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Gillian L Hirst, PhD

Gillian L Hirst, PhD

Assistant Professor
Division of General Surgery
Administrative Director
T32 Training Grant in Surgical Oncology



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University of Newcastle-upon Tyne, UK, BSc (Hons) Physiological Sciences 1991

University of Edinburgh, PhD. Molecular Oncology, 1995

  • University of Glasgow, UK, Molecular Oncology, 1995 - 2000
  • University of California, San Francisco, Genetics, Oncology 2000-2003
  • Biomarkers
  • Breast Cancer
  • Carcinogenesis
  • Drug Resistance
  • Genetic Risk
  • Precision Medicine
  • Tumor Biology

Gillian Hirst received her Ph.D. at the University of Edinburgh in the ICRF's (now CRUK) Molecular Oncology Unit, where she focused on the analysis and development of estrogen-regulated biomarkers for use in ovarian and breast cancers treated with anti-estrogenic therapies. As a postdoctoral fellow at CRUK Beatson Laboratories, University of Glasgow, she studied the molecular mechanisms of cisplatin resistance in ovarian cancer, with emphasis on the mismatch repair pathway. Building upon this work she studied the genetic susceptibility to DNA damaging agents in Allan Balmain's group here at UCSF. She has over ten years' experience working as a scientific program manager for multi-consortia projects and oversees biomarker development for the I-SPY2 TRIAL for early high-risk breast cancer, as well as multiple research initiatives within the Breast Care Center and the NIH Molecular Characterization of Screen-detected Lesions Consortium.

Dr. Hirst's areas of research interest span the continuum of disease risk in the analysis and development of biomarkers which will lead to better patient stratification and refined treatment interventions.

  Award  
  Confired By    
  Date    
  • CRC Post-Doctoral Fellowship
  • Beatson Institute, University of Glasgow
  • 1993 - 1999
  • Dr Hirst has over 15 years of research experience and managing scientific research programs. Her research interest particularly focuses on the molecular genetics of carcinogenesis, particularly as it relates to breast and ovarian cancer and understanding how we can better utilize biomarkers for risk stratification and treatment refinement. As Scientific Program Manager in the I-SPY2 TRIAL she oversees biomarker development and works with investigators from both academia and pharma to analyze data, tumor and liquid biopsy specimen using expression arrays, next-gen sequencing, multiplex-IHC and phospho-protein arrays.

    As an investigator on a U01 which is part of the NIH Molecular Characterization of Screen-Detected Lesions (MCL) consortium, her research is focused on building tissue, pathology and imaging resources to assist in the better molecular definition of DCIS and defining who will recur with aggressive invasive cancer or not. The hope is to be able to stratify patients for either less treatment intervention or more at the earliest stages of disease, and to find potentially common drivers of aggressive disease across multiple disease types, as well as markers of indolent disease by looking at both tumor and stromal microenvironment biology.

    Data provided by UCSF Profiles, powered by CTSI
    ORCID iD: 0000-0002-4502-0035 Additional info
    • Surgical Oncology Training Grant
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      Jul 2020
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      Jun 2025
      Administrative Director
    • I-SPY2 +: Evolving the I-SPY 2 TRIAL to include MRI-directed, adaptive sequential treatment to optimize breast cancer outcomes
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      Sep 2017
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      Aug 2022
      Co-Investigator
    • Elucidating the molecular and contextual basis for IDLE ultralow risk lesions and the tumor immune microenvironment of high risk in situ and invasive breast cancers
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      Sep 2015
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      Aug 2020
      Co-Investigator
    • Modeling the Impact of Targeted Therapy Based on Breast Cancer Subtypes
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      Sep 2014
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      Aug 2019
      Co-Investigator
    • Science Leadership and Integration
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      Sep 2009
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      Aug 2014
      Co-Investigator
    • A Systems Genetics Analysis of Cancer Risk, Progression and Therapeutic Response
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      Sep 1999
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      Mar 2014
      Co-Investigator
    • Program Project Grant
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      Sep 2003
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      Aug 2010
      Co-Investigator
    MOST RECENT PUBLICATIONS FROM A TOTAL OF 39
    Data provided by UCSF Profiles, powered by CTSI
    1. Magbanua MJM, Li W, Wolf DM, Yau C, Hirst GL, Swigart LB, Newitt DC, Gibbs J, Delson AL, Kalashnikova E, Aleshin A, Zimmermann B, Chien AJ, Tripathy D, Esserman L, Hylton N, van 't Veer L. Circulating tumor DNA and magnetic resonance imaging to predict neoadjuvant chemotherapy response and recurrence risk. NPJ Breast Cancer. 2021 Mar 25; 7(1):32. View in PubMed
    2. Du L, Yau C, Brown-Swigart L, Gould R, Krings G, Hirst GL, Bedrosian I, Layman RM, Carter JM, Klein M, Venters S, Sonal S, van der Noordaa M, Chien AJ, Haddad T, Isaacs C, Pusztai L, Albain K, Nanda R, Tripathy D, Liu MC, Boughey J, Schwab R, Hylton N, DeMichele A, Perlmutter J, Yee D, Berry D, Veer LV, Valero V, Esserman L, Symmans WF. Predicted sensitivity to endocrine therapy for stage II-III hormone receptor-positive and HER2-negative (HR+/HER2-) breast cancer prior to chemo-endocrine therapy. Ann Oncol. 2021 Feb 19. View in PubMed
    3. Magbanua MJM, Swigart LB, Wu HT, Hirst GL, Yau C, Wolf DM, Tin A, Salari R, Shchegrova S, Pawar H, Delson AL, DeMichele A, Liu MC, Chien AJ, Tripathy D, Asare S, Lin CJ, Billings P, Aleshin A, Sethi H, Louie M, Zimmermann B, Esserman LJ, van 't Veer LJ. Circulating tumor DNA in neoadjuvant-treated breast cancer reflects response and survival. Ann Oncol. 2020 Nov 21. View in PubMed
    4. Nachmanson D, Steward J, Yao H, Officer A, Jeong E, O'Keefe TJ, Hasteh F, Jepsen K, Hirst GL, Esserman LJ, Borowsky AD, Harismendy O. Mutational profiling of micro-dissected pre-malignant lesions from archived specimens. BMC Med Genomics. 2020 11 18; 13(1):173. View in PubMed
    5. Hyland CJ, Varghese F, Yau C, Beckwith H, Khoury K, Varnado W, Hirst GL, Flavell RR, Chien AJ, Yee D, Isaacs CJ, Forero-Torres A, Esserman LJ, Melisko ME. Use of 18F-FDG PET/CT as an Initial Staging Procedure for Stage II-III Breast Cancer: A Multicenter Value Analysis. J Natl Compr Canc Netw. 2020 11; 18(11):1510-1517. View in PubMed
    6. View All Publications

     

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