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Tippi MacKenzie, M.D.

Associate Professor of Surgery
Division of Pediatric Surgery

Contact Information

  • 1987-91, Harvard University, B.A., Biochemistry
  • 1992-97, Stanford University School of Medicine, M.D., Medicine
  • 1998-99, Brigham and Women's Hospital, Resident, Surgery
  • 2002-04, Brigham and Women's Hospital, Resident, Surgery
  • 2004-05, Brigham and Women's Hospital, Chief Resident, Surgery
  • 1999-02, Children's Hospital of Philadelphia, Fellow, Fetal Therapy
  • 2005-07, Children's Hospital of Philadelphia, Fellow, Pediatric Surgery
  • American Board of Surgery, 2006
  • Fetal Treatment Center
  • Biomedical Sciences Program
  • Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
  • Advanced Laparoscopy
  • Birth Defects
  • Endocrine and Biliary Surgery
  • Fetal Surgery
  • Pediatric Surgery
  • In-Utero Stem Cell Transplantation

Dr. Tippi MacKenzie is an Associate Professor of Surgery at the UCSF Division of Pediatric Surgery and the Fetal Treatment Center. Dr. MacKenzie obtained her undergraduate degree in Biochemistry at Harvard, then came to the Bay Area for medical school at Stanford. She did her surgical residency at Brigham and Women's Hospital in Boston. During this time, she took three years to do research on fetal surgery and in utero stem cell transplantation at the Children's Hospital of Philadelphia. Following residency, she returned to CHOP for her clinical pediatric surgery fellowship.

Dr. MacKenzie's clinical interests include fetal surgery, advanced laparoscopy, and endocrine and biliary surgery.

Dr. MacKenzie has an active laboratory and is a member of the Biomedical Sciences Program and the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research. Her research focus is on mechanisms of tolerance induction following in utero stem cell transplantation  and the pathophysiology of prenatally diagnosed diseases, such as congenital diaphragmatic hernia and gastroschisis, to identify biomarkers that predict prognosis and molecular pathways that may be targets for prenatal intervention.

  • March of Dimes Birth Defects Foundation, Basil O'Connor Starter Scholar Research Award, "The Role of Maternal-Fetal Cellular Trafficking in Preterm Labor"
  • American Surgical Association Foundation, "Maternal Immune Responses to Fetal Surgical Intervention"
  • Mentored Clinical Scientist Research Career Development Award (K08), NIH/NIAID, "Maternal and fetal immune responses to in utero HSC transplantation"
  • California Institute for Regenerative Medicine, Stem Cell Transplantation Immunology Award, "Maternal and Fetal Immune Responses to In Utero Hematopoietic Stem Cell
  • Transplantation"
  • March of Dimes Birth Defects Foundation, Prematurity Research Initiative Grant,
  • "The Role of Maternal T cells in Preterm Labor"
ResidentYearsGrant or Funding Source
Cerine Jeanty, M.D. 2011-
Eveline Shue, M.D. 2011-2013
Amar Nijagal, M.D. 2009-2012 CA Institute for Regenerative Medicine Clinical Fellow Training Award
Most recent publications from a total of 49
  1. Baer RJ, Chambers CD, Jones KL, Shew SB, MacKenzie TC, Shaw GM, Jelliffe-Pawlowski LL. Maternal factors associated with the occurrence of gastroschisis. Am J Med Genet A. 2015 Jul; 167(7):1534-41. View in PubMed
  2. MacKenzie TC, David AL, Flake AW, Almeida-Porada G. Consensus statement from the first international conference for in utero stem cell transplantation and gene therapy. Front Pharmacol. 2015; 6:15. View in PubMed
  3. Derderian SC, Jeanty C, Walters MC, Vichinsky E, MacKenzie TC. In utero hematopoietic cell transplantation for hemoglobinopathies. Front Pharmacol. 2014; 5:278. View in PubMed
  4. Derderian SC, Jeanty C, Fleck SR, Cheng LS, Peyvandi S, Moon-Grady AJ, Farrell J, Hirose S, Gonzalez J, Keller RL, MacKenzie TC. The many faces of hydrops. J Pediatr Surg. 2015 Jan; 50(1):50-4. View in PubMed
  5. Jeanty C, Kunisaki SM, MacKenzie TC. Novel non-surgical prenatal approaches to treating congenital diaphragmatic hernia. Semin Fetal Neonatal Med. 2014 Dec; 19(6):349-56. View in PubMed
  6. Derderian SC, Coleman AM, Jeanty C, Lim FY, Shaaban AM, Farrell JA, Hirose S, MacKenzie TC, Lee H. Favorable outcomes in high-risk congenital pulmonary airway malformations treated with multiple courses of maternal betamethasone. J Pediatr Surg. 2015 Apr; 50(4):515-8. View in PubMed
  7. Jeanty C, Derderian SC, Mackenzie TC. Maternal-fetal cellular trafficking: clinical implications and consequences. Curr Opin Pediatr. 2014 Jun; 26(3):377-82. View in PubMed
  8. Derderian SC, Togarrati PP, King C, Moradi PW, Reynaud D, Czechowicz A, Weissman IL, MacKenzie TC. In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice. Blood. 2014 Aug 7; 124(6):973-80. View in PubMed
  9. Sanchez Rodriguez R, Pauli ML, Neuhaus IM, Yu SS, Arron ST, Harris HW, Yang SH, Anthony BA, Sverdrup FM, Krow-Lucal E, MacKenzie TC, Johnson DS, Meyer EH, Löhr A, Hsu A, Koo J, Liao W, Gupta R, Debbaneh MG, Butler D, Huynh M, Levin EC, Leon A, Hoffman WY, McGrath MH, Alvarado MD, Ludwig CH, Truong HA, Maurano MM, Gratz IK, Abbas AK, Rosenblum MD. Memory regulatory T cells reside in human skin. J Clin Invest. 2014 Mar 3; 124(3):1027-36. View in PubMed
  10. Derderian SC, Trivedi S, Farrell J, Keller RL, Rand L, Goldstein R, Feldstein VA, Hirose S, MacKenzie TC. Outcomes of fetal intervention for primary hydrothorax. J Pediatr Surg. 2014 Jun; 49(6):900-3; discussion 903-4. View in PubMed
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