Surgery Websites
Department of Surgery »  Faculty »  Adult Cardiothoracic Surgery »  Julius M. Guccione, Jr., Ph.D.

Julius M. Guccione, Jr., Ph.D.

Professor of Surgery
Division of Adult Cardiothoracic Surgery
Co-Director, Cardiac Biomechanics Lab
Core Member, UC Berkeley & UCSF Graduate Program in Bioengineering

Contact Information

Box 0118
UC Hall Room U-158
415.750.2181 (Fax)
415.680.6285 (Cell/Mobile)
julius.guccione@ucsf.edu
Open Popup

Tulane University B.S. Biomedical Engineering, 1985

UCSD, M.S. Engineering Sciences (Bioengineering), 1987

UCSD, Ph.D. Engineering Sciences (Bioengineering), 1990

  • Postdoctoral Fellow, Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, 1990-1993
  • Member, UCB/UCSF Graduate Bioengineering Program

Julius M. Guccione, Jr., Ph.D. is Professor of Surgery, Surgery/Division of Adult Cardiothoracic Surgery at UCSF. He specializes in the realistic simulation of the efficacy of novel surgical procedures and devices for treating ischemic cardiomyopathy. Dr. Guccione graduated with a B.S. in Biomedical Engineering from Tulane University. He obtained his M.S. and Ph.D. in Bioengineering from UCSD. He completed a research fellowship in Biomedical Engineering at The Johns Hopkins University.

The American Institute for Medical and Biological Engineering (AIMBE) inducted Dr. Guccione, Jr., Ph.D.,  to its College of Fellows in March 2019. Election to the AIMBE College of Fellows is among the highest professional distinctions accorded to a medical and biological engineer.

The College of Fellows is comprised of the top two percent of medical and biological engineers. College membership honors those who have made outstanding contributions to "engineering and medicine research, practice, or education" and to "the pioneering of new and developing fields of technology, making major advancements in traditional fields of medical and biological engineering, or developing/implementing innovative approaches to bioengineering education." 

Dr. Guccione was nominated, reviewed, and elected by peers and members of the College of Fellows for "outstanding contributions to the development, validation and dissemination of a unified foundation for cardiovascular in silico medicine."

AIMBE Fellow
American Institute for Medical and Biological Engineering (AIMBE) College of Fellows
2019
Richard Skalak Best Paper Award of the ASME Bioengineering Division
1999
Individual National Research Service Award of the NIH
1991 - 1993
Institutional National Research Service Award
Johns Hopkins University, Baltimore, MD
1990 - 1991
Institutional National Research Service Award
University of California, San Diego, CA
1985 - 1990

Dr. Guccione's research interests include the development and validation of a non-invasive method for estimating regional myocardial contractility in vivo. Such a method would be of great value in the design and evaluation of new surgical and medical strategies to treat and/or prevent infarction-induced heart failure. Recently, he published the first evidence of depressed contractility in the border zone of a human myocardial infarction.

Dr. Guccione's research is focused on optimizing the design of medical devices for treating heart failure, especially polymeric injection. Large animal models and computer simulations indicate that adding non-contractile material to the damaged left ventricular wall can potentially reduce myofiber stress. Recent results from a clinical trial support the novel concept that polymeric injection plus coronary artery bypass grafting leads to decreased myofiber stress, restored left ventricular geometry and improved function.

See also: The 3D Living Heart Project Overview

Data provided by UCSF Profiles, powered by CTSI
  • Optimization of Transcatheter Treatment for Severe Tricuspid Regurgitation
    Sponsor:
    Sponsor ID:
    Funding Period:
    Mar 2020
    -
    Feb 2024
    Principal Investigator
  • Model-Guided Vagus Nerve Stimulation for Heart Failure Therapy
    Sponsor:
    Sponsor ID:
    Funding Period:
    Aug 2020
    -
    Jul 2022
  • Cost Effective Drug Screening
    Sponsor:
    Sponsor ID:
    Funding Period:
    Mar 2020
    -
    Feb 2021
    Principal Investigator
  • Real-Time Virtual Assessment of MitraClip Placement
    Sponsor:
    Sponsor ID:
    Funding Period:
    Apr 2019
    -
    Mar 2020
    Consultant
  • Multi-Scale Laws of Myocardial Growth and Remodeling
    Sponsor:
    Sponsor ID:
    Funding Period:
    Jul 2014
    -
    Jun 2019
    Principal Investigator
  • Quantitative analysis of left ventriculoplasty: CHF
    Sponsor:
    Sponsor ID:
    Funding Period:
    Apr 2000
    -
    Apr 2018
    Co-Investigator
  • Minimally Invasive Ventricular Polymeric Injection for Treatment of Heart Failure
    Sponsor:
    Sponsor ID:
    Funding Period:
    Sep 2013
    -
    Jun 2017
    Principal Investigator
  • VIRTUAL TOOLS FOR CARDIAC VENTRICULAR REMODELING SURGERY
    Sponsor:
    Sponsor ID:
    Funding Period:
    Apr 2006
    -
    Aug 2016
    Principal Investigator
  • Simulation of Coronary Artery Bypass Graft and Surgical Ventricular Restoration
    Sponsor:
    Sponsor ID:
    Funding Period:
    Aug 2009
    -
    Jul 2011
    Principal Investigator
  • REGIONAL MECHANICS OF LEFT VENTRICULAR ANEURYSM
    Sponsor:
    Sponsor ID:
    Funding Period:
    Sep 1997
    -
    Aug 2001
    Principal Investigator
  • Regional Mechanical Properties of Intact Ventricular Muscle
    Sponsor:
    Sponsor ID:
    Funding Period:
    Aug 1994
    -
    Jul 1997
    Principal Investigator
  • VENTRICULAR MUSCLE MECHANICS UNDER PHYSIOLOGICAL LOADING
    Sponsor:
    Sponsor ID:
    Funding Period:
    Dec 1991
    -
    Jan 0001
    Principal Investigator
MOST RECENT PUBLICATIONS FROM A TOTAL OF 148
Data provided by UCSF Profiles, powered by CTSI
  1. Zhang Y, Wang VY, Morgan AE, Kim J, Wallace AW, Guccione JM, Weinsaft JW, Ge L, Ratcliffe MB. Finite-element based optimization of left ventricular passive stiffness: Utility of an inverse deformation gradient calculation of diastolic strain. J Mech Behav Biomed Mater. 2020. View in PubMed
  2. Dabiri Y, Van der Velden A, Sack KL, Choy JS, Guccione JM, Kassab GS. Application of Neural Network in Simulation of Left Ventricular Mechanics. Sci Rep. 2020. View in PubMed
  3. Ramírez WA, Gizzi A, Sack KL, Guccione JM, Hurtado DE. In-silico study of the cardiac arrhythmogenic potential of biomaterial injection therapy. Sci Rep. 2020 Jul 31; 10(1):12990. View in PubMed
  4. Wisneski AD, Wang Y, Deuse T, Hill AC, Pasta S, Levine S, Yao J, Guccione JM. Impact of Aortic Stenosis on Myofiber Stress: Translational Application of Left Ventricle-Aortic Coupling Simulation. Front Physiol. 2020. View in PubMed
  5. Giao DM, Wang Y, Rojas R, Takaba K, Badathala A, Spaulding KA, Soon G, Zhang Y, Wang VY, Haraldsson H, Liu J, Saloner D, Guccione JM, Ge L, Wallace AW, Ratcliffe MB. Left ventricular geometry during unloading and the end-systolic pressure volume relationship: Measurement with a modified real-time MRI-based method in normal sheep. PLoS One. 2020; 15(6):e0234896. View in PubMed
  6. View All Publications

 

Site Directory
    X