Department of Surgery »  Faculty »  General Surgery »  Aditi Bhargava, Ph.D.

Aditi Bhargava, Ph.D.

Associate Professor
Division of General Surgery

Contact Information

UCSF Center for the Neurobiology of Digestive Diseases
Department of Surgery
513 Parnassus Avenue, Room S-1268
Campus Box 0660
San Francisco, CA 94143-0660

415-502-8453
415-476-6978 (Alternate)
415-476-3336 Lab
415-476-0936 Fax
aditi.bhargava@ucsfmedctr.org

Education

  • 1984-86, University of Rajasthan, B.S., Zoology (Honors)
  • 1986-88, University of Poona, M.S., Molecular Biology
  • 1990-1995, University of Poona, Ph.D., Molecular Biology

Postdoctoral Training

  • 1995-96, New York Medical Col., Postdoctoral Fellow, Medicine
  • 1996-00, University of California, San Francisco School of Medicine, Postdoctoral Fellow, Medicine/Physiology
  • 2000-03, University of California, San Francisco School of Medicine, Postdoctoral Fellow, Medicine/Physiology (laboratories of Drs. Mary F. Dallman and David Pearce)

Research Interests

  • Exploring and elucidating the molecular mechanisms by which components of the corticotropin releasing factor (CRF) system mediate the effect of stress on cellular function.

Biography

Aditi Bhargava, Ph.D. is an Associate Professor in the Department of Surgery at UCSF.  Her research laboratory is in the UCSF Center for the Neurobiology of Digestive Diseases.

 

Dr. Bhargava is a recipient of the several awards including:  Certificate of Merit (1986); Graduate Research Fellowship (1988-1993), CSIR, India; UNESCO/TWAS Human Genome Fellowship (1992); Senior Research Fellowship, Department of Biotechnology, India (1994-1995); Quest Diagnostic Young Investigator Award, Endocrine Society (2003); Young Investigator Travel Award, GIRI Conference, Canada (2004); New Investigator Award from the American Physiological Society (2010); and FASEB MARC Mentor Travel Award (2010). Dr. Bhargava is also a fellow of the American Gastroenterological Association (AGAF).

 


 

 

 

Research Overview

My work has far-reaching implications for many diseases in which components of the CRF system are being clinically tested. An estimated 57 million people in the US alone suffer from stress-related disorders. Stress is a major contributor towards development of Type 2 diabetes; 26 million Americans over the age of 18 are Type 2 diabetics, and an additional 79 million are thought to be pre-diabetic. Twice as many women as men suffer from stress-related disorders, including anxiety, depression, and inflammatory as well as functional bowel disease. Despite the preponderance of stress-related diseases in females, use of female animal subjects is perpetually lacking and knowledge of the sex-specific molecular pathogenesis in disease responses remain vastly understudied. Furthermore, as the dynamic relationship between stress and inflammation has become evident, CRF receptor antagonists and related molecular targets have been intensely studied and tried as promising therapeutic targets for these pathophysiologic mechanisms.  Clinical trials have attempted to treat major depression, PTSD, cardiac injury, congestive heart failure and IBS using CRF-related therapeutics. Most of the therapeutics, while extremely promising in animal models, were are ineffective in clinical trials. Thus, given the myriad diseases and disorders that stress are exacerbatesd by stress, my work seeks to understand both the mechanisms that initiate a stress response and result in stress-coping action in experimental models that include both male and female subjects.

 

Publications

Most recent publications from a total of 41
  1. Kido-Nakahara M, Buddenkotte J, Kempkes C, Ikoma A, Cevikbas F, Akiyama T, Nunes F, Seeliger S, Hasdemir B, Mess C, Buhl T, Sulk M, Müller FU, Metze D, Bunnett NW, Bhargava A, Carstens E, Furue M, Steinhoff M. Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus. J Clin Invest. 2014 Jun 2; 124(6):2683-95. View in PubMed
  2. Gong K, Kung LH, Magni G, Bhargava A, Jasmin L. Increased response to glutamate in small diameter dorsal root ganglion neurons after sciatic nerve injury. PLoS One. 2014; 9(4):e95491. View in PubMed
  3. Mahajan S, Liao M, Barkan P, Takahashi K, Bhargava A. Urocortin 3 expression at baseline and during inflammation in the colon: Corticotropin releasing factor receptors cross-talk. Peptides. 2014 Apr; 54:58-66. View in PubMed
  4. Kubat E, Mahajan S, Liao M, Ackerman L, Ohara PT, Grady EF, Bhargava A. Corticotropin-releasing factor receptor 2 mediates sex-specific cellular stress responses. Mol Med. 2013; 19:212-22. View in PubMed
  5. Kung LH, Gong K, Adedoyin M, Ng J, Bhargava A, Ohara PT, Jasmin L. Evidence for glutamate as a neuroglial transmitter within sensory ganglia. PLoS One. 2013; 8(7):e68312. View in PubMed
  6. Kim HJ, Prasad V, Hyung SW, Lee ZH, Lee SW, Bhargava A, Pearce D, Lee Y, Kim HH. Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival. J Cell Biol. 2012 Dec 24; 199(7):1145-58. View in PubMed
  7. Bhargava A, Clifton MS, Mhaske P, Mhsake P, Liao M, Pothoulakis C, Leeman SE, Grady EF. Local injection of dsRNA targeting calcitonin receptor-like receptor (CLR) ameliorates Clostridium difficile toxin A-induced ileitis. Proc Natl Acad Sci U S A. 2013 Jan 8; 110(2):731-6. View in PubMed
  8. Cottrell GS, Alemi F, Kirkland JG, Grady EF, Corvera CU, Bhargava A. Localization of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in human gastrointestinal tract. Peptides. 2012 Jun; 35(2):202-11. View in PubMed
  9. Hasdemir B, Mahajan S, Bunnett NW, Liao M, Bhargava A. Endothelin-converting enzyme-1 actions determine differential trafficking and signaling of corticotropin-releasing factor receptor 1 at high agonist concentrations. Mol Endocrinol. 2012 Apr; 26(4):681-95. View in PubMed
  10. Liu L, Li Q, Sapolsky R, Liao M, Mehta K, Bhargava A, Pasricha PJ. Transient gastric irritation in the neonatal rats leads to changes in hypothalamic CRF expression, depression- and anxiety-like behavior as adults. PLoS One. 2011; 6(5):e19498. View in PubMed
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