All Publications

  1. Heaney AP, Sumerel B, Rajalingam R, Bergsneider M, Yong WH, Liau LM. HLA Markers DQ8 and DR53 Are Associated With Lymphocytic Hypophysitis and May Aid in Differential Diagnosis. J Clin Endocrinol Metab. 2015 Nov; 100(11):4092-7. View in PubMed
  2. Lin L, Ma C, Wei B, Aziz N, Rajalingam R, Yusung S, Erlich HA, Trachtenberg EA, Targan SR, McGovern DP, Heath JR, Braun J. Human NK cells licensed by killer Ig receptor genes have an altered cytokine program that modifies CD4+ T cell function. J Immunol. 2014 Jul 15; 193(2):940-9. View in PubMed
  3. Osman AE, Mubasher M, ElSheikh NE, AlHarthi H, Al Yami AS, Rajalingam R, Al-Dehaimi A, Middleton D, ElGhazali G. Characterization of human killer immunoglobulin-like receptors (KIRs) among healthy Saudis. Hum Immunol. 2014 Jun; 75(6):536-40. View in PubMed
  4. Rajalingam R, Ashouri E. Gene-specific PCR typing of killer cell immunoglobulin-like receptors. Methods Mol Biol. 2013; 1034:239-55. View in PubMed
  5. Vierra-Green C, Roe D, Hou L, Hurley CK, Rajalingam R, Reed E, Lebedeva T, Yu N, Stewart M, Noreen H, Hollenbach JA, Guethlein LA, Wang T, Spellman S, Maiers M. Allele-level haplotype frequencies and pairwise linkage disequilibrium for 14 KIR loci in 506 European-American individuals. PLoS One. 2012; 7(11):e47491. View in PubMed
  6. Sauna ZE, Ameri A, Kim B, Yanover C, Viel KR, Rajalingam R, Cole SA, Howard TE. Observations regarding the immunogenicity of BDD-rFVIII derived from a mechanistic personalized medicine perspective. J Thromb Haemost. 2012 Sep; 10(9):1961-5. View in PubMed
  7. Rajalingam R. Overview of the killer cell immunoglobulin-like receptor system. Methods Mol Biol. 2012; 882:391-414. View in PubMed
  8. Rajalingam R. Human diversity of killer cell immunoglobulin-like receptors and disease. Korean J Hematol. 2011 Dec; 46(4):216-28. View in PubMed
  9. Abi-Rached L, Jobin MJ, Kulkarni S, McWhinnie A, Dalva K, Gragert L, Babrzadeh F, Gharizadeh B, Luo M, Plummer FA, Kimani J, Carrington M, Middleton D, Rajalingam R, Beksac M, Marsh SG, Maiers M, Guethlein LA, Tavoularis S, Little AM, Green RE, Norman PJ, Parham P. The shaping of modern human immune systems by multiregional admixture with archaic humans. Science. 2011 Oct 07; 334(6052):89-94. View in PubMed
  10. Solgi G, Ghafari H, Ashouri E, Alimoghdam K, Rajalingam R, Amirzargar A. Comparison of KIR gene content profiles revealed a difference between northern and southern Persians in the distribution of KIR2DS5 and its linked loci. Hum Immunol. 2011 Nov; 72(11):1079-83. View in PubMed
  11. Rajalingam R, Gebel HM. KIR-HLA mismatching in human renal allograft transplantation: emergence of a new concept. Am J Transplant. 2011 Sep; 11(9):1771-2. View in PubMed
  12. Sanchez-Mazas A, Fernandez-ViƱa M, Middleton D, Hollenbach JA, Buhler S, Di D, Rajalingam R, Dugoujon JM, Mack SJ, Thorsby E. Immunogenetics as a tool in anthropological studies. Immunology. 2011 Jun; 133(2):143-64. View in PubMed
  13. Mackensen F, David F, Schwenger V, Smith LK, Rajalingam R, Levinson RD, Austin CR, Houghton D, Martin TM, Rosenbaum JT. HLA-DRB1*0102 is associated with TINU syndrome and bilateral, sudden-onset anterior uveitis but not with interstitial nephritis alone. Br J Ophthalmol. 2011 Jul; 95(7):971-5. View in PubMed
  14. Abi-Rached L, Moesta AK, Rajalingam R, Guethlein LA, Parham P. Human-specific evolution and adaptation led to major qualitative differences in the variable receptors of human and chimpanzee natural killer cells. PLoS Genet. 2010 Nov 04; 6(11):e1001192. View in PubMed
  15. Levinson RD, Okada AA, Ashouri E, Keino H, Rajalingam R. Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt-Koyanagi-Harada syndrome in Japanese individuals. Hum Immunol. 2010 Feb; 71(2):192-4. View in PubMed
  16. Bonagura VR, Du Z, Ashouri E, Luo L, Hatam LJ, DeVoti JA, Rosenthal DW, Steinberg BM, Abramson AL, Gjertson DW, Reed EF, Rajalingam R. Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis. Hum Immunol. 2010 Feb; 71(2):212-9. View in PubMed
  17. Levinson RD, Martin TM, Luo L, Ashouri E, Rosenbaum JT, Smith JR, Austin CR, Lutt JR, Rajalingam R. Killer cell immunoglobulin-like receptors in HLA-B27-associated acute anterior uveitis, with and without axial spondyloarthropathy. Invest Ophthalmol Vis Sci. 2010 Mar; 51(3):1505-10. View in PubMed
  18. Ashouri E, Farjadian S, Reed EF, Ghaderi A, Rajalingam R. KIR gene content diversity in four Iranian populations. Immunogenetics. 2009 Jul; 61(7):483-92. View in PubMed
  19. Ashouri E, Ghaderi A, Reed EF, Rajalingam R. A novel duplex SSP-PCR typing method for KIR gene profiling. Tissue Antigens. 2009 Jul; 74(1):62-7. View in PubMed
  20. Alves LG, Rajalingam R, Canavez F. A novel real-time PCR method for KIR genotyping. Tissue Antigens. 2009 Feb; 73(2):188-91. View in PubMed
  21. Shastry A, Sedimbi SK, Rajalingam R, Rumba I, Kanungo A, Sanjeevi CB. Different KIRs confer susceptibility and protection to adults with latent autoimmune diabetes in Latvian and Asian Indian populations. Ann N Y Acad Sci. 2008 Dec; 1150:133-8. View in PubMed
  22. Shastry A, Sedimbi SK, Rajalingam R, Nikitina-Zake L, Rumba I, Wigzell H, Sanjeevi CB. Combination of KIR 2DL2 and HLA-C1 (Asn 80) confers susceptibility to type 1 diabetes in Latvians. Int J Immunogenet. 2008 Dec; 35(6):439-46. View in PubMed
  23. Rajalingam R. Variable interactions of recipient killer cell immunoglobulin-like receptors with self and allogenic human leukocyte antigen class I ligands may influence the outcome of solid organ transplants. Curr Opin Organ Transplant. 2008 Aug; 13(4):430-7. View in PubMed
  24. Du Z, Sharma SK, Spellman S, Reed EF, Rajalingam R. KIR2DL5 alleles mark certain combination of activating KIR genes. Genes Immun. 2008 Jul; 9(5):470-80. View in PubMed
  25. Levinson RD, Du Z, Luo L, Holland GN, Rao NA, Reed EF, Rajalingam R. KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease. Hum Immunol. 2008 Jun; 69(6):349-53. View in PubMed
  26. Rajalingam R, Du Z, Meenagh A, Luo L, Kavitha VJ, Pavithra-Arulvani R, Vidhyalakshmi A, Sharma SK, Balazs I, Reed EF, Pitchappan RM, Middleton D. Distinct diversity of KIR genes in three southern Indian populations: comparison with world populations revealed a link between KIR gene content and pre-historic human migrations. Immunogenetics. 2008 May; 60(5):207-17. View in PubMed
  27. Kulkarni S, Single RM, Martin MP, Rajalingam R, Badwe R, Joshi N, Carrington M. Comparison of the rapidly evolving KIR locus in Parsis and natives of India. Immunogenetics. 2008 Apr; 60(3-4):121-9. View in PubMed
  28. Levinson RD, Du Z, Luo L, Monnet D, Tabary T, Brezin AP, Zhao L, Gjertson DW, Holland GN, Reed EF, Cohen JH, Rajalingam R. Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals. Genes Immun. 2008 Apr; 9(3):249-58. View in PubMed
  29. Luo L, Du Z, Sharma SK, Cullen R, Spellman S, Reed EF, Rajalingam R. Chain-terminating natural mutations affect the function of activating KIR receptors 3DS1 and 2DS3. Immunogenetics. 2007 Oct; 59(10):779-92. View in PubMed
  30. Rajalingam R. Killer cell immunoglobulin-like receptors influence the innate and adaptive immune responses. Iran J Immunol. 2007 Jun; 4(2):61-78. View in PubMed
  31. Du Z, Gjertson DW, Reed EF, Rajalingam R. Receptor-ligand analyses define minimal killer cell Ig-like receptor (KIR) in humans. Immunogenetics. 2007 Jan; 59(1):1-15. View in PubMed
  32. Levinson RD, See RF, Rajalingam R, Reed EF, Park MS, Rao NA, Holland GN. HLA-DRB1 and -DQB1 alleles in mestizo patients with Vogt-Koyanagi-Harada's disease in Southern California. Hum Immunol. 2004 Dec; 65(12):1477-82. View in PubMed
  33. Levinson RD, Rajalingam R, Park MS, Reed EF, Gjertson DW, Kappel PJ, See RF, Rao NA, Holland GN. Human leukocyte antigen A29 subtypes associated with birdshot retinochoroidopathy. Am J Ophthalmol. 2004 Oct; 138(4):631-4. View in PubMed
  34. Rajalingam R, Ge P, Reed EF. A sequencing-based typing method for HLA-DQA1 alleles. Hum Immunol. 2004 Apr; 65(4):373-9. View in PubMed
  35. Jin YP, Fishbein MC, Said JW, Jindra PT, Rajalingam R, Rozengurt E, Reed EF. Anti-HLA class I antibody-mediated activation of the PI3K/Akt signaling pathway and induction of Bcl-2 and Bcl-xL expression in endothelial cells. Hum Immunol. 2004 Apr; 65(4):291-302. View in PubMed
  36. Rajalingam R, Parham P, Abi-Rached L. Domain shuffling has been the main mechanism forming new hominoid killer cell Ig-like receptors. J Immunol. 2004 Jan 01; 172(1):356-69. View in PubMed
  37. Yawata M, Yawata N, McQueen KL, Cheng NW, Guethlein LA, Rajalingam R, Shilling HG, Parham P. Predominance of group A KIR haplotypes in Japanese associated with diverse NK cell repertoires of KIR expression. Immunogenetics. 2002 Nov; 54(8):543-50. View in PubMed
  38. Rajalingam R, Krausa P, Shilling HG, Stein JB, Balamurugan A, McGinnis MD, Cheng NW, Mehra NK, Parham P. Distinctive KIR and HLA diversity in a panel of north Indian Hindus. Immunogenetics. 2002 Mar; 53(12):1009-19. View in PubMed
  39. Shum BP, Flodin LR, Muir DG, Rajalingam R, Khakoo SI, Cleland S, Guethlein LA, Uhrberg M, Parham P. Conservation and variation in human and common chimpanzee CD94 and NKG2 genes. J Immunol. 2002 Jan 01; 168(1):240-52. View in PubMed
  40. Canavez F, Young NT, Guethlein LA, Rajalingam R, Khakoo SI, Shum BP, Parham P. Comparison of chimpanzee and human leukocyte Ig-like receptor genes reveals framework and rapidly evolving genes. J Immunol. 2001 Nov 15; 167(10):5786-94. View in PubMed
  41. Mehra NK, Jaini R, Rajalingam R, Balamurugan A, Kaur G. Molecular diversity of HLA-A*02 in Asian Indians: predominance of A*0211. Tissue Antigens. 2001 Jun; 57(6):502-7. View in PubMed
  42. Gardiner CM, Guethlein LA, Shilling HG, Pando M, Carr WH, Rajalingam R, Vilches C, Parham P. Different NK cell surface phenotypes defined by the DX9 antibody are due to KIR3DL1 gene polymorphism. J Immunol. 2001 Mar 01; 166(5):2992-3001. View in PubMed
  43. Rajalingam R, Gardiner CM, Canavez F, Vilches C, Parham P. Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors. Tissue Antigens. 2001 Jan; 57(1):22-31. View in PubMed
  44. Rajalingam R, Hong M, Adams EJ, Shum BP, Guethlein LA, Parham P. Short KIR haplotypes in pygmy chimpanzee (Bonobo) resemble the conserved framework of diverse human KIR haplotypes. J Exp Med. 2001 Jan 01; 193(1):135-46. View in PubMed
  45. Vilches C, Pando MJ, Rajalingam R, Gardiner CM, Parham P. Discovery of two novel variants of KIR2DS5 reveals this gene to be a common component of human KIR 'B' haplotypes. Tissue Antigens. 2000 Nov; 56(5):453-6. View in PubMed
  46. Rajalingam R, Mehra NK, Singal DP. Polymorphism in heat-shock protein 70-1 (HSP70-1) gene promoter region and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians. Indian J Exp Biol. 2000 Jul; 38(7):658-62. View in PubMed
  47. Rajalingam R, Mehra NK, Jain RC. Cold reactive lymphocytotoxic antibodies in pulmonary tuberculosis: correlation with disease activity and HLA. Indian J Exp Biol. 2000 Jul; 38(7):643-50. View in PubMed
  48. Khakoo SI, Rajalingam R, Shum BP, Weidenbach K, Flodin L, Muir DG, Canavez F, Cooper SL, Valiante NM, Lanier LL, Parham P. Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans. Immunity. 2000 Jun; 12(6):687-98. View in PubMed
  49. Vilches C, Rajalingam R, Uhrberg M, Gardiner CM, Young NT, Parham P. KIR2DL5, a novel killer-cell receptor with a D0-D2 configuration of Ig-like domains. J Immunol. 2000 Jun 01; 164(11):5797-804. View in PubMed
  50. Shum BP, Rajalingam R, Magor KE, Azumi K, Carr WH, Dixon B, Stet RJ, Adkison MA, Hedrick RP, Parham P. A divergent non-classical class I gene conserved in salmonids. Immunogenetics. 1999 Jun; 49(6):479-90. View in PubMed
  51. Mehra NK, Mitra DK, Rajalingam R. Polymorphic MHC molecules dictate cytokine profile and clinical disease in mycobacterial diseases. Indian J Clin Biochem. 1997 Dec; 12(Suppl 1):100. View in PubMed
  52. Rajalingam R, Mehra NK, Mehra RD, Neolia S, Jain RC, Pande JN. HLA class I profile in Asian Indian patients with pulmonary tuberculosis. Indian J Exp Biol. 1997 Oct; 35(10):1055-9. View in PubMed
  53. Habeeb MA, Rajalingam R, Dhar A, Kumar A, Sharma MP, Mehra NK. HLA association and occurrence of autoantibodies in Asian-Indian patients with ulcerative colitis. Am J Gastroenterol. 1997 May; 92(5):772-6. View in PubMed
  54. Rajalingam R, Singal DP, Mehra NK. Transporter associated with antigen-processing (TAP) genes and susceptibility to tuberculoid leprosy and pulmonary tuberculosis. Tissue Antigens. 1997 Feb; 49(2):168-72. View in PubMed
  55. Mitra DK, Rajalingam R, Taneja V, Bhattacharyya BC, Mehra NK. HLA-DR polymorphism modulates the cytokine profile of Mycobacterium leprae HSP-reactive CD4+ T cells. Clin Immunol Immunopathol. 1997 Jan; 82(1):60-7. View in PubMed
  56. Rajalingam R, Mehra NK, Chopra GS, Puri MM, Jain RC. Anti-IgG autoantibodies and possible immune regulatory mechanisms in patients with pulmonary tuberculosis. Tuber Lung Dis. 1996 Dec; 77(6):502-9. View in PubMed
  57. Mehra NK, Rajalingam R, Sagar S, Jain S, Sharma BK. Direct role of HLA-B5 in influencing susceptibility to Takayasu aortoarteritis. Int J Cardiol. 1996 Aug; 54 Suppl:S71-9. View in PubMed
  58. Rajalingam R, Mehra NK, Pande JN, Jain RC, Singla R. Correlation of serum interleukin-2 receptor-alpha levels with clinical manifestations in pulmonary tuberculosis. Tuber Lung Dis. 1996 Aug; 77(4):374-9. View in PubMed
  59. Rajalingam R, Mehra NK, Jain RC, Myneedu VP, Pande JN. Polymerase chain reaction--based sequence-specific oligonucleotide hybridization analysis of HLA class II antigens in pulmonary tuberculosis: relevance to chemotherapy and disease severity. J Infect Dis. 1996 Mar; 173(3):669-76. View in PubMed
  60. Mehra NK, Rajalingam R, Giphart MJ. Generation of DR51-associated DQA1, DQB1 haplotypes in Asian Indians. Tissue Antigens. 1996 Jan; 47(1):85-9. View in PubMed
  61. Mitra DK, Mehra NK, Maiti TK, Banerjee A, Taneja V, Rajalingam R, Ahuja RK, Bhattacharya BC. CD4+ T-cell responses to recombinant hsp65 and hsp18 of M. leprae and their trypsin-digested fragments in leprosy: diversity in HLA-DR restriction. Int J Lepr Other Mycobact Dis. 1995 Dec; 63(4):518-28. View in PubMed
  62. Mehra NK, Rajalingam R, Mitra DK, Taneja V, Giphart MJ. Variants of HLA-DR2/DR51 group haplotypes and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians. Int J Lepr Other Mycobact Dis. 1995 Jun; 63(2):241-8. View in PubMed
  63. Sidharthan V, Rose PJ, Rajalingam R, Udhayakumar RC, Aruldhas MM, Govindarajulu P. Dorsolateral prostatic phosphomonoesterases and adenosine triphosphatases in hypo- and hyperthyroid rats. Indian J Exp Biol. 1994 Sep; 32(9):616-8. View in PubMed
  64. Mehra NK, Bouwens AG, Naipal A, Rajalingam R, Grubic Z, Taneja V, Tilanus MG, Giphart MJ. Asian Indian HLA-DR2-, DR4-, and DR52-related DR-DQ genotypes analyzed by polymerase chain reaction based nonradioactive oligonucleotide typing. Unique haplotypes and a novel DR4 subtype. Hum Immunol. 1994 Mar; 39(3):202-10. View in PubMed
  65. Rajalingam R, Srinivasan N, Govindarajulu P. Effects of alloxan induced diabetes on lipid profiles in renal cortex and medulla of mature albino rats. Indian J Exp Biol. 1993 Jun; 31(6):577-9. View in PubMed
  66. Sidharthan V, Rajalingam R, Aruldhas MM, Govindarajulu P. Ventral prostatic phosphomonoesterases and adenosine triphosphatases in hypo- and hyperthyroid albino rats. Indian J Exp Biol. 1993 May; 31(5):414-6. View in PubMed
  67. Mehra NK, Rajalingam R, Bovornkitti S. Human leukocyte antigen (HLA) in respiratory allergy. Asian Pac J Allergy Immunol. 1992 Dec; 10(2):151-8. View in PubMed
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