Department of Surgery »  Faculty »  Pediatric Surgery »  Tippi MacKenzie, M.D.

Tippi MacKenzie, M.D.

Associate Professor of Surgery
Division of Pediatric Surgery

Contact Information

Campus Box 0570
University of California, San Francisco
513 Parnassus Avenue
San Francisco, CA 94143-0570
415-476-2538 Office
415-476-2929 Fax
pedsurg@surgery.ucsf.edu

Education

  • 1987-91, Harvard University, B.A., Biochemistry
  • 1992-97, Stanford University School of Medicine, M.D., Medicine

Residencies

  • 1998-99, Brigham and Women's Hospital, Resident, Surgery
  • 2002-04, Brigham and Women's Hospital, Resident, Surgery
  • 2004-05, Brigham and Women's Hospital, Chief Resident, Surgery

Fellowships

  • 1999-02, Children's Hospital of Philadelphia, Fellow, Fetal Therapy
  • 2005-07, Children's Hospital of Philadelphia, Fellow, Pediatric Surgery

Board Certifications

  • American Board of Surgery, 2006

Program Affiliations

  • Fetal Treatment Center
  • Biomedical Sciences Program
  • Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research

Clinical Expertise

  • Advanced Laparoscopy
  • Birth Defects
  • Endocrine and Biliary Surgery
  • Fetal Surgery
  • Pediatric Surgery

Research Interests

  • In-Utero Stem Cell Transplantation

Biography

Dr. Tippi MacKenzie is an Associate Professor of Surgery at the UCSF Division of Pediatric Surgery and the Fetal Treatment Center. Dr. MacKenzie obtained her undergraduate degree in Biochemistry at Harvard, then came to the Bay Area for medical school at Stanford. She did her surgical residency at Brigham and Women's Hospital in Boston. During this time, she took three years to do research on fetal surgery and in utero stem cell transplantation at the Children's Hospital of Philadelphia. Following residency, she returned to CHOP for her clinical pediatric surgery fellowship.

Dr. MacKenzie's clinical interests include fetal surgery, advanced laparoscopy, and endocrine and biliary surgery.

Research Overview

Dr. MacKenzie has an active laboratory and is a member of the Biomedical Sciences Program and the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research. Her research focus is on mechanisms of tolerance induction following in utero stem cell transplantation  and the pathophysiology of prenatally diagnosed diseases, such as congenital diaphragmatic hernia and gastroschisis, to identify biomarkers that predict prognosis and molecular pathways that may be targets for prenatal intervention.

Grants & Funding

  • March of Dimes Birth Defects Foundation, Basil O'Connor Starter Scholar Research Award, "The Role of Maternal-Fetal Cellular Trafficking in Preterm Labor"
  • American Surgical Association Foundation, "Maternal Immune Responses to Fetal Surgical Intervention"
  • Mentored Clinical Scientist Research Career Development Award (K08), NIH/NIAID, "Maternal and fetal immune responses to in utero HSC transplantation"
  • California Institute for Regenerative Medicine, Stem Cell Transplantation Immunology Award, "Maternal and Fetal Immune Responses to In Utero Hematopoietic Stem Cell
  • Transplantation"
  • March of Dimes Birth Defects Foundation, Prematurity Research Initiative Grant,
  • "The Role of Maternal T cells in Preterm Labor"

Mentored Research Residents

ResidentYearsGrant or Funding Source
Cerine Jeanty, M.D. 2011-
Eveline Shue, M.D. 2011-2013
Amar Nijagal, M.D. 2009-2012 CA Institute for Regenerative Medicine Clinical Fellow Training Award
 

Publications

Most recent publications from a total of 36
  1. Jeanty C, Derderian SC, Mackenzie TC. Maternal-fetal cellular trafficking: clinical implications and consequences. Curr Opin Pediatr. 2014 Jun; 26(3):377-82. View in PubMed
  2. Derderian SC, Togarrati PP, King C, Moradi PW, Reynaud D, Czechowicz A, Weissman IL, MacKenzie TC. In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice. Blood. 2014 Aug 7; 124(6):973-80. View in PubMed
  3. Sanchez Rodriguez R, Pauli ML, Neuhaus IM, Yu SS, Arron ST, Harris HW, Yang SH, Anthony BA, Sverdrup FM, Krow-Lucal E, Mackenzie TC, Johnson DS, Meyer EH, Löhr A, Hsu A, Koo J, Liao W, Gupta R, Debbaneh MG, Butler D, Huynh M, Levin EC, Leon A, Hoffman WY, McGrath MH, Alvarado MD, Ludwig CH, Truong HA, Maurano MM, Gratz IK, Abbas AK, Rosenblum MD. Memory regulatory T cells reside in human skin. J Clin Invest. 2014 Mar 3; 124(3):1027-36. View in PubMed
  4. Derderian SC, Trivedi S, Farrell J, Keller RL, Rand L, Goldstein R, Feldstein VA, Hirose S, MacKenzie TC. Outcomes of fetal intervention for primary hydrothorax. J Pediatr Surg. 2014 Jun; 49(6):900-4. View in PubMed
  5. Wegorzewska M, Nijagal A, Wong CM, Le T, Lescano N, Tang Q, Mackenzie TC. Fetal intervention increases maternal T cell awareness of the foreign conceptus and can lead to immune-mediated fetal demise. J Immunol. 2014 Feb 15; 192(4):1938-45. View in PubMed
  6. Fleck S, Bautista G, Keating SM, Lee TH, Keller RL, Moon-Grady AJ, Gonzales K, Norris PJ, Busch MP, Kim CJ, Romero R, Lee H, Miniati D, MacKenzie TC. Fetal production of growth factors and inflammatory mediators predicts pulmonary hypertension in congenital diaphragmatic hernia. Pediatr Res. 2013 Sep; 74(3):290-8. View in PubMed
  7. Nijagal A, Derderian C, Le T, Jarvis E, Nguyen L, Tang Q, Mackenzie TC. Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice. Blood. 2013 May 30; 121(22):4595-602. View in PubMed
  8. Nijagal A, MacKenzie TC. Clinical implications of maternal-fetal cellular trafficking. Semin Pediatr Surg. 2013 Feb; 22(1):62-5. View in PubMed
  9. Schecter SC, Courtier J, Cho SJ, Saadai P, Hirose S, Mackenzie TC, Miniati D. Hepatic portocholecystostomy for biliary atresia: a 25-year follow-up and review. J Pediatr Surg. 2013 Jan; 48(1):262-6. View in PubMed
  10. Shue EH, Soares B, Courtier J, Hogue J, Shimotake T, MacKenzie TC. Type IV intestinal atresia, congenital bilateral perisylvian syndrome, and chronic pulmonary hypertension secondary to multiple vascular disruption syndrome in a monochorionic twin. J Pediatr Surg. 2012 Oct; 47(10):1938-42. View in PubMed
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