Dr. Mitchell Cohen, Assistant Professor of Surgery in Residence, joined the faculty at UCSF-SFGH in July 2006. Dr. Cohen is a Board-certified general surgeon with an additional board certification in Surgical Critical Care.
Dr. Cohen received his undergraduate degree from Brandeis University and his medical degree at the Mount Sinai School of Medicine. He then completed his Residency at Rush University/Cook County Integrated in 1994. He then completed a Research Fellowship at Loyola University Medical Center in the Department of Surgery, Burn and Shock Trauma Institute in 2001 and a Fellowship in Trauma and Critical Care UCSF-SFGH from 2004-2006.
Dr. Cohen has an active basic science research lab where he studies coagulation and inflammation perturbations after trauma. In addition he is actively involved in the CDC San Francisco Injury Center with projects related to inflammatory lung injury and monitoring of resuscitation and coagulation after injury. Dr. Cohen was recently awarded a fellowship award in Hemostasis and Resuscitation from the American Association for the Surgery of Trauma. Along with his clinical and basic science translational research, Dr. Cohen has a keen interest in in silico and informatic modeling of biological systems and patient physiology. These interests have led to work with collaborators at UCSF and UC Berkeley as well as the Intel Corporation.
Dr. Cohen currently is the Acute Care Director for the CDC San Francisco Injury Center. He continues to have a busy clinical practice and is one of the most productive research physicians at the University of California, San Francisco, San Francisco General Hospital.
Dr. Cohen's research centers on perturbations of coagulation after trauma. Specifically his lab continues to examine the mechanism of traumatic coagulopathy and complement dependent activation of the protein C system after trauma. Concurrently patient samples are collected to further examine traumatic coagulopathy and the activation of protein C after trauma. Over the past year his research group has published 5 manuscripts with two additional in review. In October, he submitted an NIH K08 application centered around in vivo, in vitro and in silico approaches to traumatic coagulopathy. Natasha Bir, MD has recently joined Dr. Cohen's lab and has begun an ambitious project looking at the effect of protein C on endothelial permeability.
In addition to the basic science work, Dr. Cohen continues work on the application of complex systems approaches to modeling coagulation, inflammation and high throughput physiologic data from severely injured patients. He contributes to and receives funding from the 2007-2009 UC Discovery Grant Grant No: GCP06 10226. This grant seeks to apply novel bioinformatics techniques to severely injured ICU patients.
Dr. Cohen has contributed to and is partially funded by the National Center for Injury Prevention and Control Grant No: R49/CCR903697-07. As part of the CDC San Francisco Injury Center he is overseeing acute care research. Specifically his work centers on the application of new monitoring technologies to detect the efficacy of our resuscitation conduct. In this role, he oversees several residents and medical students.
UCSF/SFGH surgeon and trauma researcher, Mitchell J. Cohen, MD, has teamed up with researchers around the globe to change the way acute traumatic coagulopathy is treated. His work is leading to a new understanding of the causes of and appropriate treatment for uncontrolled bleeding after trauma.
"It seems that sometimes major injuries trigger a problem with the blood-clotting process, causing blood to leak from the body faster than it can be stemmed. This clotting disorder affects as many as 1 in 4 major trauma victims. So Brohi and others have developed a way of treating people that prioritises fixing their blood over fixing their body. It's a radical departure from standard procedures, and one that is by no means widely accepted, but if they're right it could save thousands of lives every year worldwide, and a whole chapter of trauma care will have to be rewritten."
The Department of Surgery at SFGH is pleased to announce the launch of the Cohen Lab website. Led by Mitchell J. Cohen, M.D., Associate Professor of Surgery and Director of Acute Care Research at the San Francisco Injury Center, the site will highlight the application of translational discoveries to acute traumatic coagulopathy. The Cohen lab is focused on elucidating the biology of coagulation and inflammation after injury. Incorporating clinical, in vivo, in vitro, and in silico approaches, the research embodies a truly translational approach for investigating the causes of uncontrolled hemorrhage, the leading cause of (potentially preventable) death in both combat casualties and civilian injuries.
Mitchell Cohen, MD, UCSF assistant professor of surgery, has received a $225,000 research grant from the National Trauma Institute to investigate the timing and mechanism of traumatic coagulopathy.