banner
Department of Surgery »  Faculty »  Vascular Surgery »  Rong Wang, Ph.D.

Rong Wang, Ph.D.

Associate Professor of Surgery
Division of Vascular and Endovascular Surgery
Mildred V. Strouss Endowed Chair in Vascular Surgery
Director, Laboratory for Accelerated Vascular Research

Contact Information

513 Parnassus Avenue, HSW 1618
San Francisco, CA 94143-0507
Phone: (415) 476-6820
E-mail: rong.wang@ucsfmedctr.org

Education

  • 1980-84, Sichuan University, B.S., Biology
  • 1984-88, Graduate School of Chinese Science and Technology University, Inst. of Genetics, M.S. candidate, Mammalian Genetics
  • 1988-93, University of North Carolina, Chapel Hill, Ph.D., Biology (Angiogenesis)

Fellowships

  • 1994-99, University of California, San Francisco, Postdoctoral Fellow, Cancer Biology

Research Interests

  • Angiogenesis Inhibitors
  • Arteriogenesis
  • Arteriovenous Malformations
  • Carcinoma, Hepatocellular
  • Collateral Vessel Formation
  • Developmental Biology
  • Developmental Growth
  • Embryonic Development
  • EphrinB2
  • Gene Expression Regulation
  • Neovascularization
  • Notch Pathway
  • Physiologic, Ischemia
  • Stem Cells
  • Vascular Development
  • Vascular Physiology

Biography

Rong Wang, Ph.D. is the Director of the Laboratory for Accelerated Vascular Research. Previously, Dr. Wang had the distinction of being a post-doctoral fellow in the laboratory of Michael Bishop, MD, a winner of the Nobel Prize in Medicine and Chancellor of UCSF. Dr. Wang's team is engaged in state-of-the-art research involving key proteins necessary for blood vessel growth (angiogenesis) and arterial growth (arteriogenesis). They have found that the Notch 4 protein can cause dramatic blood vessel enlargement in adult animals and that the protein called focal adhesion kinase is essential for maintaining existing blood vessel structure. The ability to encourage the growth of blood vessels can increase healing in traumatic wounds, promote recovery from strokes and heart attacks, or generate the growth of new pathways around blocked arteries in the lower limbs to reduce the potential of gangrene and possible amputation.

 

Featured Publications

  1. Wang R, Kobayashi R, Bishop JM. Cellular adherence elicits ligand-independent activation of the Met cell-surface receptor. Proc Natl Acad Sci U S A. 93: 8425-30, Aug/6/1996.
  2. Wang R, Ferrell LD, Faouzi S, Maher JJ, Bishop JM. Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice. J Cell Biol. 153: 1023-34, May/28/2001.
  3. Carpenter B, Lin Y, Stoll S, Raffai RL, McCuskey R, Wang R. VEGF is crucial for the hepatic vascular development required for lipoprotein uptake. Development. 132: 3293-303, Jul/2005.
  4. Carlson TR, Yan Y, Wu X, Lam MT, Tang GL, Beverly LJ, Messina LM, Capobianco AJ, Werb Z, Wang R. Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice. Proc Natl Acad Sci U S A. 102: 9884-9, Jul/12/2005.
  5. Braren R, Hu H, Kim YH, Beggs HE, Reichardt LF, Wang R. Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. J Cell Biol. 172: 151-62, Jan/2/2006
  6. Carlson, TR, H Hu, R Braren, YH Kim, and RA Wang. Cell-autonomous requirement for Beta-1 integrin in endothelial cell adhesion, migration, and survival during angiogenesis in mice. Development, 2008 135(12):2193-202.
  7. He, C, H Hu, R Braren, S-Y Fong, A Trumpp, TR Carlson, and RA Wang. c-myc in the hematopoetic lineage is crucial for its angiogenic function in the mouse embryo. Development, 2008 135(14):2467-77.
  8. Murphy, PA, MTY Lam, X Wu, TN Kim, SM Vartanian, AW Bollen, TR Carlson, and RA Wang. Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice. Proc Natl Acad Sci U S A, 2008 105(31):10901-10906.

X