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Wen T. Shen, M.D., M.A.

Associate Professor of Clinical Surgery
Division of General Surgery

Contact Information

Campus Box 1674
University Of California San Francisco
Mt. Zion Medical Center
Hellman Bldg. Room C-349
San Francisco, CA 94115
415-885-3755 (Academic Office)
415-353-7687 (Clinic)
415-885-7617 (Fax)
Wen.Shen@ucsfmedctr.org
  • 1990-94, Harvard University, B.A., History and Science
  • 1994-99, University of California, San Francisco School of Medicine, M.D. with thesis
  • 2007-2009, University of California, San Francisco, M.A., History of Medicine
  • 1999-02 University of California San Francisco School of Medicine, Resident, Surgery
  • 2005-06 University of California San Francisco School of Medicine, Resident, Surgery
  • 2006-07 University of California San Francisco School of Medicine, Chief Resident, Surgery
  • 2002-05 University of California San Francisco School of Medicine, Research Fellow in Endocrine Surgical Oncology
  • American Board of Surgery
  • UCSF Helen Diller Family Comprehensive Cancer Center
  • San Francisco Veterans' Affairs Medical Center
  • Biomarkers of cardiovascular risk in primary hyperparathyroidism
  • Genetic profiles of adrenal metastases from solid organ and skin cancers
  • History of surgery
  • Minimally invasive endocrine surgery
  • Role of matrix metalloproteinases in thyroid cancer
  • Use of novel anti-neoplastic agents to treat thyroid cancer, including direct MMP inhibitors, histone deacetylase inhibitors, PPAR-gamma agonists, and demethylating agents.

Wen T. Shen, M.D., M.A. is an Assistant Professor in Residence in the UCSF Department of Surgery, specializing in endocrine surgery of the thyroid, parathyroid, and adrenal glands. His surgical practice is based at the  UCSF Helen Diller Family Comprehensive Cancer Center at UCSF/Mt. Zion.

Dr. Shen graduated magna cum laude with a B.A. in History and Science from Harvard University. He obtained his M.D. with thesis from UCSF and also completed his surgical residency and research fellowship in endocrine surgery at UCSF.

Dr. Shen has been the recipient of numerous awards, including the Esther Nusz Achievement Award from the UCSF Department of Surgery, the Residents' Prize from the Pacific Coast Surgical Association, the William Osler Medal from the American Association for the History of Medicine, and the Rothschild Prize from the Department of the History of Science at Harvard. Highly respected by his peers, Dr. Shen was named to the list of U.S. News "Top Doctors," which denotes the top 10% of physicians within a region practicing a given specialty.

Dr. Shen's basic science research is focused on the molecular biology and genetic underpinnings of thyroid cancer. He is particularly interested in the redifferentiatiion and growth inhibitory effects of novel anti-tumor agents such as PPAR-gamma agonists and histone deacetylase (HDAC) inhibitors in thyroid cancer. Dr. Shen is investigating the effects of modulating matrix metalloproteinase (MMP) activity as a strategy for treating thyroid cancer. He is also studying the genetic profiles of adrenal metastases from solid organ and skin cancers.

Dr. Shen's current clinical research interests include predictors of lymph node metastases in papillary thyroid cancer, treatment of adrenal metastases from solid organ and skin cancers, the development of minimally invasive endocrine surgical techniques, and the impact of primary hyperparathyroidism on cardiovascular health and aging.

Dr. Shen's research has been generously funded by grants from the American College of Surgeons, the James Ewing Foundation through the Society of Surgical Oncology, the University of California Cancer Research Coordinating Committee, and the UCSF Resource Allocation Program.

In addition to his basic and clinical research, Dr. Shen maintains a strong interest in the history of surgery. Topics of his historical research have included the use of DES and other hormonal therapies in the 1950s, the 1942 Cocoanut Grove Fire in Boston and its impact on burn care, and the history of adrenal incidentaloma. He holds a masters' degree in the History of Medicine from the UCSF Department of Anthropology, History and Social Medicine. 

Insoo Suh, M.D.
Most recent publications from a total of 46
  1. Campbell MJ, Seib CD, Candell L, Gosnell JE, Duh QY, Clark OH, Shen WT. The underestimated risk of cancer in patients with multinodular goiters after a benign fine needle aspiration. World J Surg. 2015 Mar; 39(3):695-700. View in PubMed
  2. Campbell MJ, Candell L, Seib CD, Gosnell JE, Duh QY, Clark OH, Shen WT. Unanticipated thyroid cancer in patients with substernal goiters: are we underestimating the risk? Ann Surg Oncol. 2015 Apr; 22(4):1214-8. View in PubMed
  3. Seib CD, Greenblatt DY, Campbell MJ, Shen WT, Gosnell JE, Clark OH, Duh QY. Adrenalectomy outcomes are superior with the participation of residents and fellows. J Am Coll Surg. 2014 Jul; 219(1):53-60. View in PubMed
  4. Candell L, Campbell MJ, Shen WT, Gosnell JE, Clark OH, Duh QY. Ultrasound-guided methylene blue dye injection for parathyroid localization in the reoperative neck. World J Surg. 2014 Jan; 38(1):88-91. View in PubMed
  5. Campbell MJ, McCoy KL, Shen WT, Carty SE, Lubitz CC, Moalem J, Nehs M, Holm T, Greenblatt DY, Press D, Feng X, Siperstein AE, Mitmaker E, Benay C, Tabah R, Oltmann SC, Chen H, Sippel RS, Brekke A, Vriens MR, Lodewijk L, Stephen AE, Nagar S, Angelos P, Ghanem M, Prescott JD, Zeiger MA, Aragon Han P, Sturgeon C, Elaraj DM, Nixon IJ, Patel SG, Bayles SW, Heneghan R, Ochieng P, Guerrero MA, Ruan DT. A multi-institutional international study of risk factors for hematoma after thyroidectomy. Surgery. 2013 Dec; 154(6):1283-89; discussion 1289-91. View in PubMed
  6. Scholten A, Cisco RM, Vriens MR, Shen WT, Duh QY. Variant adrenal venous anatomy in 546 laparoscopic adrenalectomies. JAMA Surg. 2013 Apr; 148(4):378-83. View in PubMed
  7. Scholten A, Cisco RM, Vriens MR, Cohen JK, Mitmaker EJ, Liu C, Tyrrell JB, Shen WT, Duh QY. Pheochromocytoma crisis is not a surgical emergency. J Clin Endocrinol Metab. 2013 Feb; 98(2):581-91. View in PubMed
  8. Cisco RM, Kuo JH, Ogawa L, Scholten A, Tsinberg M, Duh QY, Clark OH, Gosnell JE, Shen WT. Impact of race on intraoperative parathyroid hormone kinetics: an analysis of 910 patients undergoing parathyroidectomy for primary hyperparathyroidism. Arch Surg. 2012 Nov; 147(11):1036-40. View in PubMed
  9. Tsinberg M, Duh QY, Cisco RM, Gosnell JE, Scholten A, Clark OH, Shen WT. Practice patterns and job satisfaction in fellowship-trained endocrine surgeons. Surgery. 2012 Dec; 152(6):953-6. View in PubMed
  10. Schreinemakers JM, Vriens MR, Munoz-Perez N, Guerrero MA, Suh I, Rinkes IH, Gosnell J, Shen WT, Clark OH, Duh QY. Fluorodeoxyglucose-positron emission tomography scan-positive recurrent papillary thyroid cancer and the prognosis and implications for surgical management. World J Surg Oncol. 2012; 10:192. View in PubMed
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