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Amar Nijagal, M.D.

Amar Nijagal, M.D.

Assistant Professor of Surgery
Division of Pediatric Surgery
UCSF Benioff Children's Hospital, San Francisco

Contact Information

Box 0570
550 16th Street
San Francisco, CA 94158
amar.nijagal@ucsf.edu

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1996-2000, Duke University, B.A. Philosophy

2000-06, University of California, San Francisco, M.D.

  • 2006-07, University of California, San Francisco, Intern, General Surgery
  • 2007-13, University of California, San Francisco, Resident, General Surgery
  • 2013-14, University of California, San Francisco, Chief Resident, General Surgery
  • California Institute for Regenerative Medicine Clinical Fellow (2009-2012)
  • 2014-16, Boston Children's Hospital, Fellow, Pediatric General and Thoracic Surgery
  • American Board of Surgery, General Surgery
  • Hepatobiliary surgery Neonatal surgery Minimally invasive surgery Pediatric Surgery
  • Immunology at the maternal-fetal interface

Amar Nijagal, M.D. is a pediatric surgeon in the UCSF Division of Pediatric Surgery. He completed his undergraduate degree at Duke University and obtained his MD from the University of CA, San Francisco School of Medicine (UCSF).

During his general surgery residency at UCSF, he spent three years researching immune responses to in utero stem cell transplantation. He completed his pediatric general and thoracic surgery fellowship at Boston Children's Hospital.

Franklin H. Martin, MD, FACS Faculty Research Fellowship
American College of Surgeons
2019 - 2021
APSA Foundation Jay Grosfeld, MD Scholar Research Award
American Pediatric Surgical Association
2018 - 2019
Esther Nusz Achievement Award
UCSF Department of Surgery
2014
Medical Student Teaching Award
UCSF Department of Surgery
2014
Medical Student Teaching Award
UCSF Department of Surgery
2013
M. Judah Folkman Memorial Award-Best Podium Presentation
American Pediatric Surgical Association
2012
M. Judah Folkman Memorial Award-Best Podium Presentation
American Pediatric Surgical Association
2011
Camille Vandenberge-Storz Young Investigators' Award
International Fetal and Maternal Surgical Society
2011
Clinical Fellow Research Training Award
California Institute for Regenerative Medicine
2009 - 2012
Resident Research Award
Association of Academic Surgeons
2009
Alpha Omega Alpha
UCSF School of Medicine
2005

Investigating How Immune Cells Regulate the Development and Repair of Fetal Organs

We study how immune cells may regulate the development and repair of fetal organs.  Our research is currently focused on the development of the liver and bile ducts as the fetal liver is ripe with interactions between developing hepatocytes/cholangiocytes and the hematopoietic system.  We are interested in identifying key relationships and interactions between immune cells and developing tissues in both the steady state and during fetal injury.  Using advanced surgical techniques in mouse models, we are able to manipulate and induce injury in fetal organs.  We have also employed "discovery" approaches to identify novel cell types and pathways that may serve as a link between the immune system and fetal development. 

More at Nijagal Lab

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ORCID iD: 0000-0003-2200-6887 Additional info
  • The cooperative relationship between neutrophils and monocytes during neonatal liver inflammation: insight into the pathogenesis of biliary atresia
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    Jul 2019
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    Jun 2021
  • Single cell characterization and organoid development of pediatric choledochal cysts and hepatoblastoma to understand the link between liver development and hepatobiliary malignancy
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    Feb 2020
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    Jan 2021
  • The Role of Monocytes During the Resolution of Perinatal Liver Inflammation
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    Jun 2019
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    May 2020
  • Investigating the Fetal Mechanisms of Liver and Bile Duct Repair: A Link to the Prenatal Origins of Biliary Atresia
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    Jul 2018
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    Jun 2019
    PI
MOST RECENT PUBLICATIONS FROM A TOTAL OF 30
Data provided by UCSF Profiles, powered by CTSI
  1. Alkhani A, Levy CS, Tsui M, Rosenberg KA, Polovina K, Mattis AN, Mack M, Van Dyken S, Wang BM, Maher JJ, Nijagal A. Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation. Sci Rep. 2020 Apr 28; 10(1):7165. View in PubMed
  2. Ramirez JL, Kuhrau CR, Wu B, Zarkowsky DS, Conte MS, Oskowitz AZ, Nijagal A, Vartanian SM. Natural history of acute pediatric iliofemoral artery thrombosis treated with anticoagulation. J Vasc Surg. 2020 Apr 08. View in PubMed
  3. Schwab ME, Song H, Mattis A, Phelps A, Vu LT, Huang FW, Nijagal A. De novo somatic mutations and KRAS amplification are associated with cholangiocarcinoma in a patient with a history of choledochal cyst. J Pediatr Surg. 2020 Mar 24. View in PubMed
  4. Subbaraj L, Beleniski F, Courtier J, Vartanian S, Nijagal A. Congenital superior mesenteric artery aneurysm in a 6-week-old infant presenting with upper gastrointestinal bleeding. J Vasc Surg. 2020 04; 71(4):1391-1394. View in PubMed
  5. Nijagal A, Perito ER. Treating Biliary Atresia: The Challenge Continues. J Pediatr Gastroenterol Nutr. 2019 04; 68(4):464-465. View in PubMed
  6. View All Publications
  1. A Nijagal, M Wegorzewska, T Le, TC MacKenzie. Fetal intervention triggers the activation of paternal antigen-specific maternal T cells. American Pediatric Surgical Association 43rd Annual Meeting, San Antonio, TX, May 2011. accepted.
  2. A Nijagal, S Fleck, NK Hills, S Feng, Q Tang, SM Kang, P Rosenthal, TC MacKenzie. Maternal liver transplantation in patients with biliary atresia leads to lower risk of graft failure. American Academy of Pediatrics Annual Conference, Boston, MA. 2011.
  3. A Nijagal, T Le, M Wegorzewska, A Tucker, TC MacKenzie. Peripheral tolerance mechanisms are important for the maintenance of donor cell engraftment after in utero hematopoietic cell transplantation. American College of Surgeons 97th Annual Clinical Congress, San Francisco, CA. 2011.
  4. A Nijagal, M Wegorzewska, T Le, J Gonzalez, TC MacKenzie. The maternal adaptive immune response against paternal antigens incites fetal demise after detal intervention. American Pediatric Surgical Association 42nd Annual Meeting, Palm Springs, CA, May 2011.
  5. G Bautista, KD Gonzales, A Nijagal, C Ward, DN Miniati, H Lee, S Keating, P Norris, TH Lee, M Busch, TC MacKenzie. Maternal-fetal cellular signaling mechanisms in severe congenital giaphragmatic hernia. American Pediatric Surgical Association 42nd Annual Meeting, Palm Springs, CA, May 2011.
  6. A Nijagal, T Le, M Wegorzewska, A Tucker, Q Tang, TC MacKenzie. Regulatory T cells establish and maintain chimerism after in utero hematopoietic cell transplantation, IMMUNOLOGY 2011. 98th Annual Meeting of the American Association of Immunologists, San Francisco, CA 2011.
  7. A Nijagal, M Wegorzewska, T Le, A Tucker, Q Tang, TC MacKenzie. Altered T cell profiles in uterine draining lymph nodes of mice with preterm labor, IMMUNOLOGY 2011. 98th Annual Meeting of the American Association of Immunologists, San Francisco, CA 2011.
  8. M Wegorzewska, A Nijagal, T Le, A Tucker, Q Tang, TC MacKenzie. Preterm labor leads to activation and proliferation of maternal T cells which recognize the paternal alloantigen via the indirect pathway, IMMUNOLOGY 2011. 98th Annual Meeting of the American Association of Immunologists, San Francisco, CA 2011.
  9. A Nijagal, S Fleck, SM Kang, P Rosenthal, TC MacKenzie. Improved outcomes of living related liver transplantation with maternal donors in patients with biliary atresia, American Academy of Pediatrics Annual Conference, San Francisco, CA 2010.
  10. TC MacKenzie, A Nijagal, T Le, M Wegorzewska, Q Tang. Indirect antigen presentation following in utero HSC transplantation leads to clonal deletion of antigen specific T effector cells with formation of Tregs. International Society for Stem Cell Research 8th Annual Meeting, San Francisco, CA. June 2010.
  11. L Landsman, A Nijagal, WE Zimmer, T MacKenzie, M Hebrok. Transgenic studies reveal essential roles for embryonic pancreatic mesenchyme. Cold Spring Harbor Vertebrate Organogenesis, Cold Spring Harbor, NY. April 2010.
  12. A Nijagal, M Wegorzewska, E Jarvis, T Le, Q Tang, and T MacKenzie. The maternal immune response limits engraftment after in utero hematopoietic stem cell transplantation. California Institute for Regenerative Medicine 2010 Grantee Meeting. San Francisco, CA. March 2010.
  13. T MacKenzie, E Jarvis, A Nijagal, T Le, M Wegorzewska, and Q Tang. The maternal immune response to in utero hematopoietic stem cell transplantation. The American Society of Hematology, New Orleans, LA. . December 2009.
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