Department of Surgery »  Faculty »  General Surgery »  Carlos U. Corvera, M.D.

Carlos U. Corvera, M.D.

Associate Professor of Surgery
Chief, Hepatobiliary and Pancreas Surgery
Division of General Surgery

Contact Information

Univeristy of California, San Francisco
Helen Diller Family Comprehensive Cancer Center
1600 Divisadero Street, 4th Floor
San Francisco, CA 94115
tel: 415/353-9888
fax: 415/353-9931
carlos.corvera@ucsfmedctr.org

Education

  • 1983-86 University of California, Davis, CA  B.S. Biochemistry College of Agricultural and Environmental Science
  • 1989-93 University of California, San Diego Medical School.  M.D.  La Jolla, CA

Residencies

  • 1993-1995,University of California, San Francisco, Intern and Resident,Surgery
  • 1995-1998 University of California, San Francisco, Research Fellow Surgery, Division of Gastrointestinal Surgery
  • 998-2000,University of California, San Francisco, Senior Resident Surgery
  • 2000-2001,University of California, San Francisco, Chief Resident Surgery

Fellowships

  • 2001-2002, Memorial Sloan-Kettering Cancer Center, Fellow ,Surgical Oncology, New York,  New York
  • 2002-2003, Memorial Sloan-Kettering Cancer Center, Fellow, Hepatobiliary Surgery, New York,  New York

Board Certifications

  • American Board of Surgery

Program Affiliations

  • Hepatobiliary and Pancreas Surgery Program
  • UCSF Helen Diller Family Comprehensive Cancer Center
  • UCSF Department of Surgery at the San Francisco VA

Clinical Expertise

Research Interests

  • Proteases and Proteinase Activated Receptors in the Biliary Tract

Biography

Carlos Corvera, M.D. is Associate Professor of Surgery and Chief of Hepatobiliary and Pancreas Surgery at UCSF.  A trained surgical oncologist, Dr. Corvera has extensive experience in the treatment of benign and malignant hepatobiliary disease including hepatocellular carcinoma (primary liver cancer), liver metastases, and cancers of the stomach, gall bladder, bile ducts, and pancreas. Additionally, Dr. Corvera performs surgery for  melanoma and  soft tissue sarcomas. Dr. Corvera specializes in complex and intricate cancer surgeries, including minimally invasive liver resections that greatly minimize post-operative pain and speed recovery. Dr. Corvera, who performs a high volume of such procedures, is also a pioneer and innovator of surgical techniques in the field.

Dr. Corvera graduated from the University of California San Diego School of Medicine. He completed his general surgery residency at UCSF, and prestigious fellowships in surgical oncology and hepatobiliary surgery at Memorial Sloan-Kettering Cancer Center. 

In May 2013, Dr. Corvera was installed as the President of the UCSF Naffziger Surgical Society, the alumni society for the UCSF Department of Surgery. Dedicated to surgical excellence, the society has long served as a forum fostering collaboration between surgeons and promoting surgical advances through its educational forums.

Research Overview

Dr. Corvera's scientific research interest is focused on understanding the mechanisms of biliary tract fibrosis and inflammation.  More specifically, he is interested in studying the clinical consequences of biliary fibrosis-- mainly cholestatisis. Cholestasis is characterized by impaired bile flow causing a high concentration of bile acids in the liver and the circulation.  Prolonged exposure to bile acids in the liver can progress to end-stage liver disease and cirrhosis. In the gastrointestinal tract, the absence of bile flow causes profound local and systemic metabolic disturbances. Dr.Corvera is actively investigating the role of a novel cell surface receptor specific for bile acids that may play a critical role in normal and disease states.

 

Publications

Most recent publications from a total of 40
  1. Lieu T, Jayaweera G, Zhao P, Poole DP, Jensen D, Grace M, McIntyre P, Bron R, Wilson YM, Krappitz M, Haerteis S, Korbmacher C, Steinhoff MS, Nassini R, Materazzi S, Geppetti P, Corvera CU, Bunnett NW. The Bile Acid Receptor TGR5 Activates the TRPA1 Channel to Induce Itch in Mice. Gastroenterology. 2014 Dec; 147(6):1417-28. View in PubMed
  2. Leung U, Pandit-Taskar N, Corvera CU, D'Angelica MI, Allen PJ, Kingham TP, DeMatteo RP, Jarnagin WR, Fong Y. Impact of pre-operative positron emission tomography in gallbladder cancer. HPB (Oxford). 2014 Nov; 16(11):1023-30. View in PubMed
  3. Ho EY, Cozen ML, Shen H, Lerrigo R, Trimble E, Ryan JC, Corvera CU, Monto A. Expanded use of aggressive therapies improves survival in early and intermediate hepatocellular carcinoma. HPB (Oxford). 2014 Aug; 16(8):758-67. View in PubMed
  4. Jensen DD, Godfrey CB, Niklas C, Canals M, Kocan M, Poole DP, Murphy JE, Alemi F, Cottrell GS, Korbmacher C, Lambert NA, Bunnett NW, Corvera CU. The bile acid receptor TGR5 does not interact with ß-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts. J Biol Chem. 2013 Aug 9; 288(32):22942-60. View in PubMed
  5. Alemi F, Kwon E, Poole DP, Lieu T, Lyo V, Cattaruzza F, Cevikbas F, Steinhoff M, Nassini R, Materazzi S, Guerrero-Alba R, Valdez-Morales E, Cottrell GS, Schoonjans K, Geppetti P, Vanner SJ, Bunnett NW, Corvera CU. The TGR5 receptor mediates bile acid-induced itch and analgesia. J Clin Invest. 2013 Apr 1; 123(4):1513-30. View in PubMed
  6. Rajagopal S, Kumar DP, Mahavadi S, Bhattacharya S, Zhou R, Corvera CU, Bunnett NW, Grider JR, Murthy KS. Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway. Am J Physiol Gastrointest Liver Physiol. 2013 Mar 1; 304(5):G527-35. View in PubMed
  7. Alemi F, Poole DP, Chiu J, Schoonjans K, Cattaruzza F, Grider JR, Bunnett NW, Corvera CU. The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice. Gastroenterology. 2013 Jan; 144(1):145-54. View in PubMed
  8. Cottrell GS, Alemi F, Kirkland JG, Grady EF, Corvera CU, Bhargava A. Localization of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in human gastrointestinal tract. Peptides. 2012 Jun; 35(2):202-11. View in PubMed
  9. Warne JP, Alemi F, Reed AS, Varonin JM, Chan H, Piper ML, Mullin ME, Myers MG, Corvera CU, Xu AW. Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity. Cell Metab. 2011 Dec 7; 14(6):791-803. View in PubMed
  10. Thompson M, Hiniker A, Duh QY, Corvera CU. Visual vignette. What is the diagnosis? Insulin-secreting tumor. Endocr Pract. 2011 Sep-Oct; 17(5):832. View in PubMed
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