Department of Surgery »  Faculty »  Adult Cardiothoracic Surgery »  Carlo C. Maley, Ph.D.

Carlo C. Maley, Ph.D.

Associate Professor
Director of the Center for Evolution and Cancer
Division of Adult Cardiothoracic Surgery
Thoracic Oncology Program
Helen Diller Family Comprehensive Cancer Center

Contact Information

2340 Sutter Street
Room N215, Box 1351,
University of California, San Francisco
San Francisco, CA 94143-0128
(415) 514-0592
(415) 502-3179 (Fax)
carlo.maley@ucsf.edu

Education

  • 1987-1991 B.A. Oberlin College (Computer Science/Psychology)
  • 1991-1993 M.Sc. University of Oxford (Zoology, with W. D. Hamilton, Marshall Scholarship)
  • 1993-1998 Ph.D. Massachusetts Institute of Technology (Computer Science, with R. Brooks at MIT, and Organismic and Evolutionary Biology with M. J. Donoghue at Harvard)

Postdoctoral Training

  • 1998 Postdoctoral Fellow, Harvard University, Cambridge
  • 1998-2000 Visiting Professor and Postdoctoral Fellow, University of New Mexico

Program Affiliations

  • Thoracic Oncology Program
  • Thoracic Oncology Laboratory
  • UCSF Helen Diller Family Comprehensive Cancer Center
  • UCSF Bioinformatics program
  • UCSF Pharmaceutical Sciences and Pharmacogenomics program

Research Interests

  • Applying phylogenetic methods to measure somatic evolution in neoplasms (e.g., in Barrett's Esophagus).
  • Computational modeling of neoplastic progression.
  • Harnessing clonal evolution to prevent cancer and cancer mortality.
  • Measuring genetic diversity in neoplasms and testing if it predicts both progression and therapeutic resistance.
  • Peto's paradox: Why don't whales, with 1000X more cells than humans, get 1000X more cancer?
  • Single cell, high throughput sequencing of the (epi)genetics of neoplasms.
  • Therapeutic resistance in acute myeloid leukemia (AML).

Biography

Carlo C. Maley, Ph.D. is an Associate Professor in the Department of Surgery, a member of the Thoracic Oncology Program and a Principal Investigator in the Thoracic Oncology Lab and  Maley Lab. The UCSF Helen Diller Family Comprehensive Cancer Center has also tapped Dr. Maley to lead a new Center for Evolution and Cancer.

Dr. Maley received his B.A. in computer science and psychology from Oberlin College in 1991 and his M.Sc. in Zoology (evolutionary theory) from University of Oxford in 1993 where he worked with William D. Hamilton. In 1998, Dr. Maley received a Ph.D. in Computer Science from MIT where he worked with Michael Donoghue and Rodney Brooks.

Dr. Maley did his postdoctoral training at the University of New Mexico, mentored by Professor Stephanie Forrest, and at the Fred Hutchinson Cancer Research Center by Dr. Brian Reid.

Prior to joining UCSF, Dr. Maley was an assistant professor at the Wistar Institute, and a member of two other graduate programs at the University of Pennsylvania: Genomics and Computational Biology, and Cellular and Molecular Biology.

Research Overview

Dr. Maley is interested in the evolution of cancer, both at the level of cells evolving in neoplasms and at the level of the effects of cancer as a selective pressure on multicellular organisms. The Maley laboratory is exploring fundamental concepts in neoplastic progression, the process by which normal tissue becomes cancerous, and the evolution of therapeutic resistance, for purposes of developing better methods for cancer prevention and therapy.

The Maley Laboratory studies the evolution of clones during neoplastic progression of Barrett's esophagus as well as the selective effects of therapy in acute myeloid leukemia (AML) and esophageal adenocarcinoma. It is also developing the comparative biology of cancer to determine how large, long-lived organisms like whales are able to suppress cancer 1000-fold better than humans.

The Maley laboratory is applying evolutionary and ecological theory to neoplastic progression and cancer therapy in order to modulate the evolution of neoplastic cells and thereby prevent cancer and its relapse. It take three, mutually reinforcing approaches to these problems:

  1. Computational simulations to explore hypotheses
  2. Data mining of (and application of evolutionary theory to) genetic and epigenetic data from neoplasms
  3. Evolutionary experiments in tissue culture.
 

Publications

Most recent publications from a total of 49
  1. Li X, Galipeau PC, Paulson TG, Sanchez CA, Arnaudo J, Liu K, Sather CL, Kostadinov RL, Odze RD, Kuhner MK, Maley CC, Self SG, Vaughan TL, Blount PL, Reid BJ. Temporal and Spatial Evolution of Somatic Chromosomal Alterations: A Case-Cohort Study of Barrett's Esophagus. Cancer Prev Res (Phila). 2014 Jan; 7(1):114-27. View in PubMed
  2. Aktipis CA, Boddy AM, Gatenby RA, Brown JS, Maley CC. Life history trade-offs in cancer evolution. Nat Rev Cancer. 2013 Dec; 13(12):883-92. View in PubMed
  3. Kostadinov RL, Kuhner MK, Li X, Sanchez CA, Galipeau PC, Paulson TG, Sather CL, Srivastava A, Odze RD, Blount PL, Vaughan TL, Reid BJ, Maley CC. NSAIDs modulate clonal evolution in Barrett's esophagus. PLoS Genet. 2013 Jun; 9(6):e1003553. View in PubMed
  4. S Datta R, Gutteridge A, Swanton C, Maley CC, Graham TA. Modelling the evolution of genetic instability during tumour progression. Evol Appl. 2013 Jan; 6(1):20-33. View in PubMed
  5. Sprouffske K, Athena Aktipis C, Radich JP, Carroll M, Nedelcu AM, Maley CC. An evolutionary explanation for the presence of cancer nonstem cells in neoplasms. Evol Appl. 2013 Jan; 6(1):92-101. View in PubMed
  6. Sprouffske K, Merlo LM, Gerrish PJ, Maley CC, Sniegowski PD. Cancer in light of experimental evolution. Curr Biol. 2012 Sep 11; 22(17):R762-71. View in PubMed
  7. Roche B, Hochberg ME, Caulin AF, Maley CC, Gatenby RA, Misse D, Thomas F. Natural resistance to cancers: a Darwinian hypothesis to explain Peto's paradox. BMC Cancer. 2012; 12:387. View in PubMed
  8. Kosoff RE, Gardiner KL, Merlo LM, Pavlov K, Rustgi AK, Maley CC. Development and characterization of an organotypic model of Barrett's esophagus. J Cell Physiol. 2012 Jun; 227(6):2654-9. View in PubMed
  9. Greaves M, Maley CC. Clonal evolution in cancer. Nature. 2012 Jan 19; 481(7381):306-13. View in PubMed
  10. Aktipis CA, Kwan VS, Johnson KA, Neuberg SL, Maley CC. Overlooking evolution: a systematic analysis of cancer relapse and therapeutic resistance research. PLoS One. 2011; 6(11):e26100. View in PubMed
  11. View All Publications
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