Department of Surgery »  Faculty »  Garrett R. Roll, M.D.

Garrett R. Roll, M.D., FACS

Assistant Professor of Surgery
Division of Transplant Surgery

Contact Information

Academic Office
(415) 353-8725
garrett.roll@ucsf.edu
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  • Boston College, BS, Finance, 1995-1999
  • Brandeis University, Post Baccalaureate, Premedical, 1999-2001
  • Temple University School of Medicine, MD, 2001-2005
  • University of California, San Francisco, General Surgery, 2005-2012
  • UCSF Department of GI Hepatology Research Fellowship
  • University of California, San Francisco, Abdominal Transplant Surgery, 2012-2014
  • Senior international Fellow in liver transplant and retrieval, Queen Elizabeth Hospital, Birmingham, England
  • American Board of Surgery, General Surgery
  • Transplantation
  • HBP surgery
  • Cell therapy with hepatocytes and hepatocyte-like cells derived from stem cells.
  • Normothetic machine liver perfusion
  • Role of miRNA in liver regeneration

Dr. Roll is a general surgeon specializing in abdominal organ transplantation. He completed both general surgery training and the abdominal organ transplant fellowship at the University of California San Francisco. 

During his training, Dr. Roll spent 2 years in Dr. Holger Willenbring's laboratory investigating stem cell biology in the context of liver cell therapy, as well as normal and pathologic liver regeneration. His research concentrated on the use of hepatocyte-like cells derived from stem cells to be used in liver cell therapy. In particular, Dr. Roll investigated the regenerative capabilities of hepatocytes derived from induced pluripotent stem (iPS) cells. They used a genetically deficient mouse model of liver disease as a way to test the functional capabilities of these cells after transplantation. They were able to demonstrate that the profound proliferative capabilities of adult hepatocytes are retained by hepatocytes derived from iPS cells, and transplanting these cells rescued mice with liver failure. Dr. Roll also investigated the role of miRNA in liver regeneration, and the rejection of transplanted hepatocytes and hepatocyte-like cells. The principles of his research will remain valuable in liver and pancreas cell therapy translational science for years.

After fellowship Dr. Roll moved to England to become a Senior International Fellow in Liver Transplant and Multi Organ Procurement at Queen Elizabeth Hospital, Birmingham, one of the busiest liver transplant departments in the United Kingdom. There he gained valuable experience in the blossoming field of normothermic machine liver perfusion prior to returning to UCSF as an Assistant Professor of Surgery in the division of Transplant.

Most recent publications from a total of 27
  1. Wisel SA, Gardner JM, Roll GR, Harbell J, Freise CE, Feng S, Kang SM, Hirose R, Kaufman DB, Posselt A, Stock PG. Pancreas-after-Islet (PAI) transplantation in non-uremic Type 1 diabetes: A strategy for restoring durable insulin independence. Am J Transplant. 2017 May 10. View in PubMed
  2. Braun HJ, Ascher NL, Roll GR, Roberts JP. Biliary complications following living donor hepatectomy. Transplant Rev (Orlando). 2016 Oct; 30(4):247-52. View in PubMed
  3. Parekh J, Roll GR, Wisel S, Rushakoff RJ, Hirose R. Effect of Moderately Intense Perioperative Glucose Control on Renal Allograft Function: A Pilot Randomized Controlled Trial in Renal Transplantation. Clin Transplant. 2016 Jul 16. View in PubMed
  4. Roll GR, Stock PG. Strategies to improve outcomes for HCV/HIV co-infected liver transpant candidates. Liver Transpl. 2016 Jul 8. View in PubMed
  5. Pitchaimuthu M, Roll GR, Zia Z, Olliff S, Mehrzad H, Hodson J, Gunson BK, Perera MT, Isaac JR, Muiesan P, Mirza DF, Mergental H. Long-term follow-up after endovascular treatment of hepatic venous outflow obstruction following liver transplantation. Transpl Int. 2016 Jul 2. View in PubMed
  6. Battula NR, Plato M, Anbarasan R, Perera MT, Ong E, Roll GR, Ferraz Neto BH, Mergental H, Isaac J, Muiesan P, Sharif K, Mirza DF. Intention to Split Policy: A Successful Strategy in a Combined Pediatric and Adult Liver Transplant Center. Ann Surg. 2016 Jun 30. View in PubMed
  7. Braun HJ, Dodge JL, Roll GR, Freise CE, Ascher NL, Roberts JP. Impact of Graft Selection on Donor and Recipient Outcomes After Living Donor Liver Transplantation. Transplantation. 2016 Jun; 100(6):1244-50. View in PubMed
  8. Eldeen FZ, Mourad MM, Bhandari M, Roll G, Gunson B, Mergental H, Bramhall S, Isaac J, Muiesan P, Mirza DF, Perera MT. Accepting multiple simultaneous liver offers does not negatively impact transplant outcomes. Transpl Int. 2016 Feb; 29(2):227-33. View in PubMed
  9. Perera T, Mergental H, Stephenson B, Roll GR, Cilliers H, Liang R, Angelico R, Hubscher S, Neil DA, Reynolds G, Isaac J, Adams DA, Afford S, Mirza DF, Muiesan P. First human liver transplantation using a marginal allograft resuscitated by normothermic machine perfusion. Liver Transpl. 2016 Jan; 22(1):120-4. View in PubMed
  10. Roll GR, Muiesan P. The safety and efficacy of proximal splenic artery embolization after liver transplantation are still not clearly defined. Liver Transpl. 2015 Apr; 21(4):417-8. View in PubMed
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