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Department of Surgery »  Faculty »  Pediatric Surgery »  Tippi MacKenzie, M.D.

Tippi MacKenzie, M.D.

  • Professor of Surgery
  • Benioff UCSF Professor in Children’s Health
  • Director, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF
  • Co-Director, Center for Maternal-Fetal Precision Medicine
  • John G. Bowes Distinguished Professor in Stem Cell and Tissue Biology

Contact Information

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Education

  • 1987-91, Harvard University, B.A., Biochemistry
  • 1992-97, Stanford University School of Medicine, M.D., Medicine

Residencies

  • 1998-99, Brigham and Women's Hospital, Resident, Surgery
  • 2002-04, Brigham and Women's Hospital, Resident, Surgery
  • 2004-05, Brigham and Women's Hospital, Chief Resident, Surgery

Fellowships

  • 1999-02, Children's Hospital of Philadelphia, Fellow, Fetal Therapy
  • 2005-07, Children's Hospital of Philadelphia, Fellow, Pediatric Surgery

Board Certifications

  • American Board of Surgery, 2006

Program Affiliations

  • Fetal Treatment Center
  • Biomedical Sciences Program
  • Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
  • Center for Maternal-Fetal Precision Medicine

Clinical Expertise

  • Advanced Laparoscopy
  • Birth Defects
  • Endocrine and Biliary Surgery
  • Fetal Surgery
  • Pediatric Surgery

Research Interests

  • In-Utero Stem Cell Transplantation

Website Links

Biography

Dr. Tippi MacKenzie is Professor of Surgery at the UCSF Division of Pediatric Surgery and the Fetal Treatment Center. Dr. MacKenzie obtained her undergraduate degree in Biochemistry at Harvard, then came to the Bay Area for medical school at Stanford. She did her surgical residency at Brigham and Women's Hospital in Boston. During this time, she took three years to do research on fetal surgery and in utero stem cell transplantation at the Children's Hospital of Philadelphia. Following residency, she returned to CHOP for her clinical pediatric surgery fellowship.

Dr. MacKenzie's clinical interests include fetal surgery, advanced laparoscopy, and endocrine and biliary surgery.

Research Overview

Dr. MacKenzie has an active laboratory and is a member of the Biomedical Sciences Program and the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research. Her research focus is on mechanisms of tolerance induction following in utero stem cell transplantation  and the pathophysiology of prenatally diagnosed diseases, such as congenital diaphragmatic hernia and gastroschisis, to identify biomarkers that predict prognosis and molecular pathways that may be targets for prenatal intervention.

Research & Funding

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  • Phase 1 Study of In Utero Enzyme Replacement Therapy for the Treatment of Lysosomal Storage Diseases
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    Sep 2022
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    Apr 2027
    Principal Investigator
  • Developing gene therapy strategies to treat alpha thalassemia
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    Jan 2022
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    Dec 2025
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  • Autoimmune Regulator gene (Aire)-mediated tolerance to pregnancy-associated self-antigens
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    Aug 2019
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    Jul 2024
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  • In utero hematopoietic stem cell transplantation for the treatment of fetuses with alpha thalassemia major (phase I clinical trial)
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    Aug 2017
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    Jul 2022
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  • A precision medicine approach to detect dysbiosis and immune activation in preterm labor
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    Jul 2017
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    Jun 2021
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  • T cell activation and the breakdown of maternal-fetal tolerance in preterm labor
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    Jun 2015
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    May 2020
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  • Maternal and fetal immune responses to in utero HSC transplantation
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    Jul 2010
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    May 2015
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  • IN UTERO MESENCHYMAL STEM CELL TRANSPLANTATION
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    Jan 2000
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    Jan 0001
    Principal Investigator

Clinical Trials

Data provided by UCSF Profiles, powered by CTSI

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 98
Data provided by UCSF Profiles, powered by CTSI
  1. Yu TW, Kingsmore SF, Green RC, MacKenzie T, Wasserstein M, Caggana M, Gold NB, Kennedy A, Kishnani PS, Might M, Brooks PJ, Morris JA, Parisi MA, Urv TK. Are we prepared to deliver gene-targeted therapies for rare diseases? Am J Med Genet C Semin Med Genet. 2023 Jan 24. View in PubMed
  2. Cohen JL, Chakraborty P, Fung-Kee-Fung K, Schwab ME, Bali D, Young SP, Gelb MH, Khaledi H, DiBattista A, Smallshaw S, Moretti F, Wong D, Lacroix C, El Demellawy D, Strickland KC, Lougheed J, Moon-Grady A, Lianoglou BR, Harmatz P, Kishnani PS, MacKenzie TC. In Utero Enzyme-Replacement Therapy for Infantile-Onset Pompe's Disease. N Engl J Med. 2022 12 08; 387(23):2150-2158. View in PubMed
  3. Schwab ME, Lianoglou BR, Gano D, Gonzalez Velez J, Allen IE, Arvon R, Baschat A, Bianchi DW, Bitanga M, Bourguignon A, Brown RN, Chen B, Chien M, Davis-Nelson S, de Laat MWM, Ekwattanakit S, Gollin Y, Hirata G, Jelin A, Jolley J, Meyer P, Miller J, Norton ME, Ogasawara KK, Panchalee T, Schindewolf E, Shaw SW, Stumbaugh T, Thompson AA, Towner D, Tsai PS, Viprakasit V, Volanakis E, Zhang L, Vichinsky E, MacKenzie TC. The impact of in utero transfusions on perinatal outcomes in patients with alpha thalassemia major: the UCSF registry. Blood Adv. 2023 01 24; 7(2):269-279. View in PubMed
  4. Schwab ME, Shao S, Zhang L, Lianoglou B, Belter L, Jarecki J, Schroth M, Sumner CJ, MacKenzie T. Investigating attitudes toward prenatal diagnosis and fetal therapy for spinal muscular atrophy. Prenat Diagn. 2022 10; 42(11):1409-1419. View in PubMed
  5. Herzeg A, Almeida-Porada G, Charo RA, David AL, Gonzalez-Velez J, Gupta N, Lapteva L, Lianoglou B, Peranteau W, Porada C, Sanders SJ, Sparks TN, Stitelman DH, Struble E, Sumner CJ, MacKenzie TC. Prenatal Somatic Cell Gene Therapies: Charting a Path Toward Clinical Applications (Proceedings of the CERSI-FDA Meeting). J Clin Pharmacol. 2022 09; 62 Suppl 1:S36-S52. View in PubMed
  6. View All Publications

Videos

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  1. Part 1: Tippi and Elianna’s Story: Stopping a Fatal Blood Disease Before Birth
  2. Part 2: Tippi, Elliott and Elianna’s Story: Little Girl Thrives After Fetal Stem Cell Transplant
  3. First Clinical Trial of In Utero Stem Cell Transplant for Alpha Thalassemia Major
  4. Treating Disease Before Birth with Tippi MacKenzie, MD

In the News

  • Fetal Therapy Offers Hope for Patients with Rare Genetic Disorders

    UCSF Campus News - Jess Berthold - November 09, 2022
    Fetal Therapy Offers Hope for Patients with Rare Genetic Disorders Toddler Thrives with Same Disease That Ended Siblings' Lives When Zahid and Sobia Bashir discovered their fetus had the same genetic disease that took the lives of two of their young children, they didn't hesitate to sign up for a promising but experimental new therapy. "I found out (the therapy) was a possibility and I was kind of in shock; I couldn't believe it," said Zahid Basir. "I only [...]

  • 3 UCSF Faculty Elected to the National Academy of Medicine for 2022

    UCSF Campus News - Robin Marks - October 17, 2022
    Three UC San Francisco faculty members are among the 100 new national members elected this year to the National Academy of Medicine (NAM), one of the highest honors in the fields of health and medicine. Membership in the NAM recognizes individuals who have demonstrated outstanding professional achievements and commitment to service in the medical sciences, health care and public health. "This extraordinary class of new members is comprised of exceptional scholars and leaders who have been [...]

  • UCSF Medical Student Eva Gillis-Buck Awarded UCSF 2020 Long-Term Dean's Prize in Research

    UCSF General Surgery Residency Program - Alexi Callen - May 08, 2020
    Eva Gillis-Buck, UCSF School of Medicine Class of 2020 and incoming general surgery resident, was awarded the UCSF 2020 Long-Term Dean's Prize in Research.  The Long-Term Dean's Prize is available to all UCSF graduating medical students. Finalists were selected based on the submission of a one-page abstract, letter of nomination, and 5-minute presentation to the faculty review committee. Five prizes for long-term research were awarded and all winners presented a virtual pre-recorded video at [...]

  • In Utero Stem Cell Transplants, Enzyme Replacement May Offer New Treatments for Deadly Metabolic Disorders

    UCSF Pediatric Surgery - Richard Barg - March 02, 2020
    "This group of vulnerable patients has been relatively ignored in the fetal surgery world," said UCSF's Tippi MacKenzie, MD, senior author of the new study and member of the Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, who has worked for a decade developing novel therapies for heritable diseases that can be treated before birth. "We know these patients could potentially benefit from a number of medical therapies. So this is our first foray into treating one of [...]

  • Baby Born in World’s First In Utero Stem Cell Transplant Trial

    UCSF Pediatric Surgery - Richard Barg - June 25, 2018
    UCSF News reports on the first patient enrolled in the world's first clinical trial using blood stem cells transplanted prior to birth. The stem cell transplant was used to treat alpha thalassemia major, a blood disorder that is only detected in the last few months of pregnancy and has been almost uniformly fatal in the past. The clinical trial is led by Tippi MacKenzie, MD, an associate professor in the UCSF Division of Pediatric Surgery and co-Director of the UCSF Center for Maternal-Fetal [...]

  • Surgical Innovations Hosts Symposium Uniting Partners Around Children's Health

    UCSF Surgical Innovations - Stacy Kim - May 22, 2018
    UCSF 20180517 Childrens Health Symposium 075
    On May 17, the Second Annual UCSF Engineering for Children's Health Symposium was held at Mission Bay Conference Center. Over one hundred clinicians, engineers, scientists, administrators, industry professionals, and government partners gathered to discuss groundbreaking research and developing technologies in pediatric medicine. The event commenced with opening remarks by Hanmin Lee, MD, Surgeon-in-Chief of the UCSF Benioff Children's Hospitals and Professor and Chief of the UCSF Division [...]

  • CIRM Awards Tippi MacKenzie, MD $12.1M to Treat Fetuses in the Womb Alpha Thalassemia Major

    UCSF Pediatric Surgery - Richard Barg - July 10, 2017
    Pediatric Surgeon Tippi MacKenzie, MD was awarded $12.1 million by the California Institute for Regenerative Medicine (CIRM) to treat fetuses in the womb suffering from alpha thalassemia major, a blood disorder that is only detected in the last few months of pregnancy and is almost uniformly fatal.  Dr. MacKenzie, an associate professor in the UCSF Division of Pediatric Surgery and co-Director of the UCSF Center for Maternal-Fetal Precision Medicine, is using hematopoietic stem cells (HSCs), [...]

  • New Collaboration Launched to Advance Technology for Children’s Health

    Department of Surgery, Surgical Innovations Program - Stacy Kim - March 02, 2017
    On January 12, clinicians, engineers, scientists, and administrators from UCSF, UC Berkeley. UCSF Benioff Children's Hospitals, and Children's Hospital Oakland Research Institute (CHORI) convened at the Mission Bay campus for the inaugural Engineering for Children's Health Symposium. The event, reported in UCSF News, marked the launch of a collaborative effort dedicated to developing innovative technological solutions to improve patient safety, eliminate health disparities, cure disease, and [...]

  • UCSF Researchers Reappraise Treatment for Gastroschisis, Shining Light on Role of Immune System

    UCSF Pediatric Surgery - Richard Barg - May 24, 2016
    UCSF News reports on the work of a UCSF research team investigating the causes and potential treatments for gastroschisis, a rare disorder in which developing intestines protrude outside of the body through a hole alongside the belly button. Led by pediatric surgeon Tippi MacKenzie, MD, Associate Professor of Surgery in the UCSF Division of Pediatric Surgery and co-Director of the UCSF Center for Maternal-Fetal Precision Medicine, the team published findings elucidating the role of the immune [...]

  • Immune System Drives Pregnancy Complications after Fetal Surgery in Mice

    UCSF Pediatric Surgery - January 24, 2014
    UCSF News report on how the immune system drives pregnancy complications after fetal surgery in mice. As a fetal surgeon at UC San Francisco, Tippi MacKenzie, MD, has long known that conducting surgery on a fetus to correct a problems such as spina bifida often results in preterm labor and premature birth. Now, MacKenzie and her UCSF colleagues have shown that, in mice at least, pregnancy complications after fetal surgery are triggered by activation of the mother's T cells – the same T [...]

  • Maternal Liver Grafts More Tolerable for Children with Rare Disease

    UCSF Pediatric Surgery - November 16, 2012
    UCSF News reports that on a study that suggests maternal liver grafts more tolerable for children with biliary atresia, a rare, life-threatening disease, results that may have important implications for counseling parents on organ donation Children with a rare, life-threatening disease that is the most common cause of neonatal liver failure – biliary atresia – better tolerate liver transplants from their mothers than from their fathers, according to a UCSF-led study. In the study, [...]

  • Mother’s Stem Cells Likely Key To Treating Genetic Disease Before Birth

    UCSF Pediatric Surgery - January 18, 2011
    UCSF News reports on fetal stem cell transplantation, taking healthy cells from the bone marrow of a donor, and transplanting them into the fetus through ultrasound-guided injections with the goal of having the implanted cells, or graft, replenish the patient's supply of healthy blood-forming cells. UCSF researchers have tackled a decade-long scientific conundrum, and their discovery is expected to lead to significant advances in using stem cells to treat genetic diseases before birth. [...]

  • Institute for Fetal and Neonatal Health 1st Annual Research Symposium

    UCSF Pediatric Surgery - November 02, 2010
    UCSF announces the formation of the Institute for Fetal and Neonatal Health symposium brings together clinicians and basic scientists involved in different aspects of development and fetal intervention.

  • Brilliance and Precision: From Surgery to In Utero Transplantation

    UCSF Pediatric Surgery - June 15, 2009
    As a gifted pianist in high school, Assistant Professor of Surgery Tippi MacKenzie, MD, spent every Saturday studying music at Juilliard. This musical training was good preparation for her current work as a researcher and surgeon.   "When you're playing the piano, you work out the details in a dif cult passage until it's perfect," she said. "It's the same with science. If there's an issue with your experiment, you can't just sweep it under the rug. you tackle that problem." With a [...]

 

 
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