All Publications

  1. Woods EC, Kai F, Barnes JM, Pedram K, Pickup MW, Hollander MJ, Weaver VM, Bertozzi CR. A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression. Elife. 2017 Dec 21; 6. View in PubMed
  2. Miroshnikova YA, Rozenberg GI, Cassereau L, Pickup M, Mouw JK, Ou G, Templeman KL, Elloumi-Hannachi I, Gooch KJ, Sarang-Sieminski AL, García AJ, Weaver VM. a5ß1-integrinpromotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site. Mol Biol Cell. 2017 Sep 06. View in PubMed
  3. Pickup MW, Owens P, Gorska AE, Chytil A, Ye F, Shi C, Weaver VM, Kalluri R, Moses HL, Novitskiy SV. Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells. Cancer Immunol Res. 2017 Sep; 5(9):718-729. View in PubMed
  4. Salvador F, Martin A, López-Menéndez C, Moreno-Bueno G, Santos V, Vazquez-Naharro A, Santamaría PG, Morales S, Dubus P, Muinelo-Romay L, López López R, Tung JC, Weaver VM, Portillo F, Cano A. Lysyl oxidase-like protein LOXL2 promotes lung metastasis of breast cancer. Cancer Res. 2017 Jul 18. View in PubMed
  5. Weaver VM. Cell and tissue mechanics: the new cell biology frontier. Mol Biol Cell. 2017 Jul 07; 28(14):1815-1818. View in PubMed
  6. Cai E, Marchuk K, Beemiller P, Beppler C, Rubashkin MG, Weaver VM, Gérard A, Liu TL, Chen BC, Betzig E, Bartumeus F, Krummel MF. Visualizing dynamic microvillar search and stabilization during ligand detection by T cells. Science. 2017 May 12; 356(6338). View in PubMed
  7. Oudin MJ, Weaver VM. Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis. Cold Spring Harb Symp Quant Biol. 2016; 81:189-205. View in PubMed
  8. Khuc E, Bainer R, Wolf M, Clay SM, Weisenberger DJ, Kemmer J, Weaver VM, Hwang DG, Chan MF. Comprehensive characterization of DNA methylation changes in Fuchs endothelial corneal dystrophy. PLoS One. 2017; 12(4):e0175112. View in PubMed
  9. Mekhdjian AH, Kai F, Rubashkin MG, Prahl LS, Przybyla LM, McGregor AL, Bell ES, Barnes JM, DuFort CC, Ou G, Chang AC, Cassereau L, Tan SJ, Pickup MW, Lakins JN, Ye X, Davidson MW, Lammerding J, Odde DJ, Dunn AR, Weaver VM. Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. Mol Biol Cell. 2017 Jun 01; 28(11):1467-1488. View in PubMed
  10. Barnes JM, Przybyla L, Weaver VM. Tissue mechanics regulate brain development, homeostasis and disease. J Cell Sci. 2017 Jan 01; 130(1):71-82. View in PubMed
  11. Chang TT, Thakar D, Weaver VM. Force-dependent breaching of the basement membrane. Matrix Biol. 2017 Jan; 57-58:178-189. View in PubMed
  12. Takai K, Le A, Weaver VM, Werb Z. Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer. Oncotarget. 2016 Dec 13; 7(50):82889-82901. View in PubMed
  13. Kaushik S, Pickup MW, Weaver VM. From transformation to metastasis: deconstructing the extracellular matrix in breast cancer. Cancer Metastasis Rev. 2016 Dec; 35(4):655-667. View in PubMed
  14. Miroshnikova YA, Mouw JK, Barnes JM, Pickup MW, Lakins JN, Kim Y, Lobo K, Persson AI, Reis GF, McKnight TR, Holland EC, Phillips JJ, Weaver VM. Tissue mechanics promote IDH1-dependent HIF1a-tenascin C feedback to regulate glioblastoma aggression. Nat Cell Biol. 2016 Dec; 18(12):1336-1345. View in PubMed
  15. Gilbert PM, Weaver VM. Cellular adaptation to biomechanical stress across length scales in tissue homeostasis and disease. Semin Cell Dev Biol. 2017 Jul; 67:141-152. View in PubMed
  16. Przybyla L, Lakins JN, Weaver VM. Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation. Cell Stem Cell. 2016 Oct 06; 19(4):462-475. View in PubMed
  17. Ou G, Thakar D, Tung JC, Miroshnikova YA, Dufort CC, Gutierrez E, Groisman A, Weaver VM. Visualizing mechanical modulation of nanoscale organization of cell-matrix adhesions. Integr Biol (Camb). 2016 Jul 11; 8(7):795-804. View in PubMed
  18. Przybyla L, Muncie JM, Weaver VM. Mechanical Control of Epithelial-to-Mesenchymal Transitions in Development and Cancer. Annu Rev Cell Dev Biol. 2016 Oct 06; 32:527-554. View in PubMed
  19. Bhagawati M, Rubashkin MG, Lee JP, Ananthanarayanan B, Weaver VM, Kumar S. Site-Specific Modulation of Charge Controls the Structure and Stimulus Responsiveness of Intrinsically Disordered Peptide Brushes. Langmuir. 2016 Jun 14; 32(23):5990-6. View in PubMed
  20. Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med. 2016 May; 22(5):497-505. View in PubMed
  21. Kai F, Laklai H, Weaver VM. Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease. Trends Cell Biol. 2016 Jul; 26(7):486-497. View in PubMed
  22. Le LT, Cazares O, Mouw JK, Chatterjee S, Macias H, Moran A, Ramos J, Keely PJ, Weaver VM, Hinck L. Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness. J Cell Biol. 2016 Mar 14; 212(6):707-19. View in PubMed
  23. Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R. Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival. Cancer Cell. 2015 Dec 14; 28(6):831-833. View in PubMed
  24. Ou G, Weaver VM. Tumor-induced solid stress activates ß-catenin signaling to drive malignant behavior in normal, tumor-adjacent cells. Bioessays. 2015 Dec; 37(12):1293-7. View in PubMed
  25. Przybyla L, Lakins JN, Sunyer R, Trepat X, Weaver VM. Monitoring developmental force distributions in reconstituted embryonic epithelia. Methods. 2016 Feb 01; 94:101-13. View in PubMed
  26. Lin CH, Pelissier FA, Zhang H, Lakins J, Weaver VM, Park C, LaBarge MA. Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors. Mol Biol Cell. 2015 Nov 05; 26(22):3946-53. View in PubMed
  27. Lau J, Ilkhanizadeh S, Wang S, Miroshnikova YA, Salvatierra NA, Wong RA, Schmidt C, Weaver VM, Weiss WA, Persson AI. STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma. Cancer Res. 2015 Oct 15; 75(20):4302-11. View in PubMed
  28. Acerbi I, Cassereau L, Dean I, Shi Q, Au A, Park C, Chen YY, Liphardt J, Hwang ES, Weaver VM. Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration. Integr Biol (Camb). 2015 Oct; 7(10):1120-34. View in PubMed
  29. Northcott JM, Northey JJ, Barnes JM, Weaver VM. Fighting the force: Potential of homeobox genes for tumor microenvironment regulation. Biochim Biophys Acta. 2015 Apr; 1855(2):248-53. View in PubMed
  30. Tung JC, Barnes JM, Desai SR, Sistrunk C, Conklin MW, Schedin P, Eliceiri KW, Keely PJ, Seewaldt VL, Weaver VM. Tumor mechanics and metabolic dysfunction. Free Radic Biol Med. 2015 Feb; 79:269-80. View in PubMed
  31. Cassereau L, Miroshnikova YA, Ou G, Lakins J, Weaver VM. A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype. J Biotechnol. 2015 Jan 10; 193:66-9. View in PubMed
  32. Pickup MW, Mouw JK, Weaver VM. The extracellular matrix modulates the hallmarks of cancer. EMBO Rep. 2014 Dec; 15(12):1243-53. View in PubMed
  33. Mouw JK, Ou G, Weaver VM. Extracellular matrix assembly: a multiscale deconstruction. Nat Rev Mol Cell Biol. 2014 Dec; 15(12):771-85. View in PubMed
  34. Weaver VM. The microenvironment matters. Mol Biol Cell. 2014 Nov 01; 25(21):3254-8. View in PubMed
  35. Rubashkin MG, Cassereau L, Bainer R, DuFort CC, Yui Y, Ou G, Paszek MJ, Davidson MW, Chen YY, Weaver VM. Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate. Cancer Res. 2014 Sep 01; 74(17):4597-611. View in PubMed
  36. Venugopalan G, Camarillo DB, Webster KD, Reber CD, Sethian JA, Weaver VM, Fletcher DA, El-Samad H, Rycroft CH. Multicellular architecture of malignant breast epithelia influences mechanics. PLoS One. 2014; 9(8):e101955. View in PubMed
  37. Paszek MJ, DuFort CC, Rossier O, Bainer R, Mouw JK, Godula K, Hudak JE, Lakins JN, Wijekoon AC, Cassereau L, Rubashkin MG, Magbanua MJ, Thorn KS, Davidson MW, Rugo HS, Park JW, Hammer DA, Giannone G, Bertozzi CR, Weaver VM. The cancer glycocalyx mechanically primes integrin-mediated growth and survival. Nature. 2014 Jul 17; 511(7509):319-25. View in PubMed
  38. Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell. 2014 Jun 16; 25(6):719-34. View in PubMed
  39. Michor F, Weaver VM. Understanding tissue context influences on intratumour heterogeneity. Nat Cell Biol. 2014 Apr; 16(4):301-2. View in PubMed
  40. Rubashkin MG, Ou G, Weaver VM. Deconstructing signaling in three dimensions. Biochemistry. 2014 Apr 08; 53(13):2078-90. View in PubMed
  41. Mouw JK, Yui Y, Damiano L, Bainer RO, Lakins JN, Acerbi I, Ou G, Wijekoon AC, Levental KR, Gilbert PM, Hwang ES, Chen YY, Weaver VM. Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression. Nat Med. 2014 Apr; 20(4):360-7. View in PubMed
  42. Shi Q, Ghosh RP, Engelke H, Rycroft CH, Cassereau L, Sethian JA, Weaver VM, Liphardt JT. Rapid disorganization of mechanically interacting systems of mammary acini. Proc Natl Acad Sci U S A. 2014 Jan 14; 111(2):658-63. View in PubMed
  43. Bainer R, Weaver V. Cell biology. Strength under tension. Science. 2013 Aug 30; 341(6149):965-6. View in PubMed
  44. Pickup MW, Laklai H, Acerbi I, Owens P, Gorska AE, Chytil A, Aakre M, Weaver VM, Moses HL. Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-ß-deficient mouse mammary carcinomas. Cancer Res. 2013 Sep 01; 73(17):5336-46. View in PubMed
  45. Maller O, Hansen KC, Lyons TR, Acerbi I, Weaver VM, Prekeris R, Tan AC, Schedin P. Collagen architecture in pregnancy-induced protection from breast cancer. J Cell Sci. 2013 Sep 15; 126(Pt 18):4108-10. View in PubMed
  46. Damiano L, Stewart KM, Cohet N, Mouw JK, Lakins JN, Debnath J, Reisman D, Nickerson JA, Imbalzano AN, Weaver VM. Oncogenic targeting of BRM drives malignancy through C/EBPß-dependent induction of a5 integrin. Oncogene. 2014 May 08; 33(19):2441-53. View in PubMed
  47. Maller O, DuFort CC, Weaver VM. YAP forces fibroblasts to feel the tension. Nat Cell Biol. 2013 Jun; 15(6):570-2. View in PubMed
  48. Tang Y, Rowe RG, Botvinick EL, Kurup A, Putnam AJ, Seiki M, Weaver VM, Keller ET, Goldstein S, Dai J, Begun D, Saunders T, Weiss SJ. MT1-MMP-dependent control of skeletal stem cell commitment via a ß1-integrin/YAP/TAZ signaling axis. Dev Cell. 2013 May 28; 25(4):402-16. View in PubMed
  49. Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH. A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep. 2013; 3:1449. View in PubMed
  50. Li CR, Su JJ, Wang WY, Lee MT, Wang TY, Jiang KY, Li CF, Hsu JM, Chen CK, Chen M, Jiang SS, Weaver VM, Tsai KK. Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer. Am J Pathol. 2013 Feb; 182(2):363-74. View in PubMed
  51. Paszek MJ, DuFort CC, Rubashkin MG, Davidson MW, Thorn KS, Liphardt JT, Weaver VM. Scanning angle interference microscopy reveals cell dynamics at the nanoscale. Nat Methods. 2012 Jul 01; 9(8):825-7. View in PubMed
  52. Cassereau L, DuFort CC, Weaver VM. Morphogenesis: Laying down the tracks. Nat Mater. 2012 May 22; 11(6):490-2. View in PubMed
  53. Lu P, Weaver VM, Werb Z. The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol. 2012 Feb 20; 196(4):395-406. View in PubMed
  54. Lakins JN, Chin AR, Weaver VM. Exploring the link between human embryonic stem cell organization and fate using tension-calibrated extracellular matrix functionalized polyacrylamide gels. Methods Mol Biol. 2012; 916:317-50. View in PubMed
  55. Lu P, Takai K, Weaver VM, Werb Z. Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol. 2011 Dec 01; 3(12). View in PubMed
  56. Lopez JI, Kang I, You WK, McDonald DM, Weaver VM. In situ force mapping of mammary gland transformation. Integr Biol (Camb). 2011 Sep; 3(9):910-21. View in PubMed
  57. Samuel MS, Lopez JI, McGhee EJ, Croft DR, Strachan D, Timpson P, Munro J, Schröder E, Zhou J, Brunton VG, Barker N, Clevers H, Sansom OJ, Anderson KI, Weaver VM, Olson MF. Actomyosin-mediated cellular tension drives increased tissue stiffness and ß-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell. 2011 Jun 14; 19(6):776-91. View in PubMed
  58. Weaver V. Valerie Weaver: overcoming cancer's stiff resistance. Interview by Caitlin Sedwick. J Cell Biol. 2011 May 30; 193(5):802-3. View in PubMed
  59. DuFort CC, Paszek MJ, Weaver VM. Balancing forces: architectural control of mechanotransduction. Nat Rev Mol Cell Biol. 2011 May; 12(5):308-19. View in PubMed
  60. Dvorak HF, Weaver VM, Tlsty TD, Bergers G. Tumor microenvironment and progression. J Surg Oncol. 2011 May 01; 103(6):468-74. View in PubMed
  61. Miroshnikova YA, Jorgens DM, Spirio L, Auer M, Sarang-Sieminski AL, Weaver VM. Engineering strategies to recapitulate epithelial morphogenesis within synthetic three-dimensional extracellular matrix with tunable mechanical properties. Phys Biol. 2011 Apr; 8(2):026013. View in PubMed
  62. Frantz C, Stewart KM, Weaver VM. The extracellular matrix at a glance. J Cell Sci. 2010 Dec 15; 123(Pt 24):4195-200. View in PubMed
  63. Brown XQ, Bartolak-Suki E, Williams C, Walker ML, Weaver VM, Wong JY. Effect of substrate stiffness and PDGF on the behavior of vascular smooth muscle cells: implications for atherosclerosis. J Cell Physiol. 2010 Oct; 225(1):115-22. View in PubMed
  64. Yu H, Mouw JK, Weaver VM. Forcing form and function: biomechanical regulation of tumor evolution. Trends Cell Biol. 2011 Jan; 21(1):47-56. View in PubMed
  65. Egeblad M, Rasch MG, Weaver VM. Dynamic interplay between the collagen scaffold and tumor evolution. Curr Opin Cell Biol. 2010 Oct; 22(5):697-706. View in PubMed
  66. Cohet N, Stewart KM, Mudhasani R, Asirvatham AJ, Mallappa C, Imbalzano KM, Weaver VM, Imbalzano AN, Nickerson JA. SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells. J Cell Physiol. 2010 Jun; 223(3):667-78. View in PubMed
  67. Gilbert PM, Mouw JK, Unger MA, Lakins JN, Gbegnon MK, Clemmer VB, Benezra M, Licht JD, Boudreau NJ, Tsai KK, Welm AL, Feldman MD, Weber BL, Weaver VM. HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype. J Clin Invest. 2010 May; 120(5):1535-50. View in PubMed
  68. Paszek M, Weaver V. Biophysics. Enforcing order on signaling. Science. 2010 Mar 12; 327(5971):1335-6. View in PubMed
  69. Paszek MJ, Boettiger D, Weaver VM, Hammer DA. Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate. PLoS Comput Biol. 2009 Dec; 5(12):e1000604. View in PubMed
  70. Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, Fong SF, Csiszar K, Giaccia A, Weninger W, Yamauchi M, Gasser DL, Weaver VM. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell. 2009 Nov 25; 139(5):891-906. View in PubMed
  71. Kumar S, Weaver VM. Mechanics, malignancy, and metastasis: the force journey of a tumor cell. Cancer Metastasis Rev. 2009 Jun; 28(1-2):113-27. View in PubMed
  72. Gehler S, Baldassarre M, Lad Y, Leight JL, Wozniak MA, Riching KM, Eliceiri KW, Weaver VM, Calderwood DA, Keely PJ. Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension. Mol Biol Cell. 2009 Jul; 20(14):3224-38. View in PubMed
  73. Hansma P, Yu H, Schultz D, Rodriguez A, Yurtsev EA, Orr J, Tang S, Miller J, Wallace J, Zok F, Li C, Souza R, Proctor A, Brimer D, Nogues-Solan X, Mellbovsky L, Peña MJ, Diez-Ferrer O, Mathews P, Randall C, Kuo A, Chen C, Peters M, Kohn D, Buckley J, Li X, Pruitt L, Diez-Perez A, Alliston T, Weaver V, Lotz J. The tissue diagnostic instrument. Rev Sci Instrum. 2009 May; 80(5):054303. View in PubMed
  74. Engler AJ, Humbert PO, Wehrle-Haller B, Weaver VM. Multiscale modeling of form and function. Science. 2009 Apr 10; 324(5924):208-12. View in PubMed
  75. Vasilatos SN, Broadwater G, Barry WT, Baker JC, Lem S, Dietze EC, Bean GR, Bryson AD, Pilie PG, Goldenberg V, Skaar D, Paisie C, Torres-Hernandez A, Grant TL, Wilke LG, Ibarra-Drendall C, Ostrander JH, D'Amato NC, Zalles C, Jirtle R, Weaver VM, Seewaldt VL. CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis. Cancer Epidemiol Biomarkers Prev. 2009 Mar; 18(3):901-14. View in PubMed
  76. Butcher DT, Alliston T, Weaver VM. A tense situation: forcing tumour progression. Nat Rev Cancer. 2009 Feb; 9(2):108-22. View in PubMed
  77. Lopez JI, Mouw JK, Weaver VM. Biomechanical regulation of cell orientation and fate. Oncogene. 2008 Nov 24; 27(55):6981-93. View in PubMed
  78. Erler JT, Weaver VM. Three-dimensional context regulation of metastasis. Clin Exp Metastasis. 2009; 26(1):35-49. View in PubMed
  79. Rizki A, Weaver VM, Lee SY, Rozenberg GI, Chin K, Myers CA, Bascom JL, Mott JD, Semeiks JR, Grate LR, Mian IS, Borowsky AD, Jensen RA, Idowu MO, Chen F, Chen DJ, Petersen OW, Gray JW, Bissell MJ. A human breast cell model of preinvasive to invasive transition. Cancer Res. 2008 Mar 01; 68(5):1378-87. View in PubMed
  80. Fournier AK, Campbell LE, Castagnino P, Liu WF, Chung BM, Weaver VM, Chen CS, Assoian RK. Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion. J Cell Sci. 2008 Jan 15; 121(Pt 2):226-33. View in PubMed
  81. Hebner C, Weaver VM, Debnath J. Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures. Annu Rev Pathol. 2008; 3:313-39. View in PubMed
  82. Yee KL, Weaver VM, Hammer DA. Integrin-mediated signalling through the MAP-kinase pathway. IET Syst Biol. 2008 Jan; 2(1):8-15. View in PubMed
  83. Friedland JC, Lakins JN, Kazanietz MG, Chernoff J, Boettiger D, Weaver VM. alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. J Cell Sci. 2007 Oct 15; 120(Pt 20):3700-12. View in PubMed
  84. Weaver V, Werb Z. G'rab'bing the microenvironment for invasion. Dev Cell. 2007 Oct; 13(4):462-3. View in PubMed
  85. Kass L, Erler JT, Dembo M, Weaver VM. Mammary epithelial cell: influence of extracellular matrix composition and organization during development and tumorigenesis. Int J Biochem Cell Biol. 2007; 39(11):1987-94. View in PubMed
  86. Johnson KR, Leight JL, Weaver VM. Demystifying the effects of a three-dimensional microenvironment in tissue morphogenesis. Methods Cell Biol. 2007; 83:547-83. View in PubMed
  87. Underwood JM, Imbalzano KM, Weaver VM, Fischer AH, Imbalzano AN, Nickerson JA. The ultrastructure of MCF-10A acini. J Cell Physiol. 2006 Jul; 208(1):141-8. View in PubMed
  88. Boudreau N, Weaver V. Forcing the third dimension. Cell. 2006 May 05; 125(3):429-31. View in PubMed
  89. Yan Y, Weaver VM, Blair IA. Analysis of protein expression during oxidative stress in breast epithelial cells using a stable isotope labeled proteome internal standard. J Proteome Res. 2005 Nov-Dec; 4(6):2007-14. View in PubMed
  90. Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, Weaver VM. Tensional homeostasis and the malignant phenotype. Cancer Cell. 2005 Sep; 8(3):241-54. View in PubMed
  91. Yang C, Liu Y, Leskow FC, Weaver VM, Kazanietz MG. Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin. J Biol Chem. 2005 Jul 01; 280(26):24363-70. View in PubMed
  92. Cowden Dahl KD, Robertson SE, Weaver VM, Simon MC. Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression. Mol Biol Cell. 2005 Apr; 16(4):1901-12. View in PubMed
  93. Yeung T, Georges PC, Flanagan LA, Marg B, Ortiz M, Funaki M, Zahir N, Ming W, Weaver V, Janmey PA. Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion. Cell Motil Cytoskeleton. 2005 Jan; 60(1):24-34. View in PubMed
  94. Paszek MJ, Weaver VM. The tension mounts: mechanics meets morphogenesis and malignancy. J Mammary Gland Biol Neoplasia. 2004 Oct; 9(4):325-42. View in PubMed
  95. Weaver VM, Gilbert P. Watch thy neighbor: cancer is a communal affair. J Cell Sci. 2004 Mar 15; 117(Pt 8):1287-90. View in PubMed
  96. Zahir N, Weaver VM. Death in the third dimension: apoptosis regulation and tissue architecture. Curr Opin Genet Dev. 2004 Feb; 14(1):71-80. View in PubMed
  97. Zahir N, Lakins JN, Russell A, Ming W, Chatterjee C, Rozenberg GI, Marinkovich MP, Weaver VM. Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors. J Cell Biol. 2003 Dec 22; 163(6):1397-407. View in PubMed
  98. Russell AJ, Fincher EF, Millman L, Smith R, Vela V, Waterman EA, Dey CN, Guide S, Weaver VM, Marinkovich MP. Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin. J Cell Sci. 2003 Sep 01; 116(Pt 17):3543-56. View in PubMed
  99. Unger M, Weaver VM. The tissue microenvironment as an epigenetic tumor modifier. Methods Mol Biol. 2003; 223:315-47. View in PubMed
  100. Bissell MJ, Radisky DC, Rizki A, Weaver VM, Petersen OW. The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation. 2002 Dec; 70(9-10):537-46. View in PubMed
  101. Weaver VM, Lelièvre S, Lakins JN, Chrenek MA, Jones JC, Giancotti F, Werb Z, Bissell MJ. beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell. 2002 Sep; 2(3):205-16. View in PubMed
  102. Weaver VM. Membrane-associated MMP regulators: novel cell adhesion tumor suppressor proteins? Dev Cell. 2002 Jan; 2(1):6-7. View in PubMed
  103. Chrenek MA, Wong P, Weaver VM. Tumour-stromal interactions. Integrins and cell adhesions as modulators of mammary cell survival and transformation. Breast Cancer Res. 2001; 3(4):224-9. View in PubMed
  104. Weaver VM, Buckley T, Groopman JD. Lack of specificity of trans,trans-muconic acid as a benzene biomarker after ingestion of sorbic acid-preserved foods. Cancer Epidemiol Biomarkers Prev. 2000 Jul; 9(7):749-55. View in PubMed
  105. Spancake KM, Anderson CB, Weaver VM, Matsunami N, Bissell MJ, White RL. E7-transduced human breast epithelial cells show partial differentiation in three-dimensional culture. Cancer Res. 1999 Dec 15; 59(24):6042-5. View in PubMed
  106. Guerra-Vladusic FK, Scott G, Weaver V, Vladusic EA, Tsai MS, Benz CC, Lupu R. Constitutive expression of Heregulin induces apoptosis in an erbB-2 overexpressing breast cancer cell line SKBr-3. Int J Oncol. 1999 Nov; 15(5):883-92. View in PubMed
  107. Weaver VM, Bissell MJ. Functional culture models to study mechanisms governing apoptosis in normal and malignant mammary epithelial cells. J Mammary Gland Biol Neoplasia. 1999 Apr; 4(2):193-201. View in PubMed
  108. Bissell MJ, Weaver VM, Lelièvre SA, Wang F, Petersen OW, Schmeichel KL. Tissue structure, nuclear organization, and gene expression in normal and malignant breast. Cancer Res. 1999 Apr 01; 59(7 Suppl):1757-1763s; discussion 1763s-1764s. View in PubMed
  109. Wang F, Weaver VM, Petersen OW, Larabell CA, Dedhar S, Briand P, Lupu R, Bissell MJ. Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14821-6. View in PubMed
  110. Lelièvre SA, Weaver VM, Nickerson JA, Larabell CA, Bhaumik A, Petersen OW, Bissell MJ. Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14711-6. View in PubMed
  111. Schmeichel KL, Weaver VM, Bissell MJ. Structural cues from the tissue microenvironment are essential determinants of the human mammary epithelial cell phenotype. J Mammary Gland Biol Neoplasia. 1998 Apr; 3(2):201-13. View in PubMed
  112. Petersen OW, Rønnov-Jessen L, Weaver VM, Bissell MJ. Differentiation and cancer in the mammary gland: shedding light on an old dichotomy. Adv Cancer Res. 1998; 75:135-61. View in PubMed
  113. Weaver VM, Petersen OW, Wang F, Larabell CA, Briand P, Damsky C, Bissell MJ. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol. 1997 Apr 07; 137(1):231-45. View in PubMed
  114. Weaver VM, Roskelley CD. Extracellular matrix: the central regulator of cell and tissue homeostasis. Trends Cell Biol. 1997 Jan; 7(1):40-2. View in PubMed
  115. Weaver VM, Fischer AH, Peterson OW, Bissell MJ. The importance of the microenvironment in breast cancer progression: recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assay. Biochem Cell Biol. 1996; 74(6):833-51. View in PubMed
  116. Weaver VM, Carson CE, Walker PR, Chaly N, Lach B, Raymond Y, Brown DL, Sikorska M. Degradation of nuclear matrix and DNA cleavage in apoptotic thymocytes. J Cell Sci. 1996 Jan; 109 ( Pt 1):45-56. View in PubMed
  117. Lelièvre S, Weaver VM, Bissell MJ. Extracellular matrix signaling from the cellular membrane skeleton to the nuclear skeleton: a model of gene regulation. Recent Prog Horm Res. 1996; 51:417-32. View in PubMed
  118. Weaver VM, Howlett AR, Langton-Webster B, Petersen OW, Bissell MJ. The development of a functionally relevant cell culture model of progressive human breast cancer. Semin Cancer Biol. 1995 Jun; 6(3):175-84. View in PubMed
  119. Weaver VM, Lach B, Walker PR, Sikorska M. Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes. Biochem Cell Biol. 1993 Sep-Oct; 71(9-10):488-500. View in PubMed
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