM A TOTAL OF 76
Data provided by UCSF Profiles, powered by CTSI
  1. Witt RG, Blair L, Frascoli M, Rosen MJ, Nguyen QH, Bercovici S, Zompi S, Romero R, Mackenzie TC. Detection of microbial cell-free DNA in maternal and umbilical cord plasma in patients with chorioamnionitis using next generation sequencing. PLoS One. 2020; 15(4):e0231239. View in PubMed
  2. Nguyen QH, Witt RG, Wang B, Eikani C, Shea J, Smith LK, Boyle G, Cadaoas J, Sper R, MacKenzie JD, Villeda S, MacKenzie TC. Tolerance induction and microglial engraftment after fetal therapy without conditioning in mice with Mucopolysaccharidosis type VII. Sci Transl Med. 2020 02 26; 12(532). View in PubMed
  3. Halkias J, Rackaityte E, Hillman SL, Aran D, Mendoza VF, Marshall LR, MacKenzie TC, Burt TD. CD161 contributes to prenatal immune suppression of IFN?-producing PLZF+ T cells. J Clin Invest. 2019 05 30; 129(9):3562-3577. View in PubMed
  4. Almeida-Porada G, Waddington SN, Chan JKY, Peranteau WH, MacKenzie T, Porada CD. In Utero Gene Therapy Consensus Statement from the IFeTIS. Mol Ther. 2019 04 10; 27(4):705-707. View in PubMed
  5. Witt RG, Wang B, Nguyen QH, Eikani C, Mattis AN, MacKenzie TC. Depletion of murine fetal hematopoietic stem cells with c-Kit receptor and CD47 blockade improves neonatal engraftment. Blood Adv. 2018 12 26; 2(24):3602-3607. View in PubMed
  6. View All Publications

 

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