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Robert C. Mackersie, M.D.

Robert C. Mackersie, M.D.

Professor of Surgery
Division of General Surgery
Department of Surgery at Zuckerberg San Francisco General 
Medical Director, Zuckerberg San Francisco General Trauma Program
Vice-Chief of Surgery, Zuckerberg San Francisco General

Contact Information

Campus Box 0807
Department of Surgery
Zuckerberg San Francisco General Hospital and Trauma Center
San Francisco, CA 94143-0807
(415) 206-8673 Appointments
(415) 206-4622 Office
(415) 206-5484 Fax
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  • UC Berkeley, B.S., Mechanical Engineering, 1973
  • UC Berkeley, M.S., Engineering Science, 1974
  • Michigan State University, M.D., 1978
  • 1978-81, UCSF School of Medicine, Resident, Surgery
  • 1983-84, UCSF  School of Medicine, Senior Resident, Surgery
  • 1983-85, UCSF  School of Medicine,  Chief Resident, Surgery
  • 1981-83, UCSF School of Medicine, Fellow, Trauma Research (NIH sponsored)
  • American Board of Surgery, 1986
  • American Board of Surgery, Surgical Critical Care, 1988
  • General Surgery
  • Surgical Critical Care
  • Trauma Surgery
  • Vascular Surgery
  • Ventilatory management of patients with ARDS
  • Violence Prevention
  • Inflammatory lung injury following major injury
  • Trauma systems development

Mackersie is a certified by the American Board of General Surgery, general certificate with subspecialty in surgical critical care. His practice is in general and trauma surgery, which includes vascular and thoracic surgery.  In addition, he is a regular attending on the Surgical Critical Care Service at Zuckerberg San Francisco General Hospital and Trauma Center and serves as Vice-Chief of Surgery there.

Dr. Mackersie is a graduate of UC Berkeley and Michigan State University Medical School.  He completed his internship, residency and chief residency training in general surgery and surgical critical care at the University of California, San Francisco, where he continued his specialty training and completed a trauma research fellowship.  Dr. Mackersie joined the faculty at the University of California, San Diego University Hospital from 1985-1991.

Dr. Mackersie was appointed the Trauma Medical Director in 1992 at the University of California/San Francisco General Hospital (now Zuckerberg San Francisco General) and has been instrumental in expanding the multidisciplinary activities related to the Trauma Program.  Dr. Mackersie currently serves as an officer for several surgical organizations and is a Governor of the American College of Surgeons.  Dr. Mackersie has been appointed Secretary/Treasurer for the American Association for the Surgery of Trauma.  Dr. Mackersie has also expanded the Trauma Nurse Practitioner program, and has progressed in developing the first aero-medical transport facility at San Francisco General Hospital.  He has also been appointed Commissioner for the State of California Emergency Medical Services Authority, which is appointed by the Governor/California Speaker of the House.

Dr. Mackersie continues to direct the national program in Trauma System Planning and Evaluation for the American College of Surgeons, which includes the development of national benchmarks for trauma systems and trauma centers, and the creation of national guidelines for trauma systems development. 

  • Inflammatory Lung Injury following major injury: One of the main areas of focus has been post-traumatic inflammatory lung injury. This collaborative research effort has continued, with new reports of the clinical syndrome of ARDS (ref # 63), the impact of ARDS on specific outcomes (ref # 62), and a recent report examining surrogate serum markers predictive of inflammatory lung injury. (ref # 65). The most recent work, still in preparation (Abstract, WIP ref # 3), attemps to link elements of inflammation with post-traumatic coagulopathy, and to better define the nature of early coagulopathy (pre-massive transfusion) that follows shock, traumatic brain injury, and major organ injury.
  • Ventilatory management of patients with ARDS (refs # 66,67). Technical clinical studies performed in ICU patients with ARDS that attempt to expand our understanding of "optimal" modes of lung protective ventilation (LPV) in the setting or acute lung injury. LPV strategies are one of the few, if not the only demonstrable intervention having an impact on the outcome from ARDS over the past 15 years. 
  • Violence prevention recidivism (Abstracts/WIP ref # 1). Work in progress, this is part of an ongoing clinical and programmatic study that screens victims of youth violence & assesses the likelihood of recidivism. "High risk" patients are then referred into a program linking hospital services with post-discharge neighborhood/community services for violence prevention. A randomized study is being designed to compare recidivism outcomes with and without programmatic influence.
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  1. Schwartz HEM, Matthay ZA, Menza R, Fernández A, Mackersie R, Stein DM, Bongiovanni T. Inequity in Discharge Pain Management for Trauma Patients with Limited English Proficiency. J Trauma Acute Care Surg. 2021 May 25. View in PubMed
  2. Bongiovanni T, Hernandez S, Ledesma Y, Menza R, Wick E, Steinman M, Mackersie R, Stein DM, Coffin PO. Surviving traumatic injury, only to die of acute drug poisoning: Should trauma centers be a path for intervention? Surgery. 2021 Oct; 170(4):1249-1254. View in PubMed
  3. Greenberg AL, Schwartz H, Collins CR, Kelly YM, Mackersie R, Mourad M, Roberts JP, Bongiovanni T. Emergency general surgery utilization and disparities during COVID-19: an interrupted time-series analysis. Trauma Surg Acute Care Open. 2021; 6(1):e000679. View in PubMed
  4. Matthay ZA, Kornblith AE, Matthay EC, Sedaghati M, Peterson S, Boeck M, Bongiovanni T, Campbell A, Chalwell L, Colwell C, Farrell MS, Kim WC, Knudson MM, Mackersie R, Li L, Nunez-Garcia B, Langness S, Plevin RE, Sammann A, Tesoriero R, Stein DM, Kornblith LZ. The DISTANCE study: Determining the impact of social distancing on trauma epidemiology during the COVID-19 epidemic-An interrupted time-series analysis. J Trauma Acute Care Surg. 2021 04 01; 90(4):700-707. View in PubMed
  5. Stey AM, Byskosh A, Etkin C, Mackersie R, Stein DM, Bilimoria KY, Crandall ML. Describing the density of high-level trauma centers in the 15 largest US cities. Trauma Surg Acute Care Open. 2020; 5(1):e000562. View in PubMed
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