banner

Nancy Boudreau, Ph.D.

Associate Professor of Surgery
Division of General Surgery
Elsbach-Richards Professor of Surgical Research
Director, Surgical Research Lab, SFGH

Contact Information

Campus Box 1302
San Francisco, CA  94143-1302
415-206-6946 Office
415-206-6997 Fax
nboudreau@sfghsurg.ucsf.edu

Education

  • Dalhousie University, Halifax, N.S., Canada, B.Sc. (Hon), 1981, Biology
  • Dalhousie University, Halifax, N.S., Canada, M.Sc., 1984, Pharmacology
  • University of Toronto, Toronto, ON, Canada, Ph.D., 1991, Pathology

Postdoctoral Training

  • The Scripps Research Institute, La Jolla CA, Post-Doctoral Fellow, September 1995-November 1996.
  • Research:  Regulation of endothelial cell integrin and proteinase expression by Homeobox genes during angiogenesis.  Supervisor, David Cheresh.
  • Lawrence Berkeley Laboratory, University of California Berkeley, Post-Doctoral Fellow, June 1991- September 1995
  • Research:  Regulation of gene expression, oncogenesis and apoptosis by the Extracellular Matrix. Supervisor, Mina Bissell.

Research Interests

  • Homeobox genes in wound repair
  • Hox genes extracellular matrix remodeling and angiogenesis

Biography

Dr. Nancy Boudreau is an Associate Professor of Surgery and the Elsbach-Richards Professor of the UCSF Division of Surgery Research Laboratory at the San Francisco General Hospital.  Dr. Boudreau is a graduate of the Dalhousie University in Halifax NS, Canada and received her Ph. D. from the University of Toronto.  Her laboratory is investigating the role of the Homeobox (Hox) genes in the regulation of extracellular matrix remodeling during pathological angiogenesis associated with tumor growth or wound healing. At present, her laboratory is the only group to date which has conclusively demonstrated a role for this group of master transcriptional regulators during the process of neovascularization.  Dr. Boudreau's duties are limited to surgical research.

 

Publications

Most recent publications from a total of 47
  1. Kachgal S, Mace KA, Boudreau NJ. The dual roles of homeobox genes in vascularization and wound healing. Cell Adh Migr. 2012 Nov-Dec; 6(6):457-70. View in PubMed
  2. Bahrami SB, Veiseh M, Boudreau NJ. Isolation and expansion of endothelial progenitor cells derived from mouse embryonic stem cells. Methods Mol Biol. 2012; 916:81-96. View in PubMed
  3. Bahrami SB, Veiseh M, Dunn AA, Boudreau NJ. Temporal changes in Hox gene expression accompany endothelial cell differentiation of embryonic stem cells. Cell Adh Migr. 2011 Mar-Apr; 5(2):133-41. View in PubMed
  4. Gilbert PM, Mouw JK, Unger MA, Lakins JN, Gbegnon MK, Clemmer VB, Benezra M, Licht JD, Boudreau NJ, Tsai KK, Welm AL, Feldman MD, Weber BL, Weaver VM. HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype. J Clin Invest. 2010 May; 120(5):1535-50. View in PubMed
  5. Sounni NE, Dehne K, van Kempen L, Egeblad M, Affara NI, Cuevas I, Wiesen J, Junankar S, Korets L, Lee J, Shen J, Morrison CJ, Overall CM, Krane SM, Werb Z, Boudreau N, Coussens LM. Stromal regulation of vessel stability by MMP14 and TGFbeta. Dis Model Mech. 2010 May-Jun; 3(5-6):317-32. View in PubMed
  6. Chen A, Cuevas I, Kenny PA, Miyake H, Mace K, Ghajar C, Boudreau A, Bissell MJ, Bissell M, Boudreau N. Endothelial cell migration and vascular endothelial growth factor expression are the result of loss of breast tissue polarity. Cancer Res. 2009 Aug 15; 69(16):6721-9. View in PubMed
  7. Mace KA, Restivo TE, Rinn JL, Paquet AC, Chang HY, Young DM, Boudreau NJ. HOXA3 modulates injury-induced mobilization and recruitment of bone marrow-derived cells. Stem Cells. 2009 Jul; 27(7):1654-65. View in PubMed
  8. Zhu Y, Cuevas IC, Gabriel RA, Su H, Nishimura S, Gao P, Fields A, Hao Q, Young WL, Yang GY, Boudreau NJ. Restoring transcription factor HoxA5 expression inhibits the growth of experimental hemangiomas in the brain. J Neuropathol Exp Neurol. 2009 Jun; 68(6):626-32. View in PubMed
  9. Cuevas I, Boudreau N. Managing tumor angiogenesis: lessons from VEGF-resistant tumors and wounds. Adv Cancer Res. 2009; 103:25-42. View in PubMed
  10. Arderiu G, Cuevas I, Chen A, Carrio M, East L, Boudreau NJ. HoxA5 stabilizes adherens junctions via increased Akt1. Cell Adh Migr. 2007 Oct-Dec; 1(4):185-95. View in PubMed
  11. View All Publications
Publications provided by UCSF Profiles, powered by CTSI at UCSF. View profile of Nancy Boudreau, Ph.D.
Please note: UCSF Profiles publications are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact CTSI for help.

X