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Department of Surgery »  Faculty »  General Surgery »  Valerie M. Weaver, Ph.D.
Valerie M. Weaver, Ph.D.

Valerie M. Weaver, Ph.D.

Professor of Surgery
Departments of Surgery, Anatomy, and Bioengineering & Therapeutics Sciences
Director, Center for Bioengineering & Tissue Regeneration


Contact Information

513 Parnassus Avenue, Room HSE 560
San Francisco, CA 94143-0456
Telephone: 415-476-3826
Fax: 415-476-3985
http://weaverlab.ucsf.edu 
Valerie.Weaver@ucsf.edu
 
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University of Ottawa, Canada, B.Sc. (Honors), 1986
University of Ottawa, Canada, Ph.D., 1992

  • Institute for Biological Sciences, National Research Council of Canada, Postdoctoral Fellow, Molecular Cell Biology, 1992-94
  • Lawrence Berkeley National Laboratory, UC Berkeley, Postdoctoral Fellow, Cancer and Cell Biology, 1994-98

Valerie M. Weaver, Ph.D., is the Director of the Center for Bioengineering and Tissue Regeneration in the Department of Surgery. She earned her Bachelor of Science degree at the University of Waterloo in Biochemistry/Chemistry in 1985, continuing her education for an Honors Bachelor of Science in Biochemistry at the University of Ottawa (graduating Summa cum Laude). Dr. Weaver earned her doctorate degree, Ph.D, from the University of Ottawa in Biochemistry in 1992.

After receiving her doctorate, Dr. Weaver was awarded the Molecular Cell Biology and Apoptosis Research Group and the Institute for Biological Sciences of Canada Postdoctoral Fellow from 1992-1994.  From 1994-1998, she was distinguished as the Postdoctoral Fellow at the Lawrence Berkeley National Laboratory at the University of California, Berkeley, in the Cancer and Cell Biology Group, Life Sciences Division.

Following her fellowships, Dr. Weaver has held principle positions within academia. Prior to her appointment at UCSF, she was an Adjunct Associate Professor with the Department of Bioengineering at the University of Pennsylvania from 1999 to 2006. In her current position, she is an Professor with the Department of Surgery at the Universality of California, San Francisco.

Additionally, Dr. Weaver is the Director for the Center for Bioengineering & Tissue Regeneration with the Department of Surgery and UCSF, an Associate Professor in the Department of Anatomy at UCSF, and Adjunct Associate Professor for the department of Bioengineering at UPenn. From 1999 to 2006 she was a member at the Institute for Medicine and Engineering at UPenn.

Dr. Weaver's extensive honors and awards include: the Breast Cancer Scholar Award with the Department of Defense, the International Society of Differentiation Young Investigator Travel Award, the Alberta Heritable Foundation for Medical Research Lecturer Award, and the University of California Breast Cancer Research Program Postdoctoral Grant.

She also proudly serves on the Editorial Board for Cancer Biology & Therapy, was a guest editor in 2004 for J. Mammary Gland Biology and Neoplasia, and is currently an Ad Hoc Reviewer for several distinguished journals, including: Cancer Research, American Journal of Cell Biology, European Journal of Cell Biology, Molecular Carcinogenesis, Journal of the National Cancer Institute, Oncogene, FASEB Journal, Journal of Cell Science, Laboratory Investigation, Cancer Letters, Breast Cancer Research, Journal of Biological Chemistry, Molecular Biology of the Cell, Molecular and Cellular Biology, & Clinical Cancer Research. 

Dr. Weaver has over 20 years of experience in leading interdisciplinary research in oncology, including leadership of significant program projects merging approaches in the physical/engineering sciences and biology.  Her research focuses on the contribution of force, cell-intrinsic as well as extracellular matrix, to oncogenesis and tumor development. Her group employs 2- and 3-D in vitro cell culture techniques, clinical samples and animal models with force application techniques, and traction force and atomic force microscopy to assess the influence of the mechanical aspects of the cell environment on cell behavior and tumor progression. Dr. Weaver has been awarded many distinctions for her work demonstrating the critical importance of tissue structure in the treatment response of tumors, including the prestigious Department of Defense Era of Hope Breast Cancer Scholar Award for her innovative interdisciplinary research efforts on the effect of mechanical force on breast cancer progression and treatment response. Along with Dr. Jan Liphardt, PhD, UC Berkeley, she was awarded the prestigious Physical Sciences and Oncology Center Grant, whose aim is to integrate physical sciences approaches toward better understanding tumor biology. The Center encompasses close to 100 investigators in physics, engineering, mathematics, chemistry, cell and molecular biology, and clinical sciences from UC Berkeley, UCSF, and LBNL. In addition, Dr. Weaver a Co-PI on an NIH U01 grant with Dr. Werb on environmental stressors in mammary gland development and a Co-PI with Drs. Kalluri and Moses on role of fibroblasts, myeloid cells and matrix in PDAC.

Dr. Weaver is the TMEN-BCC co-PI with Dr. Bergers, as well as the leader of Project 3,in which she is testing the hypothesis that the mechanoproperties of SVZ-derived GBM, together with elevated cranial pressure and ECM stiffness, promote GBM aggressiveness and recurrence, in part by affecting the vascular and tumor stem cell compartment.

Data provided by UCSF Profiles, powered by CTSI
ORCID iD: 0000-0003-4786-6752 Additional info
  • Targeting the Cancer Glycocalyx
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    Mar 2019
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    Feb 2024
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  • Reorienting the Glioblastoma Microenvironment to Respond to Immunotherapy
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    Feb 2019
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    Jan 2024
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  • Tissue Tension, RANK and Breast Cancer Risk
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    Feb 2018
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    Jan 2023
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  • ECM geometrical and mechanical properties modulate RTK signaling
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    Sep 2015
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    Aug 2020
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  • Tension-Stat3-miR-mediated metastasis
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    Apr 2015
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    Mar 2020
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  • A biophysical stromal basis for radiation sensitivity in ductal carcinoma in situ
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    May 2014
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    Feb 2019
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  • Inside-Out Approaches to Improve Wound Repair by HoxB3
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    Jul 2016
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    Apr 2018
    Principal Investigator
  • Advanced Methods to Evaluate Extracellular Matrix and Crosslinking in the Tumor M
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    May 2014
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    Apr 2017
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  • Biophysical and molecular dialogue of glioma cells and the brain microenvironment
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    Sep 2011
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    Jul 2016
    Co-Principal Investigator
  • 2015 Fibronectin, Integrins &Related Molecules Gordon Research Conference &Gordon Research Seminar
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    May 2015
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    Apr 2016
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  • TGF-beta Suppression and Promotion of Mammary Carcinomas
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    May 2000
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    Feb 2016
    Co-Principal Investigator
  • Role of Fibroblasts, Myeloid Cells and Matrix in PDAC
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    Sep 2010
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    Aug 2015
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  • Fundamental Mechanobiology of Tumor Progression
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    Sep 2009
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    Jul 2015
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  • Collagen remodeling and tumor progression
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    May 2010
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    Feb 2015
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  • 2013 Fibronectin, Integrins &Related Molecules GRC/GRS
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    Feb 2013
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    Jan 2014
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  • NFkB, tissue polarity and apoptosis resistance
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    Jul 2000
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    Jun 2010
    Principal Investigator
MOST RECENT PUBLICATIONS FROM A TOTAL OF 146
Data provided by UCSF Profiles, powered by CTSI
  1. Weaver VM, Bissell MJ. Zena Werb (1945-2020): Mourning the loss of a tissue microenvironment icon. Proc Natl Acad Sci U S A. 2020 Oct 29. View in PubMed
  2. Barcellos-Hoff MH, Weaver VM. In Memoriam - Zena Werb 1945-2020. J Mammary Gland Biol Neoplasia. 2020 Sep 30. View in PubMed
  3. Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R, Wei L, Newcomb B, Mileva I, Canals D, Hannun YA, Chung RT, Mattis AN, Fuchs BC, Tager AM, Yimlamai D, Weaver VM, Mullen AC, Sheppard D, Chen JY. Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice. Sci Transl Med. 2020 Aug 19; 12(557). View in PubMed
  4. Jiang H, Torphy RJ, Steiger K, Hongo H, Ritchie AJ, Kriegsmann M, Horst D, Umetsu SE, Joseph NM, McGregor K, Pishvaian MJ, Blais EM, Lu B, Li M, Hollingsworth M, Stashko C, Volmar K, Yeh JJ, Weaver VM, Wang ZJ, Tempero MA, Weichert W, Collisson EA. Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix. J Clin Invest. 2020 Sep 01; 130(9):4704-4709. View in PubMed
  5. Northey JJ, Barrett AS, Acerbi I, Hayward MK, Talamantes S, Dean IS, Mouw JK, Ponik SM, Lakins JN, Huang PJ, Wu J, Shi Q, Samson S, Keely PJ, Mukhtar RA, Liphardt JT, Shepherd JA, Hwang ES, Chen YY, Hansen KC, Littlepage LE, Weaver VM. Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217. J Clin Invest. 2020 Sep 28. View in PubMed
  6. View All Publications

 

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