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Jason H. Pomerantz, M.D.

Assistant Professor of Surgery
Division of Plastic and Reconstructive Surgery

Contact Information

Plastic and Reconstructive Surgery
400 Parnassus Ave., Sixth Floor, Suite A655
San Francisco, CA 94143-0932
Phone: (415) 353-4389
Fax:     (415) 353-4330
 
Center for Craniofacial Anomalies
513 Parnassus Avenue, S-747
San Francisco, CA 94143-0570
Phone: (415) 476-2271

jason.pomerantz@ucsfmedctr.org

Education

  • 1990-1994 University of Pennsylvania, B.A. Biology
  • 1994-2000 Albert Einstein College of Medicine, M.D.

Residencies

  • 2000-2001 University of California-San Francisco, Intern General Surgery
  • 2001-2003 University of California-San Francisco, Residency General Surgery
  • 2006-2008 University of California-San Francisco, Residency Plastic Surgery

Fellowships

  • 1996-1998 Howard Hughes Medical Institute, Researh Training Fellowship
  • 2008-2009 University of Washington, Seattle, Craniofacial Surgery Fellowship

Postdoctoral Training

  • 2003-2006 Stanford University, Postdoctoral Fellowship

Board Certifications

  • American Board of Plastic Surgery 2010

Clinical Expertise

  • Cleft lip and Palate
  • Congential Deformities
  • Craniofacial Surgery
  • Craniosynostosis
  • Pediatric Plastic Surgery
  • Traumatic facial injuries

Research Interests

  • Cancer
  • Cellular Growth Control
  • Muscle Regeneration
  • Nuclear Reprogramming
  • Stem Cell Biology

Biography

Jason Pomerantz, M.D. is an Assistant Professor in the Division of Plastic & Reconstructive Surgery. An accomplished craniofacial surgeon, Dr. Pomerantz specializes in pediatric plastic and reconstructive surgery including repair of craniofacial anomalies. He cares for children and adults with congenital or acquired deformities, especially the head and face, including cleft lip and palate, craniosynostosis and traumatic facial injuries.

Dr. Pomerantz earned his medical degree at the Albert Einstein College of Medicine. He completed a residency at UCSF, a postdoctoral research fellowship in regeneration biology at Stanford University, and a fellowship in craniofacial surgery at the University of Washington.

As a physician-scientist, Dr. Pomerantz  is exploring ways to address problems that cannot be treated surgically, such as amputations and lost heart muscle. A major focus of his research  is to understand why primitive organisms such as newts and salamanders have the ability to regenerate limbs, while humans and other mammals do not.

Dr. Pomerantz is a researcher at the The UCSF Program in Craniofacial and Mesenchymal Biology, and has affiliations with the UCSF Biomedical Sciences (BMS) Graduate Program, and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF.

His scientific collaboration with the Blau Laboratory, Baxter Laboratory for Stem Cell Biology at Stanford University, resulted in a paper in the journal Cell Stem Cell that has garnered considerable public interest. (see also  First Steps in Unlocking the Human Ability to Regenerate).

Ultimately, Dr. Pomerantz and colleagues hope to identify the genes responsible for regeneration, genes that have evolved differently between species. This has implications for the reconstruction of damaged or missing tissue resulting from congenital abnormalities and those acquired as a result of trauma.

Research Overview

My research interests are in mesenchymal tissue regeneration. Our lab is taking broadly based molecular, cellular, organismal and evolutionary approaches to study skeletal and cardiac muscle regeneration and to understand how different regenerative capacities arose among species. The ultimate practical goal of our research is to develop novel approaches to repair and regenerate tissues that will have a positive impact on the treatment of a range of human diseases such as muscle loss after trauma and cardiac dysfunction after infarction. We are using the mouse, zebrafish and axolotl as model organisms.

In regenerative organisms such as the zebrafish and axolotl, evidence suggests that apart from classical tissue stem cells, regeneration can occur by an alternative mechanism whereby post-mitotic differentiated cells reenter the cell cycle, proliferate and give rise to the regenerate. The existence of such a mechanism may underlie the extraordinary ability of these animals to regenerate body parts, including the heart. By focusing on differences in the maintenance of the post-mitotic state, we are developing models of regeneration in mice where regulation mimics the scenario in regenerative organisms.

As a clinician, Dr. Pomerantz is a plastic surgeon who specializes in pediatric plastic and reconstructive surgery including the treatment of craniofacial anomalies. He cares for children and adults with congenital or acquired deformities, especially of the head and face, such as cleft lip and palate, craniosynostosis and traumatic facial injuries.

 

Publications

Most recent publications from a total of 17
  1. Pomerantz JH, Blau HM. Tumor suppressors: enhancers or suppressors of regeneration? Development. 2013 Jun; 140(12):2502-12. View in PubMed
  2. Garland CB, Pomerantz JH. Regenerative strategies for craniofacial disorders. Front Physiol. 2012; 3:453. View in PubMed
  3. Blau HM, Pomerantz JH. Re"evolutionary" regenerative medicine. JAMA. 2011 Jan 5; 305(1):87-8. View in PubMed
  4. Sacco A, Mourkioti F, Tran R, Choi J, Llewellyn M, Kraft P, Shkreli M, Delp S, Pomerantz JH, Artandi SE, Blau HM. Short telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR mice. Cell. 2010 Dec 23; 143(7):1059-71. View in PubMed
  5. Pajcini KV, Corbel SY, Sage J, Pomerantz JH, Blau HM. Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle. Cell Stem Cell. 2010 Aug 6; 7(2):198-213. View in PubMed
  6. Pomerantz JH, Mukherjee S, Palermo AT, Blau HM. Reprogramming to a muscle fate by fusion recapitulates differentiation. J Cell Sci. 2009 Apr 1; 122(Pt 7):1045-53. View in PubMed
  7. Palermo A, Doyonnas R, Bhutani N, Pomerantz J, Alkan O, Blau HM. Nuclear reprogramming in heterokaryons is rapid, extensive, and bidirectional. FASEB J. 2009 May; 23(5):1431-40. View in PubMed
  8. Pajcini KV, Pomerantz JH, Alkan O, Doyonnas R, Blau HM. Myoblasts and macrophages share molecular components that contribute to cell-cell fusion. J Cell Biol. 2008 Mar 10; 180(5):1005-19. View in PubMed
  9. Gruber RP, Weintraub J, Pomerantz J. Suture techniques for the nasal tip. Aesthet Surg J. 2008 Jan-Feb; 28(1):92-100. View in PubMed
  10. Wan DC, Pomerantz JH, Brunet LJ, Kim JB, Chou YF, Wu BM, Harland R, Blau HM, Longaker MT. Noggin suppression enhances in vitro osteogenesis and accelerates in vivo bone formation. J Biol Chem. 2007 Sep 7; 282(36):26450-9. View in PubMed
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