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Legendary Surgeon Maurice Galante Dies
Maurice Galante, M.D., a legendary master surgeon at UCSF and renaissance man, died on February 5, 2013. His career is memorialized by the Maurice Galante Lecture Program and Maurice Galante Distinguished Professorship.
Tippi MacKenzie, M.D.
Assistant Professor of Surgery
Division of Pediatric Surgery
Contact Information
University of California, San Francisco
513 Parnassus Avenue
San Francisco, CA 94143-0570
415-476-2538 Office
415-476-2929 Fax
pedsurg@surgery.ucsf.edu
BiographyEducation
- 1987-91, Harvard University, B.A., Biochemistry
- 1992-97, Stanford University School of Medicine, M.D., Medicine
Residencies
- 1998-99, Brigham and Women's Hospital, Resident, Surgery
- 2002-04, Brigham and Women's Hospital, Resident, Surgery
- 2004-05, Brigham and Women's Hospital, Chief Resident, Surgery
Fellowships
- 1999-02, Children's Hospital of Philadelphia, Fellow, Fetal Therapy
- 2005-07, Children's Hospital of Philadelphia, Fellow, Pediatric Surgery
Board Certification
- American Board of Surgery, 2006
Program Affiliations
- Biomedical Sciences Program
- Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
- Fetal Treatment Center
Clinical Expertise
- Advanced Laparoscopy
- Birth Defects
- Endocrine and Biliary Surgery
- Fetal Surgery
- Pediatric Surgery
Research Interests
- In-Utero Stem Cell Transplantation
Biography
Dr. Tippi MacKenzie is an Assistant Professor of Surgery at the UCSF Division of Pediatric Surgery and the Fetal Treatment Center. Dr. MacKenzie obtained her undergraduate degree in Biochemistry at Harvard, then came to the Bay Area for medical school at Stanford. She did her surgical residency at Brigham and Women's Hospital in Boston. During this time, she took three years to do research on fetal surgery and in utero stem cell transplantation at the Children's Hospital of Philadelphia. Following residency, she returned to CHOP for her clinical pediatric surgery fellowship.
Dr. MacKenzie's clinical interests include fetal surgery, advanced laparoscopy, and endocrine and biliary surgery.
Research Summary
Dr Tippi MacKenzie has an active laboratory and is a member of the Biomedical Sciences Program and the Institute for Regeneration Medicine. Her research focus is on mechanisms of tolerance induction following in utero stem cell transplantation.
Selected Publications
- Nijagal A, Wegorzewska M, Jarvis E, Le T, Tang Q, MacKenzie TC. Maternal T cells limit engraftment after in utero hematopoietic cell transplantation in mice. J Clin Invest. 2011 Feb 1; 121(2):582-92.
- Nijagal A, Le T, Wegorzewska M, Mackenzie TC. A mouse model of in utero transplantation. J Vis Exp. 2011; (47).
- Nijagal A, Fleck S, Hills NK, Feng S, Tang Q, Kang SM, Rosenthal P, Mackenzie TC. Decreased risk of graft failure with maternal liver transplantation in patients with biliary atresia. Am J Transplant. 2012 Feb; 12(2):409-19.
- Nijagal A, Flake AW, Mackenzie TC. In utero hematopoietic cell transplantation for the treatment of congenital anomalies. Clin Perinatol. 2012 Jun; 39(2):301-10.
- Saadai P, Lee TH, Bautista G, Gonzales KD, Nijagal A, Busch MP, Kim CJ, Romero R, Lee H, Hirose S, Rand L, Miniati D, Farmer DL, Mackenzie TC. Alterations in maternal-fetal cellular trafficking after fetal surgery. J Pediatr Surg. 2012 Jun; 47(6):1089-94.
In the News
Maternal Liver Grafts More Tolerable for Children with Rare Disease
UCSF Department of Surgery - Nov 16, 2012Children with a rare, life-threatening disease that is the most common cause of neonatal liver failure - biliary atresia - better tolerate liver transplants from their mothers than from their fathers, according to a UCSF-led study......"This result is exciting because it supports the concept that trafficking of cells between the mother and the fetus has functional significance long after the pregnancy is over," said senior author Tippi MacKenzie, M.D., assistant professor of pediatric surgery at UCSF and a fetal surgeon at UCSF Benioff Children's Hospital. "This is a topic we are actively studying both in animal models and in patients who have fetal surgery. Practically speaking, this study may allow us to counsel families in which both the mother and father are willing and able to be a donor."
Amar Nijagal, M.D. awarded M. Judah Folkman Memorial Award for two consecutive years
UCSF - Jun 21, 2012Dr. Amar Nijagal was awarded the M. Judah Folkman Memorial Award by the American Pediatric Surgical Association at the 2012 APSA Annual meeting for his work entitled "Fetal Intervention Triggers the Activation of Paternal Antigen-Specific Maternal T Cells." Dr. Nijagal is currently a General Surgery resident at UCSF and has worked in Dr. Tippi MacKenzie's laboratory in the UCSF Division of Pediatric Surgery for the past three years. In 2011, he was also awarded the M. Judah Folkman Memorial Award for his presentation on "The Maternal Adaptive Immune Response Against Paternal Antigens Incites Fetal Demise After Fetal Intervention". This award is bestowed annually for the most outstanding research presentation given during the APSA Annual Meeting. Dr. Eric Jelin also received this award in 2009 for his work on the "Effects of Notch4 On Lung Vascular Remodeling."
Treating Disease Before Birth with Tippi MacKenzie, MD
UCSF - Jul 05, 2011Stem cell transplantation may hold the promise to treating many diseases before birth such as sickle cell anemia and muscular dystrophy. But first, researchers need to overcome many barriers, including rejection of stem cell transplants by the fetus. MacKenzie's lab recently discovered that mothers' T cells are responsible for rejecting the grafts and that this rejection may be avoided by using stem cells from the mother.
Spina Bifida Study a "Huge Gamechanger for Fetal Surgery"
New York Times - Feb 09, 2011For years, surgeons have been seeking ways of operating on babies in the womb, reasoning that medical abnormalities are easier to address while the fetus is still developing. Now, for the first time, a large clinical trial has shown that fetal surgery can also benefit infants with non life-threatening conditions. The eight-year study reported in the New England Journal of Medicine, found that babies born with myelomeningocele, the most common form of spina bifida, a debilitating spinal abnormality, were twice as likely to walk and experienced fewer neurological problems with in utero repair versus standard post-natal repair.
Mother’s stem cells likely key to treating genetic disease before birth
UCSF News - Jan 18, 2011UCSF researchers have tackled a decade-long scientific conundrum, and their discovery is expected to lead to significant advances in using stem cells to treat genetic diseases before birth. Through a series of mouse model experiments, the research team determined that a mother's immune response prevents a fetus from accepting transplanted blood stem cells, and yet this response can be overcome simply by transplanting cells harvested from the mother herself.
Institute for Fetal and Neonatal Health 1st Annual Research Symposium
UCSF Pediatric Surgery - Nov 02, 2010UCSF announces the formation of the Institute for Fetal and Neonatal Health symposium brings together clinicians and basic scientists involved in different aspects of development and fetal intervention.
Brilliance and Precision: From Surgery to In Utero Transplantation
UCSF News - Jun 15, 2009As a gifted pianist in high school, Assistant Professor of Surgery Tippi MacKenzie, MD, spent every Saturday studying music at Julliard. This musical training was good preparation for her current work as a researcher and surgeon.
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