Department of Surgery »  Faculty »  Vascular Surgery »  Rong Wang, Ph.D.

Rong Wang, Ph.D.

Professor of Surgery
Division of Vascular and Endovascular Surgery
Mildred V. Strouss Endowed Chair in Vascular Surgery
Director, Laboratory for Accelerated Vascular Research
 

Contact Information

513 Parnassus Avenue, HSW 1618
San Francisco, CA 94143-0507
Phone: (415) 476-6820
rong.wang@ucsf.edu
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  • 1980-84, Sichuan University, B.S., Biology
  • 1984-88, Graduate School of Chinese Science and Technology University, Inst. of Genetics, M.S. candidate, Mammalian Genetics
  • 1988-93, University of North Carolina, Chapel Hill, Ph.D., Biology (Angiogenesis)
  • 1994-99, University of California, San Francisco, Postdoctoral Fellow, Cancer Biology
  • Angiogenesis Inhibitors
  • Arteriogenesis
  • Arteriovenous Malformations
  • Carcinoma, Hepatocellular
  • Collateral Vessel Formation
  • Developmental Biology
  • Developmental Growth
  • Embryonic Development
  • EphrinB2
  • Gene Expression Regulation
  • Neovascularization
  • Notch Pathway
  • Physiologic, Ischemia
  • Stem Cells
  • Vascular Development
  • Vascular Physiology

Rong Wang, Ph.D. is Professor of Surgery and Director of the Wang Lab. Previously, Dr. Wang had the distinction of being a post-doctoral fellow in the laboratory of Michael Bishop, MD, a winner of the Nobel Prize in Medicine and Chancellor of UCSF. Dr. Wang's team is engaged in state-of-the-art research involving key proteins necessary for blood vessel growth (angiogenesis) and arterial growth (arteriogenesis). They have found that the Notch 4 protein can cause dramatic blood vessel enlargement in adult animals and that the protein called focal adhesion kinase is essential for maintaining existing blood vessel structure.  The ability to encourage the growth of blood vessels can increase healing in traumatic wounds, promote recovery from strokes and heart attacks, or generate the growth of new pathways around blocked arteries in the lower limbs to reduce the potential of gangrene and possible amputation.

Most recent publications from a total of 34
  1. Wang RE, Wang Y, Zhang Y, Gabrelow C, Zhang Y, Chi V, Fu Q, Luo X, Wang D, Joseph S, Johnson K, Chatterjee AK, Wright TM, Nguyen-Tran VT, Teijaro J, Theofilopoulos AN, Schultz PG, Wang F. Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant. Proc Natl Acad Sci U S A. 2016 Oct 11; 113(41):11501-11506. View in PubMed
  2. Nielsen CM, Huang L, Murphy PA, Lawton MT, Wang RA. Mouse Models of Cerebral Arteriovenous Malformation. Stroke. 2016 Jan; 47(1):293-300. View in PubMed
  3. Murphy PA, Kim TN, Huang L, Nielsen CM, Lawton MT, Adams RH, Schaffer CB, Wang RA. Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):18007-12. View in PubMed
  4. Lin Y, Jiang W, Ng J, Jina A, Wang RA. Endothelial ephrin-B2 is essential for arterial vasodilation in mice. Microcirculation. 2014 Oct; 21(7):578-86. View in PubMed
  5. Nielsen CM, Cuervo H, Ding VW, Kong Y, Huang EJ, Wang RA. Deletion of Rbpj from postnatal endothelium leads to abnormal arteriovenous shunting in mice. Development. 2014 Oct; 141(19):3782-92. View in PubMed
  6. Lindskog H, Kim YH, Jelin EB, Kong Y, Guevara-Gallardo S, Kim TN, Wang RA. Molecular identification of venous progenitors in the dorsal aorta reveals an aortic origin for the cardinal vein in mammals. Development. 2014 Mar; 141(5):1120-8. View in PubMed
  7. Costa MJ, Wu X, Cuervo H, Srinivasan R, Bechis SK, Cheang E, Marjanovic O, Gridley T, Cvetic CA, Wang RA. Notch4 is required for tumor onset and perfusion. Vasc Cell. 2013; 5(1):7. View in PubMed
  8. Kim TN, Goodwill PW, Chen Y, Conolly SM, Schaffer CB, Liepmann D, Wang RA. Line-scanning particle image velocimetry: an optical approach for quantifying a wide range of blood flow speeds in live animals. PLoS One. 2012; 7(6):e38590. View in PubMed
  9. Murphy PA, Kim TN, Lu G, Bollen AW, Schaffer CB, Wang RA. Notch4 normalization reduces blood vessel size in arteriovenous malformations. Sci Transl Med. 2012 Jan 18; 4(117):117ra8. View in PubMed
  10. Miniati D, Jelin EB, Ng J, Wu J, Carlson TR, Wu X, Looney MR, Wang RA. Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice. Am J Physiol Lung Cell Mol Physiol. 2010 Feb; 298(2):L169-77. View in PubMed
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