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Legendary Surgeon Maurice Galante Dies
Maurice Galante, M.D., a legendary master surgeon at UCSF and renaissance man, died on February 5, 2013. His career is memorialized by the Maurice Galante Lecture Program and Maurice Galante Distinguished Professorship.
Nancy Boudreau, Ph.D.
Associate Professor of Surgery
Division of General Surgery
Elsbach-Richards Professor of Surgical Research
Director, Surgical Research Lab, SFGH
Contact Information
San Francisco, CA 94143-1302
415-206-6946 Office
415-206-6997 Fax
nboudreau@sfghsurg.ucsf.edu
BiographyEducation
- Dalhousie University, Halifax, N.S., Canada, B.Sc. (Hon), 1981, Biology
- Dalhousie University, Halifax, N.S., Canada, M.Sc., 1984, Pharmacology
- University of Toronto, Toronto, ON, Canada, Ph.D., 1991, Pathology
Postdoctoral Training
- The Scripps Research Institute, La Jolla CA, Post-Doctoral Fellow, September 1995-November 1996.
- Research: Regulation of endothelial cell integrin and proteinase expression by Homeobox genes during angiogenesis. Supervisor, David Cheresh.
- Lawrence Berkeley Laboratory, University of California Berkeley, Post-Doctoral Fellow, June 1991- September 1995
- Research: Regulation of gene expression, oncogenesis and apoptosis by the Extracellular Matrix. Supervisor, Mina Bissell.
Research Interests
- Homeobox genes in wound repair
- Hox genes extracellular matrix remodeling and angiogenesis
Biography
Dr. Nancy Boudreau is an Associate Professor of Surgery and the Elsbach-Richards Professor of the UCSF Division of Surgery Research Laboratory at the San Francisco General Hospital. Dr. Boudreau is a graduate of the Dalhousie University in Halifax NS, Canada and received her Ph. D. from the University of Toronto. Her laboratory is investigating the role of the Homeobox (Hox) genes in the regulation of extracellular matrix remodeling during pathological angiogenesis associated with tumor growth or wound healing. At present, her laboratory is the only group to date which has conclusively demonstrated a role for this group of master transcriptional regulators during the process of neovascularization. Dr. Boudreau's duties are limited to surgical research.
Selected Publications
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Mace KA, Yu DH, Paydar KZ, Boudreau N, Young DM. Sustained expression of Hif-1alpha in the diabetic environment promotes angiogenesis and cutaneous wound repair. Wound Repair Regen. 2007 Sep-Oct;15(5):636-45.
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Yu DH, Mace KA, Hansen SL, Boudreau N, Young DM. Effects of decreased insulin-like growth factor-1 stimulation on hypoxia inducible factor 1-alpha protein synthesis and function during cutaneous repair in diabetic mice. Wound Repair Regen. 2007 Sep-Oct;15(5):628-35.
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Vlahakis NE, Young BA, Atakilit A, Hawkridge AE, Issaka RB, Boudreau N, Sheppard D. Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis. J Biol Chem. 2007 May 18;282(20):15187-96.
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Hansen SL, Dosanjh A, Young DM, Boudreau N, Hoffman WY.Hemangiomas and homeobox gene expression.J Craniofac Surg. 2006 Jul;17(4):767-71.
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Boudreau N, Weaver V. Forcing the third dimension. Cell. 2006 May 5;125(3):429-31.
In the News
UCSF researchers identify gene involved in inhibiting breast tumor growth
UCSF Department of Surgery - Apr 14, 2010Valerie Weaver and collaborators have identified the first positive regulator of BRCA1, establishing that the loss of the homeobox gene HoxA9 promotes tumor growth in breasts. The scientists found that restoring HoxA9 in breast cancer cells inhibited their malignant behavior in culture and in vivo. Intriguingly, the researchers learned that while HoxA9 has been shown to promote leukemia, it actually functions as a tumor suppressor in the breast. This eight-year project was led by Valerie M. Weaver, PhD, a faculty member in the Department of Surgery, "The finding demonstrates what we've seen before - that a gene that drives tumors in one disease can reduce tumors in another disease," she says.
