Department of Surgery »  Faculty »  SFGH Hospital & Trauma Center »  Mitchell J. Cohen, M.D.

Mitchell J. Cohen, M.D.

Professor of Surgery
Division of General Surgery
Associate Trauma Medical Director, SFGH
Director of Trauma Research, SFGH
Director of Acute Care Research, San Francisco Injury Center 

Contact Information

Campus Box 0807
San Francisco, CA 94143-0807
(415) 206-8673 Appointments
(415) 206-4623 Office
(415) 206-5484 Fax

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  • Brandeis University, Waltham, Massachusetts, B.A., Politics, 1991
  • Mount Sinai School of Medicine, New York, New York, M.D., 1997
  • Rush University/Cook County Integrated Surgical Residency, Chicago, Illinois, 1997-2004
  • Loyola University Medical Center,Department of Surgery, Burn and Shock Trauma Institute, Maywood, Illinois,1999-2001
  • UCSF, Trauma and Critical Care Fellowships, San Francisco General Hospital, San Francisco, California, 2004-2006
  • American Board of Surgery, 2005
  • American Board of Surgery, Surgical Critical Care, 2005
  • Critical Care Surgery
  • General Surgery
  • Trauma Surgery

Dr. Mitchell Cohen, Assistant Professor of Surgery in Residence, joined the faculty at UCSF-SFGH in July 2006. Dr. Cohen is a Board-certified general surgeon with an additional board certification in Surgical Critical Care.

Dr. Cohen received his undergraduate degree from Brandeis University and his medical degree at the Mount Sinai School of Medicine.  He then completed his Residency at Rush University/Cook County Integrated in 1994.  He then completed a Research Fellowship at Loyola University Medical Center in the Department of Surgery, Burn and Shock Trauma Institute in 2001 and a Fellowship in Trauma and Critical Care UCSF-SFGH from 2004-2006.

Dr. Cohen has an active basic science research lab where he studies coagulation and inflammation perturbations after trauma. In addition he is actively involved in the CDC San Francisco Injury Center with projects related to inflammatory lung injury and monitoring of resuscitation and coagulation after injury.  Dr. Cohen was recently awarded a fellowship award in Hemostasis and Resuscitation from the American Association for the Surgery of Trauma.  Along with his clinical and basic science translational research, Dr. Cohen has a keen interest in in silico and informatic modeling of biological systems and patient physiology. These interests have led to work with collaborators at UCSF and UC Berkeley as well as the Intel Corporation.

Dr. Cohen currently is the Acute Care Director for the CDC San Francisco Injury Center. He continues to have a busy clinical practice and is one of the most productive research physicians at the University of California, San Francisco, San Francisco General Hospital.

Dr. Cohen's research centers on perturbations of coagulation after trauma. Specifically his lab continues to examine the mechanism of traumatic coagulopathy and complement dependent activation of the protein C system after trauma. Concurrently patient samples are collected to further examine traumatic coagulopathy and the activation of protein C after trauma. Over the past year his research group has published 5 manuscripts with two additional in review. In October, he submitted an NIH K08 application centered around in vivo, in vitro and in silico approaches to traumatic coagulopathy. Natasha Bir, MD has recently joined Dr. Cohen's  lab and has begun an ambitious project looking at the effect of protein C on endothelial permeability.

In addition to the basic science work, Dr. Cohen continues work on the application of complex systems approaches to modeling coagulation, inflammation and high throughput physiologic data from severely injured patients.  He contributes to and receives funding from the 2007-2009 UC Discovery Grant Grant No: GCP06 10226. This grant seeks to apply novel bioinformatics techniques to severely injured ICU patients.

Dr. Cohen has contributed to and is partially funded by the National Center for Injury Prevention and Control Grant No: R49/CCR903697-07. As part of the CDC San Francisco Injury Center he is overseeing acute care research. Specifically his work centers on the application of new monitoring technologies to detect the efficacy of our resuscitation conduct. In this role, he oversees several residents and medical students.

ResidentYearsGrant or Funding Source
Lucy Kornblith, M.D. 2012- Trauma Training Fellow
Matt Kutcher, M.D. 2010-2012 T32 Trauma Training Fellow
Lisa Marie Brown, M.D. 2008-2009 T32 Trauma Training Fellow
  1. Cohen MJ, Shankar R, Stevenson J, Fernandez R, Gamelli RL, Jones SB: Bone Marrow Norepinephrine Mediates Development of Functionally Different Macrophages Following Thermal Injury and Sepsis. Ann Surgery 2004 Jul (1) 132-41.
  2. Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF: The Pathogenetic and Prognostic Significance of The Protein C Pathway in Acute Traumatic Coagulopathy. Ann Surg 2007 May; 245 (5): 812-8.
  3. Cohen MJ, Shankar R, Carroll C, Li-ke H, Gamelli R, Jones S, Kuzhali M:  Severity of Burn Injury and Sepsis Determines the Cytokine Responses of Bone Marrow Progenitor Derived Macrophages. J Trauma 2007 Apr; 62 (4): 858-67.
  4. Cohen MJ, Brohi K, Ganter M, Grush A, Mackersie RC, Manley, GT, Pittet JF:
    Early Coagulopathy After Traumatic Brain Injury: The Role of Hypoperfusion and The Protein C Pathway. J Trauma 2007 Dec; 63 (6) 1254-63.
  5. Ganter MT, Cohen MJ*, Brohi K, Chesebro BB, Staudenmayer K, Rahn P, Christaans S, Bir N, Pittet JF: Angiopoietin-2 Marker and Mediator of Endothelial Activation with Prognostic Significance Early after Trauma. Ann Surg (2008 In press) *Co-First Author.