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Department of Surgery »  Faculty »  General Surgery »  Wen T. Shen, M.D.

Wen T. Shen, M.D., M.A.

Assistant Professor in Residence
Division of General Surgery

Contact Information

Campus Box 1674
University Of California San Francisco
Mt. Zion Medical Center
Hellman Bldg. Room C-349
San Francisco, CA 94115
415-885-3755 (Academic Office)
415-353-7687 (Clinic)
415-885-7617 (Fax)
Wen.Shen@ucsfmedctr.org

Education

  • 1990-94, Harvard University, B.A., History and Science
  • 1994-99, University of California, San Francisco School of Medicine, M.D. with thesis
  • 2007-2009, University of California, San Francisco, M.A., History of Medicine

Residencies

  • 1999-02 University of California San Francisco School of Medicine, Resident, Surgery
  • 2005-06 University of California San Francisco School of Medicine, Resident, Surgery
  • 2006-07 University of California San Francisco School of Medicine, Chief Resident, Surgery

Fellowships

  • 2002-05 University of California San Francisco School of Medicine, Research Fellow in Endocrine Surgical Oncology

Board Certifications

  • American Board of Surgery

Program Affiliations

  • UCSF Helen Diller Family Comprehensive Cancer Center
  • San Francisco Veterans' Affairs Medical Center

Clinical Expertise

Research Interests

  • Biomarkers of cardiovascular risk in primary hyperparathyroidism
  • Genetic profiles of adrenal metastases from solid organ and skin cancers
  • History of surgery
  • Minimally invasive endocrine surgery
  • Role of matrix metalloproteinases in thyroid cancer
  • Use of novel anti-neoplastic agents to treat thyroid cancer, including direct MMP inhibitors, histone deacetylase inhibitors, PPAR-gamma agonists, and demethylating agents.

Biography

Wen T. Shen, M.D., M.A. is an Assistant Professor in Residence in the UCSF Department of Surgery, specializing in endocrine surgery of the thyroid, parathyroid, and adrenal glands. His surgical practice is based at the  UCSF Helen Diller Family Comprehensive Cancer Center at UCSF/Mt. Zion.

Dr. Shen graduated magna cum laude with a B.A. in History and Science from Harvard University. He obtained his M.D. with thesis from UCSF and also completed his surgical residency and research fellowship in endocrine surgery at UCSF.

Dr. Shen has been the recipient of numerous awards, including the Esther Nusz Achievement Award from the UCSF Department of Surgery, the Residents' Prize from the Pacific Coast Surgical Association, the William Osler Medal from the American Association for the History of Medicine, and the Rothschild Prize from the Department of the History of Science at Harvard. Highly respected by his peers, Dr. Shen was named to the list of U.S. News "Top Doctors," which denotes the top 10% of physicians within a region practicing a given specialty.

Research Overview

Dr. Shen's basic science research is focused on the molecular biology and genetic underpinnings of thyroid cancer. He is particularly interested in the redifferentiatiion and growth inhibitory effects of novel anti-tumor agents such as PPAR-gamma agonists and histone deacetylase (HDAC) inhibitors in thyroid cancer. Dr. Shen is investigating the effects of modulating matrix metalloproteinase (MMP) activity as a strategy for treating thyroid cancer. He is also studying the genetic profiles of adrenal metastases from solid organ and skin cancers.

Dr. Shen's current clinical research interests include predictors of lymph node metastases in papillary thyroid cancer, treatment of adrenal metastases from solid organ and skin cancers, the development of minimally invasive endocrine surgical techniques, and the impact of primary hyperparathyroidism on cardiovascular health and aging.

Dr. Shen's research has been generously funded by grants from the American College of Surgeons, the James Ewing Foundation through the Society of Surgical Oncology, the University of California Cancer Research Coordinating Committee, and the UCSF Resource Allocation Program.

In addition to his basic and clinical research, Dr. Shen maintains a strong interest in the history of surgery. Topics of his historical research have included the use of DES and other hormonal therapies in the 1950s, the 1942 Cocoanut Grove Fire in Boston and its impact on burn care, and the history of adrenal incidentaloma. He holds a masters' degree in the History of Medicine from the UCSF Department of Anthropology, History and Social Medicine. 

 

Publications

Most recent publications from a total of 42
  1. Candell L, Campbell MJ, Shen WT, Gosnell JE, Clark OH, Duh QY. Ultrasound-guided methylene blue dye injection for parathyroid localization in the reoperative neck. World J Surg. 2014 Jan; 38(1):88-91. View in PubMed
  2. Campbell MJ, McCoy KL, Shen WT, Carty SE, Lubitz CC, Moalem J, Nehs M, Holm T, Greenblatt DY, Press D, Feng X, Siperstein AE, Mitmaker E, Benay C, Tabah R, Oltmann SC, Chen H, Sippel RS, Brekke A, Vriens MR, Lodewijk L, Stephen AE, Nagar S, Angelos P, Ghanem M, Prescott JD, Zeiger MA, Aragon Han P, Sturgeon C, Elaraj DM, Nixon IJ, Patel SG, Bayles SW, Heneghan R, Ochieng P, Guerrero MA, Ruan DT. A multi-institutional international study of risk factors for hematoma after thyroidectomy. Surgery. 2013 Dec; 154(6):1283-91. View in PubMed
  3. Scholten A, Cisco RM, Vriens MR, Shen WT, Duh QY. Variant adrenal venous anatomy in 546 laparoscopic adrenalectomies. JAMA Surg. 2013 Apr; 148(4):378-83. View in PubMed
  4. Scholten A, Cisco RM, Vriens MR, Cohen JK, Mitmaker EJ, Liu C, Tyrrell JB, Shen WT, Duh QY. Pheochromocytoma crisis is not a surgical emergency. J Clin Endocrinol Metab. 2013 Feb; 98(2):581-91. View in PubMed
  5. Cisco RM, Kuo JH, Ogawa L, Scholten A, Tsinberg M, Duh QY, Clark OH, Gosnell JE, Shen WT. Impact of race on intraoperative parathyroid hormone kinetics: an analysis of 910 patients undergoing parathyroidectomy for primary hyperparathyroidism. Arch Surg. 2012 Nov 1; 147(11):1036-40. View in PubMed
  6. Tsinberg M, Duh QY, Cisco RM, Gosnell JE, Scholten A, Clark OH, Shen WT. Practice patterns and job satisfaction in fellowship-trained endocrine surgeons. Surgery. 2012 Dec; 152(6):953-6. View in PubMed
  7. Schreinemakers JM, Vriens MR, Munoz-Perez N, Guerrero MA, Suh I, Rinkes IH, Gosnell J, Shen WT, Clark OH, Duh QY. Fluorodeoxyglucose-positron emission tomography scan-positive recurrent papillary thyroid cancer and the prognosis and implications for surgical management. World J Surg Oncol. 2012; 10:192. View in PubMed
  8. Grogan RH, Mitmaker EJ, Hwang J, Gosnell JE, Duh QY, Clark OH, Shen WT. A population-based prospective cohort study of complications after thyroidectomy in the elderly. J Clin Endocrinol Metab. 2012 May; 97(5):1645-53. View in PubMed
  9. Cisco RM, Shen WT, Gosnell JE. Extent of surgery for papillary thyroid cancer: preoperative imaging and role of prophylactic and therapeutic neck dissection. Curr Treat Options Oncol. 2012 Mar; 13(1):1-10. View in PubMed
  10. Vriens MR, Weng J, Suh I, Huynh N, Guerrero MA, Shen WT, Duh QY, Clark OH, Kebebew E. MicroRNA expression profiling is a potential diagnostic tool for thyroid cancer. Cancer. 2012 Jul 1; 118(13):3426-32. View in PubMed
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