Department of Surgery »  Faculty »  Adult Cardiothoracic Surgery »  Hassan Lemjabbar-Alaoui. Ph.D.

Hassan Lemjabbar-Alaoui, Ph.D.

Assistant Professor
Department of Surgery

Contact Information

2340 Sutter Street N-224, Box 1724
University of California, San Francisco
San Francisco, CA 94143-1724
415-476-9303 Phone
Hassan.Lemjabbar-Alaoui@ucsf.edu

Education

  • University of Paris VII, B.S., Biology, 1988-1989
  • University of Paris VII, M.S.,  Molecular Biology and Immunology, 1989-1991
  • University of Paris VI, M.S., Biochemistry, 1991-1992
  • University of Paris VI, Post-Master University Diploma (DU), Clinical Pharmacokinetics and Therapeutics, 1992-1993
  • University of Paris XIII, Post-Master DE.A of Science, Medical and Biological Engineering, 1993-1994
  • University of Paris XII, Ph.D.,  Molecular and Cell Biology, 1994-1997

Postdoctoral Training

  • 1997-1998, Scientist, Naturalia Biologia. Paris, France
  • 1998-2001, Postdoctoral Researcher, Department of Anatomy, UCSF

Program Affiliations

  • Thoracic Oncology Program
  • Thoracic Oncology Laboratory
  • Member, UCSF Helen Diller Family Comprehensive Cancer Center
  • UCSF Department of Surgery

Research Interests

  • Embryonic signaling pathways such as Wnt signaling
  • Role of the epidermal growth factor receptor (EGFR)
  • Sulf-1 and Sulf-2

Biography

Hassan Lemjabbar-Alaoui, Ph.D. is a biomedical scientist and Principal Investigator in the Thoracic Oncology Laboratory. Dr. Alaoui received his Ph.D. from the University of Paris XII.  Since receiving his Ph.D. from the University of Paris XII, he has been studying the epidermal growth factor receptor (EGFR), the reactivation of embryonic signaling pathways, and the roles these play in lung carcinogenesis.  Dr. Alaoui began these studies in 1997 as a postdoctoral fellow/Assistant Research Anatomist in Dr. Carol Basbaum's lab at UCSF, continued them as an Associate Research Anatomist in Steven Rosen's lab, and then as an Assistant Professor of Anatomy at UCSF. 

Research Overview

Dr. Alaoui's research is focused the role of the epidermal growth factor receptor (EGFR) in lung carcinogenesis as well as reactivation of embryonic signaling pathways such as Wnt signaling.The Alaoui Lab is a core component of the UCSF Thoracic Oncology Lab, Dr. Alaoui is currently investigating two extracellular regulators of Wnt signaling, Sulf-1 and Sulf-2, as new therapeutic targets and their role in promoting cell proliferation, survival, and angiogenesis, and in resistance to chemotherapy. Characterized a decade ago in the lab of Dr. Steven Rosen, these enzymes act on extracellular heparan sulfate. Sulfs remove specific internal sulfate residues from heparan sulfate proteoglycans (HSPGs) on both the cell surface and within the extracellular matrix.

 

Clinical Trials

Study ID: Rob test Sept 10 2013
 

Publications

Most recent publications from a total of 21
  1. Kim JH, Chan C, Elwell C, Singer MS, Dierks T, Lemjabbar-Alaoui H, Rosen SD, Engel JN. Endosulfatases SULF1 and SULF2 limit Chlamydia muridarum infection. Cell Microbiol. 2013 Sep; 15(9):1560-71. View in PubMed
  2. Lui NS, van Zante A, Rosen SD, Jablons DM, Lemjabbar-Alaoui H. SULF2 expression by immunohistochemistry and overall survival in oesophageal cancer: a cohort study. BMJ Open. 2012; 2(6). View in PubMed
  3. Lemjabbar-Alaoui H, Sidhu SS, Mengistab A, Gallup M, Basbaum C. TACE/ADAM-17 phosphorylation by PKC-epsilon mediates premalignant changes in tobacco smoke-exposed lung cells. PLoS One. 2011; 6(3):e17489. View in PubMed
  4. Rosen SD, Lemjabbar-Alaoui H. Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate. Expert Opin Ther Targets. 2010 Sep; 14(9):935-49. View in PubMed
  5. Sidhu SS, Nawroth R, Retz M, Lemjabbar-Alaoui H, Dasari V, Basbaum C. EMMPRIN regulates the canonical Wnt/beta-catenin signaling pathway, a potential role in accelerating lung tumorigenesis. Oncogene. 2010 Jul 22; 29(29):4145-56. View in PubMed
  6. Uchimura K, Lemjabbar-Alaoui H, van Kuppevelt TH, Rosen SD. Use of a phage display antibody to measure the enzymatic activity of the Sulfs. Methods Enzymol. 2010; 480:51-64. View in PubMed
  7. Lemjabbar-Alaoui H, van Zante A, Singer MS, Xue Q, Wang YQ, Tsay D, He B, Jablons DM, Rosen SD. Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis. Oncogene. 2010 Feb 4; 29(5):635-46. View in PubMed
  8. Lemjabbar-Alaoui H, Dasari V, Sidhu SS, Mengistab A, Finkbeiner W, Gallup M, Basbaum C. Wnt and Hedgehog are critical mediators of cigarette smoke-induced lung cancer. PLoS One. 2006; 1:e93. View in PubMed
  9. Dasari V, Gallup M, Lemjabbar H, Maltseva I, McNamara N. Epithelial-mesenchymal transition in lung cancer: is tobacco the "smoking gun"? Am J Respir Cell Mol Biol. 2006 Jul; 35(1):3-9. View in PubMed
  10. Gensch E, Gallup M, Sucher A, Li D, Gebremichael A, Lemjabbar H, Mengistab A, Dasari V, Hotchkiss J, Harkema J, Basbaum C. Tobacco smoke control of mucin production in lung cells requires oxygen radicals AP-1 and JNK. J Biol Chem. 2004 Sep 10; 279(37):39085-93. View in PubMed
  11. View All Publications
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