Department of Surgery »  Faculty »  Plastic & Reconstructive Surgery »  Jason H. Pomerantz, M.D.

Jason H. Pomerantz, M.D.

Associate Professor of Surgery
Division of Plastic and Reconstructive Surgery
Surgical Director, Craniofacial Center
Director, Pomerantz Lab

Contact Information

UCSF Medical Center
Division of Plastic & Reconstructive Surgery
(415) 353-4389 phone
(415) 353-4330 fax
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  • 1990-1994 University of Pennsylvania, B.A. Biology
  • 1994-2000 Albert Einstein College of Medicine, M.D.
  • 2000-2001 University of California-San Francisco, Intern General Surgery
  • 2001-2003 University of California-San Francisco, Residency General Surgery
  • 2006-2008 University of California-San Francisco, Residency Plastic Surgery
  • 1996-1998 Howard Hughes Medical Institute, Researh Training Fellowship
  • 2008-2009 University of Washington, Seattle, Craniofacial Surgery Fellowship
  • 2003-2006 Stanford University, Postdoctoral Fellowship
  • American Board of Plastic Surgery 2010
  • Cleft lip and Palate
  • Congential Deformities
  • Craniofacial Surgery
  • Craniosynostosis
  • Pediatric Plastic Surgery
  • Traumatic facial injuries
  • Cancer
  • Cellular Growth Control
  • Muscle Regeneration
  • Nuclear Reprogramming
  • Stem Cell Biology

Jason Pomerantz, M.D. is an Associate Professor of Surgery, Surgical Director of the UCSF Craniofacial Center, and Director of the Pomerantz Lab. Dr. Pomerantz is an expert  craniofacial surgeon specializing in pediatric plastic and reconstructive surgery and repair of craniofacial anomalies. He treats children and adults with congenital or acquired deformities, especially the head and face, including cleft lip and palate, craniosynostosis and traumatic facial injuries.

Dr. Pomerantz earned his medical degree at the Albert Einstein College of Medicine. He completed a residency at UCSF, a postdoctoral research fellowship in regeneration biology at Stanford University, and a fellowship in craniofacial surgery at the University of Washington.

As a physician-scientist, Dr. Pomerantz  is exploring ways to address problems that cannot be treated surgically, such as amputations and lost heart muscle. A major focus of his research  is to understand why primitive organisms such as newts and salamanders have the ability to regenerate limbs, while humans and other mammals do not.

Dr. Pomerantz is a researcher at the  UCSF Program in Craniofacial  Biology (PCB), and has affiliations with the UCSF Biomedical Sciences (BMS) Graduate Program, and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF.

His scientific collaboration with the Blau Laboratory, Baxter Laboratory for Stem Cell Biology at Stanford University, resulted in a paper in the journal Cell Stem Cell that has garnered considerable public interest. (see also  First Steps in Unlocking the Human Ability to Regenerate).

Ultimately, Dr. Pomerantz and colleagues hope to identify the genes responsible for regeneration, genes that have evolved differently between species. This has implications for the reconstruction of damaged or missing tissue resulting from congenital abnormalities and those acquired as a result of trauma.

The research program of our lab is closely intertwined with regenerative medicine. With foundations in muscle and cancer biology, we are investigating regenerative mechanisms including stem cell development and de-differentiation. By employing model organisms such as zebrafish and mouse and extending discoveries to human cells and tissues, we hope to gain fundamental insight that can be translated into clinical advances, most notably solving the structural and reconstructive problems of the limbs, face, and head, whether congenital or acquired.

ResidentYearsGrant or Funding Source
Xiaoti Xu, M.D.
Alvin Wong, M.D.
Most recent publications from a total of 21
  1. Xu X, Wilschut KJ, Kouklis G, Tian H, Hesse R, Garland C, Sbitany H, Hansen S, Seth R, Knott PD, Hoffman WY, Pomerantz JH. Human Satellite Cell Transplantation and Regeneration from Diverse Skeletal Muscles. Stem Cell Reports. 2015 Sep 8; 5(3):419-34. View in PubMed
  2. Balkin DM, Chen I, Oberoi S, Pomerantz JH. Bilateral Coronoidectomy by Craniofacial Approach for Hecht Syndrome-Related Trismus. J Craniofac Surg. 2015 Sep; 26(6):1954-6. View in PubMed
  3. Tamaki S, Nye C, Slorach E, Scharp D, Blau HM, Whiteley PE, Pomerantz JH. Simultaneous silencing of multiple RB and p53 pathway members induces cell cycle reentry in intact human pancreatic islets. BMC Biotechnol. 2014; 14(1):86. View in PubMed
  4. Pomerantz JH, Blau HM. Tumor suppressors: enhancers or suppressors of regeneration? Development. 2013 Jun; 140(12):2502-12. View in PubMed
  5. Garland CB, Pomerantz JH. Regenerative strategies for craniofacial disorders. Front Physiol. 2012; 3:453. View in PubMed
  6. Blau HM, Pomerantz JH. Re"evolutionary" regenerative medicine. JAMA. 2011 Jan 5; 305(1):87-8. View in PubMed
  7. Sacco A, Mourkioti F, Tran R, Choi J, Llewellyn M, Kraft P, Shkreli M, Delp S, Pomerantz JH, Artandi SE, Blau HM. Short telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR mice. Cell. 2010 Dec 23; 143(7):1059-71. View in PubMed
  8. Pajcini KV, Corbel SY, Sage J, Pomerantz JH, Blau HM. Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle. Cell Stem Cell. 2010 Aug 6; 7(2):198-213. View in PubMed
  9. Pomerantz JH, Mukherjee S, Palermo AT, Blau HM. Reprogramming to a muscle fate by fusion recapitulates differentiation. J Cell Sci. 2009 Apr 1; 122(Pt 7):1045-53. View in PubMed
  10. Palermo A, Doyonnas R, Bhutani N, Pomerantz J, Alkan O, Blau HM. Nuclear reprogramming in heterokaryons is rapid, extensive, and bidirectional. FASEB J. 2009 May; 23(5):1431-40. View in PubMed
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