A gift to the Department of Surgery helps our physicians and scientists find new treatments and cures for serious diseases.
Proteases and Proteinase Activated Receptors in the Biliary Tract
Carlos Corvera, M.D. is Associate Professor of Surgery and Chief of Hepatobiliary and Pancreas Surgery at UCSF. A trained surgical oncologist, Dr. Corvera has extensive experience in the treatment of benign and malignant hepatobiliary disease including hepatocellular carcinoma (primary liver cancer), liver metastases, and cancers of the stomach, gall bladder, bile ducts, and pancreas. Additionally, Dr. Corvera performs surgery for melanoma and soft tissue sarcomas. Dr. Corvera specializes in complex and intricate cancer surgeries, including minimally invasive liver resections that greatly minimize post-operative pain and speed recovery. Dr. Corvera, who performs a high volume of such procedures, is also a pioneer and innovator of surgical techniques in the field.
Dr. Corvera graduated from the University of California San Diego School of Medicine. He completed his general surgery residency at UCSF, and prestigious fellowships in surgical oncology and hepatobiliary surgery at Memorial Sloan-Kettering Cancer Center.
Dr. Covera's scientific research interest is focused on understanding the mechanisms of biliary tract fibrosis and inflammation. More specifically, he is interested in studying the clinical consequences of biliary fibrosis-- mainly cholestatisis. Cholestasis is characterized by impaired bile flow causing a high concentration of bile acids in the liver and the circulation. Prolonged exposure to bile acids in the liver can progress to end-stage liver disease and cirrhosis. In the gastrointestinal tract, the absence of bile flow causes profound local and systemic metabolic disturbances. Dr. Covera is actively investigating the role of a novel cell surface receptor specific for bile acids that may play a critical role in normal and disease states.
In July 2011, the Department of Surgery created a new Hepatobiliary and Pancreas Service naming Carlos Corvera M.D., a hepatobiliary surgical oncologist, as its Chief. The multidisciplinary program brings together faculty members from surgery, hepatology, medical oncology, anesthesia, radiology and pathology to care for patients with benign and malignant conditions of the liver, gallbladder, biliary tract and pancreas. The service holds clinics and weekly tumor boards at the Mt. Zion and Parnassus campuses of UCSF. "Rather than isolated silos of care, we have a team approach, which makes a big difference for the overall care of the patients," said Dr. Corvera. "When you are looking at a broad spectrum of disease, there are often competing therapies for which a patient might be a good candidate," said John Roberts, MD, FACS, chief of the UCSF Transplant Service."