Biao He, Ph.D.

Associate Professor
Division of Adult Cardiothoracic Surgery

Contact Information

2340 Sutter Street N-222, Box 1724
University of California, San Francisco
San Francisco, CA 94143-1724
(415) 476-6907 Phone
biao.he@ucsfmedctr.org

Education

  • 1988-93, Tsinghua University, Beijing, China B.Sc.  Biochemistry
  • 1993-95, Tsinghua University, Beijing, China M.S.  Biochemistry
  • 1995-01, University of Virginia Ph.D.  Molecular Genetics

Fellowships

  • 1992 Guanghua Scholarship Tsinghua University, Beijing, China
  • 1995 Hua Luogeng Memorial Fellowship Tsinghua University, Beijing, China
  • 1995-1996 Fellowship

Postdoctoral Training

  • 2001-02, Postdoctoral Researcher, UCSF Helen Diller Family Comprehensive Cancer Center,
  • 2002-04, Assistant Research Molecular Biologist, UCSF Helen Diller Family Comprehensive Cancer Center

Program Affiliations

  • Thoracic Oncology Program
  • Thoracic Oncology Laboratory
  • UCSF Helen Diller Family Comprehensive Cancer Center
  • UCSF Department of Surgery

Research Interests

  • Epigenetics
  • Isolation of lung cancer stem cells
  • Microarrays and high throughput scanning
  • Novel targeted therapies for lung & colon cancer, mesothelioma
  • Small molecule inhibitors
  • Stem cell biology, cancer stem cells
  • Wnt and Hedgehog signaling

Biography

Dr. Biao He is a molecular geneticist and senior scientist in the Thoracic Oncology Laboratory at the UCSF Helen Diller Family Comprehensive Cancer Center. Dr. He graduated from the prestigious Tsinghua University in Beijing, China with a B.S. and M.S. in Biochemistry. He later received a Ph.D. from the University of Virginia in molecular genetics. Dr. He was recruited to the Thoracic Oncology Laboratory based on his extensive knowledge of the Wnt signaling pathway and RNA interference (RNAi). He began as a postdoctoral fellow and soon advanced to the position of Assistant Research Molecular Biologist. In 2004, Dr. He joined the UCSF faculty as an Assistant Professor in the Department of Surgery. Since 2001, Dr. He has been the author of numerous peer-reviewed papers. His current research is focused on the molecular mechanisms of non-small cell lung cancer and mesothelioma. He is also developing targeted therapies against these diseases.

Dr. He has also been the recipient of numerous awards including the Hua Luogeng Memorial Fellowship, Eileen Ludwig Award for Thoracic Oncology Research, and Barbara Isackson Award for Thoracic Oncology Research.

Research Overview

Dr. He's current research focuses on the molecular mechanisms in tumorigenesis of lung cancer and malignant mesothelioma, and the development of targeted therapies for these cancer types. Dr. He has been a PI and co-PI of a number of research projects funded by NIH and Foundations, such as, identification and validation of novel potential therapeutic targets in lung cancer and mesothelioma; role of inflammation and epigenetic alterations in lung carcinogenesis; elucidation of novel molecular mechanisms involving Wnt and Hedgehog signal pathways in carcinogenesis; identification and validation of prognostic and predictive markers; and development of small molecule inhibitors of signaling pathways as potential leads for targeted cancer therapies.

 

Publications

Most recent publications from a total of 62
  1. Giroux Leprieur E, Hirata T, Mo M, Chen Z, Okamoto J, Clement G, Li H, Wislez M, Jablons DM, He B. The homeobox gene EMX2 is a prognostic and predictive marker in malignant pleural mesothelioma. Lung Cancer. 2014 Sep; 85(3):465-71. View in PubMed
  2. Yue D, Li H, Che J, Zhang Y, Tseng HH, Jin JQ, Luh TM, Giroux-Leprieur E, Mo M, Zheng Q, Shi H, Zhang H, Hao X, Wang C, Jablons DM, He B. Hedgehog/Gli promotes epithelial-mesenchymal transition in lung squamous cell carcinomas. J Exp Clin Cancer Res. 2014; 33(1):34. View in PubMed
  3. Okada N, Lin CP, Ribeiro MC, Biton A, Lai G, He X, Bu P, Vogel H, Jablons DM, Keller AC, Wilkinson JE, He B, Speed TP, He L. A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression. Genes Dev. 2014 Mar 1; 28(5):438-50. View in PubMed
  4. Mo ML, Okamoto J, Chen Z, Hirata T, Mikami I, Bosco-Clément G, Li H, Zhou HM, Jablons DM, He B. Down-regulation of SIX3 is associated with clinical outcome in lung adenocarcinoma. PLoS One. 2013; 8(8):e71816. View in PubMed
  5. Kratz JR, Tham PT, Mulvihill MS, Ziaei F, Ray MR, Hurst JW, Segal MR, Berryman DM, Chu W, He B, Jablons DM, Mann MJ. Analytical validation of a practical molecular assay prognostic of survival in nonsquamous non-small cell lung cancer. Diagn Mol Pathol. 2013 Jun; 22(2):65-9. View in PubMed
  6. Bosco-Clément G, Zhang F, Chen Z, Zhou HM, Li H, Mikami I, Hirata T, Yagui-Beltran A, Lui N, Do HT, Cheng T, Tseng HH, Choi H, Fang LT, Kim IJ, Yue D, Wang C, Zheng Q, Fujii N, Mann M, Jablons DM, He B. Targeting Gli transcription activation by small molecule suppresses tumor growth. Oncogene. 2014 Apr 17; 33(16):2087-97. View in PubMed
  7. Mo ML, Chen Z, Zhou HM, Li H, Hirata T, Jablons DM, He B. Detection of E2A-PBX1 fusion transcripts in human non-small-cell lung cancer. J Exp Clin Cancer Res. 2013; 32:29. View in PubMed
  8. Li H, Lui N, Cheng T, Tseng HH, Yue D, Giroux-Leprieur E, Do HT, Sheng Q, Jin JQ, Luh TW, Jablons DM, He B. Gli as a novel therapeutic target in malignant pleural mesothelioma. PLoS One. 2013; 8(3):e57346. View in PubMed
  9. Zhang Y, He J, Zhang F, Li H, Yue D, Wang C, Jablons DM, He B, Lui N. SMO expression level correlates with overall survival in patients with malignant pleural mesothelioma. J Exp Clin Cancer Res. 2013; 32:7. View in PubMed
  10. Tseng HH, He B. Molecular markers as therapeutic targets in lung cancer. Chin J Cancer. 2013 Feb; 32(2):59-62. View in PubMed
  11. View All Publications
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