University of Debrecen, Hungary, B.S., Biology & Chemistry, 1989
University of Debrecen, Hungary Ph.D., Organic Chemistry, 1997
Carbohydrate based therapeutics.
Small molecule kinase inhibitors
Csaba J. Peto, Ph.D. joined the Thoracic Oncology Laboratory in January 2013 as a synthetic medicinal chemist. His primary research focus is the discovery and development of small molecule drug candidates for cancer therapy. Previous to his appointment as a specialist at UCSF, Dr. Peto has has twenty years of experience in the biotech industry, notably at Tualrik and Exelixis.
Dr. Peto designs and synthesizes compounds for multi parametric optimization. During his tenure at Exelixis, Inc., Dr. Peto played a key role in research and development of orally available, small molecule kinase inhibitors that target oncogenic signaling pathways, identifying five development candidates (IND), of which four entered into clinical trials, most notably GDC-0973, a small molecule MEK inhibitor.
Liu S, Hsieh D, Yang YL, Xu Z, Peto C, Jablons DM, You L. Coumestrol from the national cancer Institute's natural product library is a novel inhibitor of protein kinase CK2. BMC Pharmacol Toxicol. 2013; 14:36. View in PubMed
Bussenius J, Blazey CM, Aay N, Anand NK, Arcalas A, Baik T, Bowles OJ, Buhr CA, Costanzo S, Curtis JK, DeFina SC, Dubenko L, Heuer TS, Huang P, Jaeger C, Joshi A, Kennedy AR, Kim AI, Lara K, Lee J, Li J, Lougheed JC, Ma S, Malek S, Manalo JC, Martini JF, McGrath G, Nicoll M, Nuss JM, Pack M, Peto CJ, Tsang TH, Wang L, Womble SW, Yakes M, Zhang W, Rice KD. Discovery of XL888: a novel tropane-derived small molecule inhibitor of HSP90. Bioorg Med Chem Lett. 2012 Sep 1; 22(17):5396-404. View in PubMed
Rice KD, Aay N, Anand NK, Blazey CM, Bowles OJ, Bussenius J, Costanzo S, Curtis JK, Defina SC, Dubenko L, Engst S, Joshi AA, Kennedy AR, Kim AI, Koltun ES, Lougheed JC, Manalo JC, Martini JF, Nuss JM, Peto CJ, Tsang TH, Yu P, Johnston S. Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973). ACS Med Chem Lett. 2012 May 10; 3(5):416-21. View in PubMed
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