Mitchell J. Cohen, M.D.

Associate Professor of Surgery
Division of General Surgery
Director of Acute Care Research, San Francisco Injury Center 

Contact Information

Campus Box 0807
San Francisco, CA 94143-0807
(415) 206-8673 Appointments
(415) 206-4623 Office
(415) 206-5484 Fax


  • Brandeis University, Waltham, Massachusetts, B.A., Politics, 1991
  • Mount Sinai School of Medicine, New York, New York, M.D., 1997


  • Rush University/Cook County Integrated Surgical Residency, Chicago, Illinois, 1997-2004


  • Loyola University Medical Center,Department of Surgery, Burn and Shock Trauma Institute, Maywood, Illinois,1999-2001
  • UCSF, Trauma and Critical Care Fellowships, San Francisco General Hospital, San Francisco, California, 2004-2006

Board Certifications

  • American Board of Surgery, 2005
  • American Board of Surgery, Surgical Critical Care, 2005

Clinical Expertise

  • Critical Care Surgery
  • General Surgery
  • Trauma Surgery


Dr. Mitchell Cohen, Assistant Professor of Surgery in Residence, joined the faculty at UCSF-SFGH in July 2006. Dr. Cohen is a Board-certified general surgeon with an additional board certification in Surgical Critical Care.

Dr. Cohen received his undergraduate degree from Brandeis University and his medical degree at the Mount Sinai School of Medicine.  He then completed his Residency at Rush University/Cook County Integrated in 1994.  He then completed a Research Fellowship at Loyola University Medical Center in the Department of Surgery, Burn and Shock Trauma Institute in 2001 and a Fellowship in Trauma and Critical Care UCSF-SFGH from 2004-2006.

Dr. Cohen has an active basic science research lab where he studies coagulation and inflammation perturbations after trauma. In addition he is actively involved in the CDC San Francisco Injury Center with projects related to inflammatory lung injury and monitoring of resuscitation and coagulation after injury.  Dr. Cohen was recently awarded a fellowship award in Hemostasis and Resuscitation from the American Association for the Surgery of Trauma.  Along with his clinical and basic science translational research, Dr. Cohen has a keen interest in in silico and informatic modeling of biological systems and patient physiology. These interests have led to work with collaborators at UCSF and UC Berkeley as well as the Intel Corporation.

Dr. Cohen currently is the Acute Care Director for the CDC San Francisco Injury Center. He continues to have a busy clinical practice and is one of the most productive research physicians at the University of California, San Francisco, San Francisco General Hospital.

Research Overview

Dr. Cohen's research centers on perturbations of coagulation after trauma. Specifically his lab continues to examine the mechanism of traumatic coagulopathy and complement dependent activation of the protein C system after trauma. Concurrently patient samples are collected to further examine traumatic coagulopathy and the activation of protein C after trauma. Over the past year his research group has published 5 manuscripts with two additional in review. In October, he submitted an NIH K08 application centered around in vivo, in vitro and in silico approaches to traumatic coagulopathy. Natasha Bir, MD has recently joined Dr. Cohen's  lab and has begun an ambitious project looking at the effect of protein C on endothelial permeability.

In addition to the basic science work, Dr. Cohen continues work on the application of complex systems approaches to modeling coagulation, inflammation and high throughput physiologic data from severely injured patients.  He contributes to and receives funding from the 2007-2009 UC Discovery Grant Grant No: GCP06 10226. This grant seeks to apply novel bioinformatics techniques to severely injured ICU patients.

Dr. Cohen has contributed to and is partially funded by the National Center for Injury Prevention and Control Grant No: R49/CCR903697-07. As part of the CDC San Francisco Injury Center he is overseeing acute care research. Specifically his work centers on the application of new monitoring technologies to detect the efficacy of our resuscitation conduct. In this role, he oversees several residents and medical students.

Grants & Funding

Mentored Research Residents

ResidentYearsGrant or Funding Source
Lucy Kornblith, M.D. 2012- Trauma Training Fellow
Matt Kutcher, M.D. 2010-2012 T32 Trauma Training Fellow
Lisa Marie Brown, M.D. 2008-2009 T32 Trauma Training Fellow


Most recent publications from a total of 50
  1. Kornblith LZ, Kutcher ME, Callcut RA, Redick BJ, Hu CK, Cogbill TH, Baker CC, Shapiro ML, Burlew CC, Kaups KL, Demoya MA, Haan JM, Koontz CH, Zolin SJ, Gordy SD, Shatz DV, Paul DB, Cohen MJ. Mechanical ventilation weaning and extubation after spinal cord injury: A Western Trauma Association multicenter study. J Trauma Acute Care Surg. 2013 Dec; 75(6):1060-70. View in PubMed
  2. Napolitano LM, Cohen MJ, Cotton BA, Schreiber MA, Moore EE. Re: Is viscoelastic evidence of hyperfibrinolysis the ideal indicator for tranexamic acid administration in trauma? J Trauma Acute Care Surg. 2013 Oct; 75(4):743-4. View in PubMed
  3. Kutcher ME, Kornblith LZ, Narayan R, Curd V, Daley AT, Redick BJ, Nelson MF, Fiebig EW, Cohen MJ. A paradigm shift in trauma resuscitation: evaluation of evolving massive transfusion practices. JAMA Surg. 2013 Sep; 148(9):834-40. View in PubMed
  4. Cripps MW, Kutcher ME, Daley A, McCreery RC, Greenberg MD, Cachola LM, Redick BJ, Nelson MF, Cohen MJ. Cause and timing of death in massively transfused trauma patients. J Trauma Acute Care Surg. 2013 Aug; 75(2 Suppl 2):S255-62. View in PubMed
  5. Robinson BR, Cotton BA, Pritts TA, Branson R, Holcomb JB, Muskat P, Fox EE, Wade CE, del Junco DJ, Bulger EM, Cohen MJ, Schreiber MA, Myers JG, Brasel KJ, Phelan HA, Alarcon LH, Rahbar MH, Callcut RA. Application of the Berlin definition in PROMMTT patients: the impact of resuscitation on the incidence of hypoxemia. J Trauma Acute Care Surg. 2013 Jul; 75(1 Suppl 1):S61-7. View in PubMed
  6. Cohen MJ, Kutcher M, Redick B, Nelson M, Call M, Knudson MM, Schreiber MA, Bulger EM, Muskat P, Alarcon LH, Myers JG, Rahbar MH, Brasel KJ, Phelan HA, del Junco DJ, Fox EE, Wade CE, Holcomb JB, Cotton BA, Matijevic N. Clinical and mechanistic drivers of acute traumatic coagulopathy. J Trauma Acute Care Surg. 2013 Jul; 75(1 Suppl 1):S40-7. View in PubMed
  7. Kornblith LZ, Kutcher ME, Evans AE, Redick BJ, Privette A, Schecter WP, Cohen MJ. The "found down" patient: a diagnostic dilemma. J Trauma Acute Care Surg. 2013 Jun; 74(6):1548-52. View in PubMed
  8. Brown JB, Cohen MJ, Minei JP, Maier RV, West MA, Billiar TR, Peitzman AB, Moore EE, Cuschieri J, Sperry JL. Goal-directed resuscitation in the prehospital setting: a propensity-adjusted analysis. J Trauma Acute Care Surg. 2013 May; 74(5):1207-12; discussion 1212-4. View in PubMed
  9. Kutcher ME, Ferguson AR, Cohen MJ. A principal component analysis of coagulation after trauma. J Trauma Acute Care Surg. 2013 May; 74(5):1223-9; discussion 1229-30. View in PubMed
  10. Callcut RA, Cotton BA, Muskat P, Fox EE, Wade CE, Holcomb JB, Schreiber MA, Rahbar MH, Cohen MJ, Knudson MM, Brasel KJ, Bulger EM, Del Junco DJ, Myers JG, Alarcon LH, Robinson BR. Defining when to initiate massive transfusion: a validation study of individual massive transfusion triggers in PROMMTT patients. J Trauma Acute Care Surg. 2013 Jan; 74(1):59-65, 67-8; discussion 66-7. View in PubMed
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