San Francisco VA Medical Center, NCIRE, Post-doctoral Training, 2012
Development of early diagnosis strategy for human cancers
Identification of cancer-specific biomarkers
Mechanisms drive cancer metastasis
Yi-Lin Yang, Ph.D. is an Assistant Adjunct Professor of Surgery at UCSF and a member of the Thoracic Oncology Laboratory at UCSF. She received her Ph.D. degree in Comparative Biomedical Sciences from Tufts University in 2010 and her M.S. degree in Biochemistry and Molecular Biology from Oregon Health & Science University in 2004. Upon the completion of her post-doctoral training in San Francisco VA Medical Center, Dr. Yang joined the Thoracic Oncology Laboratory of UCSF in 2012.
Dr. Yang's research focuses on understanding the biological and molecular mechanisms in human lung cancer and malignant pleural mesothelioma. Her studies have shown the significance of Wnt2 and Notch1 signaling in human lung cancer and in human malignant pleural mesothelioma, and blocking the signaling inhibits tumor growth. She has also established a transgenic mouse model of mesothelioma, an orthotropic malignant mesothelioma model, and brain metastasis models of human lung cancer. These animal models are useful tools for testing potential therapies in human lung cancer and mesothelioma, including immunotherapy.
Most recent publications from a total of 13
Hsu PC, You B, Yang YL, Zhang WQ, Wang YC, Xu Z, Dai Y, Liu S, Yang CT, Li H, Hu B, Jablons DM, You L. YAP promotes erlotinib resistance in human non-small cell lung cancer cells. Oncotarget. 2016 Jul 7. View in PubMed
Yang YL, Ni J, Hsu PC, Mao JH, Hsieh D, Xu A, Chan G, Au A, Xu Z, Jablons DM, You L. Cul4A overexpression associated with Gli1 expression in malignant pleural mesothelioma. J Cell Mol Med. 2015 Oct; 19(10):2385-96. View in PubMed
You B, Yang YL, Xu Z, Dai Y, Liu S, Mao JH, Tetsu O, Li H, Jablons DM, You L. Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells. Oncotarget. 2015 Feb 28; 6(6):4357-68. View in PubMed
Zhang S, Yang YL, Wang Y, You B, Dai Y, Chan G, Hsieh D, Kim IJ, Fang LT, Au A, Stoppler HJ, Xu Z, Jablons DM, You L. CK2a, over-expressed in human malignant pleural mesothelioma, regulates the Hedgehog signaling pathway in mesothelioma cells. J Exp Clin Cancer Res. 2014; 33:93. View in PubMed
Yang YL, Jablons D, You L. An alternative way to initiate Notch1 signaling in non-small cell lung cancer. Transl Lung Cancer Res. 2014 Aug; 3(4):238-41. View in PubMed
Yang YL, Hung MS, Wang Y, Ni J, Mao JH, Hsieh D, Au A, Kumar A, Quigley D, Fang LT, Yeh CC, Xu Z, Jablons DM, You L. Lung tumourigenesis in a conditional Cul4A transgenic mouse model. J Pathol. 2014 Jun; 233(2):113-23. View in PubMed
Liu S, Hsieh D, Yang YL, Xu Z, Peto C, Jablons DM, You L. Coumestrol from the national cancer Institute's natural product library is a novel inhibitor of protein kinase CK2. BMC Pharmacol Toxicol. 2013; 14:36. View in PubMed
Bravo DT, Yang YL, Kuchenbecker K, Hung MS, Xu Z, Jablons DM, You L. Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer. BMC Cancer. 2013; 13:316. View in PubMed
Zhang S, Long H, Yang YL, Wang Y, Hsieh D, Li W, Au A, Stoppler HJ, Xu Z, Jablons DM, You L. Inhibition of CK2a down-regulates Notch1 signalling in lung cancer cells. J Cell Mol Med. 2013 Jul; 17(7):854-62. View in PubMed
Yeh CC, Malhotra D, Yang YL, Xu Y, Fan Y, Li H, Mann MJ. MEK1-induced physiological hypertrophy inhibits chronic post-myocardial infarction remodeling in mice. J Cell Biochem. 2013 Jan; 114(1):47-55. View in PubMed
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