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Department of Surgery »  Faculty »  General Surgery »  M. Margaret Knudson, M.D.

M. Margaret Knudson, M.D., F.A.C.S.

Professor and Interim Chief of Surgery,
San Francisco General Hospital and Trauma Center
UCSF Division of General Surgery

Contact Information

Campus Box 0807
University of California, San Francisco
San Francisco, CA 94143-0807
(415) 206-8673 Appointments
(415) 206-4622 Office
(415) 206-5484 Fax
pknudson@sfghsurg.ucsf.edu

Education

  • University of Dayton, B.S., 1972
  • University of Michigan Medical School, M.D., 1976

Residencies

  • Beth Israel Hospital, Harvard Medical School, Intern Surgery, 1976-1977
  • Beth Israel Hospital, Harvard Medical School, Resident Surgery, 1977-1979
  • University of Michigan Medical School, Resident, Surgery, 1979-1981
  • University of Michigan Medical School, Chief Resident, Surgery, 1981-1982

Fellowships

  • Stanford University School of Medicine, Fellow, Pediatric Surgery, 1982-1983

Board Certifications

  • American Board of Surgery, 1983
  • American Board of Surgery, Surgical Critical Care, 1988

Clinical Expertise

  • Breast Surgery
  • General Surgery
  • Pediatric Trauma Surgery
  • Trauma Surgery
  • Ultrasound

Research Interests

  • Head Injuries
  • Injury Prevention
  • Pediatric Trauma
  • Resuscitation
  • Simulation
  • Trauma
  • Ultrasound
  • Venous Thromboembolism

Biography

Dr. Knudson attended medical school and completed her general surgical residency at the University of Michigan in Ann Arbor. After a fellowship in pediatric surgery at Stanford University, she became involved with the development of trauma systems in California, with a special interest in pediatric trauma. After serving as the Associate Trauma Director at Stanford Medical Center, she joined the teaching faculty at the University of California, San Francisco in 1989. 

Dr. Knudson is currently a Professor of Surgery at UCSF, and the Principal Investigator of the CDC- funded San Francisco Injury Center and serves as the Interim Chief of Surgery at San Francisco General Hospital.   She also serves as the Vice Chair of the Committee on Trauma, a member of the Executive Committee, American College of Surgeons Committee on Trauma, Board of Managers, American Association for the Surgery of Trauma, on the editorial board of the Journal of Trauma, and as the Chair of the Western Trauma Association's MultiCenter Trials Committee. Her major areas of research include simulation training for medical personnel, the prevention of thromboembolic complications in trauma patients, the use of ultrasound in trauma evaluation, resuscitation following hemorrhagic shock, and injury prevention. Highly respected by her peers, Dr. Knudson was named to the list of U.S. News "America's Top Doctors," a distinction reserved for the top 1% of physicians in the nation for a given specialty.

Research Summary

As the Principal Investigator of the CDC-Sponsored San Francisco Injury Center, Dr. Knudson is involved in a number of projects related to injury and injury prevention. These projects include:  

  • Resuscitation following Traumatic Brain Injury (Laboratory Study): In a controlled model of traumatic brain injury, the research group is using tissue oxygen probes placed at various locations to better define the brain injury and the effects of ventilation, oxygenation, hemorrhage, and resuscitation on tissue oxygen and capillary metabolism (Lactate/pyruvate/glutamate) following brain injury. 
  • A Comparison of Muscle Lactate Levels with Tissue Oxygen and Metabolism (Laboratory Study): In a small animal model, the  research group is comparing serum and tissue lactate levels with other markers (tissue oxygen, bicarbonate, pyruvate) in order to better define the role of lactate as a measure of resuscitation. They are also measuring lactate levels following shock and resuscitation with fluids and various vasoactive agents.
  • Brain Tissue Oxygen Monitoring and Microdialysis Following Severe Traumatic Brain Injury (Clinical Study): Patients with severe brain injury who require ICP monitors are also being monitored with brain oxygen ad microdialysis probes in order to better define their brain injury and response to interventions.
  • Muscle Oxygen Monitoring in Critically Ill Patients (Clinical Study): Tissue oxygen levels measured in the muscle of critically ill trauma patients may be used to help guide resuscitation. The research group is comparing two methods of measuring tissue oxygen (direct probes versus near infra-red techniques) and correlating these measurements with microdialysis data as well as standard variable used to measure resuscitation (blood pressure, pulse, serum bicarbonate levels etc).
  • Posttraumatic Stress Disorder in Injured Children (Clinical Study): Injured children are particularly vulnerable to the development of PTSD. In a prospective study being conducted at Children's Hospital, Oakland, the research group is following children for up to one year post injury for the development of PTSD and comparing interventions designed to lessen these symptoms.
  • Use of ultrasound in patients with Solid Organ Injuries managed nonoperatively: (Clinical study) Using ultrasound, The research group is attempting to define the grade of liver/spleen/ or renal injuries resulting from blunt trauma and following these patients with serial ultrasound exams for progression of their injury, need for operative intervention based on the amount of hemorrhage, and the development of complications associated with non-operative management.
  • Prevention Research and Activities: Through the Injury Center, the research group is involved in a wide range of prevention projects that include pedestrian crashes, violent injuries, pediatric trauma, advocacy, and the development of educational programs in injury prevention for surgeons, medical students, and elementary students.
  • Posttraumatic Thromboembolism: (Analytical Study): Using the National Trauma Data Base, the research group is developing a report on the current incidence of DVT/PE in the United States following injury, describing risk factors, and analyzing the effectiveness of prevention strategies.
  • Simulation and Trauma: (Clinical Study): The research group is designing clinical scenarios that can be utilized in simulation in order to prepare senior surgical residents for their rotation on the trauma service. They hopes to validate the use of simulation for this purpose.
  • Outcome following isolated, mild traumatic brain injury: (Clinical Study) As part of a multi-institutional study, the research group is prospectively following patients with isolated brain injuries for their functional outcomes for a period of one year, and comparing outcomes in elderly versus younger patients.
 

Publications

Most recent publications from a total of 33
  1. Cohen MJ, Kutcher M, Redick B, Nelson M, Call M, Knudson MM, Schreiber MA, Bulger EM, Muskat P, Alarcon LH, Myers JG, Rahbar MH, Brasel KJ, Phelan HA, del Junco DJ, Fox EE, Wade CE, Holcomb JB, Cotton BA, Matijevic N. Clinical and mechanistic drivers of acute traumatic coagulopathy. J Trauma Acute Care Surg. 2013 Jul; 75(1 Suppl 1):S40-7. View in PubMed
  2. Knudson MM. Hospital-specific risk factors for filter fever. JAMA Surg. 2013 Jul; 148(7):687-8. View in PubMed
  3. Shackford SR, Kahl JE, Calvo RY, Shackford MC, Danos LA, Davis JW, Vercruysse GA, Feliciano DV, Moore EE, Moore HB, Knudson MM, Howard BM, Sise MJ, Coimbra RS, Costantini TW, Brakenridge SC, Tominaga GT, Schaffer KB, Steele JT, Kennedy FR, Cogbill TH. Limb salvage after complex repairs of extremity arterial injuries is independent of surgical specialty training. J Trauma Acute Care Surg. 2013 Mar; 74(3):716-23; discussion 723-4. View in PubMed
  4. Callcut RA, Cotton BA, Muskat P, Fox EE, Wade CE, Holcomb JB, Schreiber MA, Rahbar MH, Cohen MJ, Knudson MM, Brasel KJ, Bulger EM, Del Junco DJ, Myers JG, Alarcon LH, Robinson BR. Defining when to initiate massive transfusion: a validation study of individual massive transfusion triggers in PROMMTT patients. J Trauma Acute Care Surg. 2013 Jan; 74(1):59-65, 67-8; discussion 66-7. View in PubMed
  5. Knudson MM, Rasmussen TE. The Senior Visiting Surgeons program: a model for sustained military-civilian collaboration in times of war and peace. J Trauma Acute Care Surg. 2012 Dec; 73(6 Suppl 5):S536-42. View in PubMed
  6. Yeh DD, Kutcher ME, Knudson MM, Tang JF. Epidural analgesia for blunt thoracic injury--which patients benefit most? Injury. 2012 Oct; 43(10):1667-71. View in PubMed
  7. Moore HB, Moore PK, Grant AR, Tello TL, Knudson MM, Kornblith LZ, Song TE, Sauaia A, Zuckerbahn B, Moore EE. Future of acute care surgery: a perspective from the next generation. J Trauma Acute Care Surg. 2012 Jan; 72(1):94-9. View in PubMed
  8. Kutcher ME, Pepper MB, Morabito D, Sunjaya D, Knudson MM, Cohen MJ. Finding the sweet spot: identification of optimal glucose levels in critically injured patients. J Trauma. 2011 Nov; 71(5):1108-14. View in PubMed
  9. Knudson MM, Gomez D, Haas B, Cohen MJ, Nathens AB. Three thousand seven hundred thirty-eight posttraumatic pulmonary emboli: a new look at an old disease. Ann Surg. 2011 Oct; 254(4):625-32. View in PubMed
  10. Knudson MM. Commentary on "Vascular injuries in the young". Perspect Vasc Surg Endovasc Ther. 2011 Jun; 23(2):111. View in PubMed
  11. View All Publications
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